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Artikel ; Online: From reflux esophagitis to Barrett's esophagus and esophageal adenocarcinoma.

Wang, Rui-Hua

2015 Band 21, Heft 17, Seite(n) 5210–5219

Abstract: The occurrence of gastroesophageal reflux disease is common in the human population. Almost all cases of esophageal adenocarcinoma are derived from Barrett's esophagus, which is a complication of esophageal adenocarcinoma precancerous lesions. Chronic ... ...

Abstract	The occurrence of gastroesophageal reflux disease is common in the human population. Almost all cases of esophageal adenocarcinoma are derived from Barrett's esophagus, which is a complication of esophageal adenocarcinoma precancerous lesions. Chronic exposure of the esophagus to gastroduodenal intestinal fluid is an important determinant factor in the development of Barrett's esophagus. The replacement of normal squamous epithelium with specific columnar epithelium in the lower esophagus induced by the chronic exposure to gastroduodenal fluid could lead to intestinal metaplasia, which is closely associated with the development of esophageal adenocarcinoma. However, the exact mechanism of injury is not completely understood. Various animal models of the developmental mechanisms of disease, and theoretical and clinical effects of drug treatment have been widely used in research. Recently, animal models employed in studies on gastroesophageal reflux injury have allowed significant progress. The advantage of using animal models lies in the ability to accurately control the experimental conditions for better evaluation of results. In this article, various modeling methods are reviewed, with discussion of the major findings on the developmental mechanism of Barrett's esophagus, which should help to develop better prevention and treatment strategies for Barrett's esophagus.
Mesh-Begriff(e)	Adenocarcinoma/etiology ; Adenocarcinoma/pathology ; Animals ; Barrett Esophagus/etiology ; Barrett Esophagus/pathology ; Cell Transformation, Neoplastic/pathology ; Disease Models, Animal ; Disease Progression ; Esophageal Neoplasms/etiology ; Esophageal Neoplasms/pathology ; Esophagitis, Peptic/complications ; Esophagitis, Peptic/pathology ; Esophagus/pathology ; Humans ; Mucous Membrane/pathology ; Precancerous Conditions/etiology ; Precancerous Conditions/pathology ; Risk Factors ; Species Specificity
Sprache	Englisch
Erscheinungsdatum	2015-05-07
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v21.i17.5210
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effects of Aloe Gel on Lactating Women with Nipple Trauma.

Wang, Rui-Hua / Gong, Jing-Ya / Liu, Peng-Cheng / Liu, Li-Fen / Zhang, Jin-Ting / Yao, Lan / Dong, Qin / Jia, Su-Hong

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

2024

Abstract: Background: ...

Abstract	Background:
Sprache	Englisch
Erscheinungsdatum	2024-03-26
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2234680-6
ISSN	1556-8342 ; 1556-8253
ISSN (online)	1556-8342
ISSN	1556-8253
DOI	10.1089/bfm.2023.0265
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Comparative transcriptome analysis identifies genes associated with chlorophyll levels and reveals photosynthesis in green flesh of radish taproot.

Li, Yuan-Yuan / Han, Min / Wang, Rui-Hua / Gao, Ming-Gang

PloS one

2021 Band 16, Heft 5, Seite(n) e0252031

Abstract: The flesh of the taproot of Raphanus sativus L. is rich in chlorophyll (Chl) throughout the developmental process, which is why the flesh is green. However, little is known about which genes are associated with Chl accumulation in this non-foliar, ... ...

