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Article ; Online: miR-330 alleviates dextran sodium sulfate-induced ulcerative colitis through targeting IRAK1 in rats.

Zhang, Qing / Wang, Shu-Fang

The Kaohsiung journal of medical sciences

2021 Volume 37, Issue 6, Page(s) 497–504

Abstract: Ulcerative colitis (UC) is a chronic multifactorial inflammatory bowel disease that severely impairs patients' life quality. microRNAs (miRNAs) have been reported to exhibit potential therapeutic effects in the management of UC. With the aim to ... ...

Abstract	Ulcerative colitis (UC) is a chronic multifactorial inflammatory bowel disease that severely impairs patients' life quality. microRNAs (miRNAs) have been reported to exhibit potential therapeutic effects in the management of UC. With the aim to investigate the regulatory effects of miR-330 on UC-related colon tissue damage and inflammation, a rat model of experimental colitis was established by oral administration of dextran sodium sulfate (DSS). DSS-treated rats showed mucosal damage, colonic inflammation, and elevated myeloperoxidase activity compared with the healthy controls. Dual-luciferase reporter assay confirmed the binding of interleukin-1 receptor-associated kinase 1 (IRAK1) and miR-330. Subsequently, rats were intracolonically injected with miR-330 argomir with/without administration of IRAK1 during DSS treatment. The miR-330 overexpression reduced DSS-induced colonic injury and the production of proinflammatory cytokines. The level of IRAK1 was negatively regulated by the expression of miR-330. IRAK1 overexpression abolished the protective effect of miR-330 on DSS-induced colonic inflammation and mucosal injury in rats. In conclusion, we clarify the role of miR-330 in pathogenesis of UC, suggesting miR-330 alleviated DSS-induced colitis by downregulating IRAK1, shedding lights on miR-330 as a therapeutic candidate for UC treatment.
MeSH term(s)	Animals ; Colitis, Ulcerative/metabolism ; Colon/metabolism ; Cytokines/metabolism ; Dextrans/pharmacology ; Disease Models, Animal ; Down-Regulation ; Gene Expression Regulation ; Inflammation ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Intestinal Mucosa/metabolism ; Intestines/pathology ; Male ; MicroRNAs/metabolism ; Peroxidase/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Sulfates/pharmacology
Chemical Substances	Cytokines ; Dextrans ; MIRN330 microRNA, rat ; MicroRNAs ; Sulfates ; sodium sulfate (0YPR65R21J) ; Peroxidase (EC 1.11.1.7) ; IRAK1 protein, rat (EC 2.7.11.1) ; Interleukin-1 Receptor-Associated Kinases (EC 2.7.11.1)
Language	English
Publishing date	2021-01-28
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12359
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Zs.B 3187: Show issues

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Article ; Online: Recent strategies for improving hemocompatibility and endothelialization of cardiovascular devices and inhibition of intimal hyperplasia.

Feng, Li-An / Shi, Jie / Guo, Jing-Yue / Wang, Shu-Fang

Journal of materials chemistry. B

2022 Volume 10, Issue 20, Page(s) 3781–3792

Abstract: Cardiovascular diseases have become one of the leading causes of mortality worldwide. Stents and artificial grafts have been used to treat cardiovascular diseases. Thrombosis and restenosis seriously impact the clinical outcome of stents and artificial ... ...

Abstract	Cardiovascular diseases have become one of the leading causes of mortality worldwide. Stents and artificial grafts have been used to treat cardiovascular diseases. Thrombosis and restenosis seriously impact the clinical outcome of stents and artificial vascular grafts. For the purpose of antithrombosis and anti-restenosis, numerous strategies have been developed to construct highly hemocompatible surfaces, enhance endothelialization, and inhibit intimal hyperplasia. Rapid endothelialization and inhibited intimal hyperplasia play an important role in artery repair after stent implantation and coronary artery bypass graft surgery. This review focuses on the recently developed strategies for improving the hemocompatibility and endothelialization of cardiovascular devices. We also introduce drug, gene and RNA delivery technologies for inhibiting intimal hyperplasia. The challenges and future perspectives about promoting endothelialization are also briefly discussed with the hope to help inspire further innovations.
MeSH term(s)	Blood Vessel Prosthesis ; Cardiovascular Diseases ; Cardiovascular System ; Humans ; Hyperplasia ; Stents
Language	English
Publishing date	2022-05-25
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d2tb00478j
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Article ; Online: Identification of vitamin D-dependent rickets type IA caused by a mutation of the CYP27B1 using whole exome sequencing.

