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  1. Article ; Online: Editorial: Prevention of viral diseases by gene targeting.

    Luo, Fan / Wang, Qiankun / Chen, Shuliang

    Frontiers in genome editing

    2024  Volume 6, Page(s) 1395468

    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-3439
    ISSN (online) 2673-3439
    DOI 10.3389/fgeed.2024.1395468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inflammasomes in Human Immunodeficiency Virus Type 1 Infection.

    Wang, Qiankun / Shan, Liang

    Infectious diseases & immunity

    2022  Volume 2, Issue 4, Page(s) 248–252

    Abstract: Innate immune responses are the host's first line of defense against human immunodeficiency virus type 1 (HIV-1) infection, with pattern recognition receptors detecting viral specific pathogen-associated molecular patterns and initiating antiviral ... ...

    Abstract Innate immune responses are the host's first line of defense against human immunodeficiency virus type 1 (HIV-1) infection, with pattern recognition receptors detecting viral specific pathogen-associated molecular patterns and initiating antiviral responses. In response to HIV-1 nucleic acids or proteins, some pattern recognition receptors have the ability to assemble a large multiprotein complex called the inflammasome, which triggers pro-inflammatory cytokine release and a form of lytic programmed cell death called pyroptosis. Here, we review our current understanding of the mechanism of the inflammasome in sensing HIV-1 infection. Furthermore, we discuss the contribution of inflammasome activation in HIV-1 pathogenesis as well as potential strategies of targeting inflammasome activation for the treatment of HIV-1 infection.
    Language English
    Publishing date 2022-09-22
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2693-8839
    ISSN (online) 2693-8839
    DOI 10.1097/ID9.0000000000000070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CARD8 makes coxsackievirus more "heartbreaking".

    Wang, Qiankun / Shan, Liang

    The Journal of experimental medicine

    2022  Volume 219, Issue 10

    Abstract: In this issue of JEM, Nadkarni et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212117) identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral ...

    Abstract In this issue of JEM, Nadkarni et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212117) identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation.
    MeSH term(s) Endothelial Cells ; Myocytes, Cardiac ; Peptide Hydrolases ; Virus Replication
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20221240
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  4. Article ; Online: CARD8 Inflammasome Activation by HIV-1 Protease.

    Clark, Kolin M / Wang, Qiankun / Shan, Liang

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2641, Page(s) 67–79

    Abstract: The pattern recognition receptor CARD8 is an inflammasome sensor for intracellular HIV-1 protease activity. Previously, the only method for studying the CARD8 inflammasome has been through utilizing DPP8/DPP9 inhibitors including Val-boroPro (VbP) to ... ...

    Abstract The pattern recognition receptor CARD8 is an inflammasome sensor for intracellular HIV-1 protease activity. Previously, the only method for studying the CARD8 inflammasome has been through utilizing DPP8/DPP9 inhibitors including Val-boroPro (VbP) to modestly and nonspecifically activate the CARD8 inflammasome. The identification of HIV-1 protease as a target for sensing by CARD8 has opened the door for a new method of studying the underlying mechanism of CARD8 inflammasome activation. Additionally, triggering the CARD8 inflammasome offers a promising strategy for reducing HIV-1 latent reservoirs. Here we describe the methods to study CARD8 sensing of HIV-1 protease activity through non-nucleoside reverse transcriptase inhibitor (NNRTI)-mediated pyroptosis of HIV-1-infected immune cells and through an HIV and CARD8 co-transfection model.
    MeSH term(s) Inflammasomes/metabolism ; CARD Signaling Adaptor Proteins/metabolism ; Apoptosis Regulatory Proteins/metabolism ; HIV Protease
    Chemical Substances Inflammasomes ; CARD Signaling Adaptor Proteins ; p16 protease, Human immunodeficiency virus 1 (EC 3.4.23.-) ; Apoptosis Regulatory Proteins ; HIV Protease (EC 3.4.23.-)
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3040-2_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cervical cancer prevention in China: where are we now, and what's next?

    Yan, Huijiao / Wang, Qiankun / Qiao, Youlin

    Cancer biology & medicine

    2023  Volume 21, Issue 3

    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/prevention & control ; China/epidemiology
    Language English
    Publishing date 2023-12-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 2676322-9
    ISSN 2095-3941
    ISSN 2095-3941
    DOI 10.20892/j.issn.2095-3941.2023.0432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: PRKCSH serves as a potential immunological and prognostic biomarker in pan-cancer.

