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  1. Article ; Online: Regional augmented PPP-RTK using reference networks with different scales

    WANG Siyao

    Acta Geodaetica et Cartographica Sinica, Vol 50, Iss 7, Pp 993-

    2021  Volume 993

    Keywords Mathematical geography. Cartography ; GA1-1776
    Language Chinese
    Publishing date 2021-07-01T00:00:00Z
    Publisher Surveying and Mapping Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Effect of pyrolysis temperature on adsorption and degradation of THI and IMI by biochar

    Wang Siyao / Peng Hongbo

    E3S Web of Conferences, Vol 338, p

    2022  Volume 01023

    Abstract: In order to explore the effects of biochar prepared at different pyrolysis temperatures and different solid-liquid ratios on the adsorption and degradation of thiacloprid and imidacloprid in biochar, three biochar were prepared by oxygen pyrolysis with ... ...

    Abstract In order to explore the effects of biochar prepared at different pyrolysis temperatures and different solid-liquid ratios on the adsorption and degradation of thiacloprid and imidacloprid in biochar, three biochar were prepared by oxygen pyrolysis with sawdust and as raw materials at 300, 500 °C and 600 °C respectively. The effects of biochar on the adsorption degradation of thiacloprid and Imidacloprid in biochar were studied. The results showed that the addition of biochar could significantly increase the soil pH, available phosphorus and organic carbon content, and reduce the soil H / C. The addition of biochar significantly improved the adsorption of thiacloprid and imidacloprid, and the adsorption capacity increased with the increase of biochar pyrolysis temperature. Biochar with different pyrolysis temperatures had different effects on the degradation of thiacloprid and imidacloprid. The strong adsorption capacity of high temperature biochar system reduces the chemical degradation rate of thiacloprid and imidacloprid. Proper solid-liquid ratio can avoid the waste of adsorbent and achieve the optimal utilization rate. Therefore, the types and properties of biochar should be fully considered when using biochar to repair pesticide contaminated soil.
    Keywords biochar ; thi ; imi ; adsorption ; degradation ; Environmental sciences ; GE1-350
    Subject code 660
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Recent advances in host-focused molecular tools for investigating host-gut microbiome interactions.

    Wang, Siyao / Gong, Xu / Xiao, Fei / Yang, Yun

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1335036

    Abstract: Microbial communities in the human gut play a significant role in regulating host gene expression, influencing a variety of biological processes. To understand the molecular mechanisms underlying host-microbe interactions, tools that can dissect ... ...

    Abstract Microbial communities in the human gut play a significant role in regulating host gene expression, influencing a variety of biological processes. To understand the molecular mechanisms underlying host-microbe interactions, tools that can dissect signaling networks are required. In this review, we discuss recent advances in molecular tools used to study this interplay, with a focus on those that explore how the microbiome regulates host gene expression. These tools include CRISPR-based whole-body genetic tools for deciphering host-specific genes involved in the interaction process, Cre-
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1335036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cardiometabolic and Metabolic Profiles of Lean/Normal, Overweight and Obese Patients with Nonalcoholic Fatty Liver Disease.

    Wang, Siyao / Zhang, Yong / Qi, Xiaoya / Xu, Xiaoyang

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2024  Volume 17, Page(s) 2027–2036

    Abstract: Purpose: Disagreements about the risk of non-obese, non-alcoholic fatty liver disease for cardiometabolic outcomes occurred widely. This study aims to characterize the cardiometabolic and metabolic profile of lean/normal, overweight and obese patients ... ...

    Abstract Purpose: Disagreements about the risk of non-obese, non-alcoholic fatty liver disease for cardiometabolic outcomes occurred widely. This study aims to characterize the cardiometabolic and metabolic profile of lean/normal, overweight and obese patients with nonalcoholic fatty liver disease on a big sample.
    Patients and methods: Appeared healthy adults who participated in health examinations during the year of 2019-2022 were screened for fatty liver diagnosis. BMI classified fatty livers as lean, overweight and obese. Eleven cardiometabolic metrics (SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol) and metabolic metrics (GLU: blood glucose; GHB: glycated haemoglobin; UA: uric acid; AST: aspartate aminotransferase; ALT: alanine aminotransferase) were included, described and compared among BMI categories.
    Results: There were 56,496 fatty livers diagnosed by ultrasound in this study. In total, the lean fatty liver had lowest mean SBP, DBP, GLU, TG, UA, AST, and ALT but highest TC and HDL among BMI categories (all p < 0.001). The number of abnormal metrics in total was 2.5, 2.9 and 3.4 in lean, overweight, and obesity, respectively (p < 0.001, p_trend < 0.001). Visualized data showed that lean fatty liver was similar but milder in all metabolic metrics than overweight and obesity at the young ages. However, lean fatty liver had higher coefficients of age and risk of metabolic abnormality regression (p <0.001 for SBP, DBP, GLU, GHB, TC).
    Conclusion: The lean type of fatty livers at a younger age has a relatively favourable cardiometabolic and metabolic profile compared to overweight and obese fatty livers. Due to the possible catch-up effect of metabolic dysfunctions in young lean fatty liver, lean fatty liver may have the same health outcomes as overweight/obesity fatty liver in long term. The evaluation and intervention may be critical for young lean fatty liver management to slowdown the rapid progress of metabolic dysfunction.
    Language English
    Publishing date 2024-05-13
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S462003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: How to motivate student engagement in emergency online learning? Evidence from the COVID-19 situation.

