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Article: Toward Economic Growth and Value Creation Through Social Entrepreneurship: Modelling the Mediating Role of Innovation.

Wang, Wenjie

2022 Volume 13, Page(s) 914700

Abstract: The concept of social entrepreneurship emerged as a significant factor that contributes toward public welfare and prosperity. Recent studies showed that social entrepreneurship influences the economic growth and sustainability of the state. Therefore, ... ...

Abstract	The concept of social entrepreneurship emerged as a significant factor that contributes toward public welfare and prosperity. Recent studies showed that social entrepreneurship influences the economic growth and sustainability of the state. Therefore, the underlying aim of this study was to investigate the impact of social entrepreneurship on sustainable economic growth and value creation. This study also undertook to observe the mediating role of innovation in the relationship between social entrepreneurship and sustainable economic growth and between social entrepreneurship and value creation. A questionnaire technique was adopted to obtain data from 343 tour operators in China. The Smart-PLS software was used to analyze the data through the aid of a structural equation modelling (SEM) technique. The results revealed that social entrepreneurship has an effect on sustainable economic growth and value creation. The results also demonstrated that innovation has an effect on sustainable economic growth and value creation. Moreover, it was also observed that innovation mediated the relationship between social entrepreneurship and sustainable economic growth and between social entrepreneurship and value creation. Theoretically, this study made a valuable contribution by examining the impact of social entrepreneurship on sustainable economic growth and value creation and innovation as a mediator. In terms of practical implications, this study would certainly aid the policymakers to devise policies and strategies aim to encourage and promote social entrepreneurship. Moreover, future studies can introduce other mediating and moderating variables in order to gain a deeper insight into the phenomenon.
Language	English
Publishing date	2022-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.914700
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Article ; Online: Author Correction: Primase promotes the competition between transcription and replication on the same template strand resulting in DNA damage.

Zhang, Weifeng / Yang, Zhuo / Wang, Wenjie / Sun, Qianwen

Nature communications

2024 Volume 15, Issue 1, Page(s) 521

Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-44904-0
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Article ; Online: Professor Chengru Huang: A great doctor who is sincere, kindhearted, and trustful.

Wang, Wenjie

Pediatric investigation

2019 Volume 3, Issue 1, Page(s) 1–3

Language	English
Publishing date	2019-03-22
Publishing country	United States
Document type	Journal Article
ISSN	2574-2272
ISSN (online)	2574-2272
DOI	10.1002/ped4.12120
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Article ; Online: Primase promotes the competition between transcription and replication on the same template strand resulting in DNA damage.

Zhang, Weifeng / Yang, Zhuo / Wang, Wenjie / Sun, Qianwen

Nature communications

2024 Volume 15, Issue 1, Page(s) 73

Abstract: Transcription-replication conflicts (TRCs), especially Head-On TRCs (HO-TRCs) can introduce R-loops and DNA damage, however, the underlying mechanisms are still largely unclear. We previously identified a chloroplast-localized RNase H1 protein AtRNH1C ... ...

Abstract	Transcription-replication conflicts (TRCs), especially Head-On TRCs (HO-TRCs) can introduce R-loops and DNA damage, however, the underlying mechanisms are still largely unclear. We previously identified a chloroplast-localized RNase H1 protein AtRNH1C that can remove R-loops and relax HO-TRCs for genome integrity. Through the mutagenesis screen, we identify a mutation in chloroplast-localized primase ATH that weakens the binding affinity of DNA template and reduces the activities of RNA primer synthesis and delivery. This slows down DNA replication, and reduces competition of transcription-replication, thus rescuing the developmental defects of atrnh1c. Strand-specific DNA damage sequencing reveals that HO-TRCs cause DNA damage at the end of the transcription unit in the lagging strand and overexpression of ATH can boost HO-TRCs and exacerbates DNA damage. Furthermore, mutation of plastid DNA polymerase Pol1A can similarly rescue the defects in atrnh1c mutants. Taken together these results illustrate a potentially conserved mechanism among organisms, of which the primase activity can promote the occurrence of transcription-replication conflicts leading to HO-TRCs and genome instability.
MeSH term(s)	DNA Primase/genetics ; DNA Primase/metabolism ; DNA Replication/genetics ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; DNA Damage ; Mutation
Chemical Substances	DNA Primase (EC 2.7.7.-) ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44443-0
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Article ; Online: FGF12 restrains mitochondria-dependent ferroptosis in doxorubicin-induced cardiomyocytes through the activation of FGFR1/AMPK/NRF2 signaling.

