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  1. Book ; Online: Real-time Streaming Perception System for Autonomous Driving

    Gu, Yongxiang / Wang, Qianlei / Qin, Xiaolin

    2021  

    Abstract: Nowadays, plenty of deep learning technologies are being applied to all aspects of autonomous driving with promising results. Among them, object detection is the key to improve the ability of an autonomous agent to perceive its environment so that it can ...

    Abstract Nowadays, plenty of deep learning technologies are being applied to all aspects of autonomous driving with promising results. Among them, object detection is the key to improve the ability of an autonomous agent to perceive its environment so that it can (re)act. However, previous vision-based object detectors cannot achieve satisfactory performance under real-time driving scenarios. To remedy this, we present the real-time steaming perception system in this paper, which is also the 2nd Place solution of Streaming Perception Challenge (Workshop on Autonomous Driving at CVPR 2021) for the detection-only track. Unlike traditional object detection challenges, which focus mainly on the absolute performance, streaming perception task requires achieving a balance of accuracy and latency, which is crucial for real-time autonomous driving. We adopt YOLOv5 as our basic framework, data augmentation, Bag-of-Freebies, and Transformer are adopted to improve streaming object detection performance with negligible extra inference cost. On the Argoverse-HD test set, our method achieves 33.2 streaming AP (34.6 streaming AP verified by the organizer) under the required hardware. Its performance significantly surpasses the fixed baseline of 13.6 (host team), demonstrating the potentiality of application.

    Comment: 6 pages,6 figures
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 629
    Publishing date 2021-07-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis.

    Wang, Qianlei / Asenso, James / Xiao, Ning / Gao, Jinzhang / Xiao, Feng / Kuai, Jiajie / Wei, Wei / Wang, Chun

    Journal of immunology research

    2022  Volume 2022, Page(s) 2280973

    Abstract: Rheumatoid arthritis (RA) is a chronic, persistent autoimmune disease that causes severe joint tissue damage and irreversible disability. Cumulative evidence suggests that patients suffering from RA for long durations are at risk of functional damage to ... ...

    Abstract Rheumatoid arthritis (RA) is a chronic, persistent autoimmune disease that causes severe joint tissue damage and irreversible disability. Cumulative evidence suggests that patients suffering from RA for long durations are at risk of functional damage to cardiovascular, kidney, lung, and other tissues. This seriously affects the quality of work and life of patients. To date, no clear etiology of RA has been found. Recent studies have revealed that the massive proliferation of synoviocytes and immune cells requires a large amount of energy supply. Rapid energy supply depends on the anaerobic glucose metabolic pathway in both RA animal models and clinical patients. Anaerobic glycolysis can increase intracellular lactic acid (LA) content. LA induces the overexpression of monocarboxylate transporters (MCTs) in cell membranes. MCTs rapidly transport LA from the intracellular to the intercellular or articular cavity. Hence, a relatively high accumulation of LA could be formed in the intercellular and articular cavities of inflammatory joints. Moreover, LA contributes to the migration and activation of immune cells. Immune cells proliferate and secrete interleukins (IL) including IL-1, IL-2, IL-13, IL-17, and other inflammatory factors. These inflammatory factors enhance the immune inflammatory response of the body and aggravate the condition of RA patients. In this paper, the effects of LA on RA pathogenesis will be summarized from the perspective of the production, transport, and metabolism of synoviocytes and immune cells. Additionally, the drugs involved in the production, transport, and metabolism of LA are highlighted.
    MeSH term(s) Animals ; Arthritis, Rheumatoid ; Interleukins/metabolism ; Joints/pathology ; Lactic Acid ; Synoviocytes/pathology
    Chemical Substances Interleukins ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2022-08-24
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-7156
    ISSN (online) 2314-7156
    ISSN 2314-7156
    DOI 10.1155/2022/2280973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: OAT3 mediates methotrexate resistance in the treatment of rheumatoid arthritis.

    Gao, Jinzhang / Xiao, Ning / Wang, Qianlei / Xu, Zhengkun / Xiao, Feng / Yang, Zhaoyi / Wei, Wei / Wang, Chun

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 153, Page(s) 113558

    Abstract: Objective: To study whether organic anion transporter 3 (OAT3) is involved in the development of methotrexate (MTX) resistance in the treatment of rheumatoid arthritis.: Methods: The experimental components of the animals were the normal group, ... ...