    Wang, Qiankun / Wang, Xiong / Li, Jiaoyuan / Yin, Tongxin / Wang, Yi / Cheng, Liming

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1778

    Abstract: Protein kinase C substrate 80K-H (PRKCSH) plays a crucial role in the protein N-terminal glycosylation process, with emerging evidence implicating its involvement in tumorigenesis. To comprehensively assess PRKCSH's significance across cancers, we ... ...

    Abstract Protein kinase C substrate 80K-H (PRKCSH) plays a crucial role in the protein N-terminal glycosylation process, with emerging evidence implicating its involvement in tumorigenesis. To comprehensively assess PRKCSH's significance across cancers, we conducted a pan-cancer analysis using data from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Cancer Cell Line Encyclopedia (CCLE). We assessed aberrant PRKCSH mRNA and protein expression, examined its prognostic implications, and identified correlations with clinical features, tumor mutational burden (TMB), microsatellite instability (MSI), and tumor immunity across cancer types. We explored PRKCSH gene alterations, DNA methylation, and their impact on patient prognosis. Gene Set Enrichment Analysis (GSEA) and single-cell analysis revealed potential biological roles. Additionally, we investigated drug susceptibility and conducted Connectivity Map (Cmap) analysis. Key findings revealed that PRKCSH exhibited overexpression in most tumors, with a significant association with poor overall survival (OS) in six cancer types. Notably, PRKCSH expression demonstrated variations across disease stages, primarily increasing in advanced stages among eleven tumor types. Moreover, PRKCSH exhibited significant correlations with TMB in five cancer categories, MSI in eight, and displayed associations with immune cell populations in pan-cancer analysis. Genetic variations in PRKCSH were identified across 26 tumor types, suggesting favorable disease-free survival. Furthermore, PRKCSH methylation displayed a significant negative correlation with its expression in 27 tumor types, with a marked decrease compared to normal tissues in ten tumors. Cmap predicted 24 potential therapeutic small molecules in over four cancer types. This study highlights that PRKCSH, as a potential oncogene, may be a promising prognostic marker and therapeutic target of immunotherapy for a range of malignancies.
    MeSH term(s) Humans ; Prognosis ; Neoplasms/genetics ; Oncogenes ; Carcinogenesis ; Microsatellite Instability ; Biomarkers ; Calcium-Binding Proteins ; Glucosidases
    Chemical Substances Biomarkers ; PRKCSH protein, human (EC 3.2.1.-) ; Calcium-Binding Proteins ; Glucosidases (EC 3.2.1.-)
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52153-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Enhanced natural degradation of cyanide tailings: Integrated application of solar drying system and UV irradiation.

    Liu, Qiang / Wu, Zengling / Sun, Zhongmei / Wang, Qiankun / Shi, Jiyan

    Journal of hazardous materials

    2023  Volume 458, Page(s) 131871

    Abstract: Cyanide tailings are the bulk solid waste generated by the production processes of gold mines. Since the highly toxicity of cyanide affects its disposal and comprehensive utilization, a decyanation treatment is needed. However, wide-ranging industrial ... ...

    Abstract Cyanide tailings are the bulk solid waste generated by the production processes of gold mines. Since the highly toxicity of cyanide affects its disposal and comprehensive utilization, a decyanation treatment is needed. However, wide-ranging industrial uses of the current decyanation methods are restricted due to the treatment effects and costs. Based on the natural degradation method, the cyanide treatment effect was enhanced by raising the treatment temperature, increasing the ultraviolet (UV) irradiation and turning the pile periodically. Using the Arrhenius equation, the activation energies of the cyanide hydrolysis reactions were calculated as 52.22 kJ/mol and 34.59 kJ/mol for heating alone and for heating combined with UV irradiation, respectively. At 60 ℃, the cyanide tailings reached the discharge standard (leachate, total cyanide (CNt)< 5 mg/L) after 8 h of treatment. Moreover, after adding UV irradiation (with an intensity of 120 μW/cm
    Language English
    Publishing date 2023-06-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2023.131871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Development and Vibration Control of Frequency Adjustable Tuned Mass Damper Based on Magnetorheological Elastomer.

    Zhang, Jiarui / Zhu, Yaoyang / Tu, Jianwei / Li, Zhao / Wang, Qiankun

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 5

    Abstract: Tuned mass dampers (TMD) have been widely used in passive vibration control, but their main disadvantage is that the vibration reduction effect may be greatly affected by the natural frequency of the main structure. In order to solve this limitation, we ... ...

