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  1. AU="Wang, Shih-Yun"
  2. AU="Sharma, Podila Satya Venkata Narasimha"
  3. AU="Distefano, Marco"
  4. AU="Malleda, Neeraja R"
  5. AU="Framme, Jenny Lingman"
  6. AU="Howells, Laurence"
  7. AU="Golubeva, M"
  8. AU="Pavlyk, Iuliia"
  9. AU="Persons, A K"
  10. AU="Carbone, Vincenzo"
  11. AU="R.G.Ormiston, " AU="R.G.Ormiston, "
  12. AU=Sinha Surabhi
  13. AU="Whitby, Thomas Michael"
  14. AU="F Hossain"
  15. AU="Xavier, Joicymara S."
  16. AU="Heidenreich, Sebastian"
  17. AU="Clifford, Muireann"
  18. AU="Armendariz, R."
  19. AU="Cho, Yoon-Kyoung"
  20. AU="Payne, Emily"
  21. AU="Desseauve, David"
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  23. AU=Alpaydin Aylin O AU=Alpaydin Aylin O
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  25. AU="Subramanian, Prem S"
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  27. AU="Kotrotsiou, Evagelia"
  28. AU="Belnap, Ethan"
  29. AU="Luo, Jianming"
  30. AU=Hsu Pin-Jui
  31. AU=Debaud Charlotte
  32. AU="García-Rubia, Alfonso"
  33. AU=Belot Alexandre
  34. AU="Jorge Ospina Duque"
  35. AU="Chalot, Michel"
  36. AU="Gunsolley, J N"
  37. AU="Tuè, Giovanni"
  38. AU="de Laat, Bart"
  39. AU=Drory Omri
  40. AU="Pothlichet, Julien"
  41. AU="Douwes, Rianne M"
  42. AU="Jarzebowski, Mary"
  43. AU="Shetty, Sunil"
  44. AU="Ricardo Ryoshim Kunyioshi"
  45. AU=Santos Maria Cristina Leme Godoy Dos AU=Santos Maria Cristina Leme Godoy Dos

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  1. Artikel: Development of a respiratory syncytial virus vaccine using human hepatitis B core-based virus-like particles to induce mucosal immunity

    Huang, Jen-Min / Wang, Shih-Yun / Lai, Mei-Ru / Tseng, Yu-Kai / Chi, Ya-Hui / Huang, Li-Min

    Vaccine. 2021 June 02, v. 39, no. 24

    2021  

    Abstract: Respiratory syncytial virus (RSV) is an important viral pathogen responsible for severe infection of the lower respiratory tract in children under the age of 5 years. No vaccines against RSV are currently in clinical use. Vaccine-associated enhanced ... ...

    Abstract Respiratory syncytial virus (RSV) is an important viral pathogen responsible for severe infection of the lower respiratory tract in children under the age of 5 years. No vaccines against RSV are currently in clinical use. Vaccine-associated enhanced respiratory disease (ERD) caused by excess Th2 type responses was observed in a clinical trial of formalin-inactivated RSV (FI-RSV) in antigen-naïve infants. Thus, inducing a balanced immune response is a crucial issue in the development of an RSV vaccine.In this study, we constructed, expressed, and purified a recombinant RSV vaccine candidate (i.e., HRØ24) containing the two heptad repeat regions and the antigenic sites Ø, II, and IV of the RSV F protein. The RSV vaccine candidate was intranasally administrated to BALB/c and C57BL/6 mice in combination with virus-like particles (VLPs) derived from the core protein of the hepatitis B virus (HBc). Mucosal immunity to HRØ24 was then assessed.Intranasal administration of HBc VLPs in combination with HRØ24 induced serum IgGs against HRØ24 as well as lung HRØ24-specific sIgAs in both C57BL/6 and BALB/c mouse models. The secretion of IFN-γ from splenocyte re-stimulation and an elevated ratio of serum IgG2a to IgG1 indicated that the immune response induced by the HBc VLPs/HRØ24 mixture was Th1-biased. Weight loss of <5% and no to low eosinophil infiltration was observed in histological analysis of the lung following a challenge with the RSV A2 strain. These results suggest that the HBc VLPs/HRØ24 combination conferred substantial partial protection against RSV-induced illness in mice.Long-term immunity to RSV-induced illness was achieved via intranasal vaccination using a mixture of HBc VLPs and HRØ24 in mouse models.
    Schlagwörter Hepatitis B virus ; Respiratory syncytial virus ; blood serum ; clinical trials ; hepatitis B ; histology ; humans ; immune response ; immunoglobulin G ; lungs ; mice ; mucosal immunity ; pathogens ; respiratory tract diseases ; secretion ; splenocytes ; vaccination ; vaccines ; weight loss
    Sprache Englisch
    Erscheinungsverlauf 2021-0602
    Umfang p. 3259-3269.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.04.038
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury.