Wang, Shu-Fang / Zhou, Ting / Du, Meng-Ru / Sheng, Jiang

Asian journal of surgery

2022 Volume 45, Issue 5, Page(s) 1160–1161

MeSH term(s)	25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; Humans ; Mutation ; Rickets/genetics ; Vitamin D ; Whole Exome Sequencing
Chemical Substances	Vitamin D (1406-16-2) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.15.18) ; CYP27B1 protein, human (EC 1.14.15.18)
Language	English
Publishing date	2022-03-10
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.01.085
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Article ; Online: Comparison of the Efficacy and Safety Between Intravenous Thrombolysis, Direct Endovascular Therapy, and Bridging Therapy for Acute Basilar Artery Occlusion in Cerebral Infarction Patients.

Shen, Yuan / Li, Mingchao / Wang, ShuFang / Xia, Lei / Ni, Xiaoyu / Zhou, Li / Zhong, Jianguo / Shi, Haicun / Dong, Zhifeng

World neurosurgery

2024

Abstract: Objective: To compare the efficacy and safety of intravenous thrombolysis, direct endovascular therapy (EVT), and bridging therapy (BT = intravenous thrombolysis + EVT) for acute basilar artery occlusion cerebral infarction.: Methods: One hundred and ...

Abstract	Objective: To compare the efficacy and safety of intravenous thrombolysis, direct endovascular therapy (EVT), and bridging therapy (BT = intravenous thrombolysis + EVT) for acute basilar artery occlusion cerebral infarction. Methods: One hundred and fourteen patients with acute basilar artery occlusion cerebral infarctions admitted between January 2020 and August 2023 were selected. Differences in the reperfusion rate, prognosis, incidence of stroke-associated pneumonia, and mortality rate were compared among the 3 groups. Results: There was no statistically significant difference in the percentage of patients who achieved successful reperfusion (86.8% vs. 84.2%) or complete reperfusion (72.1% vs. 68.4%) between the direct EVT and BT groups (both P > 0.05). There were no statistically significant differences in the rates of symptomatic intracranial hemorrhage (3.7% vs. 10.3% vs. 10.5%, P = 0.763). There were statistically significant differences in the rates of good prognosis (modified ranking scale score 0-2) (59.3% vs. 30.9% vs. 26.3%, P = 0.021), stroke-related pneumonia (29.6% vs. 66.2% vs. 36.8%, P = 0.002), and mortality (14.8% vs. 48.5% vs. 42.1%, P = 0.010) among the 3 treatment groups. According to the binary logistic regression analysis, a good prognosis was independently associated with a baseline National Institutes of Health Stroke Scale score ≤ 10 (odds ratio, 3.714; 95% confidence interval, 1.207-11.430; P = 0.022) and the incidence of stroke-associated pneumonia (odds ratio, 0.640; 95% confidence interval, 0.484-0.845; P = 0.002). Conclusions: Although there were differences in prognosis, mortality, and incidence of complications among the 3 treatment groups, after adjusting for confounding factors, prognosis was independently correlated only with the baseline NIHSS score and stroke-associated pneumonia but not with treatment methods.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.03.106
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Zs.A 1159: Show issues

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Article: Recent strategies for improving hemocompatibility and endothelialization of cardiovascular devices and inhibition of intimal hyperplasia

