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Article: Discovery and Potential Utility of a Novel Non-Invasive Ocular Delivery Platform.

Wang, Weizhen Jenny / Snider, Nonna

2023 Volume 15, Issue 9

Abstract: To this day, the use of oily eye drops and non-invasive retinal delivery remain a major challenge. Oily eye drops usually cause ocular irritation and interfere with the normal functioning of the eye, while ocular injections for retinal drug delivery ... ...

Abstract	To this day, the use of oily eye drops and non-invasive retinal delivery remain a major challenge. Oily eye drops usually cause ocular irritation and interfere with the normal functioning of the eye, while ocular injections for retinal drug delivery cause significant adverse effects and a high burden on the healthcare system. Here, the authors report a novel topical non-invasive ocular delivery platform (NIODP) through the periorbital skin for high-efficiency anterior and posterior ocular delivery in a non-human primate model (NHP). A single dose of about 7 mg JV-MD2 (omega 3 DHA) was delivered via the NIODP and reached the retina at a Cmax of 111 µg/g and the cornea at a Cmax of 66 µg/g. The NIODP also delivered JV-DE1, an anti-inflammatory agent in development for dry eye diseases, as efficiently as eye drops did to the anterior segments of the NHP. The topical NIODP seems to transport drug candidates through the corneal pathway to the anterior and via the conjunctiva/sclera pathway to the posterior segments of the eye. The novel NIODP method has the potential to reshape the landscape of ocular drug delivery. This is especially the case for oily eye drops and retinal delivery, where the success of the treatment lies in the ocular tolerability and bioavailability of drugs in the target tissue.
Language	English
Publishing date	2023-09-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15092344
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Symptom management and nursing interventions for postoperative bladder instillation chemotherapy in bladder cancer patients.

Wang, Liping / Wang, Weizhen

Minerva surgery

2023

Language	English
Publishing date	2023-12-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3067899-7
ISSN	2724-5438
ISSN (online)	2724-5438
DOI	10.23736/S2724-5691.23.10162-6
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Zs.A 25: Show issues

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Article ; Online: A review of biocontrol agents in controlling late blight of potatoes and tomatoes caused by Phytophthora infestans and the underlying mechanisms.

Wang, Weizhen / Long, Youhua

Pest management science

2023 Volume 79, Issue 12, Page(s) 4715–4725

Abstract: Phytophthora infestans causes late blight on potatoes and tomatoes, which has a significant economic impact on agriculture. The management of late blight has been largely dependent on the application of synthetic fungicides, which is not an ultimate ... ...

Abstract	Phytophthora infestans causes late blight on potatoes and tomatoes, which has a significant economic impact on agriculture. The management of late blight has been largely dependent on the application of synthetic fungicides, which is not an ultimate solution for sustainable agriculture and environmental safety. Biocontrol strategies are expected to be alternative methods to the conventional chemicals in controlling plant diseases in the integrated pest management (IPM) programs. Well-studied biocontrol agents against Phytophthora infestans include fungi, oomycetes, bacteria, and compounds produced by these antagonists, in addition to certain bioactive metabolites produced by plants. Laboratory and glasshouse experiments suggest a potential for using biocontrol in practical late blight disease management. However, the transition of biocontrol to field applications is problematic for the moment, due to low and variable efficacies. In this review, we provide a comprehensive summary on these biocontrol strategies and the underlying corresponding mechanisms. To give a more intuitive understanding of the promising biocontrol agents against Phytophthora infestans in agricultural systems, we discuss the utilizations, modes of action and future potentials of these antagonists based on their taxonomic classifications. To achieve a goal of best possible results produced by biocontrol agents, it is suggested to work on field trials, strain modifications, formulations, regulations, and optimizations of application. Combined biocontrol agents having different modes of action or biological adaptation traits may be used to strengthen the biocontrol efficacy. More importantly, biological control agents should be applied in the coordination of other existing and forthcoming methods in the IPM programs. © 2023 Society of Chemical Industry.
MeSH term(s)	Phytophthora infestans ; Solanum tuberosum/microbiology ; Solanum lycopersicum ; Plants ; Phenotype ; Plant Diseases/prevention & control ; Plant Diseases/microbiology
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.7706
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Article ; Online: Exact interval estimation for the linear combination of binomial proportions.