    Liu, Pei-Yao / Chen, Chih-Yuan / Lin, Yu-Lung / Lin, Chien-Ming / Tsai, Wen-Chiuan / Tsai, Yu-Ling / Lin, Gu-Jiun / Chen, Yu-Guang / Wang, Shih-Yun / Sun, Rui-Nong / Huang, Yu-Chuan / Chang, Hung / Chen, Ying-Chuan

    Cell death & disease

    2023  Band 14, Heft 6, Seite(n) 369

    Abstract: Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore, establishing effective therapeutic targets for ALI prevention is crucial. The present study reports a novel ...

    Abstract Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore, establishing effective therapeutic targets for ALI prevention is crucial. The present study reports a novel function of RNF128 in regulating LPS-induced ALI. Severe lung damage and increased immune cell infiltration were detected in RNF128-deficient mice. In vitro experiments revealed that RNF128 inhibits neutrophil activation by binding to myeloperoxidase (MPO) and reducing its levels and activity. Moreover, RNF128 regulates alveolar macrophage activation and neutrophil infiltration by interacting with TLR4, targeting it for degradation, and inhibiting NF-κB activation, hence decreasing pro-inflammatory cytokines. Our results demonstrate for the first time that RNF128 is a negative regulator of MPO and TLR4 in neutrophils and alveolar macrophages, respectively. However, AAV9-mediated RNF128 overexpression alleviated lung tissue damage and reduced inflammatory cell infiltration. Thus, RNF128 is a promising therapeutic candidate for pharmacological interventions in ALI.
    Mesh-Begriff(e) Animals ; Mice ; Acute Lung Injury/chemically induced ; Acute Lung Injury/genetics ; Acute Lung Injury/prevention & control ; Lipopolysaccharides/pharmacology ; Lung/metabolism ; Neutrophil Infiltration ; NF-kappa B/metabolism ; Peroxidase/metabolism ; Toll-Like Receptor 4/metabolism ; Ubiquitin-Protein Ligases/metabolism
    Chemische Substanzen Lipopolysaccharides ; NF-kappa B ; Peroxidase (EC 1.11.1.7) ; Toll-Like Receptor 4 ; RNF128 protein, mouse (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Sprache Englisch
    Erscheinungsdatum 2023-06-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-023-05890-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Prediction of 5-Year Weight Loss and Weight Regain According to Early Weight Loss after Sleeve Gastrectomy.

    Su, Yi-Ting / Su, Yen-Hao / Tam, Ka-Wai / Yen, Yu-Chun / Wang, Weu / Huang, Ming-Te / Wang, Shih-Yun / Pai, Fang-Yi / Kuo, Chih-Ying / Shen, Shih-Chiang

    Obesity surgery

    2023  Band 33, Heft 5, Seite(n) 1366–1372

    Abstract: Background: Patients with morbid obesity exhibit sustained weight loss after sleeve gastrectomy (SG), but some individuals exhibit subsequent weight regain in the following years. Early weight loss was proven as a predictor of short- and mid-term weight ...

    Abstract Background: Patients with morbid obesity exhibit sustained weight loss after sleeve gastrectomy (SG), but some individuals exhibit subsequent weight regain in the following years. Early weight loss was proven as a predictor of short- and mid-term weight loss and regain. However, the long-term effects of early weight loss have yet to be fully investigated. This study investigated the predictive effects of early weight loss on long-term weight loss and regain after SG.
    Methods: Data of patients who underwent SG from November 2011 to July 2016 and followed through July 2021 were collected retrospectively. Weight regain was defined by weight increase more than 25% of their lost weight at the first postoperative year. Linear regression analysis and Cox proportional hazards analysis were performed to evaluate the correlations among early weight loss, weight loss, and weight regain.
    Results: Data of 408 patients were included. The percentages of total weight loss (%TWL) at postoperative months 1, 3, 12, and 60 were 10.6%, 18.1%, 29.3%, and 26.6%, respectively. The %TWL at months 1 and 3 were significantly correlated with %TWL after 5 years (P < .01). The weight regain rate was 29.8% at 5 years. The %TWL at months 1 and 3 significantly influenced weight regain (hazard ratio: 0.87 and 0.89, P = .017 and .008).
    Conclusion: Early weight loss may be used to predict weight loss and regain 5 years after SG. Patients with poor early weight loss are recommended to receive early interventions to achieve long-term weight loss and prevent weight regain.
    Mesh-Begriff(e) Humans ; Obesity, Morbid/surgery ; Retrospective Studies ; Gastrectomy ; Weight Loss ; Weight Gain ; Treatment Outcome ; Laparoscopy ; Gastric Bypass
    Sprache Englisch
    Erscheinungsdatum 2023-03-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-023-06527-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial cells.

