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Article ; Online: Machine Learning Seams of Conical Intersection: A Characteristic Polynomial Approach.

Wang, Tzu Yu / Neville, Simon P / Schuurman, Michael S

The journal of physical chemistry letters

2023 Volume 14, Issue 35, Page(s) 7780–7786

Abstract: The machine learning of potential energy surfaces (PESs) has undergone rapid progress in recent years. The vast majority of this work, however, has been focused on the learning of ground state PESs. To reliably extend machine learning protocols to ... ...

Abstract	The machine learning of potential energy surfaces (PESs) has undergone rapid progress in recent years. The vast majority of this work, however, has been focused on the learning of ground state PESs. To reliably extend machine learning protocols to excited state PESs, the occurrence of seams of conical intersections between adiabatic electronic states must be correctly accounted for. This introduces a serious problem, for at such points, the adiabatic potentials are not differentiable to any order, complicating the application of standard machine learning methods. We show that this issue may be overcome by instead learning the coordinate-dependent coefficients of the characteristic polynomial of a simple decomposition of the potential matrix. We demonstrate that, through this approach, quantitatively accurate machine learning models of seams of conical intersection may be constructed.
Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c01649
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Article: Biologic Disease-Modifying Antirheumatic Drugs for Preventing Radiographic Progression in Psoriatic Arthritis: A Systematic Review and Network Meta-Analysis.

Wang, Szu-Hsuan / Yu, Chia-Ling / Wang, Tzu-Yu / Yang, Chung-Han / Chi, Ching-Chi

Pharmaceutics

2022 Volume 14, Issue 10

Abstract: The prevention of joint deformity is among the most important treatment goals of psoriatic arthritis. Some biologics disease-modifying antirheumatic drugs (bDMARDs) have been demonstrated to be effective for both the skin and joints, as well as for ... ...

Abstract	The prevention of joint deformity is among the most important treatment goals of psoriatic arthritis. Some biologics disease-modifying antirheumatic drugs (bDMARDs) have been demonstrated to be effective for both the skin and joints, as well as for slowing radiographic progression. However, there has been a lack of direct comparisons of bDMARDs. To evaluate the comparative effects of bDMARDs in preventing radiographic progression in psoriatic arthritis, we conducted a systematic review and network meta-analysis. On March 7 2022, a search for relevant randomized trials was conducted on MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials. Our outcomes included radiographic non-progression, a mean change in the total radiographic score, and adverse events leading to discontinuation (DAE) at week 24. We included 11 trials on 10 bDMARDs, involving 4010 participants. Most bDMARDs were more effective than placebos in achieving radiographic non-progression, including adalimumab (odds ratio (OR) 4.7, 95% confidence interval (CI) 2.66-8.29), etanercept (OR 4.19, 95% CI 1.65-10.61), certolizumab pegol (OR 2.83, 95% CI 1.55-5.2), secukinumab 300 mg (OR 2.63, CI 1.62-4.27), infliximab (OR 2.54, CI 1.13-5.69), ixekizumab (OR 2.22, 95% CI 1.06-4.65), golimumab (OR 2.21, 95% CI 1.24-3.93), and abatacept (OR 1.54, 95% CI 1.03-2.28). A significant reduction in the total radiographic score was found in infliximab (standardized mean difference (SMD) -0.59, 95% CI -0.87, -0.3), etanercept (SMD -0.51, 95% CI -0.78, -0.23), adalimumab (SMD -0.45, 95% CI -0.64, -0.26), ixekizumab (SMD -0.37, 95% CI -0.62, -0.12), secukinumab 300 mg (SMD -0.33, 95% CI -0.50, -0.15), golimumab (SMD -0.33, 95% CI -0.58, -0.09), secukinumab 150 mg (SMD -0.25, 95% CI -0.43, -0.07), certolizumab pegol (SMD -0.23, 95% CI -0.44, -0.03), and ustekinumab (SMD -0.19, 95% CI -0.35, -0.33). No significant differences in DAE were detected between bDMARDs. In conclusion, anti-tumor necrosis factor agents (adalimumab, infliximab, and etanercept) may be preferred for treating psoriatic arthritis for their superiority in preventing radiographic progression.
Language	English
Publishing date	2022-10-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14102140
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Article ; Online: Risk for incident suicidality among psoriasis patients: a systematic review and meta-analysis.

Hung, Wei-Kai / Tung, Tao-Hsin / Wang, Tzu-Yu / Liao, Shih-Cheng / Chi, Ching-Chi

Archives of dermatological research

2022 Volume 315, Issue 3, Page(s) 455–465

Abstract: Previous meta-analyses have produced conflicting conclusions about suicidality risk among psoriasis patients. We aimed to update the evidence on the risk for the whole continuum of incident suicidality in psoriasis patients. We performed an update ... ...