Feng, Li-An / Shi, Jie / Guo, Jing-Yue / Wang, Shu-Fang

Journal of materials chemistry B. 2022 May 25, v. 10, no. 20

2022

Abstract	Cardiovascular diseases have become one of the leading causes of mortality worldwide. Stents and artificial grafts have been used to treat cardiovascular diseases. Thrombosis and restenosis seriously impact the clinical outcome of stents and artificial vascular grafts. For the purpose of antithrombosis and anti-restenosis, numerous strategies have been developed to construct highly hemocompatible surfaces, enhance endothelialization, and inhibit intimal hyperplasia. Rapid endothelialization and inhibited intimal hyperplasia play an important role in artery repair after stent implantation and coronary artery bypass graft surgery. This review focuses on the recently developed strategies for improving the hemocompatibility and endothelialization of cardiovascular devices. We also introduce drug, gene and RNA delivery technologies for inhibiting intimal hyperplasia. The challenges and future perspectives about promoting endothelialization are also briefly discussed with the hope to help inspire further innovations.
Keywords	RNA ; biocompatibility ; coronary vessels ; drugs ; genes ; hyperplasia ; mortality ; thrombosis
Language	English
Dates of publication	2022-0525
Size	p. 3781-3792.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d2tb00478j
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Meta-Analysis of the Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists in the Treatment of Patients With Polycystic Ovary Syndrome.

Li, Lei / Wang, Shu-Fang / Du, Meng-Ru / Jiang, Sheng

American journal of therapeutics

2021 Volume 29, Issue 2, Page(s) e245–e248

MeSH term(s)	Diabetes Mellitus, Type 2/drug therapy ; Female ; Glucagon-Like Peptide-1 Receptor/agonists ; Humans ; Hypoglycemic Agents/adverse effects ; Polycystic Ovary Syndrome/drug therapy
Chemical Substances	Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents
Language	English
Publishing date	2021-07-01
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1280786-2
ISSN	1536-3686 ; 1075-2765
ISSN (online)	1536-3686
ISSN	1075-2765
DOI	10.1097/MJT.0000000000001418
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Article ; Online: Efficacy of Xiyanping in the Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease and Its Effect on the Expression of GDF-15 and HIF-1

Wang, Jun Xia / Zhang, Ying / Wang, Shu Fang / Li, Juan / Li, Peng Cheng

publication RETRACTED

Computational and mathematical methods in medicine

2022 Volume 2022, Page(s) 6193110

Abstract: Background: COPD is a chronic respiratory disease with a long course and recurrent characteristics. According to relevant statistics, the global incidence of COPD is more than 30%, which seriously affects the life of patients and endangers their health.! ...

Abstract	Background: COPD is a chronic respiratory disease with a long course and recurrent characteristics. According to relevant statistics, the global incidence of COPD is more than 30%, which seriously affects the life of patients and endangers their health. Objective: To observe the curative effect of Xiyanping in elderly patients with COPD and its influence on the expressions of growth differentiation GDF-15 and HIF-1 Methods: From August 2019 to December 2021, 86 elderly patients with acute exacerbation of COPD were admitted to our hospital. As the research objects, they were divided into the control group ( Results: On the 3rd and 7th days after being treated, the sputum excretion in them was higher than before, but on the 3rd day of treatment, the sputum excretion in the observation group was higher than that in the control group, while on the 7th day of treatment, the sputum excretion was lower than that in the control group with statistically significant differences ( Conclusion: Xiyanping can improve pulmonary function of elderly patients with acute exacerbation of COPD, reduce the response of airway hyperreactivity, and promote the excretion of sputum.
MeSH term(s)	Humans ; Anti-Bacterial Agents ; Asthma ; Growth Differentiation Factor 15 ; Interleukin-8 ; Pulmonary Disease, Chronic Obstructive ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha ; Aged
Chemical Substances	Anti-Bacterial Agents ; Growth Differentiation Factor 15 ; Interleukin-8 ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2022-10-12
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Retracted Publication
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2022/6193110
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Zs.A 6373: Show issues

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Article ; Online: Factors correlated with excessive daytime sleepiness in patients with Parkinson's disease: A polysomnography study.

Shen, Yuan / Shi, Haicun / Zhong, JianGuo / Pan, PingLei / Wang, ShuFang / Chen, MingZhu / Chen, ZhiPeng / Liu, ChunFeng

Brain and behavior

2023 Volume 13, Issue 10, Page(s) e3202

Abstract: Objective: To explore the factors correlated with excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD).: Methods: A total of 239 PD patients were divided into two groups based on the presence of EDS (Epworth Sleepiness Scale ... ...