Abstract	The flesh of the taproot of Raphanus sativus L. is rich in chlorophyll (Chl) throughout the developmental process, which is why the flesh is green. However, little is known about which genes are associated with Chl accumulation in this non-foliar, internal green tissue and whether the green flesh can perform photosynthesis. To determine these aspects, we measured the Chl content, examined Chl fluorescence, and carried out comparative transcriptome analyses of taproot flesh between green-fleshed "Cuishuai" and white-fleshed "Zhedachang" across five developmental stages. Numerous genes involved in the Chl metabolic pathway were identified. It was found that Chl accumulation in radish green flesh may be due to the low expression of Chl degradation genes and high expression of Chl biosynthesis genes, especially those associated with Part Ⅳ (from Protoporphyrin Ⅸ to Chl a). Bioinformatics analysis revealed that differentially expressed genes between "Cuishuai" and "Zhedachang" were significantly enriched in photosynthesis-related pathways, such as photosynthesis, antenna proteins, porphyrin and Chl metabolism, carbon fixation, and photorespiration. Twenty-five genes involved in the Calvin cycle were highly expressed in "Cuishuai". These findings suggested that photosynthesis occurred in the radish green flesh, which was also supported by the results of Chl fluorescence. Our study provides transcriptome data on radish taproots and provides new information on the formation and function of radish green flesh.
Mesh-Begriff(e)	Chlorophyll/analogs & derivatives ; Chlorophyll/biosynthesis ; Computational Biology/methods ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Plant ; Metabolic Networks and Pathways/genetics ; Photosynthesis/genetics ; Plant Proteins/classification ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Roots/anatomy & histology ; Plant Roots/genetics ; Plant Roots/growth & development ; Plant Roots/metabolism ; Protoporphyrins/biosynthesis ; Raphanus/anatomy & histology ; Raphanus/genetics ; Raphanus/growth & development ; Raphanus/metabolism ; Transcriptome
Chemische Substanzen	Plant Proteins ; Protoporphyrins ; Chlorophyll (1406-65-1) ; chlorophyll a' (22309-13-3) ; protoporphyrin IX (C2K325S808)
Sprache	Englisch
Erscheinungsdatum	2021-05-27
Erscheinungsland	United States
Dokumenttyp	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0252031
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Musculoskeletal ultrasound diagnosis of quadrilateral space syndrome: A case report.

Zhang, Jingfeng / Zhang, Tian / Wang, RuiHua / Wang, Ting

Medicine

2021 Band 100, Heft 10, Seite(n) e24976

Abstract: Introduction: Quadrilateral space syndrome (QSS) is a peripheral nerve entrapment disease, which can be misdiagnosed in clinic. In the past, QSS was mainly diagnosed by clinical symptoms combined with magnetic resonance imaging (MRI), electromyography ( ... ...

Abstract	Introduction: Quadrilateral space syndrome (QSS) is a peripheral nerve entrapment disease, which can be misdiagnosed in clinic. In the past, QSS was mainly diagnosed by clinical symptoms combined with magnetic resonance imaging (MRI), electromyography (EMG), and arterial angiography. There are few reports on the diagnosis of QSS by musculoskeletal ultrasound (MSKUS) combined with clinical symptoms. Patient concerns: A middle-aged female patient had posterolateral pain and numbness in her right shoulder for 2 months. Diagnoses: At first, she was diagnosed as suprascapular nerve entrapment, while EMG of suprascapular nerve and axillary nerve indicated that nerve conduction was normal. Then, MRI was performed, showing the shoulder had no abnormalities, and EMG and arterial angiography of upper limb showed no abnormalities too. Finally, she was diagnosed as QSS according to MSKUS and lidocaine block test. Interventions: Two sealing treatments of axillary nerve block in quadrilateral space under the guidance of MSKUS were performed. Outcomes: After 2 treatments, the pain and numbness in her shoulder disappeared, and her shoulder could move normally. There was no recurrence after 3 months of follow-up. Conclusion: MSKUS is an effective method to diagnose QSS. It is fast, convenient and inexpensive, and is worth popularizing in clinic.
Mesh-Begriff(e)	Brachial Plexus/diagnostic imaging ; Brachial Plexus Neuropathies/complications ; Brachial Plexus Neuropathies/diagnosis ; Brachial Plexus Neuropathies/therapy ; Deltoid Muscle/diagnostic imaging ; Deltoid Muscle/innervation ; Diagnosis, Differential ; Electromyography ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Nerve Block ; Nerve Compression Syndromes/complications ; Nerve Compression Syndromes/diagnosis ; Nerve Compression Syndromes/therapy ; Rotator Cuff/diagnostic imaging ; Rotator Cuff/innervation ; Shoulder/diagnostic imaging ; Shoulder/innervation ; Shoulder Pain/diagnosis ; Shoulder Pain/etiology ; Shoulder Pain/therapy ; Treatment Outcome ; Ultrasonography
Sprache	Englisch
Erscheinungsdatum	2021-03-24
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024976
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Analysis of internal spermatic vein embolization through catheter versus laparoscopic high ligation in treatment of left varicocele.

