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  1. Article ; Online: Analysing sinonasal microbiota of fungal rhinosinusitis by next-generation sequencing.

    Huang, Yu-Wen / Wang, Wei-Hsin / Lan, Ming-Ying

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2022  Volume 48, Issue 2, Page(s) 313–320

    Abstract: Objectives: Fungal rhinosinusitis is an inflammatory disease of the nose that may lead to life-threatening complications. This study compared the bacterial and fungal microbiomes between patients with invasive fungal rhinosinusitis (IFRS) and non-IFRS ( ... ...

    Abstract Objectives: Fungal rhinosinusitis is an inflammatory disease of the nose that may lead to life-threatening complications. This study compared the bacterial and fungal microbiomes between patients with invasive fungal rhinosinusitis (IFRS) and non-IFRS (NIFRS).
    Design: This was a prospective study including 18 IFRS and NIFRS patients. Fungal and bacterial microbiomes from surgical specimens were sequenced from amplicons of the internal transcribed spacer 1 (ITS1) region and the V3-V4 region of the 16S locus, respectively. Microbiomes were generated using the Illumina MiSeq System 2 x 301 base pair chemistry with a paired-end protocol.
    Setting: Tertiary medical centre.
    Results: Targeted metagenomics identified Aspergillus spp. as the predominant fungus in both IFRS and NIFRS patients. Based on phylum and genera level diversity, and abundance differences, significant differences of operational taxonomic units (OTUs) (Fusobacterium, Prevotella, Pseudomonas, Neisseria and Streptococcus) were more abundant in NIFRS compared with IFRS patients.
    Conclusions: This is the first study to analyse bacterial and fungal microbiomes in patients with IFRS and NIFRS via ITS1 and 16S genomics sequencing. Bacterial microbiomes from patients with IFRS demonstrated dysbiosis (alterations in diversity and abundance) compared to those from patients with NIFRS.
    MeSH term(s) Humans ; Prospective Studies ; Microbiota/genetics ; Bacteria/genetics ; Streptococcus ; High-Throughput Nucleotide Sequencing/methods
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.13980
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    Zs.A 1309: Show issues Location:
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  2. Article ; Online: Endoscopic endonasal transcavernous approach for invasive corticotroph pituitary adenoma.

    Lan, Ming-Ying / Wang, Wei-Hsin

    Neurosurgical focus: Video

    2020  Volume 2, Issue 2, Page(s) V2

    Abstract: This is a 37-year-old woman who presented with weight gain, a moon-shaped face, and muscle weakness for 4 months. Cushing's disease was confirmed after a series of diagnostic tests. MRI demonstrated a pituitary macroadenoma with right cavernous sinus ... ...

    Abstract This is a 37-year-old woman who presented with weight gain, a moon-shaped face, and muscle weakness for 4 months. Cushing's disease was confirmed after a series of diagnostic tests. MRI demonstrated a pituitary macroadenoma with right cavernous sinus invasion and encasement of the right ICA. An endoscopic endonasal approach was performed, and gross-total resection could be achieved without injury of the cranial nerves. The Cushing's syndrome improved gradually after the surgery. Histopathology revealed a corticotroph adenoma. In this surgical video, we demonstrate the strategies of tumor resection according to a surgical anatomy-based classification of the cavernous sinus from an endonasal perspective. The video can be found here: https://youtu.be/aNXFRdGfjpI.
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 2643-5217
    ISSN (online) 2643-5217
    DOI 10.3171/2020.4.FocusVid.19949
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  3. Article ; Online: The role of nasopharyngectomy in the management of nasopharyngeal carcinoma.

    Wang, Wei-Hsin / Yeh, Chien-Fu / Lan, Ming-Ying

    Current opinion in otolaryngology & head and neck surgery

    2021  Volume 30, Issue 1, Page(s) 3–12

    Abstract: Purpose of review: Recently, endoscopic nasopharyngectomy (ENPG) has become an effective treatment for locally recurrent nasopharyngeal carcinoma (NPC). This article reviews recent publications on ENPG and specifically addresses the surgical anatomy of ... ...

