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Article ; Online: Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions.

Liu, Yuzhuo / Lv, Wei / Wang, Weiqing

Clinical reviews in allergy & immunology

2024

Abstract: Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal inflammation of the upper airway. Researches of CRS have progressed from phenotype-based to endotype-based, looking more deeply into molecular biomarkers, signaling ...

Abstract	Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal inflammation of the upper airway. Researches of CRS have progressed from phenotype-based to endotype-based, looking more deeply into molecular biomarkers, signaling pathways, and immune microenvironment. Single-cell RNA sequencing is an effective tool in analyzing composition, function, and interaction of cells in disease microenvironment at transcriptome level, showing great advantage in analyzing potential biomarkers, pathogenesis, and heterogeneity of chronic airway inflammation in an unbiased manner. In this article, we will review the latest advances in scRNA-seq studies of CRS to provide new perspectives for the diagnosis and treatment of this heterogeneous disease.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1239045-8
ISSN	1559-0267 ; 1080-0549
ISSN (online)	1559-0267
ISSN	1080-0549
DOI	10.1007/s12016-024-08992-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: End-to-end Online Speaker Diarization with Target Speaker Tracking

Wang, Weiqing / Li, Ming

2023

Abstract: This paper proposes an online target speaker voice activity detection system for speaker diarization tasks, which does not require a priori knowledge from the clustering-based diarization system to obtain the target speaker embeddings. By adapting the ... ...

Abstract	This paper proposes an online target speaker voice activity detection system for speaker diarization tasks, which does not require a priori knowledge from the clustering-based diarization system to obtain the target speaker embeddings. By adapting the conventional target speaker voice activity detection for real-time operation, this framework can identify speaker activities using self-generated embeddings, resulting in consistent performance without permutation inconsistencies in the inference phase. During the inference process, we employ a front-end model to extract the frame-level speaker embeddings for each coming block of a signal. Next, we predict the detection state of each speaker based on these frame-level speaker embeddings and the previously estimated target speaker embedding. Then, the target speaker embeddings are updated by aggregating these frame-level speaker embeddings according to the predictions in the current block. Our model predicts the results for each block and updates the target speakers' embeddings until reaching the end of the signal. Experimental results show that the proposed method outperforms the offline clustering-based diarization system on the DIHARD III and AliMeeting datasets. The proposed method is further extended to multi-channel data, which achieves similar performance with the state-of-the-art offline diarization systems. Comment: Submitted to IEEE/ACM Transactions on Audio, Speech, and Language Processing
Keywords	Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Sound
Subject code	420
Publishing date	2023-10-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Correlation between hearing impairment and the Triglyceride Glucose Index: based on a national cross-sectional study.

Liu, Long / Qin, Maolin / Ji, Jiabiao / Wang, Weiqing

Frontiers in endocrinology

2023 Volume 14, Page(s) 1216718

Abstract: Objective: Data from the National Health and Nutrition Examination Survey (NHANES) were used to assess the association between the triglyceride-glucose (TyG) index and hearing impairment (HI).: Methods: We used eight survey cycles from NHANES 2001- ... ...

Abstract	Objective: Data from the National Health and Nutrition Examination Survey (NHANES) were used to assess the association between the triglyceride-glucose (TyG) index and hearing impairment (HI). Methods: We used eight survey cycles from NHANES 2001-2012 and 2015-2018 to conduct this cross-sectional study. HI was designed as an dependent variable, and the TyG index was selected as an exposure factor (independent variable). The correlation between the two variables was assessed using multiple logistic regression. In order to assess whether there was a non-linear relationship between the TyG index and HI, the TyG index was distributed and a test for trend was conducted (P for trend), followed by smooth curve fitting (penalized spline) and generalized additive model (GAM) regression. We also performed a subgroup analysis to identify sensitive groups whose responses were clearly associated with independent variables. Results: 10,906 participants were finally included in the study, and those with a higher TyG index had a higher frequency of hearing impairment. There was a linear positive correlation between the TyG index and HI. For the low-frequency HI, however, this positive correlation was not statistically significant (OR = 1.05, 95% CI: 0.98, 1.14); however, it was more stable for the high-frequency HI (OR = 1.12, 95% CI: 1.03, 1.22). Additionally, as the TyG index increased, this positive association increased as well (P for trend = 0.05). The HPTA test showed a positive association with more severe HI (simultaneous) as the independent variable increased (OR = 1.14, 95% CI: 1.05-1.24), and this association was even more significant with increasing severity (P for trend 0.05). According to the subgroup analysis, the positive association between TyG index and high-frequency HI was more significant in females, 40-69 years old, without hypertension or diabetes, and when strict high-frequency HI was significant in males, females, 40-69 years old, with hypertension and diabetes. Conclusion: Participants with a higher TyG index may have a higher risk of HI. TyG index and HI risk showed a linear relationship, which became even more significant when HPTA was included.
MeSH term(s)	Female ; Male ; Humans ; Adult ; Middle Aged ; Aged ; Cross-Sectional Studies ; Nutrition Surveys ; Hearing Loss/epidemiology ; Glucose ; Hypertension ; Triglycerides
Chemical Substances	Glucose (IY9XDZ35W2) ; Triglycerides
Language	English
Publishing date	2023-06-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1216718
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Distribution Characteristics and Risk Assessment of 57 Pesticides in Farmland Soil and the Surrounding Water.