Tian, Ge / Li, Jing / Wang, Wenjie / Zhou, Lina

Drug development research

2024 Volume 85, Issue 1, Page(s) e22149

Abstract: Fibroblast growth factor-12 (FGF12) has been reported to play important role in regulating heart diseases. We aimed to explore the role of FGF12 in doxorubicin (DOX)-induced myocardial injury. DOX-induced mice and DOX-induced HL-1 cells were used as the ... ...

Abstract	Fibroblast growth factor-12 (FGF12) has been reported to play important role in regulating heart diseases. We aimed to explore the role of FGF12 in doxorubicin (DOX)-induced myocardial injury. DOX-induced mice and DOX-induced HL-1 cells were used as the myocardial injury in vivo and in vitro. Then, FGF12, Anp, Bnp, and Myh7 expression was detected. The pathological injury in myocardium tissue was observed by H&E staining. The levels of markers related to myocardial damage and oxidative stress were assessed. Then, immunohistochemistry and immunofluorescence staining were used to detect FGF12 and 4-HNE expression. Ferroptosis were detected by Prussian blue staining and western blot. The FGFR1/AMPK/NRF2 signaling was measured by western blot. FGF12 expression was downregulated in DOX-induced mice myocardium tissues. FGF12 overexpression alleviated DOX-induced myocardial tissue pathological injury and reduced Anp, Bnp, and Myh7 expression. Additionally, the levels of CK-MB, LDH and cTnT in serum were decreased after FGF12 upregulation in DOX-induced mice. Moreover, FGF12 overexpression reduced the levels of ROS, MDA, and 4-HNE but increased SOD and GSH-Px activities. Meanwhile, FGF12 led to less deposition of iron ion, decreased ACSL4, PTGS2 and increased GPX4, FTH1 expression. Additionally, FGF12 activated the expressions of FGFR1, p-AMPK, and NRF2. Moreover, FGFR1 silencing reversed the protective effects of FGF12 overexpression on cell viability, oxidative stress, ferroptosis, and FGFR1/AMPK/NRF2 pathway. To sum up, FGF12 inhibited mitochondria-dependent ferroptosis in cardiomyocytes induced by DOX through activation of FGFR1/AMPK/NRF2 signaling. These findings clarify a new mechanism of DOX-induced cardiac injury and provide a promising target to limit the disease development.
MeSH term(s)	Animals ; Mice ; AMP-Activated Protein Kinases ; Doxorubicin/adverse effects ; Ferroptosis ; Fibroblast Growth Factors ; Mitochondria ; Myocytes, Cardiac ; NF-E2-Related Factor 2
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; Doxorubicin (80168379AG) ; Fibroblast Growth Factors (62031-54-3) ; NF-E2-Related Factor 2
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/ddr.22149
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Article ; Online: Construction of a Comprehensive Mental Health Evaluation System for Clinicians.

Wang, Wenjie / Wang, Xumei

Journal of healthcare engineering

2022 Volume 2022, Page(s) 7651549

Abstract: Objective: To detect problems of mental health disorders early and actively by constructing a comprehensive evaluation system of mental health.: Methods: The evaluation system was constructed by the Minnesota personality questionnaire (MMPI), the ... ...