    Abstract Purpose of review: Recently, endoscopic nasopharyngectomy (ENPG) has become an effective treatment for locally recurrent nasopharyngeal carcinoma (NPC). This article reviews recent publications on ENPG and specifically addresses the surgical anatomy of the nasopharynx and discusses several important issues regarding ENPG.
    Recent findings: The surgical techniques for ENPG have been previously described in several studies. The latest published data revealed good outcomes of ENPG compared with intensity-modulated radiation therapy (IMRT) in recurrent NPC. In addition, ENPG avoids severe reirradiation side effects. This review highlights the surgical anatomy of ENPG, which is important in preventing possible serious complications.
    Summary: ENPG is a good option for managing recurrent NPC. Careful preoperative evaluation and a full understanding of the surgical anatomy help in preventing damage to nearby critical neurovascular structure. Long-term follow-up is still needed to evaluate its eventual morbidity and efficacy.
    MeSH term(s) Humans ; Nasopharyngeal Carcinoma/surgery ; Nasopharyngeal Neoplasms/surgery ; Neoplasm Recurrence, Local/surgery ; Pharyngectomy ; Radiotherapy, Intensity-Modulated
    Language English
    Publishing date 2021-12-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4814: Show issues Location:
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  4. Article ; Conference proceedings: Managing CSF Leak with Temporalis Muscle Flap for Challenging Skull Base Defect after Radiation Therapy

    Wang, Wei-Hsin / Lan, Ming-Ying

    Journal of Neurological Surgery Part B: Skull Base

    2020  Volume 81, Issue S 01

    Event/congress 30th Annual Meeting North American Skull Base Society, La Cantera Resort & Spa San Antonio, Texas, 2020-02-07
    Language English
    Publishing date 2020-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0040-1702551
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    Zs.A 3425: Show issues Location:
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  5. Article ; Online: Combined Endoscopic Endonasal and Contralateral Transmaxillary Approach for Petrous Cholesteatoma: 2-Dimensional Operative Video.

    Wang, Wei-Hsin / Lan, Ming-Ying / Snyderman, Carl H / Gardner, Paul A

    Operative neurosurgery (Hagerstown, Md.)

    2021  Volume 20, Issue 6, Page(s) E434–E435

    Abstract: This 59-yr-old man presented with headache, dizziness, diplopia, and right-side hearing impairment for years. The objective degree of hearing impairment was not available. Magnetic resonance imaging (MRI) showed a right petrous apex lesion centered ... ...

    Abstract This 59-yr-old man presented with headache, dizziness, diplopia, and right-side hearing impairment for years. The objective degree of hearing impairment was not available. Magnetic resonance imaging (MRI) showed a right petrous apex lesion centered behind the right petrous internal carotid artery and extending lateral to the medial aspect of the right internal auditory canal. A combined endoscopic endonasal and left contralateral transmaxillary (CTM) approach was performed, and gross-total resection was achieved. Peeling the cyst wall from the dura resulted in minor weeping. It was covered with a left-sided, vascularized nasoseptal flap. His dizziness and diplopia improved immediately after the surgery. Histopathology revealed an epidermoid cyst. In this surgical video, we demonstrate the key steps of the CTM approach for access to the petrous apex posterior to the petrous internal carotid artery (ICA). The patient gave informed consent for surgery and video recording.
    MeSH term(s) Cholesteatoma/diagnostic imaging ; Cholesteatoma/surgery ; Humans ; Male ; Natural Orifice Endoscopic Surgery ; Nose ; Petrous Bone/diagnostic imaging ; Petrous Bone/surgery ; Skull Base
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1093/ons/opab004
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    Zs.A 1424 -ON-: Show issues Location:
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  6. Article ; Online: The learning curve for cavernous sinus surgery illustrated by symptomatic intracavernous aneurysm clipping through a pretemporal transcavernous approach.

    Liao, Chih-Hsiang / Lin, Chun-Fu / Wang, Jui-To / Wang, Wei-Hsin / Chen, Shao-Ching / Hsu, Sanford P C

    Journal of neurosurgery

    2023  Volume 140, Issue 1, Page(s) 183–193

    Abstract: Objective: The anatomy of the cavernous sinus (CS) has been well studied in the laboratory for decades; however, performing surgery in and around the CS is still a challenge. To reveal the learning curve for CS surgery via the pretemporal transcavernous ...

