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Article ; Online: Validation and identification of anoikis-related lncRNA signatures for improving prognosis in clear cell renal cell carcinoma.

Zhu, Zhenjie / Wang, Qibo / Zeng, Xiaowei / Zhu, Shaoxing / Chen, Jinchao

Aging

2024 Volume 16, Issue 4, Page(s) 3915–3933

Abstract: Background: Clear cell carcinoma (ccRCC) usually has a high metastasis rate and high mortality rate. To enable precise risk stratification, there is a need for novel biomarkers. As one form of apoptosis, anoikis results from the disruption of cell-cell ... ...

Abstract	Background: Clear cell carcinoma (ccRCC) usually has a high metastasis rate and high mortality rate. To enable precise risk stratification, there is a need for novel biomarkers. As one form of apoptosis, anoikis results from the disruption of cell-cell connection or cell-ECM attachment. However, the impact of anoikis-related lncRNAs on ccRCC has not yet received adequate attention. Methods: The study utilized univariate Cox regression analysis in order to identify the overall survival (OS) associated anoikis-related lncRNAs (ARLs), followed by the LASSO algorithm for selection. On this basis, a risk model was subsequently established using five anoikis-related lncRNAs. To dig the inner molecular mechanism, KEGG, GO, and GSVA analyses were conducted. Additionally, the immune infiltration landscape was estimated using the ESTIMATE, CIBERSORT, and ssGSEA algorithms. Results: The study constructed a novel risk model based on five ARLs (AC092611.2, AC027601.2, AC103809.1, AL133215.2, and AL162586.1). Patients categorized as low-risk exhibited significantly better OS. Notably, the study observed marked different immune infiltration landscapes and drug sensitivity by risk stratification. Additionally, the study preliminarily explored potential signal pathways associated with risk stratification. Conclusion: The study exhibited the crucial role of ARLs in the carcinogenesis of ccRCC, potentially through differential immune infiltration. Furthermore, the established risk model could serve as a valuable stratification factor for predicting OS prognosis.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/genetics ; Anoikis/genetics ; RNA, Long Noncoding/genetics ; Prognosis ; Carcinoma ; Kidney Neoplasms/genetics
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205568
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Autophagy-related gene LAPTM4B promotes the progression of renal clear cell carcinoma and is associated with immunity.

Wang, He / Wang, Qibo / Wu, Yaoyao / Lou, Jianmin / Zhu, Shaoxing / Xu, Yipeng

Frontiers in pharmacology

2023 Volume 14, Page(s) 1118217

Abstract: Renal cell carcinoma (RCC) is a common urologic disease. Currently, surgery is the primary treatment for renal cancer; immunotherapy is not as effective a treatment strategy as expected. Hence, understanding the mechanism in the tumor immune ... ...

Abstract	Renal cell carcinoma (RCC) is a common urologic disease. Currently, surgery is the primary treatment for renal cancer; immunotherapy is not as effective a treatment strategy as expected. Hence, understanding the mechanism in the tumor immune microenvironment (TME) and exploring novel immunotherapeutic targets are considered important. Recent studies have demonstrated that autophagy could affect the immune environment of renal cell carcinoma and induce proliferation and apoptosis of cancer cells. By comparing lysosomal genes and regulating autophagy genes, we identified the LAPTM4B gene to be related to RCC autophagy. By analyzing the TCGA-KIRC cohort using bioinformatics, we found M2 macrophages associated with tumor metastasis to be significantly increased in the immune microenvironment of patients with high expression of LAPTM4B. GO/KEGG/GSEA/GSVA results showed significant differences in tumor autophagy- and metastasis-related pathways. Single-cell sequencing was used to compare the expression of LAPTM4B in different cell types and obtain the differences in lysosomal and autophagy pathway activities in different ccRCC cells. Subsequently, we confirmed the differential expression of LAPTM4B in renal cell carcinoma of different Fuhrman grades using western blotting. Downregulation of LAPTM4B expression significantly reduced the proliferation of renal cell carcinoma cells and promoted cell apoptosis through cell experiments. Overall, our study demonstrated that the autophagy-related gene LAPTM4B plays a critical role in the TME of RCC, and suggested that LAPTM4B is a potential therapeutic target for RCC immunotherapy.
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1118217
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Article ; Online: Economic evaluation of stent retrievers in basilar artery occlusion: An analysis from Chinese healthcare system perspective.

Xia, Hailong / Yang, Qi / Wang, Qibo / Jia, Jielin / Liu, Xipeng / Meng, Shu

PloS one

2023 Volume 18, Issue 11, Page(s) e0294929

Abstract: Purpose: This study aimed to investigate the cost-effectiveness of stent retriever (SR) versus best medical management (BMM) in patients with basilar artery occlusion (BAO) in China.: Methods: We used a two-step approach to compare the cost- ... ...