    Abstract Tuned mass dampers (TMD) have been widely used in passive vibration control, but their main disadvantage is that the vibration reduction effect may be greatly affected by the natural frequency of the main structure. In order to solve this limitation, we designed a frequency adjustable tuned mass damper (FATMD) based on a magneto rheological elastomer (MRE), which is a new type of magneto rheological smart material, with adjustable stiffness, obtained by changing the magnetic induction. We used MRE to change the stiffness of FATMD to track the natural frequency of the main structure. However, adding TMD will change the natural frequency of the system. Therefore, we combined Hilbert-Huang transform (HHT) and a natural excitation technique (NExT), with Simulink/dSPACE, to identify the natural frequency of the system in real time, and then calculated the natural frequency of the main structure through the TMD optimal design theory. This can help adjust FATMD to its optimum tuning state. To verify the applicability and effectiveness of FATMD, this paper compares the FATMD and traditional TMD experimental results. The natural frequency of steel beams can be changed by adding mass blocks. The experimental results indicate that FATMD, using the frequency tracking method, can effectively track the natural frequency of the main structure to ensure that the system is always in the optimum tuning state. In addition, FATMD can still achieve a good vibration reduction effect when the natural frequency of the main structure changes.
    Language English
    Publishing date 2022-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15051829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Mechanical Behavior and Healing Efficiency of Microcapsule-Based Cemented Coral Sand under Various Water Environments.

    Qin, Yue / Wang, Qiankun / Xu, Dongsheng / Chen, Wei

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 19

    Abstract: The cracks in the cemented coral sand (CCS) would result in significant damage for the marine structures. In this study, the effective and efficiency of microcapsules in self-healing CCS under various water environments were investigated with a series of ...

    Abstract The cracks in the cemented coral sand (CCS) would result in significant damage for the marine structures. In this study, the effective and efficiency of microcapsules in self-healing CCS under various water environments were investigated with a series of experimental tests. Firstly, a new preparation method was proposed to fabricate the microcapsules with a wide particle size distribution, which was adapted to the high porosity, large difference in pore size, and uneven distribution of CCS. Secondly, the mechanical properties of microcapsule-based CCS were examined by the uniaxial compressive tests and split Hopkinson pressure bar (SHPB) tests. The results indicated that the microcapsule could improve the initial strength of CCS. The CCS mixed with 3% of the microcapsule that synthesized under a rotating speed of 450 rmp had the highest compressive strength at the initial strain state. Finally, the healing efficiency of microcapsule for CCS was investigated in various environmental conditions, which were freshwater, seawater, and water of various pH values. The non-destructive experiment approach of the piezoelectric transducer (PZT) test was adopted to evaluate the healing efficiency of microcapsules. Experimental results indicated that the healing efficiency of microcapsules in freshwater and seawater were 75% and 59.56%, respectively. In contrast, the acid and alkali water environment would greatly reduce the healing efficiency of microcapsules in CCS.
    Language English
    Publishing date 2021-09-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14195571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The CARD8 inflammasome in HIV infection.

    Clark, Kolin M / Pal, Priya / Kim, Josh G / Wang, Qiankun / Shan, Liang

    Advances in immunology

    2023  Volume 157, Page(s) 59–100

    Abstract: The biggest challenge to immune control of HIV infection is the rapid within-host viral evolution, which allows selection of viral variants that escape from T cell and antibody recognition. Thus, it is impossible to clear HIV infection without targeting " ...

    Abstract The biggest challenge to immune control of HIV infection is the rapid within-host viral evolution, which allows selection of viral variants that escape from T cell and antibody recognition. Thus, it is impossible to clear HIV infection without targeting "immutable" components of the virus. Unlike the adaptive immune system that recognizes cognate epitopes, the CARD8 inflammasome senses the essential enzymatic activity of the HIV-1 protease, which is immutable for the virus. Hence, all subtypes of HIV clinical isolates can be recognized by CARD8. In HIV-infected cells, the viral protease is expressed as a subunit of the viral Gag-Pol polyprotein and remains functionally inactive prior to viral budding. A class of anti-HIV drugs, the non-nucleoside reverse transcriptase inhibitors (NNRTIs), can promote Gag-pol dimerization and subsequent premature intracellular activation of the viral protease. NNRTI treatment triggers CARD8 inflammasome activation, which leads to pyroptosis of HIV-infected CD4
    MeSH term(s) Humans ; HIV Infections ; Inflammasomes ; HIV-1 ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/therapeutic use ; Neoplasm Proteins/pharmacology ; Neoplasm Proteins/therapeutic use ; CARD Signaling Adaptor Proteins
    Chemical Substances Inflammasomes ; Anti-HIV Agents ; Reverse Transcriptase Inhibitors ; CARD8 protein, human ; Neoplasm Proteins ; CARD Signaling Adaptor Proteins
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80226-8
    ISSN 1557-8445 ; 0065-2776
    ISSN (online) 1557-8445
    ISSN 0065-2776
    DOI 10.1016/bs.ai.2022.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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