Abstract	Objective: To detect problems of mental health disorders early and actively by constructing a comprehensive evaluation system of mental health. Methods: The evaluation system was constructed by the Minnesota personality questionnaire (MMPI), the personality questionnaire (EPQ), and the depression experience questionnaire (DEQ). Total 341 interns and residents in a general hospital were investigated with the questionnaire about psychological status, and the results were analyzed by SPSS22.0. Results: The KMO was 0.879, and the factor load of the seven factors was 0.49 to 0.856. The cumulative variance contribution reached 72.18%, and the overall consistency coefficient was 0.871. The relationship, emotional disorder, paranoia, reflection, and positive response were 0.893, 0.614, 0.867, 0.771 and 0.621, respectively. In this study, the mental health composite scores of all study subjects met a normal distribution, so level 3 scores of clinical interns and residents were established according to the deviation method. Conclusion: The constructed index system contains comprehensive indicators, good reliability efficiency, and a level 3 score, which helps individuals and hospitals to detect problems early, and provide guidance and advice for active intervention.
MeSH term(s)	Humans ; Mental Disorders/diagnosis ; Mental Health ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2022-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2022/7651549
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Article ; Online: Oxidative stress resistance prompts pyrroloquinoline quinone biosynthesis in Hyphomicrobium denitrificans H4-45.

Liang, Jiale / Tang, Mingjie / Chen, Lang / Wang, Wenjie / Liang, Xinle

Applied microbiology and biotechnology

2024 Volume 108, Issue 1, Page(s) 204

Abstract: Pyrroloquinoline quinone (PQQ) is a natural antioxidant with diverse applications in food and pharmaceutical industries. A lot of effort has been devoted toward the discovery of PQQ high-producing microbial species and characterization of biosynthesis, ... ...

Abstract	Pyrroloquinoline quinone (PQQ) is a natural antioxidant with diverse applications in food and pharmaceutical industries. A lot of effort has been devoted toward the discovery of PQQ high-producing microbial species and characterization of biosynthesis, but it is still challenging to achieve a high PQQ yield. In this study, a combined strategy of random mutagenesis and adaptive laboratory evolution (ALE) with fermentation optimization was applied to improve PQQ production in Hyphomicrobium denitrificans H4-45. A mutant strain AE-9 was obtained after nearly 400 generations of UV-LiCl mutagenesis, followed by an ALE process, which was conducted with a consecutive increase of oxidative stress generated by kanamycin, sodium sulfide, and potassium tellurite. In the flask culture condition, the PQQ production in mutant strain AE-9 had an 80.4% increase, and the cell density increased by 14.9% when compared with that of the initial strain H4-45. Moreover, batch and fed-batch fermentation processes were optimized to further improve PQQ production by pH control strategy, methanol and H
MeSH term(s)	Antioxidants ; PQQ Cofactor ; Hydrogen Peroxide ; Methanol ; Oxidative Stress ; Hyphomicrobium
Chemical Substances	Antioxidants ; PQQ Cofactor (72909-34-3) ; Hydrogen Peroxide (BBX060AN9V) ; Methanol (Y4S76JWI15)
Language	English
Publishing date	2024-02-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-024-13053-1
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Article ; Online: Efficacy of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms and cognitive functioning in schizophrenia: An umbrella review of systematic reviews and meta-analyses.

Yi, Shuwei / Wang, Qing / Wang, Wenjie / Hong, Chaokun / Ren, Zhibin

Psychiatry research

2024 Volume 333, Page(s) 115728

Abstract: Negative symptoms and cognitive dysfunction are core characteristics of schizophrenia that profoundly impact daily function and quality of life. As a noninvasive brain stimulation, repetitive transcranial magnetic stimulation (rTMS) has been proposed as ... ...

