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Article ; Online: Prevention and Control of Porcine Epidemic Diarrhea: The Development of Recombination-Resistant Live Attenuated Vaccines.

Niu, Xiaoyu / Wang, Qiuhong

2022 Volume 14, Issue 6

Abstract: Porcine epidemic diarrhea (PED), causing up to 100% mortality in neonatal pigs, is a highly contagious enteric disease caused by PED virus (PEDV). The highly virulent genogroup 2 (G2) PEDV emerged in 2010 and has caused huge economic losses to the pork ... ...

Abstract	Porcine epidemic diarrhea (PED), causing up to 100% mortality in neonatal pigs, is a highly contagious enteric disease caused by PED virus (PEDV). The highly virulent genogroup 2 (G2) PEDV emerged in 2010 and has caused huge economic losses to the pork industry globally. It was first reported in the US in 2013, caused country-wide outbreaks, and posed tremendous hardship for many pork producers in 2013-2014. Vaccination of pregnant sows/gilts with live attenuated vaccines (LAVs) is the most effective strategy to induce lactogenic immunity in the sows/gilts and provide a passive protection via the colostrum and milk to suckling piglets against PED. However, there are still no safe and effective vaccines available after about one decade of endeavor. One of the biggest concerns is the potential reversion to virulence of an LAV in the field. In this review, we summarize the status and the major obstacles in PEDV LAV development. We also discuss the function of the transcriptional regulatory sequences in PEDV transcription, contributing to recombination, and possible strategies to prevent the reversion of LAVs. This article provides insights into the rational design of a promising LAV without safety issues.
MeSH term(s)	Animals ; Coronavirus Infections/prevention & control ; Coronavirus Infections/veterinary ; Diarrhea/prevention & control ; Diarrhea/veterinary ; Dysentery ; Female ; Porcine epidemic diarrhea virus ; Pregnancy ; Recombination, Genetic ; Sus scrofa ; Swine ; Swine Diseases/epidemiology ; Vaccines, Attenuated ; Viral Vaccines
Chemical Substances	Vaccines, Attenuated ; Viral Vaccines
Language	English
Publishing date	2022-06-16
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14061317
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prevention and Control of Porcine Epidemic Diarrhea: The Development of Recombination-Resistant Live Attenuated Vaccines

Niu, Xiaoyu / Wang, Qiuhong

Viruses. 2022 June 16, v. 14, no. 6

2022

Abstract	Porcine epidemic diarrhea (PED), causing up to 100% mortality in neonatal pigs, is a highly contagious enteric disease caused by PED virus (PEDV). The highly virulent genogroup 2 (G2) PEDV emerged in 2010 and has caused huge economic losses to the pork industry globally. It was first reported in the US in 2013, caused country-wide outbreaks, and posed tremendous hardship for many pork producers in 2013–2014. Vaccination of pregnant sows/gilts with live attenuated vaccines (LAVs) is the most effective strategy to induce lactogenic immunity in the sows/gilts and provide a passive protection via the colostrum and milk to suckling piglets against PED. However, there are still no safe and effective vaccines available after about one decade of endeavor. One of the biggest concerns is the potential reversion to virulence of an LAV in the field. In this review, we summarize the status and the major obstacles in PEDV LAV development. We also discuss the function of the transcriptional regulatory sequences in PEDV transcription, contributing to recombination, and possible strategies to prevent the reversion of LAVs. This article provides insights into the rational design of a promising LAV without safety issues.
Keywords	colostrum ; diarrhea ; immunity ; live vaccines ; milk ; mortality ; pork ; pork industry ; transcription (genetics) ; vaccination ; virulence ; viruses
Language	English
Dates of publication	2022-0616
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14061317
Database	NAL-Catalogue (AGRICOLA)

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Article: The transcriptomic and epigenetic alterations in type 2 diabetes mellitus patients of Chinese Tibetan and Han populations.

Wang, Xian / Liu, Jie / Wang, Qiuhong / Chen, Qiu

Frontiers in endocrinology

2023 Volume 14, Page(s) 1122047

Abstract: Background: Due to the distinctive living environment, lifestyle, and diet, the Tibetan community in China has the lowest prevalence of T2DM and prediabetes among numerous ethnic groups, while Han community shows the highest statistic. In this study, we ...

