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  1. AU="Wang, Taihuan"
  2. AU="Hodsman, Anthony B"
  3. AU="Zheng, Bai-Feng"
  4. AU="Lawless, Nathan"
  5. AU="Lim, Ji Young"
  6. AU="Sehdev, Simran"
  7. AU="Del Amor, Francisco M"
  8. AU="Chen, Hanbo"
  9. AU=Song Shiyu
  10. AU="Shen, Chien-Wen"
  11. AU="Philip D King"
  12. AU="Yan, Zhongyu"
  13. AU="Cicalini, Carolina" AU="Cicalini, Carolina"
  14. AU="Magdalena Lange"
  15. AU="Riley, Julie"
  16. AU="Benherrif, Oussama"
  17. AU="Grau, A."
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  19. AU="Qin, Guole"
  20. AU="Reis, Jennifer"
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  22. AU="Bruszel, Bella"
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  28. AU="Martínez Fernández, Lidia"
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  31. AU="Shackira, A M"
  32. AU="Fukui, Mototaka"
  33. AU="Jones, Clare A"
  34. AU="Chen, Yonghua"
  35. AU=Das Nilay Kanti
  36. AU="Christine Brittsan"
  37. AU="Skinner, Henry"
  38. AU=Wang Wan-Ying
  39. AU="Ingrid Natalia Muñoz Quijano"
  40. AU="Xu, Jianrong"
  41. AU="Klutts, Abigail"
  42. AU="Corumlu, Ufuk"
  43. AU="Frank Dickmann"
  44. AU="Paz-Priel, Ido"
  45. AU=Budhraja Anshul

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  1. Artikel: Liang-Ge Decoction Ameliorates Coagulation Dysfunction in Cecal Ligation and Puncture-Induced Sepsis Model Rats through Inhibiting PAD4-Dependent Neutrophil Extracellular Trap Formation.

    He, Wenju / Xi, Qiang / Cui, Huantian / Zhang, Pingping / Huang, Rui / Wang, Taihuan / Wang, Dongqiang

    Evidence-based complementary and alternative medicine : eCAM

    2023  Band 2023, Seite(n) 5042953

    Abstract: Liang-Ge (LG) decoction could ameliorate coagulation dysfunction in septic model rats. However, the mechanism of LG in treating sepsis still needs to be clarified. Our current study established a septic rat model to evaluate the effect of LG on ... ...

    Abstract Liang-Ge (LG) decoction could ameliorate coagulation dysfunction in septic model rats. However, the mechanism of LG in treating sepsis still needs to be clarified. Our current study established a septic rat model to evaluate the effect of LG on coagulation dysfunction in septic rats first. Second, we investigated the effect of LG on NET formation in septic rats. Finally, NETs and PAD4 inhibitors were further used to clarify if LG could improve the mechanism of sepsis coagulation dysfunction by inhibiting NET formation. Our findings indicated that treatment with LG improved the survival rate, reduced inflammatory factor levels, enhanced hepatic and renal function, and reduced pathological changes in rats with sepsis. LG could also alleviate coagulation dysfunction in septic model rats. Besides, LG treatment reduced NETs formation and decreased PAD4 expression in neutrophiles. In addition, LG treatment showed a similar result in comparison to the treatment with either NET inhibitors or PAD4 inhibitors alone. In conclusion, this study confirmed that LG has therapeutic effects on septic rats. Furthermore, the improvement of coagulation dysfunction in septic rats by LG was achieved through inhibiting PAD4-mediated NET formation.
    Sprache Englisch
    Erscheinungsdatum 2023-04-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2023/5042953
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Forsythiaside B ameliorates coagulopathies in a rat model of sepsis through inhibition of the formation of PAD4-dependent neutrophil extracellular traps.

    He, Wenju / Xi, Qiang / Cui, Huantian / Zhang, Pingping / Huang, Rui / Wang, Taihuan / Wang, Dongqiang

    Frontiers in pharmacology

    2022  Band 13, Seite(n) 1022985

    Abstract: Forsythiaside B (FTB) is one of the main components ... ...

    Abstract Forsythiaside B (FTB) is one of the main components of
    Sprache Englisch
    Erscheinungsdatum 2022-11-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1022985
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Liang-Ge decoction ameliorates acute lung injury in septic model rats through reducing inflammatory response, oxidative stress, apoptosis, and modulating host metabolism.

    He, Wenju / Xi, Qiang / Cui, Huantian / Zhang, Pingping / Huang, Rui / Wang, Taihuan / Wang, Dongqiang

    Frontiers in pharmacology

    2022  Band 13, Seite(n) 926134

    Abstract: Liang-Ge decoction (LG) has been used in the treatment of early stage of spesis and can ameliorate sepsis-associated lung injury. However, the mechanism of LG on sepsis-associated lung injury remains unknown. In this study, we established a rat model of ... ...

    Abstract Liang-Ge decoction (LG) has been used in the treatment of early stage of spesis and can ameliorate sepsis-associated lung injury. However, the mechanism of LG on sepsis-associated lung injury remains unknown. In this study, we established a rat model of sepsis-associated lung injury using the cecal ligation and puncture (CLP) method, and investigated the therapeutic effects of LG on lung injury in rats with sepsis. In addition, the anti-inflammatory, anti-oxidative and anti-apoptotic effects of LG on sepsis-associated lung injury model rats were evaluated. Besides, untargeted metabolomics was used to investigate the regulation of metabolites in rats with sepsis-associated lung injury after LG treatment. Our results showed that LG could decrease the wet/dry (W/D) ratio in lung and the total cell count and total protein concentration in bronchoalveolar lavage fluid (BALF) in septic model rats. Hematoxylin and eosin (HE) staining showed that LG reduced the infiltration of pro-inflammatory cells in lung. In addition, LG treatmment down-regulated the gene and protein expression of pro-inflammatory cytokins in lung tissue and BALF. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were increased and the level of methane dicarboxylic aldehyde (MDA) was decreased in lung tissue homogenate in septic model rats after LG treament. Moreover, the numbers of apoptotic cells in lung were reduced and the activity of lactic dehydrogenase (LDH) in BALF was decreased in septic model rats after LG treament. Untargeted metabolomics analysis showed that LG treatment affected the levels of 23 metabolites in lung in septic model rats such as citric acid, methionine, threonine, alpha-ketoglutaric acid, and inositol, these metabolites were associated with the glycine, serine and threonine metabolism, cysteine and methionine metabolism, inositol phosphate metabolism and citrate cycle (TCA cycle) pathways. In conclusion, our study demonstrated the therapeutic effetcts of LG on sepsis-associated lung injury model rats. Moreover, LG could inhibit the inflammatory response, oxidative stress, apoptosis and regulate metabolites related to glycine, serine and threonine metabolism, cysteine and methionine metabolism, inositol phosphate metabolism and TCA cycle in lung in sepsis-associated lung injury model rats.
    Sprache Englisch
    Erscheinungsdatum 2022-09-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.926134
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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