Abstract	Purpose: This study aimed to investigate the cost-effectiveness of stent retriever (SR) versus best medical management (BMM) in patients with basilar artery occlusion (BAO) in China. Methods: We used a two-step approach to compare the cost-effectiveness of SR plus BMM with that of BMM alone over 20 years. A decision tree was initially constructed for the first 3 months, followed by a Markov model for the subsequent period. Collected data on clinical aspects were extracted from the BAOCHE investigation, while costs-related information was sourced from previously published research. The key metric for evaluating the primary outcome was the incremental cost-effectiveness ratio (ICER), achieved $/QALY. The threshold for identifying SR as highly cost-effective was set at an ICER below $12,551/QALY, SR was deemed cost-effective if the ICER ranged from $12,551 to $37,654 per QALY. Uncertainty was addressed using scenario, one-way sensitivity, and probabilistic sensitivity analyses (PSA). Findings: For Chinese patients with BAO, the 20-year cost per patient was $8678 with BMM alone and $21,988 for SR plus BMM. Effectiveness was 1.45 QALY for BMM alone, and 2.77 QALY for SR plus BMM. The ICER of SR + BMM versus BMM alone was $10,050 per QALY. The scenario and one-way sensitivity analyses revealed that in certain situations the ICER could exceed $12,551 per QALY, but remain below $37,654 per QALY. Results from the PSA suggested that SR was likely to be cost-effective for Chinese patients with BAO, with a probability exceeding 98% when considering a willingness-to-pay (WTP) threshold of $12,551 per QALY. Implications: Our study indicates that SR is an intervention option that is highly likely to be cost-effective for Chinese patients with BAO, with a probability of over 98% under the current WTP threshold of $12,551 per QALY.
MeSH term(s)	Humans ; Basilar Artery ; Cost-Benefit Analysis ; Delivery of Health Care ; East Asian People ; Stents ; Thrombectomy/instrumentation ; Thrombectomy/methods
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0294929
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Article ; Online: PIK3C2A is a prognostic biomarker that is linked to immune infiltrates in kidney renal clear cell carcinoma.

Qin, Chengdong / Liu, Siyuan / Zhou, Shiqi / Wang, Qibo / Xia, Xianghou / Hu, Jiejie / Yuan, Xiaohong / Wang, Zongping / Yu, Yang / Ma, Dening

Frontiers in immunology

2023 Volume 14, Page(s) 1114572

Abstract: Background: Phosphoinositide 3-kinases (PI3Ks) are lipid enzymes that regulate a wide range of intracellular functions. In contrast to Class I and Class III PI3K, which have more detailed descriptions, Class II PI3K has only recently become the focus of ...

Abstract	Background: Phosphoinositide 3-kinases (PI3Ks) are lipid enzymes that regulate a wide range of intracellular functions. In contrast to Class I and Class III PI3K, which have more detailed descriptions, Class II PI3K has only recently become the focus of functional research. PIK3C2A is a classical member of the PI3Ks class II. However, the role of PIK3C2A in cancer prognosis and progression remains unknown. Methods: The expression pattern and prognostic significance of PIK3C2A in human malignancies were investigated using multiple datasets and scRNA-seq data. The PIK3C2A expression in renal clear cell carcinoma (KIRC) was then validated utilizing Western blot. The functional role of PIK3C2A in KIRC was assessed using combined function loss experiments with Results: Significant decrease in PIK3C2A expression in KIRC, demonstrated that it potentially influences the prognosis of diverse tumors, particularly KIRC. In addition, PIK3C2A was significantly correlated with the T stage, M stage, pathologic stage, and histologic grade of KIRC. Nomogram models were constructed and used to predict patient survival based on the results of multivariate Cox regression analysis. PIK3C2A knockdown resulted in significantly increased KIRC cell proliferation. Of note, PIK3C2A expression demonstrated a significant correlation with the infiltrating levels of primary immune cells in KIRC. Conclusion: These findings support the hypothesis that PIK3C2A is a novel biomarker for tumor progression and indicates dynamic shifts in immune infiltration in KIRC. Furthermore, aberrant PIK3C2A expression can influence the biological activity of cancer cells.
MeSH term(s)	Humans ; Prognosis ; Carcinoma, Renal Cell/genetics ; Blotting, Western ; Kidney Neoplasms/genetics ; Kidney ; Phosphatidylinositol 3-Kinases/genetics
Chemical Substances	PIK3C2A protein, human (EC 2.7.1.137) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1114572
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Article ; Online: Vapor-Liquid-Solid Growth of Site-Controlled Monolayer MoS

Wang, Qi-Bo / Xu, Qin-Qin / Yang, Ming-Zhe / Wu, Zhong-Shuai / Xia, Xiao-Chuan / Yin, Jian-Zhong / Han, Zhen-Hua

ACS applied materials & interfaces

2023 Volume 15, Issue 13, Page(s) 17396–17405

Abstract: In this study, a novel pressure-induced supercritical phase nucleation method is proposed to synthesize monolayer ... ...