    Abstract Objective: The anatomy of the cavernous sinus (CS) has been well studied in the laboratory for decades; however, performing surgery in and around the CS is still a challenge. To reveal the learning curve for CS surgery via the pretemporal transcavernous approach (PTTC), surgical procedures were examined. The authors proposed 4 levels of surgical difficulty in opening the walls of the CS through this approach. Details of the approach were illustrated by surgical videos of symptomatic intracavernous aneurysm clipping.
    Methods: Four levels of surgical difficulty were proposed. The higher the level, the more the CS walls were opened. Pathologies corresponding to each level of difficulty in and around the CS were categorized in each level together with explanations. From 2015 to 2021, 5 patients with symptomatic intracavernous aneurysms (diplopia due to compressive cranial neuropathy) underwent the PTTC at the authors' institute and served as representative cases in opening the walls of the CS. All CS cases from 2009 to 2021 were reviewed and categorized to demonstrate the learning curve.
    Results: Four levels of surgical difficulty are as follows: level 1, a basic Dolenc extradural approach, which involves opening the anterior third of the superior and lateral walls of the CS; level 2, mobilizing the internal carotid artery (ICA) and opening the proximal dural ring to enter the roof of the CS and treat lesions around the clinoid and upper cavernous ICA; level 3, opening the entire aspect of the superior and lateral walls of the CS, which involves opening the oculomotor triangle and peeling the lateral wall of the CS to the tentorial incisura; and level 4, mobilizing cranial nerves III, IV, and V1 to gain access to the supra-/infratrochlear triangles to have proximal ICA control and opening the posterior wall as the last step to enter the posterior fossa. Surgical steps were described and illustrated with surgical videos of symptomatic intracavernous aneurysm clipping.
    Conclusions: The learning curve for CS surgery is long. The authors use 4 levels of surgical difficulty to describe applications of the PTTC in CS surgery. This approach serves as an effective workhorse in treating CS pathologies with low morbidity and high success rates when performed by experienced neurosurgeons.
    MeSH term(s) Humans ; Neurosurgical Procedures/methods ; Cavernous Sinus/diagnostic imaging ; Cavernous Sinus/surgery ; Cavernous Sinus/anatomy & histology ; Learning Curve ; Aneurysm/surgery ; Skull
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2023.5.JNS2328
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    Uk I Zs.135: Show issues Location:
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  7. Article ; Conference proceedings: Headache as the Primary Surgical Indication for Small Pituitary Lesions

    Wang, Wei-Hsin / Lan, Ming-Ying / Huang, Yu-Wen / Yeh, Chien-Fu / Chao, Yun-Ting / Hong, Li-Ting

    Journal of Neurological Surgery Part B: Skull Base

    2024  Volume 85, Issue S 01

    Event/congress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1780281
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    Zs.A 3425: Show issues Location:
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  8. Article: Predicting the Need for Desmopressin Treatment During Inpatient and After Discharge Following Endoscopic Sellar Surgery.

    Wong, Chia-En / Wang, Wei-Hsin / Lan, Ming-Ying / Lee, Po-Hsuan / Huang, Chi-Chen / Su, Pei-Fang / Lee, Jung-Shun

    Frontiers in neurology

    2022  Volume 13, Page(s) 843646

    Abstract: Introduction: Postoperative diabetes insipidus (DI) is a common complication following endoscopic sellar surgery. However, the requirement of desmopressin treatment for patients with DI are heterogenous. Although the predictors of postoperative DI have ... ...

    Abstract Introduction: Postoperative diabetes insipidus (DI) is a common complication following endoscopic sellar surgery. However, the requirement of desmopressin treatment for patients with DI are heterogenous. Although the predictors of postoperative DI have been reported, whether these patients required desmopressin treatment remained uninvestigated. Predicting the need of desmopressin can benefit clinical decision making more directly than predicting the occurence of postoperative DI. This study aimed to identify variables that predict the need for desmopressin treatment following sellar surgery.
    Methods: Patients undergoing endoscopic sellar surgery between 2016 and 2019 were retrospectively reviewed. Twenty-three variables, characterized as potential predictors for requiring desmopressin treatment, were analyzed. To assess the capability to generalize the identified predictors, external validation with receiver operating characteristic (ROC) analysis was performed using a second series from 2019 to 2020.
    Results: Postoperative DI occurred in 40 of 159 included patients. Twelve patients required inpatient desmopressin treatment and 20 patients needed desmopressin prescription after discharge. The potential predictors of requiring any desmopressin use included higher peak sodium (Na) level (
    Conclusion: The required treatments for patients with postoperative DI following endoscopic sellar surgery are heterogenous. Elevated peak Na and large peak Na-minimum Na levels in the perioperative period predicted requiring desmopressin after hospital discharge. Patients with peak Na <150 mmol/L and peak Na-minimum Na <10 can be safely discharged without desmopressin prescription.
    Language English
    Publishing date 2022-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.843646
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  9. Article ; Conference proceedings: Free Middle Turbinate Mucosal Grafts for Reconstruction of Septal Donor Site after Harvesting Nasoseptal Flap in Endoscopic Endonasal Pituitary Surgery

    Lan, Ming-Ying / Wang, Wei-Hsin

    Journal of Neurological Surgery Part B: Skull Base

    2017  Volume 78, Issue S 01

    Event/congress Presentation Abstracts 27th Annual Meeting North American Skull Base Society, The Roosevelt New Orleans New Orleans, Louisiana, 2017-03-03
    Language English
    Publishing date 2017-03-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0037-1600775
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  10. Article: Commentary.

    Lee, Cheng-Chia / Wang, Wei-Hsin

    Journal of neurosciences in rural practice

    2013  Volume 4, Issue Suppl 1, Page(s) S129–30

    Language English
    Publishing date 2013-09-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
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