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  1. Article ; Online: CenterNet-Saccade: Enhancing Sonar Object Detection with Lightweight Global Feature Extraction.

    Wang, Wenling / Zhang, Qiaoxin / Qi, Zhisheng / Huang, Mengxing

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 2

    Abstract: Sonar imaging technology is widely used in the field of marine and underwater monitoring because sound waves can be transmitted in elastic media, such as the atmosphere and seawater, without much interference. In underwater object detection, due to the ... ...

    Abstract Sonar imaging technology is widely used in the field of marine and underwater monitoring because sound waves can be transmitted in elastic media, such as the atmosphere and seawater, without much interference. In underwater object detection, due to the unique characteristics of the monitored sonar image, and since the target in an image is often accompanied by its own shadow, we can use the relative relationship between the shadow and the target for detection. To make use of shadow-information-aided detection and realize accurate real-time detection in sonar images, we put forward a network based on a lightweight module. By using the attention mechanism with a global receptive field, the network can make the target pay attention to the shadow information in the global environment, and because of its exquisite design, the computational time of the network is greatly reduced. Specifically, we design a ShuffleBlock model adapted to Hourglass to make the backbone network lighter. The concept of CNN dimension reduction is applied to MHSA to make it more efficient while paying attention to global features. Finally, CenterNet's unreasonable distribution method of positive and negative samples is improved. Simulation experiments were carried out using the proposed sonar object detection dataset. The experimental results further verify that our improved model has obvious advantages over many existing conventional deep learning models. Moreover, the real-time monitoring performance of our proposed model is more conducive to the implementation in the field of ocean monitoring.
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24020665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Politicization of science in the Lancang–Mekong Basin: the Eyes on Earth Study

    Grünwald, Richard / Feng, Yan / Wang, Wenling

    International Journal of Water Resources Development. 2023 Mar. 04, v. 39, no. 2 p.184-210

    2023  

    Abstract: In April 2020, the Eyes on Earth published a comprehensive research study presenting new evidence about the changing dynamics of the Lancang–Mekong River water flow. The Eyes on Earth Study (EoE Study) received significant media attention and raised ... ...

    Abstract In April 2020, the Eyes on Earth published a comprehensive research study presenting new evidence about the changing dynamics of the Lancang–Mekong River water flow. The Eyes on Earth Study (EoE Study) received significant media attention and raised concerns about hydrological changes that negatively affect the downstream countries. By drawing on the politicization of science theories and using the Lancang–Mekong Cooperation and Conflict Database, we (1) provide an overview the EoE Study’s findings; (2) outline the scientific and non-scientific responses to the EoE Study’s conclusions; and (3) study various implications of the politicization of the EoE Study.
    Keywords basins ; databases ; river water ; water flow ; Eyes on Earth Study ; politicization of science ; water conflict ; water cooperation ; Lancang–Mekong Cooperation and Conflict Database (LMCCD)
    Language English
    Dates of publication 2023-0304
    Size p. 184-210.
    Publishing place Routledge
    Document type Article ; Online
    ZDB-ID 2016525-0
    ISSN 1360-0648 ; 0790-0627
    ISSN (online) 1360-0648
    ISSN 0790-0627
    DOI 10.1080/07900627.2021.1990025
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Serum hsa-miR-30e As a Potential Biomarker to Predict the Effect of Neoadjuvant Chemoradiation Therapy in Locally Advanced Rectal Cancer.

    Chen, Weiwei / Wang, Wenling

    Genetic testing and molecular biomarkers

    2021  Volume 25, Issue 11, Page(s) 696–706

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphocytes, Tumor-Infiltrating/drug effects ; Male ; MicroRNAs/blood ; MicroRNAs/genetics ; Middle Aged ; Neoadjuvant Therapy ; Prognosis ; Real-Time Polymerase Chain Reaction ; Rectal Neoplasms/blood ; Rectal Neoplasms/genetics ; Rectal Neoplasms/therapy ; Tissue Array Analysis ; Up-Regulation
    Chemical Substances Biomarkers, Tumor ; MIRN30e microRNA, human ; MicroRNAs
    Language English
    Publishing date 2021-12-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2486664-7
    ISSN 1945-0257 ; 1945-0265
    ISSN (online) 1945-0257
    ISSN 1945-0265
    DOI 10.1089/gtmb.2020.0300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: EXOSC5 maintains cancer stem cell activity in endometrial cancer by regulating the NTN4/integrin β1 signalling axis.