Jing, Ye-Xiang / Wang, Rui-Hua / Liu, Zhao-Xuan / Meng, Qing-Yi

Vascular

2020 Band 28, Heft 5, Seite(n) 583–590

Abstract: Objective: Varicocele is a common disease in young and middle-aged men. This study aims to compare the efficacy of internal spermatic vein embolization of left varicocele versus laparoscopic high ligation.: Methods: From January 2017 to September ... ...

Abstract	Objective: Varicocele is a common disease in young and middle-aged men. This study aims to compare the efficacy of internal spermatic vein embolization of left varicocele versus laparoscopic high ligation. Methods: From January 2017 to September 2018, a total of 69 varicocele patients were admitted and given the opportunity to choose the treatment option. Among these, 26 patients were treated with sclerosing agent injection, while 43 patients underwent laparoscopic surgery. They were followed up for 12 months after surgery, and the technical success rate, recurrence rate, complication rate, cost, operative time, and hospitalization time with regard to these two methods were analyzed. Results: All patients completed the medical procedures. There was no recurrence in patients in the sclerotherapy group during the follow-up period; however, the complication rate was 19.2%. Furthermore, the operative time, hospitalization time, and cost of treatment were 31.1 ± 11.1 min, 1.2 ± 0.49 days, and 9613.11 ± 895.97 Yuan, respectively. In the laparoscopic group, 9 patients underwent laparoscopic bilateral high ligation, while 34 patients received treatment on the left side alone. The recurrence rate of left varicocele was 4.7% and the complication rate was 44.2%. Furthermore, the operative time, hospitalization time, and treatment cost were 50.4 ± 14.48 min, 4.0 ± 2.02 days, and 10,948.29 ± 2547.00 Yuan, respectively. Moreover, there were statistically significant differences ( Conclusion: Patients who underwent sclerotherapy showed a higher technical success rate, a lower recurrence rate, fewer complications, and shorter hospitalization time compared to those treated with laparoscopic ligation. Transcatheter sclerosing agent injection may be a preferable treatment option for patients with unilateral varicocele.
Mesh-Begriff(e)	Adolescent ; Adult ; Catheterization/adverse effects ; Embolization, Therapeutic/adverse effects ; Humans ; Laparoscopy/adverse effects ; Length of Stay ; Ligation ; Male ; Middle Aged ; Postoperative Complications/etiology ; Recurrence ; Retrospective Studies ; Risk Factors ; Sclerosing Solutions/administration & dosage ; Sclerosing Solutions/adverse effects ; Sclerotherapy/adverse effects ; Testis/blood supply ; Time Factors ; Treatment Outcome ; Varicocele/diagnostic imaging ; Varicocele/therapy ; Veins/diagnostic imaging ; Veins/surgery ; Young Adult
Chemische Substanzen	Sclerosing Solutions
Sprache	Englisch
Erscheinungsdatum	2020-05-09
Erscheinungsland	England
Dokumenttyp	Comparative Study ; Journal Article
ZDB-ID	2137151-9
ISSN	1708-539X ; 1708-5381
ISSN (online)	1708-539X
ISSN	1708-5381
DOI	10.1177/1708538120923548
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [New developments for endoscopic management of Barrett's esophagus with high grade dysplasia].