    Huang, Yating / Wang, Siyao

    Higher education

    2022  Volume 85, Issue 5, Page(s) 1101–1123

    Abstract: COVID-19 has caused the overnight migration of learning and teaching to online platforms and has significantly impacted students' learning opportunities and experiences worldwide. The results of emergency online learning have heavily relied on students' ... ...

    Abstract COVID-19 has caused the overnight migration of learning and teaching to online platforms and has significantly impacted students' learning opportunities and experiences worldwide. The results of emergency online learning have heavily relied on students' abilities to exercise agency in maintaining active motivation and engagement with online learning. Despite the wide application of motivation theories to diverse contexts, how to adapt motivation theories to develop online learning effectively and sustainably in complex and situational online learning environments is still under-investigated. Using a large sample of 14,935 postgraduate students from 31 universities in China, this study examined the effects of student motivation and engagement on students' academic achievement in the COVID-induced online learning anchored by the theoretical perspective of self-determination theory. This study made contribution to the self-determination theory by extending it to the complex emergency situation and supported its main argument that online emergency learning environments satisfying students' psychological needs of autonomy and competence promote optimal motivation, positive engagement and academic achievement. This study also contributed to reveal the 'sophisticated' nature of relatedness satisfaction in the case wherein its specific effects depend on the cultural configuration of the contexts and on the specific types of engagement. Given the fact that COVID-19 continues to be a public challenge throughout the world, implications for improving the quality of online teaching in the future were also discussed.
    Language English
    Publishing date 2022-06-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2015566-9
    ISSN 1573-174X ; 0018-1560
    ISSN (online) 1573-174X
    ISSN 0018-1560
    DOI 10.1007/s10734-022-00880-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Author Correction: Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy.

    Soltanmohammadi, Najmeh / Wang, Siyao / Schumacher, Björn

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 270

    Language English
    Publishing date 2023-01-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-35831-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genome Instability and DNA Repair in Somatic and Reproductive Aging.

    Panier, Stephanie / Wang, Siyao / Schumacher, Björn

    Annual review of pathology

    2023  Volume 19, Page(s) 261–290

    Abstract: Genetic material is constantly subjected to genotoxic insults and is critically dependent on DNA repair. Genome maintenance mechanisms differ in somatic and germ cells as the soma only requires maintenance during an individual's lifespan, while the ... ...

    Abstract Genetic material is constantly subjected to genotoxic insults and is critically dependent on DNA repair. Genome maintenance mechanisms differ in somatic and germ cells as the soma only requires maintenance during an individual's lifespan, while the germline indefinitely perpetuates its genetic information. DNA lesions are recognized and repaired by mechanistically highly diverse repair machineries. The DNA damage response impinges on a vast array of homeostatic processes and can ultimately result in cell fate changes such as apoptosis or cellular senescence. DNA damage causally contributes to the aging process and aging-associated diseases, most prominently cancer. By causing mutations, DNA damage in germ cells can lead to genetic diseases and impact the evolutionary trajectory of a species. The mechanisms ensuring tight control of germline DNA repair could be highly instructive in defining strategies for improved somatic DNA repair. They may provide future interventions to maintain health and prevent disease during aging.
    MeSH term(s) Humans ; Aging ; DNA Repair ; Genomic Instability ; Mutation ; Apoptosis
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2227429-7
    ISSN 1553-4014 ; 1553-4006
    ISSN (online) 1553-4014
    ISSN 1553-4006
    DOI 10.1146/annurev-pathmechdis-051122-093128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Low-carbon technological innovation of coal production and utilization impetus carbon neutrality in China.