Abstract	Background: Due to the distinctive living environment, lifestyle, and diet, the Tibetan community in China has the lowest prevalence of T2DM and prediabetes among numerous ethnic groups, while Han community shows the highest statistic. In this study, we aim to conclude the clinical manifestations of both Tibetan and Han T2DM patients and their association with transcriptomic and epigenetic alterations. Methods: A cross-sectional study including 120 T2DM patients from Han and Tibetan ethnic groups were conducted between 2019 to 2021 at the Hospital of Chengdu University of Traditional Chinese Medicine. The various clinical features and laboratory tests were recorded and analyzed between the two groups. The genome-wide methylation pattern and RNA expression were determined by Reduced Representation Bisulfite Sequencing (RBBS) and Poly (A) RNA sequencing (RNA-seq) from leucocytes of peripheral blood samples in 6 Han and 6 Tibetan patients. GO analysis and KEGG analysis were conducted in differentially expressed genes and those with differentially methylated regions. Results: Compared to Han, Tibetan T2DM individuals intake more coarse grains, meat and yak butter, but less refined grains, vegetables and fruit. They also showed increased BMI, Hb, HbA1c, LDL, ALT, GGT and eGFR, and decreased level of BUN. Among the 12 patients in the exploratory cohort, we identified 5178 hypomethylated and 4787 hypermethylated regions involving 1613 genes in the Tibetan group. RNA-seq showed a total of 947 differentially expressed genes (DEGs) between the two groups, with 523 up-regulated and 424 down-regulated in Tibetan patients. By integrating DNA methylation and RNA expression data, we identified 112 DEGs with differentially methylated regions (overlapping genes) and 14 DEGs with promoter-related DMRs. The functional enrichment analysis demonstrated that the overlapping genes were primarily involved in metabolic pathways, PI3K-Akt signaling pathway, MAPK signaling pathway, pathways in cancer and Rap1 signaling pathway. Conclusion: Our study demonstrates the clinical characteristics of T2DM differ subtly between various ethnic groups that may be related to epigenetic modifications, thus providing evidence and ideas for additional research on the genetic pattern of T2DM.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Tibet/epidemiology ; Transcriptome ; Cross-Sectional Studies ; Phosphatidylinositol 3-Kinases/genetics ; Epigenesis, Genetic ; RNA
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; RNA (63231-63-0)
Language	English
Publishing date	2023-02-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1122047
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Article: Prevention and Control of Swine Enteric Coronaviruses in China: A Review of Vaccine Development and Application.

Kong, Fanzhi / Jia, Huilin / Xiao, Qi / Fang, Liurong / Wang, Qiuhong

Vaccines

2023 Volume 12, Issue 1

Abstract: Swine enteric coronaviruses (SECs) cause significant economic losses to the pig industry in China. Although many commercialized vaccines against transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) are available, viruses ... ...

Abstract	Swine enteric coronaviruses (SECs) cause significant economic losses to the pig industry in China. Although many commercialized vaccines against transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) are available, viruses are still widespread. The recent emergence of porcine deltacoronavirus (PDCoV) and swine acute diarrhea syndrome coronavirus (SADS-CoV), for which no vaccines are available, increases the disease burden. In this review, we first introduced the genomic organization and epidemiology of SECs in China. Then, we discussed the current vaccine development and application in China, aiming to provide suggestions for better prevention and control of SECs in China and other countries.
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines12010011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neuroprotective Iridoids and Lignans from

Ye, Minhui / Lin, Xiaoju / Wang, Qiuhong / Yang, Bingyou / Wang, Changfu

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 15

Abstract: Valeriana ... ...

Abstract	Valeriana amurensis
MeSH term(s)	Rats ; Animals ; Lignans/pharmacology ; Amyloid beta-Peptides ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Valerian ; Iridoids/pharmacology ; Plant Roots
Chemical Substances	Lignans ; Amyloid beta-Peptides ; Neuroprotective Agents ; Iridoids
Language	English
Publishing date	2023-08-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28155793
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Article ; Online: Intestinal colonization with Escherichia fergusonii enhances infectivity of GII.12 human norovirus in gnotobiotic pigs.