Wang, Rui-Hua

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

2010 Band 39, Heft 5, Seite(n) 534–541

Abstract: Barrett's esophagus is now clearly recognized as a preneoplasic condition. Progression of metaplasia through dysplasia to adenocarcinoma is a widely accepted theory for esophageal carcinogenesis. That high grade dysplasia is frequently found in ... ...

Abstract	Barrett's esophagus is now clearly recognized as a preneoplasic condition. Progression of metaplasia through dysplasia to adenocarcinoma is a widely accepted theory for esophageal carcinogenesis. That high grade dysplasia is frequently found in association with esophageal adenocarcinoma. Long-term endoscopic surveillance of high grade dysplasia in Barrett's esophagus facilitates detection and treatment of esophageal cancers in the early stage.
Mesh-Begriff(e)	Barrett Esophagus/diagnosis ; Barrett Esophagus/pathology ; Barrett Esophagus/therapy ; Esophageal Neoplasms/diagnosis ; Esophagoscopy ; Humans ; Hyperplasia/pathology ; Precancerous Conditions/diagnosis
Sprache	Chinesisch
Erscheinungsdatum	2010
Erscheinungsland	China
Dokumenttyp	English Abstract ; Journal Article ; Review
ISSN	1008-9292
ISSN	1008-9292
DOI	10.3785/j.issn.1008-9292.2010.05.016
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ceramides regulate defense response by binding to RbohD in Arabidopsis.

Li, Jian / Yin, Jian / Wu, Jian-Xin / Wang, Ling-Yan / Liu, Yu / Huang, Li-Qun / Wang, Rui-Hua / Yao, Nan

The Plant journal : for cell and molecular biology

2022 Band 109, Heft 6, Seite(n) 1427–1440

Abstract: Sphingolipids, a class of bioactive lipids, play a critical role in signal transduction. Ceramides, which are central components of sphingolipid metabolism, are involved in plant development and defense. However, the mechanistic link between ceramides ... ...

Abstract	Sphingolipids, a class of bioactive lipids, play a critical role in signal transduction. Ceramides, which are central components of sphingolipid metabolism, are involved in plant development and defense. However, the mechanistic link between ceramides and downstream signaling remains unclear. Here, the mutation of alkaline ceramidase in a ceramide kinase mutant acd5 resulted in spontaneous programmed cell death early in development and was accompanied by ceramide accumulation, while other types of sphingolipids, such as long chain base, glucosylceramide, and glycosyl inositol phosphorylceramide, remained at the same level as the wild-type plants. Analysis of the transcriptome indicated that genes related to the salicylic acid (SA) pathway and oxidative stress pathway were induced dramatically in acer acd5 plants. Comparison of the level of reactive oxygen species (ROS), SA, and ceramides in the wild-type and acer acd5 plants at different developmental stages indicated that the acer acd5 mutant exhibited constitutive activation of SA and ROS signaling, which occurred simultaneously with the alteration of ceramides. Overexpressing NahG in the acer acd5 mutant could completely suppress its cell death and ceramide accumulation, while benzo-(1,2,3)-thiadiazole-7-carbothioc acid S-methyl ester treatment restored its phenotype again. Moreover, we found that the plasma membrane of acer acd5 mutant was the main site of ROS production. Ceramides accumulated in the plasma membrane of acer acd5, directly binding and activating the NADPH oxidase RbohD and promoting hydrogen peroxide generation and SA- or defense-related gene activation. Our data illustrated that ceramides play an essential role in plant defense.
Mesh-Begriff(e)	Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Ceramides/metabolism ; Mutation ; Salicylic Acid/metabolism ; Sphingolipids/metabolism
Chemische Substanzen	Arabidopsis Proteins ; Ceramides ; Sphingolipids ; Salicylic Acid (O414PZ4LPZ)
Sprache	Englisch
Erscheinungsdatum	2022-01-17
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.15639
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Ceramides regulate defense response by binding to RbohD in Arabidopsis