Abstract	Previous meta-analyses have produced conflicting conclusions about suicidality risk among psoriasis patients. We aimed to update the evidence on the risk for the whole continuum of incident suicidality in psoriasis patients. We performed an update systematic review and meta-analysis and searched CENTRAL, PubMed, and Embase from January 1, 2017 to August 14, 2021 for relevant new cohort studies and incorporated new studies into our previous systematic review. Random-effects model meta-analysis was used to obtain pooled hazard ratio (HR) with 95% confidence interval (CI). Subgroup analysis was conducted according to age and disease severity. A total of 12 studies were included in this meta-analysis. We detected no significant differences in the risk for incident completed suicide (HR 1.33, 95% CI 0.91-1.95), suicide attempt (HR 1.22, 95% CI 0.96-1.56), suicidal behavior (HR 1.08, 95% CI 0.98-1.19), and suicide ideation (HR 1.74, 95% CI 0.99-3.06) between psoriasis patients and non-psoriatic controls. In the subgroup analysis based on age, an increased risk for incident suicide ideation was observed in pediatric subgroup (HR 1.50, 95% CI 1.12-2.03). The updated evidence suggests no increased risk for whole continuum of incident suicidality spectrum in psoriasis patients but an increased risk for incident suicide ideation among pediatric psoriasis patients. Involving mental health professionals may be crucial in psoriasis management especially in young patients.
MeSH term(s)	Humans ; Child ; Suicidal Ideation ; Suicide ; Psoriasis/epidemiology ; Psoriasis/psychology ; Suicide, Attempted/psychology ; Cohort Studies
Language	English
Publishing date	2022-08-12
Publishing country	Germany
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-022-02377-5
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Article ; Online: Isotretinoin Exposure and Risk of Inflammatory Bowel Disease: A Systematic Review with Meta-Analysis and Trial Sequential Analysis.

Yu, Chia-Ling / Chou, Po-Yi / Liang, Chih-Sung / Chiang, Li-Huei / Wang, Tzu-Yu / Tu, Yu-Kang / Chi, Ching-Chi

American journal of clinical dermatology

2023 Volume 24, Issue 5, Page(s) 721–730

Abstract: Background: Cases of inflammatory bowel disease (IBD) following isotretinoin use have been reported previously, but whether isotretinoin exposure is associated with IBD has been unclear.: Objective: The aim was to evaluate whether isotretinoin use is ...

Abstract	Background: Cases of inflammatory bowel disease (IBD) following isotretinoin use have been reported previously, but whether isotretinoin exposure is associated with IBD has been unclear. Objective: The aim was to evaluate whether isotretinoin use is associated with IBD. Methods: We performed a systematic review and searched MEDLINE, Embase, and CENTRAL databases from inception to January 27, 2023 for relevant case-control and cohort studies. Our outcome was the pooled odds ratio (OR) for IBD and its two subtypes (Crohn disease and ulcerative colitis) in relation to isotretinoin exposure. We conducted a random-effects model meta-analysis and a sensitivity analysis by excluding low-quality studies. A subgroup analysis was undertaken by including studies considering antibiotic use. A trial sequential analysis (TSA) was performed to test the robustness of the conclusiveness of our results. Results: We included eight studies (four case-control and four cohort studies) with a total of 2,522,422 participants. The meta-analysis found no increased odds for IBD among patients receiving isotretinoin (OR 1.01; 95% confidence interval [CI] 0.80-1.27). Nor did the meta-analysis find increased odds for either Crohn disease (OR 0.87; 95% CI 0.65-1.15) or ulcerative colitis (OR 1.27; 95% CI 0.94-1.73) associated with isotretinoin exposure. The sensitivity and subgroup analyses produced similar results. In TSA, the Z-curve reached the futility boundaries when using relative risk reduction thresholds ranging from 5% to 15%. Conclusion: This meta-analysis with TSA found no evidence of an association of isotretinoin use with IBD. Isotretinoin should not be withheld because of unnecessary concerns for the development of IBD. Prospero registration no: CRD42022298886.
MeSH term(s)	Humans ; Isotretinoin/adverse effects ; Crohn Disease/drug therapy ; Crohn Disease/epidemiology ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/epidemiology ; Inflammatory Bowel Diseases/chemically induced ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/epidemiology ; Odds Ratio
Chemical Substances	Isotretinoin (EH28UP18IF)
Language	English
Publishing date	2023-04-03
Publishing country	New Zealand
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	1502476-3
ISSN	1179-1888 ; 1175-0561
ISSN (online)	1179-1888
ISSN	1175-0561
DOI	10.1007/s40257-023-00765-9
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Article ; Online: Authors' Reply to Chen and Chen: Comment on: "Isotretinoin Exposure and Risk of Inflammatory Bowel Disease: A Systematic Review with Meta-Analysis and Trial Sequential Analysis".