Jung, Kwonil / Wang, Qiuhong / Chang, Kyeong-Ok / Saif, Linda J

Virus research

2023 Volume 336, Page(s) 199219

Abstract: The role of gut microbiota [especially, histo-blood group antigen (HBGA)-expressing bacteria] in influencing human norovirus (HuNoV) infections is unclear. We investigated if infectivity of GII.12 HuNoV in gnotobiotic (Gn) pigs is altered by intestinal ... ...

Abstract	The role of gut microbiota [especially, histo-blood group antigen (HBGA)-expressing bacteria] in influencing human norovirus (HuNoV) infections is unclear. We investigated if infectivity of GII.12 HuNoV in gnotobiotic (Gn) pigs is altered by intestinal colonization with Escherichia fergusonii known to express HBGA A and H on their cell surface. Fifteen piglets were randomly grouped: (1) E. fergusonii + HuNoV (n = 6), (2) HuNoV alone (n = 6), and (3) Mock-inoculated (n = 3). Pigs (8-11-day-old) were inoculated orally with GII.12 HuNoV strain HS206 (9.5 log
MeSH term(s)	Swine ; Humans ; Animals ; Norovirus/genetics ; Intestines ; Blood Group Antigens/metabolism ; Germ-Free Life ; RNA
Chemical Substances	Blood Group Antigens ; RNA (63231-63-0)
Language	English
Publishing date	2023-09-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	605780-9
ISSN	1872-7492 ; 0168-1702
ISSN (online)	1872-7492
ISSN	0168-1702
DOI	10.1016/j.virusres.2023.199219
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Article: Investigating the causal mediating effect of type 2 diabetes on the relationship between traits and systolic blood pressure: A two-step Mendelian randomization study.

Hao, Xuezeng / Li, Weixin / Shi, Ruiqing / Wang, Qiuhong

Frontiers in endocrinology

2022 Volume 13, Page(s) 1090867

Abstract: Background: Type 2 diabetes mellitus (T2DM) and hypertension commonly coexist, and we presumed that T2DM might mediate the relationship between some shared risk factors and systolic blood pressure (SBP).: Methods: The causal association between T2DM ... ...

Abstract	Background: Type 2 diabetes mellitus (T2DM) and hypertension commonly coexist, and we presumed that T2DM might mediate the relationship between some shared risk factors and systolic blood pressure (SBP). Methods: The causal association between T2DM and SBP was first confirmed using Mendelian randomization (MR) analyses, and a two-step MR design was then used to test the causal mediating effect of T2DM on the relationship between 107 traits and SBP using summary statistics from genome-wide association studies. Results: T2DM was causally associated with SBP. The univariable MR of the two-step causal mediation analyses suggested that 44 and 45 of the 107 traits had causal associations with T2DM and SBP, respectively. Five of the 27 traits that were significantly associated with both T2DM and SBP could not be reversely altered by T2DM and were included in the second step of the causal mediation analyses. The results indicated that most of the investigated traits causally altered SBP independent of T2DM, but the partial causal mediating effect of T2DM on the association between fasting insulin and SBP was successfully identified with a mediation proportion of 33.6%. Conclusions: Our study provides novel insights into the role of risk factors in the comorbidity of T2DM and high blood pressure, which is important for long-term disease prevention and management.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Blood Pressure ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Risk Factors ; Hypertension/complications ; Hypertension/epidemiology ; Hypertension/genetics
Language	English
Publishing date	2022-12-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1090867
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Secretome of human umbilical cord mesenchymal stem cell maintains skin homeostasis by regulating multiple skin physiological function

Wang, Xin / Wang, Qiuhong / Yin, Panpan / Liang, Zhen / Zhao, Xiaohui / Wen, Dingke / Tan, Yi

Cell Tissue Res. 2023 Jan., v. 391, no. 1 p.111-125

2023

Abstract: Skin is the largest organ in the body and the first defense to resist various diseases and external stimuli that easily cause infection and inflammation. Aseptic inflammation, barrier damage, and foreign aid pressure induce the destruction and damage to ... ...