Abstract	In this study, a novel pressure-induced supercritical phase nucleation method is proposed to synthesize monolayer MoS
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c01407
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Article: A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.

Puray-Chavez, Maritza / LaPak, Kyle M / Jasuja, Ria / Pan, Jiehong / Xu, Jian / Eschbach, Jenna E / Mohammed, Shawn / Lawson, Dana Q / Wang, Qibo / Brody, Steven L / Major, Michael B / Goldfarb, Dennis / Kutluay, Sebla B

bioRxiv : the preprint server for biology

2024

Abstract: Host factors that define the cellular tropism of SARS-CoV-2 beyond the cognate ACE2 receptor are poorly defined. From a screen of human airway derived cell lines that express varying levels of ACE2/TMPRSS2, we found a subset that express comparably high ... ...

Abstract	Host factors that define the cellular tropism of SARS-CoV-2 beyond the cognate ACE2 receptor are poorly defined. From a screen of human airway derived cell lines that express varying levels of ACE2/TMPRSS2, we found a subset that express comparably high endogenous levels of ACE2 but surprisingly did not support SARS-CoV-2 replication. Here we report that this resistance is mediated by a basally active cGAS-STING pathway culminating in interferon (IFN)-mediated restriction of SARS-CoV-2 replication at a post-entry step. Pharmacological inhibition of JAK1/2, depletion of the IFN-α receptor and cGAS-STING pathway effectors substantially increased SARS-CoV-2 replication in these cell models. While depletion of cGAS or STING was sufficient to reduce the preexisting levels of IFN-stimulated genes (ISGs), SARS-CoV-2 infection in STING knockout cells independently induced ISG expression. Remarkably, SARS-CoV-2-induced ISG expression in STING knockout cell as well as in primary human airway cultures was limited to uninfected bystander cells, demonstrating efficient antagonism of the type I/III IFN-pathway, but not viral sensing or IFN production, in productively infected cells. Of note, SARS-CoV-2-infected primary human airway cells also displayed markedly lower levels of STING expression, raising the possibility that SARS-CoV-2 can target STING expression or preferentially infect cells that express low levels of STING. Finally, ectopic ACE2 overexpression overcame the IFN-mediated blocks, suggesting the ability of SARS-CoV-2 to overcome these possibly saturable blocks to infection. Our study highlights that in addition to viral receptors, basal activation of the cGAS-STING pathway and innate immune defenses may contribute to defining SARS-CoV-2 cellular tropism.
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.07.574522
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Article: High-pressure induced exfoliation for regulating the morphology of graphene in supercritical CO2 system

Zhu, Hong-Yue / Wang, Qi-Bo / Yin, Jian-Zhong

Carbon. 2021 June 30, v. 178

2021

Abstract: We mixed high-pressure supercritical carbon dioxide (scCO₂) and graphite together without any auxiliary means for exfoliation. Combined with small-angle X-ray scattering (SAXS) and other characterizations, the influence of process parameters on the ... ...

Abstract	We mixed high-pressure supercritical carbon dioxide (scCO₂) and graphite together without any auxiliary means for exfoliation. Combined with small-angle X-ray scattering (SAXS) and other characterizations, the influence of process parameters on the quantity and quality of graphene was studied. We calculated the Hansen solubility parameters and the critical conditions for exfoliation and used the response surface method to probe the effect of process parameters on the graphene exfoliation. The mechanism for exfoliation was critically discussed. The results showed that the highest (1.625 mg/mL) concentration was obtained after mixing at 45 MPa for 48 h and centrifuging at 1000 rpm for 30min. The number of layers and lateral dimensions of graphene sheets could be controlled by adjusting process parameters. Up to 75% of the produced graphene after mixing at 45 MPa for 48 h was about 3-6layers, and 90% of the lateral dimensions were less than 1.4 μm. The kinetic energy generated by the flowing CO₂ was the main reason for exfoliation. The critical speed of exfoliation at 50 °C and 45 MPa was about 2.851–2.981 m/s. This method had no complicated operation steps, the obtained graphene surface was not oxidized, no solvent remained, and few-layer graphene did not need further purification.
Keywords	carbon dioxide ; graphene ; kinetic energy ; response surface methodology ; small-angle X-ray scattering ; solubility ; solvents
Language	English
Dates of publication	2021-0630
Size	p. 211-222.
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ISSN	0008-6223
DOI	10.1016/j.carbon.2021.02.076
Database	NAL-Catalogue (AGRICOLA)

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Article: Experimental Study on the Coating Removing Characteristics of High-Pressure Water Jet by Micro Jet Flow.