    Abstract Objective: To study whether organic anion transporter 3 (OAT3) is involved in the development of methotrexate (MTX) resistance in the treatment of rheumatoid arthritis.
    Methods: The experimental components of the animals were the normal group, collagen-induced arthritis (CIA) model group, and MTX treatment group. MTX-treated rats were divided into the MTX effective group (MTX-E) and the MTX ineffective group (MTX-N). MTX-N receives additional treatment with OAT3 lentivirus injected into the joint cavity. Transient transfection was used to alter the expression of OAT3 in rat fibroblast-like synovial (rat-FLS).
    Results: The rate of effectiveness of MTX in treating CIA rats was 48.98%. Compared with CIA rats, MTX-E can greatly improve ankle joint synovial hyperplasia and joint damage, but MTX-N has no significant changes. The expression of OAT3 in the synovium of MTX-E was significantly higher than that of MTX-N. The MTX content in the MTX-E synovium was also higher than that in the MTX-N synovium. After injection of OAT3 overexpression lentivirus into the joint cavity of MTX-N, the effective rate of MTX reached 80%. The ankle synovial hyperplasia and joint damage were significantly improved in the overexpression group, and the MTX content was also significantly increased in the synovium. After rat FLS overexpressed OAT3, the inhibitory effect of MTX on rat FLS proliferation activity was significantly enhanced, and the absorption of MTX was also significantly increased, while silencing the expression of rat FLS OAT3 reversed the outcomes.
    Conclusion: OAT3 mediates the formation of MTX resistance and is a potential target for improving MTX resistance.
    MeSH term(s) Animals ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/pathology ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology ; Hyperplasia/pathology ; Methotrexate/pharmacology ; Methotrexate/therapeutic use ; Rats ; Synovial Membrane/pathology
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2022-08-16
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.113558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Traditional Chinese medicine targeting cancer stem cells as an alternative treatment for hepatocellular carcinoma.

    Tang, Kai-Yue / Du, Shi-Lin / Wang, Qian-Lei / Zhang, Yi-Fan / Song, Hai-Yan

    Journal of integrative medicine

    2020  Volume 18, Issue 3, Page(s) 196–202

    Abstract: Hepatocellular carcinoma (HCC) is a prevalent and highly malignant cancer throughout the world. Effective treatment of this disease is impeded by the high rate of metastasis, recurrence, and chemoresistance. Recent studies have revealed the close ... ...

    Abstract Hepatocellular carcinoma (HCC) is a prevalent and highly malignant cancer throughout the world. Effective treatment of this disease is impeded by the high rate of metastasis, recurrence, and chemoresistance. Recent studies have revealed the close relationship between the malignant phenotype of HCC and cancer stem cells (CSCs). Therefore, CSC-targeted therapy is considered a promising strategy to eradicate HCC. Traditional Chinese medicine (TCM) can be effective in preventing recurrence and metastasis of some advanced HCC. A growing amount of literature has discovered that extracts or compounds derived from TCM exert an anti-CSC effect. This review introduces some formulas and chemical compounds derived from TCMs that have been reported to inhibit CSCs of HCC; these TCM-related drugs may help to provide an alternative approach to help manage cancers, especially for HCC which has a great potential of metastasis, recurrence, and chemoresistance.
    MeSH term(s) Carcinoma, Hepatocellular/therapy ; Humans ; Liver Neoplasms/therapy ; Medicine, Chinese Traditional ; Neoplastic Stem Cells
    Language English
    Publishing date 2020-02-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2705612-0
    ISSN 2095-4964
    ISSN 2095-4964
    DOI 10.1016/j.joim.2020.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of paeoniflorin-6'-O-benzene sulfonate on the pharmacokinetics, excretion and tissue distribution of leflunomide in rats.

    Xiao, Ning / Xiao, Feng / Gao, Jinzhang / Xu, Zhengkun / Wang, Qianlei / Kuai, Jiajie / Wei, Wei / Wang, Chun

    Basic & clinical pharmacology & toxicology

    2021  Volume 130, Issue 3, Page(s) 364–374

    Abstract: Paeoniflorin-6'-O-benzene sulfonate (CP-25) is a novel ester derivative of paeoniflorin, which has been shown to have synergistic pharmacodynamic effects with leflunomide (LEF). To determine the effects of CP-25 on the pharmacokinetics of LEF in rats, we ...