Li, Jian / Yin, Jian / Wu, Jian‐Xin / Wang, Ling‐Yan / Liu, Yu / Huang, Li‐Qun / Wang, Rui‐Hua / Yao, Nan

plant journal. 2022 Mar., v. 109, no. 6

2022

Abstract	Sphingolipids, a class of bioactive lipids, play a critical role in signal transduction. Ceramides, which are central components of sphingolipid metabolism, are involved in plant development and defense. However, the mechanistic link between ceramides and downstream signaling remains unclear. Here, the mutation of alkaline ceramidase in a ceramide kinase mutant acd5 resulted in spontaneous programmed cell death early in development and was accompanied by ceramide accumulation, while other types of sphingolipids, such as long chain base, glucosylceramide, and glycosyl inositol phosphorylceramide, remained at the same level as the wild‐type plants. Analysis of the transcriptome indicated that genes related to the salicylic acid (SA) pathway and oxidative stress pathway were induced dramatically in acer acd5 plants. Comparison of the level of reactive oxygen species (ROS), SA, and ceramides in the wild‐type and acer acd5 plants at different developmental stages indicated that the acer acd5 mutant exhibited constitutive activation of SA and ROS signaling, which occurred simultaneously with the alteration of ceramides. Overexpressing NahG in the acer acd5 mutant could completely suppress its cell death and ceramide accumulation, while benzo‐(1,2,3)‐thiadiazole‐7‐carbothioc acid S‐methyl ester treatment restored its phenotype again. Moreover, we found that the plasma membrane of acer acd5 mutant was the main site of ROS production. Ceramides accumulated in the plasma membrane of acer acd5, directly binding and activating the NADPH oxidase RbohD and promoting hydrogen peroxide generation and SA‐ or defense‐related gene activation. Our data illustrated that ceramides play an essential role in plant defense.
Schlagwörter	Arabidopsis ; NAD(P)H oxidase (H2O2-forming) ; ceramides ; gene activation ; glucosylceramides ; hydrogen peroxide ; inositols ; mutants ; mutation ; oxidative stress ; pathogenesis-related proteins ; phenotype ; plant development ; plasma membrane ; programmed cell death ; salicylic acid ; signal transduction ; transcriptome
Sprache	Englisch
Erscheinungsverlauf	2022-03
Umfang	p. 1427-1440.
Erscheinungsort	John Wiley & Sons, Ltd
Dokumenttyp	Artikel
Anmerkung	JOURNAL ARTICLE
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.15639
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Orosomucoid proteins limit endoplasmic reticulum stress in plants

Wang, Ling‐Yan / Li, Jian / Gong, Benqiang / Wang, Rui‐Hua / Chen, Yi‐Li / Yin, Jian / Yang, Chang / Lin, Jia‐Ting / Liu, Hao‐Zhuo / Yang, Yubing / Li, Jianfeng / Li, Chunyu / Yao, Nan

New Phytologist. 2023 Nov., v. 240, no. 3 p.1134-1148

2023

Abstract: Sphingolipids are cell membrane components and signaling molecules that induce endoplasmic reticulum (ER) stress responses, but the underlying mechanism is unknown. Orosomucoid proteins (ORMs) negatively regulate serine palmitoyltransferase activity, ... ...

