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  1. Article ; Online: Lymph node metastasis in small intestinal gastrointestinal stromal tumors: A rare case report and literature review.

    Wang, Sheng Jin / Sun, Feng

    Asian journal of surgery

    2023  Volume 47, Issue 1, Page(s) 592–595

    MeSH term(s) Humans ; Gastrointestinal Stromal Tumors/surgery ; Gastrointestinal Stromal Tumors/pathology ; Imatinib Mesylate ; Intestinal Neoplasms/surgery ; Intestinal Neoplasms/pathology ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Stomach Neoplasms/pathology ; Female ; Aged
    Chemical Substances Imatinib Mesylate (8A1O1M485B)
    Language English
    Publishing date 2023-10-30
    Publishing country Netherlands
    Document type Review ; Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.09.123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Association of Serum Neurofilament Light Chain and Acute Ischaemic Stroke Is Influenced by Effective Revascularization

    Fa-Ying Zhou / Dong-Wan Chen / Hui-Yun Li / Chi Zhu / Ying-Ying Shen / Ze-Yan Peng / Ling Li / Xian-Le Bu / Gui-Hua Zeng / Meng Zhang / Yan-Jiang Wang / Wang-Sheng Jin

    Disease Markers, Vol

    2022  Volume 2022

    Abstract: Objective. To explore associations of serum neurofilament light chain (sNfL) at admission with clinical deficits and the long-term prognosis of acute ischaemic stroke (AIS). Methods. We recruited 110 AIS patients with serum sampled at hospital arrival. ... ...

    Abstract Objective. To explore associations of serum neurofilament light chain (sNfL) at admission with clinical deficits and the long-term prognosis of acute ischaemic stroke (AIS). Methods. We recruited 110 AIS patients with serum sampled at hospital arrival. The concentrations of sNfL were detected by a Simoa HD-1 analyser. We first investigated the determinants of sNfL levels at admission within the study population. Associations of sNfL levels with National Institutes of Health Stroke Scale (NIHSS) scores and modified Rankin Scale (mRS) scores were then tested. We further divided the patients into revascularized and nonrevascularized groups, and the associations of sNfL levels with NIHSS and mRS scores were assessed in these subgroups. Results. Age, sex, stroke history, and the time between the onset of illness and arrival at the hospital were independent influencing factors of sNfL levels within the study population. The sNfL levels at admission were correlated with the NIHSS scores 7 days after stroke (p=0.004) across all subjects but showed no correlation with the NIHSS scores at admission (p=0.293) or the mRS scores 6 months after stroke (p=0.065). Further analysis revealed that in the nonrevascularized group of AIS patients, the sNfL levels at admission were positively correlated with NIHSS scores (NIHSS at admission, p=0.005; NIHSS 7 days after stroke, p=0.003) and negatively correlated with mRS scores (p=0.011). Conclusion. sNfL levels at admission could be a potential biomarker for predicting clinical deficits and prognosis in the natural course of AIS.
    Keywords Medicine (General) ; R5-920
    Subject code 333
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Correlations of Plasma and Cerebrospinal Fluid Amyloid-Beta Levels with Platelet Count in Patients with Alzheimer’s Disease

    Hao-Lun Sun / Wei-Wei Li / Chi Zhu / Wang-Sheng Jin / Yu-Hui Liu / Fan Zeng / Yan-Jiang Wang / Xian-Le Bu

    BioMed Research International, Vol

    2018  Volume 2018

    Abstract: Purpose. Recent study shows that blood-derived amyloid-beta (Aβ) can induce cerebral amyloidosis and is involved in the pathogenesis of Alzheimer’s disease (AD). The vast majority of blood Aβ is generated from platelet. Whether blood Aβ levels are ... ...

    Abstract Purpose. Recent study shows that blood-derived amyloid-beta (Aβ) can induce cerebral amyloidosis and is involved in the pathogenesis of Alzheimer’s disease (AD). The vast majority of blood Aβ is generated from platelet. Whether blood Aβ levels are associated with the count of platelets remains unknown. Methods. 58 clinically diagnosed AD patients, 18 11C-PIB-PET diagnosed AD patients, and 61 age- and gender-matched cognitively normal controls were included to analyze the correlation of plasma Aβ levels with platelet count. 13 AD patients and 40 controls with cerebrospinal fluid (CSF) samples were included to further analyze the correlation of CSF Aβ levels with platelet count. Aβ40 and Aβ42 levels in plasma and CSF were measured by ELISA kits. Results. The plasma Aβ42 level was positively correlated with platelet count in both AD patients and control group, especially in AD patients with positive PIB-PET, while there was no correlation as to Aβ40. The CSF Aβ levels also had no significant correlation with platelet count. Conclusion. It suggests that platelets may be involved in the pathogenesis of AD and become a potential peripheral biomarker for AD.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Comorbidity burden of patients with Parkinson’s disease and Parkinsonism between 2003 and 2012

    Xin Wang / Fan Zeng / Wang-Sheng Jin / Chi Zhu / Qing-Hua Wang / Xian-Le Bu / Hong-Bo Luo / Hai-Qiang Zou / Jie Pu / Zhong-He Zhou / Xiao-Ping Cui / Qing-Song Wang / Xiang-Qun Shi / Wei Han / Qiang Wu / Hui-Sheng Chen / Hang Lin / Li-Li Zhang / Meng Zhang /
    Yan Lian / Zhi-Qiang Xu / Hua-Dong Zhou / Tao Zhang / Yan-Jiang Wang

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    A multicentre, nationwide, retrospective study in China

    2017  Volume 6

    Abstract: Abstract Parkinson’s disease (PD) and Parkinsonism are common neurodegenerative disorders with continuously increasing prevalence, causing high global burdens. However, data concerning the comorbidity burden of patients with PD or Parkinsonism in China ... ...

    Abstract Abstract Parkinson’s disease (PD) and Parkinsonism are common neurodegenerative disorders with continuously increasing prevalence, causing high global burdens. However, data concerning the comorbidity burden of patients with PD or Parkinsonism in China are lacking. To investigate the health condition and comorbidity burden, a total of 3367 PD and 823 Parkinsonism patients were included from seven tertiary hospitals in seven cities across China from 2003 to 2012. Their comorbidity burden was collected and quantified by the Elixhauser Comorbidity Index (ECI) and Charlson Comorbidity Index (CCI). The comorbidity spectra differed between PD and Parkinsonism patients. Compared with PD patients, Parkinsonism patients were older (69.8 ± 11.5 vs. 67.9 ± 11.4, P < 0.001); had a higher comorbidity burden, including ECI (1.1 ± 1.2 vs. 1.0 ± 1.2, P < 0.001) and CCI (1.3 ± 1.6 vs. 1.1 ± 1.5, P < 0.001); and had higher hospitalization expenses. The ECI (1.1 ± 1.3 vs. 0.9 ± 1.1, P < 0.001) and CCI (1.3 ± 1.6 vs. 0.9 ± 1.2, P < 0.001) were higher in males than in females. The average length of stay and daily hospitalization expenses increased with age, as did ECI and CCI. This is the first study to report the disease burden of Chinese PD and Parkinsonism patients. It provides useful information to better understand their health status, and to raise the awareness of clinicians for providing better health care.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2017-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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