    Abstract Paeoniflorin-6'-O-benzene sulfonate (CP-25) is a novel ester derivative of paeoniflorin, which has been shown to have synergistic pharmacodynamic effects with leflunomide (LEF). To determine the effects of CP-25 on the pharmacokinetics of LEF in rats, we developed a ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)-based method for the determination of levels of teriflunomide (TER, an active metabolite of LEF). This method was used to determine TER concentrations in the plasma, urine, faeces and bile; heart, liver, spleen, lung, kidney, intestinal, brain and synovial tissues; and peripheral blood mononuclear cells (PBMCs) of rats in the control (LEF [10 mg/kg]) and combined (CP-25 [50 mg/kg × 7d] plus LEF [10 mg/kg]) groups. TER area under the curve [AUC], T
    MeSH term(s) Administration, Oral ; Animals ; Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid ; Glucosides ; Leflunomide ; Leukocytes, Mononuclear ; Monoterpenes ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods ; Tissue Distribution
    Chemical Substances Glucosides ; Monoterpenes ; paeoniflorin-6'-O-benzenesulfonate ; Leflunomide (G162GK9U4W)
    Language English
    Publishing date 2021-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.13685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Study on the Therapeutic Efficacy of San Zi Yang Qin Decoction for Non-Alcoholic Fatty Liver Disease and the Underlying Mechanism Based on Network Pharmacology.

    Li, Yiping / Liu, Yang / Yang, Ming / Wang, Qianlei / Zheng, Yu / Xu, Jiaoya / Zheng, Peiyong / Song, Haiyan

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 8819245

    Abstract: Objective: This study aims to explore the therapeutic efficacy of San Zi Yang Qin Decoction (SZ) and its potential mechanism in the treatment of non-alcoholic fatty liver disease (NAFLD) based on network pharmacology and : Methods: Effective ... ...

    Abstract Objective: This study aims to explore the therapeutic efficacy of San Zi Yang Qin Decoction (SZ) and its potential mechanism in the treatment of non-alcoholic fatty liver disease (NAFLD) based on network pharmacology and
    Methods: Effective chemicals and targets of SZ were searched in online databases, according to the drug-likeness of compounds and the binomial distribution of targets. A disease-target-chemical network was established using NAFLD-associated genes screened through GeneCards database, Gene Ontology (GO) terms, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Furthermore, animal experiments were conducted to verify the efficacy and mechanism of SZ predicted by network pharmacology. The NAFLD mouse model was established with C57BL/6J mice fed with a high-fat diet for 22 weeks. The mice in the control group were fed with a chow diet. From the 23
    Results: A total of 27 effective compounds and 20 targets of SZ were screened. GO analysis uncovered a significant correlation between the targets of SZ and those of NAFLD. KEGG analysis presented the signaling pathways enriched in SZ and NAFLD, including NAFLD, TNF-
    Conclusions: According to the network pharmacology analysis and
    Language English
    Publishing date 2021-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/8819245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Integrated analysis of hepatic mRNA and miRNA profiles identified molecular networks and potential biomarkers of NAFLD.

    Zhu, Mingzhe / Wang, Qianlei / Zhou, Wenjun / Liu, Tao / Yang, Lili / Zheng, Peiyong / Zhang, Li / Ji, Guang

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 7628

    Abstract: To enhance our understanding of molecular mechanisms and mine novel biomarkers of non-alcoholic fatty liver disease (NAFLD), RNA sequencing was performed to gain hepatic expression profiles of mRNAs and miRNAs in NAFLD and normal rats. Using DESeq with ... ...