Ning, Dayong / Wang, Qibo / Tian, Jinxin / Gong, Yongjun / Du, Hongwei / Chen, Shengtao / Hou, Jiaoyi

Micromachines

2021 Volume 12, Issue 2

Abstract: In this paper, coating removal characteristics of water jet by micro jet flow affected by cleaning parameters is analyzed. Numerical simulation of fluid field calculates the velocity and pressure distribution of a water jet impinging on a rigid wall, ... ...

Abstract	In this paper, coating removal characteristics of water jet by micro jet flow affected by cleaning parameters is analyzed. Numerical simulation of fluid field calculates the velocity and pressure distribution of a water jet impinging on a rigid wall, which is used for design experiments of coating removal affected by jet pressure, traversal speed, and repeated impacting times. The removal width is used as a measure of water jet coating removal capability. Experiment results show that the coating removal width is constant, independent with traversal speed or repeated times when total exposure time of waterjet impingement is fixed. According to results of coating removal by a linear moving water jet, this study also analyzes characteristics of coating removal by rotating jet disc, especially residual coating affected by rotational and moving speed of the cleaning disc. The research is helpful to improve the coating removal efficiency of cleaning disc devices.
Language	English
Publishing date	2021-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi12020173
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Article: Design and Performance Study for Electrothermally Deep-Sea Drive Microunits Using a Paraffin Phase Change Material.

Ning, Dayong / Li, Zihao / Liang, Gangda / Wang, Qibo / Zou, Weifeng / Gong, Yongjun / Hou, Jiaoyi

Micromachines

2021 Volume 12, Issue 4

Abstract: Considering the further exploration of the ocean, the requirements for deep-sea operation equipment have increased. Many problems existing in the widely used deep-sea hydraulic system have become increasingly prominent. Compared with the traditional deep- ...

Abstract	Considering the further exploration of the ocean, the requirements for deep-sea operation equipment have increased. Many problems existing in the widely used deep-sea hydraulic system have become increasingly prominent. Compared with the traditional deep-sea hydraulic system, actuators using a paraffin phase change material (PCM) have incomparable advantages, including lightweight structure, low energy consumption, high adaptability to the deep sea, and good biocompatibility. Thus, a deep-sea drive microunit (DDM) based on paraffin PCM is proposed in this paper. The device adopts a flexible shell, adapting to the high-pressure environment of the deep-sea based on the principle of pressure compensation. The device realizes the output of displacement and force through the electrothermal drive, which can be used as actuator or power source of other underwater operation equipment. The microunit successfully completes the functional verification experiments in air, shallow water, and hydrostatic pressure of 110 MPa. In accordance with experimental results, a reasonable control curve is fitted, highlighting its potential application in deep-sea micro electro mechanical systems, especially in underwater soft robot.
Language	English
Publishing date	2021-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi12040415
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Article: ZC3H13 Inhibits the Progression of Hepatocellular Carcinoma through m

Wang, Qibo / Xie, Haichuan / Peng, Hao / Yan, Jianjian / Han, Limin / Ye, Gang

Journal of oncology

2021 Volume 2021, Page(s) 1328444

Abstract: Objective: N: Methods: Expression of ZC3H13 was examined in collected HCC and normal tissues, and its prognostic significance was investigated in a public database. Gain/loss of functional assays were presented for defining the roles of ZC3H13 in HCC ...

Abstract	Objective: N Methods: Expression of ZC3H13 was examined in collected HCC and normal tissues, and its prognostic significance was investigated in a public database. Gain/loss of functional assays were presented for defining the roles of ZC3H13 in HCC progression. The specific interactions of ZC3H13 with PKM2 were validated in HCC cells via mRNA stability, RNA immunoprecipitation, and luciferase reporter and MeRIP-qPCR assays. Moreover, rescue experiments were carried out for uncovering the mechanisms. Results: ZC3H13 expression was downregulated in HCC, and its loss was in relation to dismal survival outcomes. Functionally, overexpressed ZC3H13 suppressed proliferation, migration, and invasion and elevated apoptotic levels of HCC cells. Moreover, ZC3H13 overexpression sensitized to cisplatin and weakened metabolism reprogramming of HCC cells. Mechanically, ZC3H13-induced m Conclusion: Collectively, ZC3H13 suppressed the progression of HCC through m
Language	English
Publishing date	2021-12-30
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2461349-6
ISSN	1687-8469 ; 1687-8450
ISSN (online)	1687-8469
ISSN	1687-8450
DOI	10.1155/2021/1328444
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