    Yang, Po-Min / Cheng, Kai-Chun / Huang, Jing-Yao / Wang, Shih-Yun / Lin, Yung-Ni / Tseng, Yen-Tzu / Hsieh, Chia-Wen / Wung, Being-Sun

    Toxicology and applied pharmacology

    2021  Band 421, Seite(n) 115545

    Abstract: The present study elucidated mechanisms through which sulforaphane (SFN) protects retinal pigment epithelial (RPE) cells from blue light-induced impairment. SFN could activate the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) ...

    Abstract The present study elucidated mechanisms through which sulforaphane (SFN) protects retinal pigment epithelial (RPE) cells from blue light-induced impairment. SFN could activate the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and increase the expression of the heme oxygenease-1 (HO-1) gene and production of glutathione. SFN reduced blue light-induced oxidative stress, and effectively activated cytoprotective components including Nrf-2, HO-1, thioredoxin-1, and glutathione. The protective effect of SFN on blue light-induced injury was blocked by the Nrf2 inhibitor ML385, suggesting that the SFN-induced Nrf2 pathway is involved in the cytoprotective effect of SFN. SFN inhibited intercellular adhesion molecule-1 expression induced by TNF-α or blue light, suggesting the anti-inflammatory activity of SFN. The inhibitory effect of SFN was associated with the blocking of NF-κB p65 nuclear translocation in blue light-exposed RPE cells. SFN protected RPE cells from blue light-induced interruption of the mitochondrial membrane potential and reduction of the Bcl-2/Bax ratio and cleaved caspase-3 and PARP-1 expression, suggesting the antiapoptotic activity of SFN. SFN alone or together with blue light exposure increased the expression of the autophagy-related proteins LC3BII and p62. An autophagy inhibitor, 3-MA, inhibited the protective effect of SFN on blue light-induced cell damage. SFN increased sirtuin-1 (SIRT1) expression; however, treatment with blue light induced peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) expression. Our study results demonstrated that SFN exerts its protective effect under blue light exposure by maintaining the Nrf2-related redox state and upregulating SIRT1 and PGC-1α expression and autophagy.
    Mesh-Begriff(e) Anti-Inflammatory Agents/pharmacology ; Apoptosis/drug effects ; Apoptosis/radiation effects ; Autophagy/drug effects ; Autophagy/radiation effects ; Coculture Techniques ; Epithelial Cells/drug effects ; Epithelial Cells/enzymology ; Epithelial Cells/pathology ; Epithelial Cells/radiation effects ; Glutathione/metabolism ; Humans ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Isothiocyanates/pharmacology ; Light ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Retinal Pigment Epithelium/drug effects ; Retinal Pigment Epithelium/enzymology ; Retinal Pigment Epithelium/pathology ; Retinal Pigment Epithelium/radiation effects ; Signal Transduction ; Sirtuin 1/metabolism ; Sulfoxides/pharmacology ; THP-1 Cells ; Transcription Factor RelA/metabolism
    Chemische Substanzen Anti-Inflammatory Agents ; ICAM1 protein, human ; Isothiocyanates ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; PPARGC1A protein, human ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; RELA protein, human ; Sulfoxides ; Transcription Factor RelA ; Intercellular Adhesion Molecule-1 (126547-89-5) ; SIRT1 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-) ; sulforaphane (GA49J4310U) ; Glutathione (GAN16C9B8O)
    Sprache Englisch
    Erscheinungsdatum 2021-04-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2021.115545
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Development of a respiratory syncytial virus vaccine using human hepatitis B core-based virus-like particles to induce mucosal immunity.

    Huang, Jen-Min / Wang, Shih-Yun / Lai, Mei-Ru / Tseng, Yu-Kai / Chi, Ya-Hui / Huang, Li-Min

    Vaccine

    2021  Band 39, Heft 24, Seite(n) 3259–3269

    Abstract: Background: Respiratory syncytial virus (RSV) is an important viral pathogen responsible for severe infection of the lower respiratory tract in children under the age of 5 years. No vaccines against RSV are currently in clinical use. Vaccine-associated ... ...

