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  1. Article: Clinical application of medical adhesive in endovascular embolization treatment of peripheral pseudoaneurysm.

    Jiang, Li-Ping / Wang, Qi-Bin

    Journal of clinical imaging science

    2024  Volume 14, Page(s) 2

    Abstract: Objectives: This study explores the clinical application value of medical adhesive in endovascular embolization treatment of peripheral pseudoaneurysm.: Material and methods: This was a retrospective review on 31 patients with peripheral ... ...

    Abstract Objectives: This study explores the clinical application value of medical adhesive in endovascular embolization treatment of peripheral pseudoaneurysm.
    Material and methods: This was a retrospective review on 31 patients with peripheral pseudoaneurysm treated with medical adhesive endovascular embolization at the First Affiliated Hospital of Shihezi University from July 2021 to July 2023. Follow-up for 3-6 months was to observe the clinical efficacy and postoperative complications of medical adhesive embolization treatment.
    Results: A total of 32 pseudoaneurysms were embolized in 31 patients with peripheral pseudoaneurysms. All pseudoaneurysms originated from visceral arteries. Among them, 29 pseudoaneurysms were embolized with medical adhesive alone, and three pseudoaneurysms were embolized with coil-assisted medical adhesive. After endovascular embolization with medical adhesive, all pseudoaneurysms were successfully embolized. Technical success was 100%. All patients experienced cessation of bleeding after endovascular embolization with medical adhesive, and there were no serious post-operative complications. Clinical success was 100%. During the follow-up period, two patients experienced recurrent bleeding but no pseudoaneurysm recurrence was observed.
    Conclusion: Endovascular medical adhesive embolization is a safe and effective method for treating pseudoaneurysm, with high hemostatic efficiency and permanent occlusion of the pseudoaneurysm after embolization, which is worthy of clinical promotion and application.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601233-9
    ISSN 2156-5597 ; 2156-7514
    ISSN (online) 2156-5597
    ISSN 2156-7514
    DOI 10.25259/JCIS_120_2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Influence of ORM1 polymorphism on serum concentration of free nortriptyline].

    Zhang, Che / Tu, Zi-Liang / Wang, Qi-Bin / Cheng, Xiao-Li / Zhang, Peng-Hua

    Yao xue xue bao = Acta pharmaceutica Sinica

    2007  Volume 42, Issue 8, Page(s) 843–848

    Abstract: To study the effect of alpha1-acid glycoprotein 1 (ORM1) polymorphism on the concentration of free nortriptyline in serum, genotyping analysis was employed in ORM1 by sequencing. Eighteen unrelated male adults were chosen and given a single dose of 25 mg ...

    Abstract To study the effect of alpha1-acid glycoprotein 1 (ORM1) polymorphism on the concentration of free nortriptyline in serum, genotyping analysis was employed in ORM1 by sequencing. Eighteen unrelated male adults were chosen and given a single dose of 25 mg nortriptyline orally, then the blood samples were taken at 0, 1, 2, 3, 4, 6, 8, 12, 24, 32, 48, 72, 96 and 168 hours after drug administration. Nortriptyline and 10-OH-nortriptyline in serum and ultrafiltrate were detected for the total and free concentration by using HPLC-MS/MS. Pharmacokinetic parameters were compared among different ORM1 genotypes. No significant differences were shown in the pharmacokinetic parameters of total nortriptyline and 10-OH-nortriptyline. The mean AUC(0-infinity) of free nortritpyline in ORM1 * F/ * F1 subjects was significantly higher than that in ORM1 * F1/ * S and ORM1 * S/ * S subjects [(119.1 +/- 74.4) ng x mL(-1) x h vs (51.4 +/- 23.2) ng x mL(-1) x h and (42.4 +/- 11.6) ng x mL(-1) x h]. The percentage of protein binding in subjects with ORM1 * F1/ * F1 genotype at 2, 3, 4, 6, 8 and 12 h after administration was slightly lower than in those with ORM1 * F1/ * S and ORM1 * S/ * S genotypes while the distinct difference was shown at 4 h (P < 0.05). Different ORM1 genotypes might affect the protein binding percentage and the concentration of serum free nortriptyline. The ability binding to the drug was higher in subjects with ORM1 * S/ * S genotype than in those with other two genotypes, so as to cause the lower concentration of free nortriptyline.
    MeSH term(s) Adult ; Area Under Curve ; Genotype ; Humans ; Male ; Nortriptyline/analogs & derivatives ; Nortriptyline/blood ; Nortriptyline/pharmacokinetics ; Orosomucoid/genetics ; Orosomucoid/metabolism ; Polymorphism, Genetic ; Protein Binding
    Chemical Substances Orosomucoid ; 10-hydroxynortriptyline (1156-99-6) ; Nortriptyline (BL03SY4LXB)
    Language Chinese
    Publishing date 2007-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 788758-9
    ISSN 0513-4870
    ISSN 0513-4870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Variable food-specific IgG antibody levels in healthy and symptomatic Chinese adults.

    Zeng, Qiang / Dong, Sheng-Yong / Wu, Liu-Xin / Li, Hong / Sun, Zhi-Jian / Li, Jing-Bo / Jiang, Hong-Xia / Chen, Zhi-Heng / Wang, Qi-Bin / Chen, Wei-Wei

    PloS one

    2013  Volume 8, Issue 1, Page(s) e53612

    Abstract: Background: The presence of food-specific IgG antibodies in human serum may be useful for diagnosis of adverse food reactions. However, the clinical utility of testing for such antibodies remains very controversial. The aim of this study was to evaluate ...

    Abstract Background: The presence of food-specific IgG antibodies in human serum may be useful for diagnosis of adverse food reactions. However, the clinical utility of testing for such antibodies remains very controversial. The aim of this study was to evaluate the serum levels and population distribution of food-specific IgGs and their association with chronic symptoms in a large-scale Chinese population.
    Methodology/principal findings: A total of 21305 adult participants from different regions of China had 14 type of food-specific serum IgG antibodies that were measured by enzyme-linked immunosorbent assay. Among these, 5,394 participants were randomly chosen to complete follow-up questionnaire surveys on their dietary characteristics and chronic symptoms. The concentrations of food-specific IgGs against 14 foods ranged from a median (interquartile range) of 7.3 (3.8, 12.6) U/mL of pork-specific IgG to 42.3 (28.8, 60.2) U/mL of crab-specific IgG. The concentration of food-specific IgGs was closely related to gender; after adjustment for region and age, women had higher concentrations of food-specific IgGs against all of the 14 foods except chicken (regression coefficient (95% CI): 0.01 (-0.003, 0.023); P = 0.129) and corn (0.002 (-0.013, 0.016); P = 0.825). Similar results were also found in the relationship of geographic region to the food-specific IgG concentrations for the 14 foods. Chronic symptoms were negatively associated with the concentrations of a few food-specific IgGs, and were positively associated with the concentrations of other food-specific IgGs.
    Conclusions: The levels of food-specific IgGs were variable both in healthy and in symptomatic Chinese adults. These findings raise awareness that demographic factors, the type of food and specific chronic symptoms should be considered before food elimination treatment based on IgG testing in patients with chronic symptoms is used in clinical practice.
    MeSH term(s) Adolescent ; Adult ; Aged ; China ; Enzyme-Linked Immunosorbent Assay ; Female ; Food ; Food Hypersensitivity/blood ; Food Hypersensitivity/immunology ; Humans ; Immunoglobulin G/blood ; Male ; Meat ; Middle Aged ; Regression Analysis ; Surveys and Questionnaires ; Young Adult ; Zea mays
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2013-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0053612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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