Lu, Shuiyun / Wang, Weizhen / Xie, Tianfa

Statistical methods in medical research

2024 Volume 33, Issue 3, Page(s) 465–479

Abstract: The weighted sum of binomial proportions and the interaction effect are two important cases of the linear combination of binomial proportions. Existing confidence intervals for these two parameters are approximate. We apply ... ...

Abstract	The weighted sum of binomial proportions and the interaction effect are two important cases of the linear combination of binomial proportions. Existing confidence intervals for these two parameters are approximate. We apply the
MeSH term(s)	Binomial Distribution ; Confidence Intervals ; Models, Statistical
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1136948-6
ISSN	1477-0334 ; 0962-2802
ISSN (online)	1477-0334
ISSN	0962-2802
DOI	10.1177/09622802241229200
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Zs.A 3564: Show issues

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Article ; Online: Efficacy of laparoscopic pyeloplasty for pediatric hydronephrosis caused by symptomatic versus asymptomatic endogenous ureteropelvic junction obstruction: a retrospective analysis.

Shao, Guanghui / Sun, Zhihao / Zhou, Zhihang / Wang, Weizhen / Li, Aiwu

The Journal of international medical research

2024 Volume 52, Issue 3, Page(s) 3000605241232968

Abstract: Objective: To retrospectively compare the differences in the surgical efficacy and prognosis of laparoscopic pyeloplasty for hydronephrosis caused by symptomatic versus asymptomatic ureteropelvic junction obstruction (UPJO) in children and determine ... ...

Abstract	Objective: To retrospectively compare the differences in the surgical efficacy and prognosis of laparoscopic pyeloplasty for hydronephrosis caused by symptomatic versus asymptomatic ureteropelvic junction obstruction (UPJO) in children and determine whether clinical symptoms affect the surgical outcome and prognosis. Methods: Children who underwent laparoscopic pyeloplasty in our hospital from January 2018 to December 2022 were retrospectively analyzed. The children were divided into symptomatic and asymptomatic groups according to their main symptoms. The primary outcomes were the surgical success rate, change in renal parenchymal thickness, and change in renal pelvis anteroposterior diameter. The secondary outcomes were postoperative complications, reoperation rate, operative duration, intraoperative blood loss, and drainage tube indwelling time. Results: In total, 224 children with UPJO were enrolled; 148 (66.1%) were symptomatic and 76 (33.9%) were asymptomatic. The symptomatic group showed a significantly greater mean change in renal parenchymal thickness, significantly higher surgical success rate, and significantly lower postoperative complication rate. Conclusions: In the present study, asymptomatic children had a lower surgical success rate, less postoperative imaging improvement, and more postoperative complications than symptomatic children. The presence or absence of clinical symptoms may affect the surgical outcome and prognosis.
MeSH term(s)	Humans ; Child ; Retrospective Studies ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Urologic Surgical Procedures/methods ; Hydronephrosis/diagnostic imaging ; Hydronephrosis/surgery ; Hydronephrosis/complications ; Ureteral Obstruction/surgery ; Ureteral Obstruction/etiology ; Postoperative Complications/surgery ; Treatment Outcome
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605241232968
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Zs.A 925: Show issues

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Article ; Online: Performance of the improved two-source energy balance model for estimating evapotranspiration over the heterogeneous surface

Feng, Jiaojiao / Wang, Weizhen / Che, Tao / Xu, Feinan

Agricultural Water Management. 2023 Mar., v. 278 p.108159-

2023

Abstract: Accurate quantification of land surface evapotranspiration (ET) is desperately crucial for agricultural irrigation strategy, drought monitoring, and water resource management in semiarid and arid regions. The two-source energy balance (TSEB) model is an ... ...