Abstract	Negative symptoms and cognitive dysfunction are core characteristics of schizophrenia that profoundly impact daily function and quality of life. As a noninvasive brain stimulation, repetitive transcranial magnetic stimulation (rTMS) has been proposed as a relatively new treatment for ameliorating negative symptoms and cognitive dysfunction in schizophrenia. However, there is controversy over the treatment methods and efficacy. We aimed to provide a quantitative integration of the published evidence regarding the efficacy of rTMS and analyze the feasibility of rTMS for treating negative symptoms and cognitive dysfunction in schizophrenia. A total of twenty reviews were ultimately selected and divided into thirty-three latitudes. Twenty-six analyses showed that rTMS significantly decreased the negative symptom score, and seventeen analyses were performed. Six analyses showed that rTMS treatment can increase working memory scores, and two of them had significant effects. Two analyses from the same review showed that rTMS had a long-term significant effect on treating language function. Only one analysis showed that rTMS had a significant effect on treating executive function. The analyses showed that rTMS had no significant effect on attention function and processing speed. Most reviews indicate that rTMS has an effect on negative symptoms, executive function, working memory, and language function in patients with schizophrenia. Although the quality of evidence was not high, these results are still positive and worthwhile for further study.
MeSH term(s)	Humans ; Transcranial Magnetic Stimulation/methods ; Schizophrenia/complications ; Schizophrenia/therapy ; Schizophrenia/diagnosis ; Quality of Life ; Treatment Outcome ; Systematic Reviews as Topic ; Cognition
Language	English
Publishing date	2024-01-12
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2024.115728
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Article ; Online: A comparison of the effects of NOAC and VKA therapy on the incidence of dementia in patients with atrial fibrillation: A systematic review and meta-analysis.

Wang, Wenjie / Fan, Weiguo / Su, Yuhao / Hong, Kui

Clinical cardiology

2023 Volume 46, Issue 8, Page(s) 866–876

Abstract: Atrial fibrillation (AF) patients are more susceptible to dementia, but the results about the effect of oral anticoagulants (OACs) on the risk of dementia are not consistent. We hypothesize that OAC is associated with a reduced risk of dementia with AF ... ...

Abstract	Atrial fibrillation (AF) patients are more susceptible to dementia, but the results about the effect of oral anticoagulants (OACs) on the risk of dementia are not consistent. We hypothesize that OAC is associated with a reduced risk of dementia with AF and that nonvitamin K antagonist oral anticoagulants (NOAC) are superior to vitamin K antagonists (VKA). Four databases were systematically searched until July 1, 2022. Two reviewers independently selected literature, evaluated quality, and extracted data. Data were examined using pooled hazard ratios (HRs) and 95% confidence intervals (CIs). Fourteen research studies involving 910 patients were enrolled. The findings indicated that OACs were associated with a decreased risk of dementia (pooled HR: 0.68, 95% CI: 0.55-0.82, I
MeSH term(s)	Humans ; Aged ; Anticoagulants/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Incidence ; Administration, Oral ; Prospective Studies ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Dementia/diagnosis ; Dementia/epidemiology ; Dementia/prevention & control ; Vitamin K
Chemical Substances	Anticoagulants ; Vitamin K (12001-79-5)
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.24076
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Article ; Online: Development and Prospect of Smart Materials and Structures for Aerospace Sensing Systems and Applications.

Wang, Wenjie / Xiang, Yue / Yu, Jingfeng / Yang, Long

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 3

Abstract: The rapid development of the aviation industry has put forward higher and higher requirements for material properties, and the research on smart material structure has also received widespread attention. Smart materials (e.g., piezoelectric materials, ... ...

Abstract	The rapid development of the aviation industry has put forward higher and higher requirements for material properties, and the research on smart material structure has also received widespread attention. Smart materials (e.g., piezoelectric materials, shape memory materials, and giant magnetostrictive materials) have unique physical properties and excellent integration properties, and they perform well as sensors or actuators in the aviation industry, providing a solid material foundation for various intelligent applications in the aviation industry. As a popular smart material, piezoelectric materials have a large number of application research in structural health monitoring, energy harvest, vibration and noise control, damage control, and other fields. As a unique material with deformation ability, shape memory materials have their own outstanding performance in the field of shape control, low-shock release, vibration control, and impact absorption. At the same time, as a material to assist other structures, it also has important applications in the fields of sealing connection and structural self-healing. Giant magnetostrictive material is a representative advanced material, which has unique application advantages in guided wave monitoring, vibration control, energy harvest, and other directions. In addition, giant magnetostrictive materials themselves have high-resolution output, and there are many studies in the direction of high-precision actuators. Some smart materials are summarized and discussed in the above application directions, aiming at providing a reference for the initial development of follow-up related research.
Language	English
Publishing date	2023-01-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23031545
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