Wang, Weiqing / Wang, Donghong / Liu, Quanzhen / Lin, Lihua / Xie, Yongchang / Du, Chuan

Toxics

2024 Volume 12, Issue 1

Abstract: To investigate the effect of pesticide use on surface water, the concentration and distribution characteristics of 57 pesticides and 3 degradation products were analyzed in the farmland soil and surface water in the Xingkai Lake area, including water ... ...

Abstract	To investigate the effect of pesticide use on surface water, the concentration and distribution characteristics of 57 pesticides and 3 degradation products were analyzed in the farmland soil and surface water in the Xingkai Lake area, including water from paddy fields, drainages and the Xingkai Lake, in Heilongjiang Province, China. Forty-three pesticides and three degradation products were detected in farmland soil. In dry field (corn and soybean field) soil, the main detected pesticides were atrazine and acetochlor with mean concentrations of 26.09 ng·g
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics12010085
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Effects of Pesticides Use on Pesticides Residues and Its Environmental Risk Assessment in Xingkai Lake（China）].

Wang, Wei-Qing / Xu, Xiong / Liu, Quan-Zhen / Lin, Li-Hua / Lü, Jing / Wang, Dong-Hong

Huan jing ke xue= Huanjing kexue

2024 Volume 45, Issue 5, Page(s) 2678–2685

Abstract: Xingkai Lake, located in Heilongjiang Province, is an important fishery and agricultural base and is seriously polluted by agricultural non-point sources. To clarify the residual status of many pesticides in the surface water of Xingkai Lake, 27 types of ...

Abstract	Xingkai Lake, located in Heilongjiang Province, is an important fishery and agricultural base and is seriously polluted by agricultural non-point sources. To clarify the residual status of many pesticides in the surface water of Xingkai Lake, 27 types of pesticides, herbicides, and their degradation products were analyzed in rice paddy, drainage, and surface water around Xingkai Lake (China) during the rice heading and maturity periods. The results showed that all 27 types of pesticides, herbicides, and their degradation products were detected during the rice heading period, and the total concentration ranged from 247.97 to 6 094.49 ng·L
MeSH term(s)	Pesticides/analysis ; Pesticide Residues/analysis ; Atrazine ; Lakes ; Environmental Monitoring ; Herbicides ; Water/chemistry ; China ; Risk Assessment ; Water Pollutants, Chemical/analysis ; Thiophenes
Chemical Substances	Pesticides ; Pesticide Residues ; isoprothiolane (88HCS898G6) ; Atrazine (QJA9M5H4IM) ; Herbicides ; Water (059QF0KO0R) ; Water Pollutants, Chemical ; Thiophenes
Language	Chinese
Publishing date	2024-04-17
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202305228
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Research on a cross-regional robust trading strategy based on multiple market mechanisms

Yan, Sizhe / Wang, Weiqing / Li, Xiaozhu / Zhao, Yi

Energy. 2022 Dec. 15, v. 261

2022

Abstract: With the increase in the variety of market players in cross-regional trading, the interaction of interests among multiple participants is complicated, resulting in unbalanced interests in the cross-regional trading market. Therefore, a robust trading ... ...

Abstract	With the increase in the variety of market players in cross-regional trading, the interaction of interests among multiple participants is complicated, resulting in unbalanced interests in the cross-regional trading market. Therefore, a robust trading model with joint multi-market mechanisms is proposed in this paper to cope with the intricate interactions among market players. The proposed model builds a joint trading market framework of carbon emission rights and green certificates to incentivize more market players to participate in cross-region trading. To better balance the interests among the market players, a multi-market player alliance based on the cooperative game theory is established, and a profit distribution method based on the contribution degree of system power balance is proposed. To ensure the balance of energy supply and demand for cross-regional trading, the distributed robust optimization method based on the Wasserstein metric is proposed considering the uncertainty of renewable energy generation. Finally, the feasibility of the proposed dispatching model is demonstrated with the modified IEEE 39 bus system and the Hami power grid as an example. The results show that the proposed model can obtain a conservative and economical operating scheme with fast operation time, and the joint trading mechanism can further save the operating cost.
Keywords	carbon ; energy ; game theory ; markets ; models ; renewable energy sources ; supply balance ; system optimization ; uncertainty
Language	English
Dates of publication	2022-1215
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2022.125253
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evaluation of Mask-Induced Cardiopulmonary Stress: A Randomized Crossover Trial.

