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  1. Article ; Online: Enhanced Recovery After Surgery Protocols for Head and Neck Cancer: Systematic Review and Meta-analysis.

    Kattar, Nrusheel / Wang, Steven X / Trojan, Jeffrey D / Ballard, Craig R / McCoul, Edward D / Moore, Brian A

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2023  Volume 168, Issue 4, Page(s) 593–601

    Abstract: Objective: Enhanced recovery after surgery (ERAS) protocols aim to optimize the pre-, intra-, and postoperative care of patients to improve surgery outcomes, reduce complications, decrease length of stay, and more. We aim to perform a systematic review ... ...

    Abstract Objective: Enhanced recovery after surgery (ERAS) protocols aim to optimize the pre-, intra-, and postoperative care of patients to improve surgery outcomes, reduce complications, decrease length of stay, and more. We aim to perform a systematic review and meta-analysis of ERAS protocols for head and neck cancer surgery with or without microvascular reconstruction.
    Data sources: PubMed, Embase, and Web of Science databases were queried, and abstracts were screened independently by 2 investigators.
    Review methods: This review was conducted in accordance with the PRISMA guidelines. We included comparative observational studies but excluded animal studies, case reports, and case series.
    Results: Of 557 articles initially reviewed by title and/or abstract, we identified 30 for full-text screening, and 9 met the criteria for qualitative synthesis. Meta-analysis of length of stay revealed a mean decrease of 1.37 days (95% CI, 0.77-1.96; I
    Conclusion: Implementation of ERAS protocols can lead to decreases in length of stay and opioid drug utilization. However, further high-quality prospective studies of ERAS protocols are needed, especially with stratified analysis of outcomes based on the type of head and neck cancer surgery.
    MeSH term(s) Humans ; Enhanced Recovery After Surgery ; Head and Neck Neoplasms/surgery ; Length of Stay ; Postoperative Care ; Postoperative Complications/prevention & control ; Prospective Studies ; Clinical Protocols
    Language English
    Publishing date 2023-02-05
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/01945998221082541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps.

    Johnson, Chad J / Cabezas-Olcoz, Jonathan / Kernien, John F / Wang, Steven X / Beebe, David J / Huttenlocher, Anna / Ansari, Hamayail / Nett, Jeniel E

    PLoS pathogens

    2016  Volume 12, Issue 9, Page(s) e1005884

    Abstract: Neutrophils release extracellular traps (NETs) in response to planktonic C. albicans. These complexes composed of DNA, histones, and proteins inhibit Candida growth and dissemination. Considering the resilience of Candida biofilms to host defenses, we ... ...

    Abstract Neutrophils release extracellular traps (NETs) in response to planktonic C. albicans. These complexes composed of DNA, histones, and proteins inhibit Candida growth and dissemination. Considering the resilience of Candida biofilms to host defenses, we examined the neutrophil response to C. albicans during biofilm growth. In contrast to planktonic C. albicans, biofilms triggered negligible release of NETs. Time lapse imaging confirmed the impairment in NET release and revealed neutrophils adhering to hyphae and migrating on the biofilm. NET inhibition depended on an intact extracellular biofilm matrix as physical or genetic disruption of this component resulted in NET release. Biofilm inhibition of NETosis could not be overcome by protein kinase C activation via phorbol myristate acetate (PMA) and was associated with suppression of neutrophil reactive oxygen species (ROS) production. The degree of impaired NET release correlated with resistance to neutrophil attack. The clinical relevance of the role for extracellular matrix in diminishing NET production was corroborated in vivo using a rat catheter model. The C. albicans pmr1Δ/Δ, defective in production of matrix mannan, appeared to elicit a greater abundance of NETs by scanning electron microscopy imaging, which correlated with a decreased fungal burden. Together, these findings show that C. albicans biofilms impair neutrophil response through an inhibitory pathway induced by the extracellular matrix.
    MeSH term(s) Animals ; Biofilms/growth & development ; Candida albicans/physiology ; Candida albicans/ultrastructure ; Extracellular Traps/immunology ; Female ; Humans ; Hyphae/immunology ; Hyphae/ultrastructure ; Male ; Neutrophils/immunology ; Neutrophils/ultrastructure ; Rats
    Language English
    Publishing date 2016-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1005884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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