Abstract	Objective: To explore the factors correlated with excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD). Methods: A total of 239 PD patients were divided into two groups based on the presence of EDS (Epworth Sleepiness Scale score≥10) (PD-EDS vs. PD-non-EDS). Participants underwent an extensive assessment to determine demographic features, disease severity, polysomnography characteristics, and nonmotor symptoms. Results: Of the 239 patients, 56 patients (23.4%) were classified as having PD combined with EDS. Binary logistic regression analysis showed that fatigue (Fatigue Severity Scale [FSS] score ≥4) (odds ratio [OR] [95% CI] = 4.897 [2.376-10.095], p < .001) and the respiratory-related microarousal index (OR [95% CI] = 2.063 [1.085-3.923], p = .027) were independent risk factors for EDS in PD patients. A priori-determined stratified analysis showed that after adjustment for confounding factors, the association of the respiratory-related microarousal index with EDS was significant (OR = 4.404, 95% CI 1.673-11.592, p trend = .036) in patients with respiratory arousal index scores in the highest quintile compared with those with scores in the lowest quintile. Conclusion: Our data revealed a close association among the respiratory-related microarousal index, FSS scores, and EDS. It can be speculated that fragmented sleep and pathological abnormalities of the central nervous system resulting in changes in arousal are major influencing factors of EDS in PD.
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.3202
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Article ; Online: Arginase from Priestia megaterium and the Effects of CMCS Conjugation on Its Enzymological Properties.

Jiao, Yu Liang / Shen, Pin Quan / Wang, Shu Fang / Chen, Jing / Zhou, Xiang Hong / Ma, Gui Zhen

Current microbiology

2023 Volume 80, Issue 9, Page(s) 292

Abstract: Arginase has shown promising potential in treating cancers by arginine deprivation therapy; however, low enzymatic activity and stability of arginase are impeding its development. This study was aimed to improve the enzymological properties of a marine ... ...

Abstract	Arginase has shown promising potential in treating cancers by arginine deprivation therapy; however, low enzymatic activity and stability of arginase are impeding its development. This study was aimed to improve the enzymological properties of a marine bacterial arginase by carboxymethyl chitosan (CMCS) conjugation. An arginase producing marine bacterium Priestia megaterium strain P6 was isolated and identified. The novel arginase PMA from the strain was heterologously expressed, purified, and then conjugated to CMCS by ionic gelation with calcium chloride as the crosslinking agent. Enzymological properties of both PMA and CMCS-PMA conjugate were determined. The optimum temperature for PMA and CMCS-PMA at pH 7 were 60 °C and 55 °C, respectively. The optimum pH for PMA and CMCS-PMA at 37 °C were pH 10 and 9, respectively. CMCS-PMA showed higher thermostability than PMA over 55-70 °C and higher pH stability over pH 4-11 with the highest pH stability at pH 7. At 37 °C and pH of 7, i.e., around the human blood temperature and pH, CMCS-PMA was higher than the free PMA in enzymatic activity and stability by 24% and 21%, respectively. CMCS conjugation not only changed the optimum temperature, optimum pH, and enzymatic activity of PMA, but also improved its pH stability and temperature stability, and thus made it more favorable for medical application.
MeSH term(s)	Humans ; Arginase ; Chitosan/chemistry ; Chemical Phenomena ; Temperature ; Hydrogen-Ion Concentration
Chemical Substances	Arginase (EC 3.5.3.1) ; Chitosan (9012-76-4)
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-023-03406-w
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Zs.A 1446: Show issues

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Article ; Online: Correction: Chen et al. Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing.

Chen, Yue-Hua / Rao, Zhou-Feng / Liu, Yu-Jie / Liu, Xiang-Sheng / Liu, Yu-Fei / Xu, Lan-Ju / Wang, Ze-Qi / Guo, Jing-Yue / Zhang, Lin / Dong, Yun-Sheng / Qi, Chun-Xiao / Yang, Chao / Wang, Shu-Fang

Biomolecules

2024 Volume 14, Issue 3

Abstract: The authors would like to replace Figure 4A of the following published paper [ ... ]. ...

Abstract	The authors would like to replace Figure 4A of the following published paper [...].
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14030283
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