Yu, Chia-Ling / Chou, Po-Yi / Liang, Chih-Sung / Chiang, Li-Huei / Wang, Tzu-Yu / Tu, Yu-Kang / Chi, Ching-Chi

American journal of clinical dermatology

2023 Volume 24, Issue 5, Page(s) 855–858

MeSH term(s)	Humans ; Isotretinoin/adverse effects ; Inflammatory Bowel Diseases/chemically induced ; Inflammatory Bowel Diseases/drug therapy
Chemical Substances	Isotretinoin (EH28UP18IF)
Language	English
Publishing date	2023-06-27
Publishing country	New Zealand
Document type	Letter ; Comment
ZDB-ID	1502476-3
ISSN	1179-1888 ; 1175-0561
ISSN (online)	1179-1888
ISSN	1175-0561
DOI	10.1007/s40257-023-00803-6
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Article ; Online: 85% internal quantum efficiency of 280-nm AlGaN multiple quantum wells by defect engineering.

Wang, Tzu-Yu / Tasi, Chi-Tsung / Lin, Chia-Feng / Wuu, Dong-Sing

Scientific reports

2017 Volume 7, Issue 1, Page(s) 14422

Abstract: In this study, high internal-quantum-efficiency (IQE) AlGaN multiple quantum wells (MQWs) were successfully demonstrated on low-defect-density AlN templates with nano-patterned sapphire substrates. These templates consisted of AlN structures with 0∼30 ... ...

Abstract	In this study, high internal-quantum-efficiency (IQE) AlGaN multiple quantum wells (MQWs) were successfully demonstrated on low-defect-density AlN templates with nano-patterned sapphire substrates. These templates consisted of AlN structures with 0∼30 periods superlattices (SLs) by alternating high (100) and low (25) V/III ratios under a low growth temperature (1130 °C). Compared to conventional high crystal-quality AlN epilayers achieved at temperatures ≥1300 °C, lower thermal budget can reduce the production cost and wafer warpage. Via optimization of the SL period, the AlN crystallinity was systematically improved. Strong dependence of SL period number on the X-ray full-width-at-half-maximum (FWHM) of the AlN epilayer was observed. The AlN template with 20-period SLs exhibited the lowest FWHM values for (0002) and (10ī2), namely 331 and 652 arcsec, respectively, as well as an ultra-low etching pit density of 1 × 10
Language	English
Publishing date	2017-10-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-14825-8
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Article ; Online: Effect of non-vacuum thermal annealing on high indium content InGaN films deposited by pulsed laser deposition.

Wang, Tzu-Yu / Ou, Sin-Liang / Shen, Kun-Ching / Wuu, Dong-Sing

Optics express

2013 Volume 21, Issue 6, Page(s) 7337–7342

Abstract: InGaN films with 33% and 60% indium contents were deposited by pulsed laser deposition (PLD) at a low growth temperature of 300 °C. The films were then annealed at 500-800 °C in the non-vacuum furnace for 15 min with an addition of N(2) atmosphere. X-ray ...

Abstract	InGaN films with 33% and 60% indium contents were deposited by pulsed laser deposition (PLD) at a low growth temperature of 300 °C. The films were then annealed at 500-800 °C in the non-vacuum furnace for 15 min with an addition of N(2) atmosphere. X-ray diffraction results indicate that the indium contents in these two films were raised to 41% and 63%, respectively, after annealing in furnace. In(2)O(3) phase was formed on InGaN surface during the annealing process, which can be clearly observed by the measurements of auger electron spectroscopy, transmission electron microscopy and x-ray photoelectron spectroscopy. Due to the obstruction of indium out-diffusion by forming In(2)O(3) on surface, it leads to the efficient increment in indium content of InGaN layer. In addition, the surface roughness was greatly improved by removing In(2)O(3) with the etching treatment in HCl solution. Micro-photoluminescence measurement was performed to analyze the emission property of InGaN layer. For the as-grown InGaN with 33% indium content, the emission wavelength was gradually shifted from 552 to 618 nm with increasing the annealing temperature to 800 °C. It reveals the InGaN films have high potential in optoelectronic applications.
MeSH term(s)	Gallium/chemistry ; Gallium/radiation effects ; Hardness ; Hot Temperature ; Indium/chemistry ; Indium/radiation effects ; Lasers ; Membranes, Artificial ; Surface Properties/radiation effects ; Vacuum
Chemical Substances	Membranes, Artificial ; Indium (045A6V3VFX) ; gallium nitride (1R9CC3P9VL) ; Gallium (CH46OC8YV4) ; indium nitride (D66UAC005A)
Language	English
Publishing date	2013-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.21.007337
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Article ; Online: High thermal stability of high indium content InGaN films grown by pulsed laser deposition.