Abstract	Accurate quantification of land surface evapotranspiration (ET) is desperately crucial for agricultural irrigation strategy, drought monitoring, and water resource management in semiarid and arid regions. The two-source energy balance (TSEB) model is an appropriate method for estimating ET over the mixed surface of vegetation and soil since it considers both energy contributions from soil and vegetation. The key parameters of the TSEB model, additional heat transfer resistance (kB⁻¹) and soil resistance, are vital to the estimation of water vapor and heat fluxes over the heterogeneous surface. In this study, the kB⁻¹ parameterization and soil resistance formulation with different coefficients were integrated into the TSEB model to improve the original model performance over the heterogeneous surface in the midstream area of the Heihe River Basin (HRB). The effect of kB⁻¹ on the TSEB model performance was greater than the soil resistance coefficient by validating the model output using the Eddy Covariance (EC) measurement installed at vegetables, maize, residential, orchard, Gobi Desert, sandy desert, and desert steppe surface. The optimized TSEB model would significantly reduce the uncertainty of the original model and improve the consistency between the simulated and observed sensible heat flux (H) and latent heat flux (LE) over the heterogeneous surfaces; RMSE values of H and LE decreased to 53 and 78 W m⁻² from 67 and 104 W m⁻² for seven-sites-average in 2012. The daily ET of this study area ranged from 0.69 to 6.48 mm day⁻¹ during the growing period; it agreed well with EC flux observations for the vegetated area, especially irrigated cropland with MBE, RMSE, and MAPE values of 0.21 mm d⁻¹, 1.02 mm d⁻¹, and 14.62% at maize site, 0.39 mm d⁻¹, 1.14 mm d⁻¹ and 20.25% at vegetables site. This research enhances the utility of TSEB in flux estimation over heterogeneous landscapes and thus is of great help in formulating sustainable water resource management schemes.
Keywords	corn ; drought ; eddy covariance ; energy balance ; evapotranspiration ; heat transfer ; irrigated farming ; irrigation management ; latent heat flux ; model validation ; models ; orchards ; sensible heat flux ; soil ; steppes ; uncertainty ; water vapor ; watersheds ; Gobi Desert ; Two-source energy balance ; Additional heat transfer resistance ; Soil resistance ; Heihe River Basin ; Heterogeneous surface
Language	English
Dates of publication	2023-03
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	751144-9
ISSN	1873-2283 ; 0378-3774
ISSN (online)	1873-2283
ISSN	0378-3774
DOI	10.1016/j.agwat.2023.108159
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Advanced statistical methods and designs for clinical trials for COVID-19.

Shan, Guogen / Wang, Weizhen

International journal of antimicrobial agents

2021 Volume 57, Issue 1, Page(s) 106167

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Antimalarials/therapeutic use ; Antiviral Agents/therapeutic use ; Azithromycin/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Clinical Trials as Topic ; Drug Combinations ; Drug Repositioning ; Drug Synergism ; Humans ; Hydroxychloroquine/therapeutic use ; SARS-CoV-2/pathogenicity ; Statistics as Topic
Chemical Substances	Anti-Bacterial Agents ; Antimalarials ; Antiviral Agents ; Drug Combinations ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
Language	English
Publishing date	2021-01-06
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2020.106167
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

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Article ; Online: Atomic-level imaging of beam-sensitive COFs and MOFs by low-dose electron microscopy.

Zhan, Zhen / Liu, Yuxin / Wang, Weizhen / Du, Guangyu / Cai, Songhua / Wang, Peng

Nanoscale horizons

2024

Abstract: Electron microscopy, an important technique that allows for the precise determination of structural information with high spatiotemporal resolution, has become indispensable in unravelling the complex relationships between material structure and ... ...