    Wang, Siyao / Chen, Fu / Wang, Yinghong

    Environmental science and pollution research international

    2023  Volume 30, Issue 33, Page(s) 80916–80930

    Abstract: European energy crisis, triggered by the conflict between Russia and Ukraine, has again drawn attention to the decarbonization of fossil energy sources. However, few studies have objectively considered coal from an integrated life cycle and its position ... ...

    Abstract European energy crisis, triggered by the conflict between Russia and Ukraine, has again drawn attention to the decarbonization of fossil energy sources. However, few studies have objectively considered coal from an integrated life cycle and its position in the energy system. In the present study, we used the integrated life cycle analysis and fixed-effect panel threshold model to reveal that (1) power generation and heating and iron and steel smelting are the highest CO
    MeSH term(s) Coal/analysis ; Carbon Dioxide/analysis ; Carbon/analysis ; Inventions ; Energy-Generating Resources ; Power Plants ; China
    Chemical Substances Coal ; Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-06-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-28104-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Nanomaterials in modulating tumor-associated macrophages and enhancing immunotherapy.

    Liang, Chen / Zhang, Yihan / Wang, Siyao / Jiao, Wangbo / Guo, Jingyi / Zhang, Nan / Liu, Xiaoli

    Journal of materials chemistry. B

    2024  

    Abstract: Tumor-associated macrophages (TAMs) are predominantly present in the tumor microenvironment (TME) and play a crucial role in shaping the efficacy of tumor immunotherapy. These TAMs primarily exhibit a tumor-promoting M2-like phenotype, which is ... ...

    Abstract Tumor-associated macrophages (TAMs) are predominantly present in the tumor microenvironment (TME) and play a crucial role in shaping the efficacy of tumor immunotherapy. These TAMs primarily exhibit a tumor-promoting M2-like phenotype, which is associated with the suppression of immune responses and facilitation of tumor progression. Interestingly, recent research has highlighted the potential of repolarizing TAMs from an M2 to a pro-inflammatory M1 status-a shift that has shown promise in impeding tumor growth and enhancing immune responsiveness. This concept is particularly intriguing as it offers a new dimension to cancer therapy by targeting the tumor microenvironment, which is a significant departure from traditional approaches that focus solely on tumor cells. However, the clinical application of TAM-modulating agents is often challenged by issues such as insufficient tumor accumulation and off-target effects, limiting their effectiveness and safety. In this regard, nanomaterials have emerged as a novel solution. They serve a dual role: as delivery vehicles that can enhance the accumulation of therapeutic agents in the tumor site and as TAM-modulators. This dual functionality of nanomaterials is a significant advancement as it addresses the key limitations of current TAM-modulating strategies and opens up new avenues for more efficient and targeted therapies. This review provides a comprehensive overview of the latest mechanisms and strategies involving nanomaterials in modulating macrophage polarization within the TME. It delves into the intricate interactions between nanomaterials and macrophages, elucidating how these interactions can be exploited to drive macrophage polarization towards a phenotype that is more conducive to anti-tumor immunity. Additionally, the review explores the burgeoning field of TAM-associated nanomedicines in combination with tumor immunotherapy. This combination approach is particularly promising as it leverages the strengths of both nanomedicine and immunotherapy, potentially leading to synergistic effects in combating cancer.
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d4tb00230j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Separation of high-purity plasma extracellular vesicles for investigating proteomic signatures in diabetic retinopathy.

    Wang, Siyao / Xia, Kangfu / Zhu, Xinxi / Liu, Yuhan / Sun, Lei / Zhu, Qingfu

    Journal of chromatography. A

    2024  Volume 1718, Page(s) 464700

    Abstract: Extracellular vesicles (EVs) play a multifaceted role in intercellular communication and hold significant promise as bio-functional indicators for clinical diagnosis. Although plasma samples represent one of the most critical sources of circulating EVs, ... ...

    Abstract Extracellular vesicles (EVs) play a multifaceted role in intercellular communication and hold significant promise as bio-functional indicators for clinical diagnosis. Although plasma samples represent one of the most critical sources of circulating EVs, the existing technical challenges associated with plasma-EV isolation have restricted their application in disease diagnosis and biomarker discovery. In this study, we introduce a two-step purification method utilizing ultracentrifugation (UC) to isolate crude extracellular vesicle (EV) samples, followed by a phospholipid affinity-based technique for the selective isolation of small EVs, ensuring a high level of purity for downstream proteomic analysis. Our research demonstrates that the UC & TiO
    MeSH term(s) Humans ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/metabolism ; Proteomics/methods ; Vascular Endothelial Growth Factor A/metabolism ; Extracellular Vesicles/metabolism ; Ultracentrifugation ; Diabetes Mellitus
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2024.464700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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