Bao, Riqiang / Ning, Guang / Sun, Yingkai / Pan, Shijia / Wang, Weiqing

JAMA network open

2023 Volume 6, Issue 6, Page(s) e2317023

MeSH term(s)	Humans ; Cross-Over Studies ; Influenza, Human ; Masks/adverse effects
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.17023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: OntoMedRec

Tan, Weicong / Wang, Weiqing / Zhou, Xin / Buntine, Wray / Bingham, Gordon

Logically-Pretrained Model-Agnostic Ontology Encoders for Medication Recommendation

2024

Abstract: Most existing medication recommendation models learn representations for medical concepts based on electronic health records (EHRs) and make recommendations with learnt representations. However, most medications appear in the dataset for limited times, ... ...

Abstract	Most existing medication recommendation models learn representations for medical concepts based on electronic health records (EHRs) and make recommendations with learnt representations. However, most medications appear in the dataset for limited times, resulting in insufficient learning of their representations. Medical ontologies are the hierarchical classification systems for medical terms where similar terms are in the same class on a certain level. In this paper, we propose OntoMedRec, the logically-pretrained and model-agnostic medical Ontology Encoders for Medication Recommendation that addresses data sparsity problem with medical ontologies. We conduct comprehensive experiments on benchmark datasets to evaluate the effectiveness of OntoMedRec, and the result shows the integration of OntoMedRec improves the performance of various models in both the entire EHR datasets and the admissions with few-shot medications. We provide the GitHub repository for the source code on https://anonymous.4open.science/r/OntoMedRec-D123
Keywords	Computer Science - Machine Learning
Subject code	006
Publishing date	2024-01-28
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New energy power system operation security evaluation based on the SWOT analysis.

Maihemuti, Saniye / Wang, Weiqing / Wu, Jiahui / Wang, Haiyun

Scientific reports

2022 Volume 12, Issue 1, Page(s) 12680

Abstract: Grid-connection of new energy is highly important in promoting the use of clean and renewable energy. However, it will bring huge risks to the power grid operation security, such as frequency stability, voltage stability, small signal stability, and ... ...

Abstract	Grid-connection of new energy is highly important in promoting the use of clean and renewable energy. However, it will bring huge risks to the power grid operation security, such as frequency stability, voltage stability, small signal stability, and transient stability, etc.,. In the study, SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis has been employed to construct 24 kinds of internal and external evaluation factors and 8 kinds of improvement strategies, for assessing operation security prospective with new energy power system of HM in China. The weights of SWOT factors are determined with the fuzzy-AHP method. Moreover, the fuzzy-MARCOS approach is used to select the most suitable strategies for power system operation security effective implementation. The reported research reveals that new energy in HM area not only has an ample potential for full development and generating electricity, but also brings operation security problems due to large-scale grid connection. Therefore, 8 kinds of improvement strategies are suggested to encourage the government to exploit and develop new resources, improve the investment pay, power generation and transmission technologies to mitigate the current energy crisis, and increase the energy security for sustainable development of the country. The methodology proposed herein is applicable with a case study concerning the operation security prospective of HM power grid, and all phases of the comparative analysis and sensitivity analysis illustrate the validity of MARCOS method. Furthermore, the ranked order of strategies is obtained as A
Language	English
Publishing date	2022-07-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-16444-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: One-Size-Fits-All Policies Are Unacceptable: A Sustainable Management and Decision-Making Model for Schools in the Post-COVID-19 Era.

Yang, Cunwei / Wang, Weiqing / Li, Fengying / Yang, Degang

International journal of environmental research and public health

2022 Volume 19, Issue 10

Abstract: This paper proposes a sustainable management and decision-making model for COVID-19 control in schools, which makes improvements to current policies and strategies. It is not a case study of any specific school or country. The term one-size-fits-all has ... ...

Abstract	This paper proposes a sustainable management and decision-making model for COVID-19 control in schools, which makes improvements to current policies and strategies. It is not a case study of any specific school or country. The term one-size-fits-all has two meanings: being blind to the pandemic, and conducting inflexible and harsh policies. The former strategy leads to more casualties and does potential harm to children. Conversely, under long-lasting strict policies, people feel exhausted. Therefore, some administrators pretend that they are working hard for COVID-19 control, and people pretend to follow pandemic control rules. The proposed model helps to alleviate these problems and improve management efficiency. A customized queue model is introduced to control social gatherings. An indoor-outdoor tracking system is established. Based on tracing data, we can assess people's infection risk, and allocate medical resources more effectively in case of emergency. We consider both social and technical feasibility. Test results demonstrate the improvements and effectiveness of the model. In conclusion, the model has patched up certain one-size-fits-all strategies to balance pandemic control and normal life.
MeSH term(s)	COVID-19/epidemiology ; Child ; Humans ; Organizational Policy ; Pandemics/prevention & control ; Policy ; Schools
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19105913
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