Abstract	Electron microscopy, an important technique that allows for the precise determination of structural information with high spatiotemporal resolution, has become indispensable in unravelling the complex relationships between material structure and properties ranging from mesoscale morphology to atomic arrangement. However, beam-sensitive materials, particularly those comprising organic components such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), would suffer catastrophic damage from the high energy electrons, hindering the determination of atomic structures. A low-dose approach has arisen as a possible solution to this problem based on the integration of advancements in several aspects: electron optical system, detector, image processing, and specimen preservation. This article summarizes the transmission electron microscopy characterization of MOFs and COFs, including local structures, host-guest interactions, and interfaces at the atomic level. Revolutions in advanced direct electron detectors, algorithms in image acquisition and processing, and emerging methodology for high quality low-dose imaging are also reviewed. Finally, perspectives on the future development of electron microscopy methodology with the support of computer science are presented.
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article ; Review
ISSN	2055-6764
ISSN (online)	2055-6764
DOI	10.1039/d3nh00494e
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Article ; Online: The Size Differences of Breast Cancer and Benign Tumors Measured by Two-Dimensional Ultrasound and Contrast-Enhanced Ultrasound.

Tian, Yang / Wang, Weizhen / Hu, Yanbin / Chen, Fei / Liu, Zheng / Li, Liangzi / Tang, Jiawei

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2024

Abstract: Objectives: Ultrasound (US) imaging has been observed to underestimate tumor size in clinical practice. This study aims to compare the size measurements of breast cancer and benign tumors using two-dimensional ultrasound (2DUS) and contrast-enhanced ... ...

Abstract	Objectives: Ultrasound (US) imaging has been observed to underestimate tumor size in clinical practice. This study aims to compare the size measurements of breast cancer and benign tumors using two-dimensional ultrasound (2DUS) and contrast-enhanced ultrasound (CEUS). Methods: The study included 42 clinically confirmed breast cancer and 47 benign breast tumors. Two experienced physicians independently measured the maximal longitudinal and transverse diameters of the masses in 2DUS and CEUS. All analyses were performed in R (4.2.2) and GraphPad Prism 6. Results: The maximal longitudinal and transverse diameters of breast cancer measured by CEUS were 26.61 ± 0.21% and 26.24 ± 0.19% larger compared with 2DUS, and benign breast tumors had an 11.74 ± 0.21% and 11.06 ± 0.14% increase in size compared with 2DUS. The area under the curve (AUC) of the receiver operating characteristic curve (ROC) for the difference between 2DUS and CEUS was 0.870 for longitudinal diameters (95% CI: 0.795-0.945, sensitivity 0.842, specificity 0.783, threshold value 0.215), and 0.863 for transverse diameters (95% CI: 0.785-0.942, sensitivity 0.667, specificity 0.936, threshold value 0.203). Conclusions: The size measurements of both breast cancer and benign tumors were larger in CEUS compared with 2DUS, with CEUS measurements of breast cancer being more pronounced than those of benign breast tumors. These findings suggest that CEUS may provide a more precise assessment of tumor size, which is crucial for determining optimal treatment strategies and improving patient outcomes in breast cancer management.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.16449
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Zs.A 1793: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 495: Show issues

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Article ; Online: Effect of endogenous protein and lipid removal on the physicochemical and digestion properties of sand rice (Agriophyllum squarrosum) flour.

Wu, Chunsen / Wang, Weizhen / Jia, Juan / Guo, Lunan / Zhang, Chen / Qian, Jian-Ya

International journal of biological macromolecules

2024 Volume 266, Issue Pt 1, Page(s) 131269

Abstract: The study investigated the effect of removing protein and/or lipid on the physicochemical characteristics and digestibility of sand rice flour (SRF). Morphological images showed that protein removal had a greater impact on exposing starch granules, while ...

Abstract	The study investigated the effect of removing protein and/or lipid on the physicochemical characteristics and digestibility of sand rice flour (SRF). Morphological images showed that protein removal had a greater impact on exposing starch granules, while lipids acted as an adhesive. The treatment altered starch content in SRF samples, leading to increased starch crystallinity, denser semi-crystalline region, lower onset gelatinization temperature (T
MeSH term(s)	Starch/chemistry ; Starch/metabolism ; Flour ; Lipids/chemistry ; Digestion ; Plant Proteins/chemistry ; Plant Proteins/metabolism ; Hydrolysis ; Oryza/chemistry ; Chemical Phenomena ; Viscosity ; Temperature
Chemical Substances	Starch (9005-25-8) ; Lipids ; Plant Proteins
Language	English
Publishing date	2024-03-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131269
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