    Abstract Background: Respiratory syncytial virus (RSV) is an important viral pathogen responsible for severe infection of the lower respiratory tract in children under the age of 5 years. No vaccines against RSV are currently in clinical use. Vaccine-associated enhanced respiratory disease (ERD) caused by excess Th2 type responses was observed in a clinical trial of formalin-inactivated RSV (FI-RSV) in antigen-naïve infants. Thus, inducing a balanced immune response is a crucial issue in the development of an RSV vaccine.
    Methods: In this study, we constructed, expressed, and purified a recombinant RSV vaccine candidate (i.e., HRØ24) containing the two heptad repeat regions and the antigenic sites Ø, II, and IV of the RSV F protein. The RSV vaccine candidate was intranasally administrated to BALB/c and C57BL/6 mice in combination with virus-like particles (VLPs) derived from the core protein of the hepatitis B virus (HBc). Mucosal immunity to HRØ24 was then assessed.
    Results: Intranasal administration of HBc VLPs in combination with HRØ24 induced serum IgGs against HRØ24 as well as lung HRØ24-specific sIgAs in both C57BL/6 and BALB/c mouse models. The secretion of IFN-γ from splenocyte re-stimulation and an elevated ratio of serum IgG2a to IgG1 indicated that the immune response induced by the HBc VLPs/HRØ24 mixture was Th1-biased. Weight loss of <5% and no to low eosinophil infiltration was observed in histological analysis of the lung following a challenge with the RSV A2 strain. These results suggest that the HBc VLPs/HRØ24 combination conferred substantial partial protection against RSV-induced illness in mice.
    Conclusions: Long-term immunity to RSV-induced illness was achieved via intranasal vaccination using a mixture of HBc VLPs and HRØ24 in mouse models.
    Mesh-Begriff(e) Animals ; Antibodies, Viral ; Hepatitis B ; Humans ; Immunity, Mucosal ; Lung ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Vaccines ; Respiratory Syncytial Virus, Human ; Viral Fusion Proteins
    Chemische Substanzen Antibodies, Viral ; Respiratory Syncytial Virus Vaccines ; Viral Fusion Proteins
    Sprache Englisch
    Erscheinungsdatum 2021-05-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.04.038
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice.

    Lee, Shih-Chieh / Wang, Shih-Yun / Li, Chien-Chun / Liu, Cheng-Tzu

    Journal of food and drug analysis

    2017  Band 26, Heft 1, Seite(n) 211–220

    Abstract: Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously ... ...