    Abstract To enhance our understanding of molecular mechanisms and mine novel biomarkers of non-alcoholic fatty liver disease (NAFLD), RNA sequencing was performed to gain hepatic expression profiles of mRNAs and miRNAs in NAFLD and normal rats. Using DESeq with thresholds of a two-fold change and a false discovery rate (FDR) less than 0.05, 336 mRNAs and 21 miRNAs were identified as differentially expressed. Among those, 17 miRNAs (e.g., miR-144-3p, miR-99a-3p, miR-200b-3p, miR-200b-5p, miR-200c-3p, etc.) might serve as novel biomarkers of NAFLD. MiRNA target genes (13565) were predicted by the miRWalk database. Using DAVID 6.8, the intersection (195 genes) of differentially expressed mRNAs and miRNA-predicted target genes were enriched in 47 gene ontology (GO) terms and 28 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Using Cytoscape, pathway interaction and protein-protein interaction (PPI) networks were constructed, and hub genes (e.g., Abcg8, Cyp1a1, Cyp51, Hmgcr, etc.) associated with NAFLD were obtained. Moreover, 673 miRNA-mRNA negative regulatory pairs were obtained, and networks were constructed. Finally, several representative miRNAs and mRNAs were validated by real-time qPCR. In conclusion, potential molecular mechanisms of NAFLD could be inferred from integrated analysis of mRNA and miRNA profiles, which may indicate novel biomarkers of NAFLD.
    MeSH term(s) Animals ; Biomarkers/analysis ; Computational Biology/methods ; Diet, High-Fat/adverse effects ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Liver/metabolism ; Liver/pathology ; Male ; MicroRNAs/genetics ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Sequence Analysis, RNA
    Chemical Substances Biomarkers ; MicroRNAs ; RNA, Messenger
    Language English
    Publishing date 2018-05-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-25743-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Phytoestrogen genistein supplementation increases eNOS and decreases caveolin-1 expression in ovariectomized rat hearts.

    Tang, Yong-Bo / Wang, Qian-Lei / Zhu, Bing-Yang / Huang, Hong-Lin / Liao, Duan-Fang

    Sheng li xue bao : [Acta physiologica Sinica

    2005  Volume 57, Issue 3, Page(s) 373–378

    Abstract: This study examined whether genistein influences the production of nitric oxide (NO) and expression of endothelial nitric oxide synthase (eNOS) and the modulators of eNOS activity in ovariectomized (OVX) rat hearts. Female mature Sprague-Dawley rats were ...

    Abstract This study examined whether genistein influences the production of nitric oxide (NO) and expression of endothelial nitric oxide synthase (eNOS) and the modulators of eNOS activity in ovariectomized (OVX) rat hearts. Female mature Sprague-Dawley rats were subjected to bilateral ovariectomy, OVX rats were randomly divided into four groups: 17beta-estradiol (0.1 mg/kg, s.c. daily) was used as the positive control; low dose of genistein (0.5 mg/kg, s.c. daily); high dose of genistein (5.0 mg/kg, s.c. daily) and model. Sham operations as controls, the treatment lasted 6 weeks. Blood pressure, heart rate, plasma estradiol, heart and uterine weights were measured. Nitrite production in the myocardium was determined by nitrate reductase method. Protein level of eNOS, caveolin-1 and calmodulin was determined by Western blot. The results showed that nitrite production and eNOS protein in homogenized ventricular tissue was attenuated by approximately 53% and 67% in OVX rats compared with those in sham rats, respectively. Genistein increased nitrite production in rat heart in a dose-dependent manner, genistein at the dose of 5 mg/kg.d(-1) resumed nitrite production to a level similar to that in sham operated rats. Administration of genistein also increased eNOS protein expression in OVX rats myocardium with a concomitant decrease in the expression of caveolin-1, an endogenous eNOS inhibitory protein. Another eNOS stimulatory protein, calmodulin, was unchanged in these treatments. These effects were also observed in rats treated with 17beta-estradiol. Genistein at the dose of 5.0 mg/kg.d(-1) augmented uterine weight but this side effect in reproductive system was less than that of 17beta-estradiol. These results suggest that genistein supplementation and estrogen replacement therapy directly increase eNOS functional activity and NO production in the hearts of the OVX rats, but genistein has less side effects on the reproductive system than 17beta-estradiol.
    MeSH term(s) Animals ; Calmodulin/biosynthesis ; Calmodulin/genetics ; Caveolin 1/biosynthesis ; Caveolin 1/genetics ; Dose-Response Relationship, Drug ; Female ; Genistein/pharmacology ; Myocardium/metabolism ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type III/biosynthesis ; Nitric Oxide Synthase Type III/genetics ; Ovariectomy ; Phytoestrogens/pharmacology ; Random Allocation ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Calmodulin ; Caveolin 1 ; Phytoestrogens ; Nitric Oxide (31C4KY9ESH) ; Genistein (DH2M523P0H) ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Language English
    Publishing date 2005-06-25
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604308-2
    ISSN 0371-0874
    ISSN 0371-0874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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