Abstract	Skin is the largest organ in the body and the first defense to resist various diseases and external stimuli that easily cause infection and inflammation. Aseptic inflammation, barrier damage, and foreign aid pressure induce the destruction and damage to the skin microenvironment. Subsequently, it destroys the skin’s physiological function, leading to the maintenance and circulation of steady-state imbalance and aggravating the process of skin disorders. Our study evaluated the therapeutic potential of the secretome of human umbilical cord mesenchymal stem cells (UC-CM) for dermatological diseases in adult human skin cells, ex vivo skin tissue, and a 3D skin model. Our data suggested several advantages of UC-CM due to (1) their low cytotoxicity and sensitization properties; (2) their anti-inflammatory capacity for treating inflammatory chronic cutaneous diseases; (3) their enhanced capacity of the skin barrier for treating abnormal barrier metabolism; and (4) their positive impact on restoring skin homeostasis due to effective regulation ability of skin physiological function including cell apoptosis, detoxification, and anti-aging. We thus envisage that the possibility of harnessing the therapeutic potential of UC-CM might benefit patients suffering from inflammatory skin disorders such as atopic dermatitis, acne, and psoriasis.
Keywords	acne ; apoptosis ; atopic dermatitis ; cytotoxicity ; development aid ; homeostasis ; humans ; inflammation ; mesenchymal stromal cells ; metabolism ; models ; psoriasis ; skin (animal) ; therapeutics ; umbilical cord
Language	English
Dates of publication	2023-01
Size	p. 111-125.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-022-03697-8
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses

Su, Jiaming / Du, Yijun / Rowland, Raymond R. R. / Wang, Qiuhong / Yoo, Dongwan

Frontiers in Immunology. 2023 Apr. 17, v. 14

2023

Abstract: Type I interferons (IFNs-α/β) are antiviral cytokines that constitute the innate immunity of hosts to fight against viral infections. Recent studies, however, have revealed the pleiotropic functions of IFNs, in addition to their antiviral activities, for ...

Abstract	Type I interferons (IFNs-α/β) are antiviral cytokines that constitute the innate immunity of hosts to fight against viral infections. Recent studies, however, have revealed the pleiotropic functions of IFNs, in addition to their antiviral activities, for the priming of activation and maturation of adaptive immunity. In turn, many viruses have developed various strategies to counteract the IFN response and to evade the host immune system for their benefits. The inefficient innate immunity and delayed adaptive response fail to clear of invading viruses and negatively affect the efficacy of vaccines. A better understanding of evasion strategies will provide opportunities to revert the viral IFN antagonism. Furthermore, IFN antagonism-deficient viruses can be generated by reverse genetics technology. Such viruses can potentially serve as next-generation vaccines that can induce effective and broad-spectrum responses for both innate and adaptive immunities for various pathogens. This review describes the recent advances in developing IFN antagonism-deficient viruses, their immune evasion and attenuated phenotypes in natural host animal species, and future potential as veterinary vaccines.
Keywords	RNA ; adaptive immunity ; animals ; antagonism ; cytokines ; immune evasion ; immune system ; innate immunity ; reverse genetics
Language	English
Dates of publication	2023-0417
Publishing place	Frontiers Media SA
Document type	Article ; Online
Note	Resource is Open Access
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1172000
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: 11

Li, Qiulin / Yang, Yawen / Wang, Qingfeng / Han, Xiang / Zhu, Junfeng / Zhang, Nan / Wang, Qiuhong / Li, Kanshe / Gong, Pin / Chen, Fuxin

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 1

Abstract: This article applies nuclear magnetic resonance technology to the study of boron-containing traditional Chinese medicine, in order to explore the morphological evolution of boron elements in traditional Chinese medicine. Borax is a traditional Chinese ... ...

Abstract	This article applies nuclear magnetic resonance technology to the study of boron-containing traditional Chinese medicine, in order to explore the morphological evolution of boron elements in traditional Chinese medicine. Borax is a traditional Chinese medicine with anti-corrosion, anti-inflammatory, antibacterial, and anticonvulsant effects. It is made by boiling, removing stones, and drying borax minerals like borate salts. This article introduces an
MeSH term(s)	Borates ; Boron ; Medicine, Chinese Traditional ; Magnetic Resonance Spectroscopy
Chemical Substances	borax (1303-96-4) ; Borates ; Boron (N9E3X5056Q)
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29010251
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