Abstract	Sphingolipids are cell membrane components and signaling molecules that induce endoplasmic reticulum (ER) stress responses, but the underlying mechanism is unknown. Orosomucoid proteins (ORMs) negatively regulate serine palmitoyltransferase activity, thus helping maintain proper sphingolipid levels in humans, yeast, and plants. In this report, we explored the roles of ORMs in regulating ER stress in Arabidopsis thaliana. Loss of ORM1 and ORM2 function caused constitutive activation of the unfolded protein response (UPR), as did treatment with the ceramide synthase inhibitor Fumonisin B1 (FB1) or ceramides. FB1 treatment induced the transcription factor bZIP28 to relocate from the ER membrane to the nucleus. The transcription factor WRKY75 positively regulates the UPR and physically interacted with bZIP28. We also found that the orm mutants showed impaired ER‐associated degradation (ERAD), blocking the degradation of misfolded MILDEW RESISTANCE LOCUS‐O 12 (MLO‐12). ORM1 and ORM2 bind to EMS‐MUTAGENIZED BRI1 SUPPRESSOR 7 (EBS7), a plant‐specific component of the Arabidopsis ERAD complex, and regulate its stability. These data strongly suggest that ORMs in the ER membrane play vital roles in the UPR and ERAD pathways to prevent ER stress in Arabidopsis. Our results reveal that ORMs coordinate sphingolipid homeostasis with ER quality control and play a role in stress responses.
Schlagwörter	Arabidopsis thaliana ; cell membranes ; ceramides ; endoplasmic reticulum ; endoplasmic reticulum stress ; fumonisin B1 ; homeostasis ; mildews ; quality control ; serine C-palmitoyltransferase ; sphingosine N-acyltransferase ; transcription factors ; unfolded protein response ; yeasts
Sprache	Englisch
Erscheinungsverlauf	2023-11
Umfang	p. 1134-1148.
Erscheinungsort	John Wiley & Sons, Ltd
Dokumenttyp	Artikel ; Online
Anmerkung	JOURNAL ARTICLE
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.19200
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Aberrant accumulation of ceramides in mitochondria triggers cell death by inducing autophagy in Arabidopsis.

Bao, He-Nan / Yin, Jian / Wang, Ling-Yan / Wang, Rui-Hua / Huang, Li-Qun / Chen, Yi-Li / Wu, Jian-Xin / Sun, Jia-Qi / Liu, Wei-Wei / Yao, Nan / Li, Jian

Journal of experimental botany

2023 Band 75, Heft 5, Seite(n) 1314–1330

Abstract: Sphingolipids are membrane lipids and play critical roles in signal transduction. Ceramides are central components of sphingolipid metabolism that are involved in cell death. However, the mechanism of ceramides regulating cell death in plants remains ... ...

Abstract	Sphingolipids are membrane lipids and play critical roles in signal transduction. Ceramides are central components of sphingolipid metabolism that are involved in cell death. However, the mechanism of ceramides regulating cell death in plants remains unclear. Here, we found that ceramides accumulated in mitochondria of accelerated cell death 5 mutant (acd5), and expression of mitochondrion-localized ceramide kinase (ACD5) suppressed mitochondrial ceramide accumulation and the acd5 cell death phenotype. Using immuno-electron microscopy, we observed hyperaccumulation of ceramides in acer acd5 double mutants, which are characterized by mutations in both ACER (alkaline ceramidase) and ACD5 genes. The results confirmed that plants with specific ceramide accumulation exhibited localization of ceramides to mitochondria, resulting in an increase in mitochondrial reactive oxygen species production. Interestingly, when compared with the wild type, autophagy-deficient mutants showed stronger resistance to ceramide-induced cell death. Lipid profiling analysis demonstrated that plants with ceramide accumulation exhibited a significant increase in phosphatidylethanolamine levels. Furthermore, exogenous ceramide treatment or endogenous ceramide accumulation induces autophagy. When exposed to exogenous ceramides, an increase in the level of the autophagy-specific ubiquitin-like protein, ATG8e, associated with mitochondria, where it directly bound to ceramides. Taken together, we propose that the accumulation of ceramides in mitochondria can induce cell death by regulating autophagy.
Mesh-Begriff(e)	Ceramides/metabolism ; Ceramides/pharmacology ; Arabidopsis/metabolism ; Mitochondria/metabolism ; Autophagy ; Cell Death ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism
Chemische Substanzen	Ceramides ; ACD5 protein, Arabidopsis (EC 2.7.1.138) ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; Arabidopsis Proteins
Sprache	Englisch
Erscheinungsdatum	2023-12-06
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2976-2
ISSN	1460-2431 ; 0022-0957
ISSN (online)	1460-2431
ISSN	0022-0957
DOI	10.1093/jxb/erad456
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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