Shen, Kun-Ching / Wang, Tzu-Yu / Wuu, Dong-Sing / Horng, Ray-Hua

Optics express

2012 Volume 20, Issue 19, Page(s) 21173–21180

Abstract: Thermal stability on the structural and optical properties of high indium content InGaN films grown using pulsed laser deposition (PLD) was investigated through long-duration and high-temperature annealing. X-ray diffraction and cathode- luminescence ... ...

Abstract	Thermal stability on the structural and optical properties of high indium content InGaN films grown using pulsed laser deposition (PLD) was investigated through long-duration and high-temperature annealing. X-ray diffraction and cathode- luminescence measurements of the 33% indium InGaN revealed no differences in the line-shape and peak position even after annealing at 800°C for 95 min; similar structural stability was found for the 60% samples after annealing for 75 min. The higher thermal stability is attributed to nanoscale InN domains with different orientations create mixed-polarity InGaN/InN interfaces, resulting in higher activation energies at interfaces and increasing the thermal stability of the material. Furthermore, the InGaN films were subjected to metalorganic chemical vapor deposition treatment to regrow a GaN layer; results are promising for the development of high thermal stability InGaN films using the PLD technique.
Language	English
Publishing date	2012-09-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.20.021173
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Article ; Online: High indium content InGaN films grown by pulsed laser deposition using a dual-compositing target.

Shen, Kun-Ching / Wang, Tzu-Yu / Wuu, Dong-Sing / Horng, Ray-Hua

Optics express

2012 Volume 20, Issue 14, Page(s) 15149–15156

Abstract: High indium compositions InGaN films were grown on sapphires using low temperature pulse laser deposition (PLD) with a dual-compositing target. This target was used to overcome the obstacle in the InGaN growth by PLD due to the difficulty of target ... ...

Abstract	High indium compositions InGaN films were grown on sapphires using low temperature pulse laser deposition (PLD) with a dual-compositing target. This target was used to overcome the obstacle in the InGaN growth by PLD due to the difficulty of target preparation, and provided a co-deposition reaction, where InGaN grains generated from the indium and GaN vapors deposit on sapphire surface and then act as nucleation seeds to promote further InGaN growth. The effects of co-deposition on growth mechanisms, surface morphology, and electrical properties of films were thoroughly investigated and the results clearly show promise for the development of high indium InGaN films using PLD technique with dual-compositing targets.
Language	English
Publishing date	2012-07-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.20.015149
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Article ; Online: Donnan potential of dilute colloidal dispersions: Monte Carlo simulations.

Wang, Tzu-Yu / Sheng, Yu-Jane / Tsao, Heng-Kwong

Journal of colloid and interface science

2009 Volume 340, Issue 2, Page(s) 192–201

Abstract: Donnan equilibrium between a salt-free colloidal dispersion and an electrolyte solution has been investigated by Monte Carlo simulations. The Donnan potential is directly calculated by considering two compartments separated by a semipermeable membrane. ... ...

Abstract	Donnan equilibrium between a salt-free colloidal dispersion and an electrolyte solution has been investigated by Monte Carlo simulations. The Donnan potential is directly calculated by considering two compartments separated by a semipermeable membrane. In order to understand the role played by colloid-ion interactions, the influences of colloidal characteristics, including particle size R, intrinsic particle charge Z, counterion valency z(c), and concentration c(p), on Donnan potential Psi(D) and effective charge Z(eff) are examined. Our simulations show that the electroneutrality condition is not followed in both compartments and the Donnan potential arises due to the net charge density. The Donnan potential grows by increasing c(p) and Z(eff) and by decreasing dielectric constant epsilon(r), i.e., Psi(D) approximately Z(eff)c(p)/epsilon(r) approximately. Note that the effective charge varies with R,Z,c(p),epsilon(r) and z(c) as well. When the salt concentration is increased, the net charge density is lowered and thus the Donnan potential decays accordingly. The validity of the classical theory based on the Nernst equation and the electroneutrality assumption is also examined. In general, the simulation results at high-salt condition can be well represented by such mean-field theory.
MeSH term(s)	Algorithms ; Colloids/chemistry ; Electrochemistry ; Electrolytes/chemistry ; Membrane Potentials ; Monte Carlo Method ; Particle Size ; Salts/chemistry ; Static Electricity ; Thermodynamics
Chemical Substances	Colloids ; Electrolytes ; Salts
Language	English
Publishing date	2009-12-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2009.07.070
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