    Abstract Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously demonstrated the chemical composition and anti-inflammatory effect of leaf essential oil of Cinnamomum osmophloeum Kanehira of linalool chemotype in streptozotocin-induced diabetic rats and on endotoxin-injected mice. The aim of the present study is to evaluate whether cinnamaldehyde and linalool the active anti-inflammatory compounds in leaf essential oil of Cinnamomum osmophloeum Kanehira. Before the injection of endotoxin, C57BL/6 mice of the experimental groups were administered cinnamaldehyde (0.45 or 0.9 mg/kg body weight) or linalool (2.6 or 5.2 mg/kg body weight), mice of the positive control group were administered the leaf essential oil (13 mg/kg body weight), and mice of the negative group were administered vehicle (corn oil, 4 mL/kg body weight) by gavage every other day for two weeks. All mice received endotoxin (i.p. 10 mg/mL/kg body weight) the next day after the final administration and were killed 12 h after the injection. Normal control mice were pretreated with vehicle followed by the injection with saline. None of the treatment found to affect body weight or food or water intake of mice before the injection of endotoxin. Cinnamaldehyde and linalool were found significantly reversed endotoxin-induced body weight loss and lymphoid organ enlargement compared with vehicle (P < 0.05). Both compounds also significantly lowered endotoxin-induced levels of peripheral nitrate/nitrite, interleukin (IL)-1β, IL-18, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and High-mobility group box 1 protein (HMGB-1), and levels of nitrate/nitrite, IL-1β, TNF-α, and IFN-γ in spleen and mesenteric lymph nodes (MLNs) (P < 0.05). Endotoxin-induced expression of toll-like receptor 4 (TLR4), Myeloid differentiation primary response gene 88 (MyD88), myeloid differentiation protein 2 (MD2), Nod-like receptor family, pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC), and caspase-1 in spleen and mesenteric lymph nodes (MLNs) were inhibited by all tested doses of cinnamaldehyde and linalool (P < 0.05). Subsequently, the activation of nuclear factor (NF)-κB and the activity of caspase-1 in spleen and MLNs were also suppressed by these two compounds (P < 0.05). In addition, cinnamaldehyde and linalool at the dose equivalent to their corresponding content in the tested dose of the leaf essential oil, which was 0.9 mg/kg and 5.2 mg/kg, respectively, showed similar or slightly less inhibitory activity for most of these inflammatory parameters compared with that of the leaf essential oil. Our data confirmed the potential use of leaf essential oil of Cinnamomum osmophloeum Kanehira as an anti-inflammatory natural product and provide evidence for cinnamaldehyde and linalool as two potent agents for prophylactic use in health problems associated with inflammations that being attributed to over-activated TLR4 and/or NLRP3 signaling pathways.
    Mesh-Begriff(e) Acrolein/analogs & derivatives ; Acrolein/chemistry ; Acrolein/pharmacology ; Animals ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Biomarkers ; Cinnamomum/chemistry ; Cytokines/metabolism ; Endotoxins/adverse effects ; Humans ; Inflammation/drug therapy ; Inflammation/etiology ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Male ; Mice ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Oils, Volatile/chemistry ; Oils, Volatile/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Signal Transduction/drug effects
    Chemische Substanzen Anti-Inflammatory Agents ; Biomarkers ; Cytokines ; Endotoxins ; Inflammation Mediators ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Oils, Volatile ; Plant Extracts ; Acrolein (7864XYD3JJ) ; cinnamaldehyde (SR60A3XG0F)
    Sprache Englisch
    Erscheinungsdatum 2017-04-19
    Erscheinungsland China (Republic : 1949- )
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2224-6614
    ISSN (online) 2224-6614
    DOI 10.1016/j.jfda.2017.03.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Validating Risk Prediction Models of Diabetes Remission After Sleeve Gastrectomy.

    Shen, Shih-Chiang / Wang, Weu / Tam, Ka-Wai / Chen, Hsin-An / Lin, Yen-Kuang / Wang, Shih-Yun / Huang, Ming-Te / Su, Yen-Hao

    Obesity surgery

    2018  Band 29, Heft 1, Seite(n) 221–229

    Abstract: Introduction: Many risk prediction models of diabetes remission after bariatric and metabolic surgery have been proposed. Most models have been created using Roux-en-Y gastric bypass cohorts. However, validation of these models in sleeve gastrectomy (SG) ...

    Abstract Introduction: Many risk prediction models of diabetes remission after bariatric and metabolic surgery have been proposed. Most models have been created using Roux-en-Y gastric bypass cohorts. However, validation of these models in sleeve gastrectomy (SG) is limited. The objective of our study is to validate the performance of risk prediction models of diabetes remission in obese patients with diabetes who underwent SG.
    Method: This retrospective cohort study included 128 patients who underwent SG with at least 1 year follow-up from Dec 2011 to Sep 2016 as the validation cohort. A literature review revealed total 11 models with 2 categories (scoring system and logistic regression), which were validated by our study dataset. Discrimination was evaluated by area under the receiver operating characteristic (AUC) while calibration by Hosmer-Lemeshow test and predicted versus observed remission ratio.
    Results: At 1 year after surgery, 71.9% diabetes remission (HbA1c < 6.0 off medication) and 61.4% excess weight loss were observed. Individual metabolic surgery, ABCD, DiaRem, Advanced-DiaRem, DiaBetter, Ana et al., and Dixon et al. models showed excellent discrimination power (AUC > 0.8). In calibration, all models overestimated diabetes remission from 5 to 30% but did not lose their goodness of fit.
    Conclusion: This is the first comprehensive external validation of current risk prediction models of diabetes remission at 1 year after SG. Seven models showed excellent predicting power, and scoring models were recommended more because of their easy utility.
    Mesh-Begriff(e) Adult ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/surgery ; Female ; Gastrectomy/adverse effects ; Gastrectomy/methods ; Gastrectomy/statistics & numerical data ; Humans ; Male ; Middle Aged ; Models, Statistical ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology ; Obesity/surgery ; Predictive Value of Tests ; Prognosis ; Remission Induction ; Retrospective Studies ; Risk Assessment ; Treatment Outcome ; Weight Loss
    Sprache Englisch
    Erscheinungsdatum 2018-09-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Validation Study
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-018-3510-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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