    Huang, Yu-Hao / Wang, Wen-Ling / Wang, Po-Hui / Lee, Hsueh-Te / Chang, Wen-Wei

    International journal of biological sciences

    2024  Volume 20, Issue 1, Page(s) 265–279

    Abstract: Endometrial carcinoma (EC) is a common type of uterine cancer in developed countries, originating from the uterine epithelium. The incidence rate of EC in Taiwan has doubled from 2005. Cancer stem cells (CSCs) are a subpopulation of cancer cells that ... ...

    Abstract Endometrial carcinoma (EC) is a common type of uterine cancer in developed countries, originating from the uterine epithelium. The incidence rate of EC in Taiwan has doubled from 2005. Cancer stem cells (CSCs) are a subpopulation of cancer cells that have high tumorigenicity and play a crucial role in the malignant processes of cancer. Targeting molecules associated with CSCs is essential for effective cancer treatments. This study delves into the role of Exosome component 5 (EXOSC5) in EC. Data from The Cancer Genome Atlas suggests a correlation between high EXOSC5 mRNA expression and unfavorable EC prognosis. EXOSC5 knockdown diminished EC-CSC self-renewal and reduced expression of key cancer stemness proteins, including c-MYC and SOX2. Intriguingly, this knockdown significantly curtailed tumorigenicity and CSC frequency in EC tumor spheres. A mechanistic examination revealed a reduction in netrin4 (NTN4) levels in EXOSC5-depleted EC cells. Moreover, NTN4 treatment amplified EC cell CSC activity and, when secreted, NTN4 partnered with integrin β1, subsequently triggering the FAK/SRC axis to elevate c-MYC activity. A clear positive relation between EXOSC5 and NTN4 was evident in 93 EC tissues. In conclusion, EXOSC5 augments NTN4 expression, activating c-MYC via the integrin β1/FAK/SRC pathway, offering potential avenues for EC diagnosis and treatment.
    MeSH term(s) Humans ; Female ; Integrin beta1/metabolism ; Signal Transduction/genetics ; Endometrial Neoplasms/metabolism ; Neoplastic Stem Cells/metabolism ; Cell Line, Tumor ; Antigens, Neoplasm/metabolism ; RNA-Binding Proteins/metabolism ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Netrins/metabolism
    Chemical Substances Integrin beta1 ; EXOSC5 protein, human ; Antigens, Neoplasm ; RNA-Binding Proteins ; Exosome Multienzyme Ribonuclease Complex (EC 3.1.-) ; NTN4 protein, human ; Netrins
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.86275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation.

    Ho, Chien-Yi / Tang, Chih-Hsin / Ho, Trung-Loc / Wang, Wen-Ling / Yao, Chun-Hsu

    Aging

    2024  Volume 16, Issue 5, Page(s) 4832–4840

    Abstract: Osteoporosis is a usual bone disease in aging populations, principally in postmenopausal women. Anti-resorptive and anabolic drugs have been applied to prevent and cure osteoporosis and are associated to a different of adverse effects. Du-Zhong is ... ...

    Abstract Osteoporosis is a usual bone disease in aging populations, principally in postmenopausal women. Anti-resorptive and anabolic drugs have been applied to prevent and cure osteoporosis and are associated to a different of adverse effects. Du-Zhong is usually applied in Traditional Chinese Medicine to strengthen bone, regulate bone metabolism, and treat osteoporosis. Chlorogenic acid is a major polyphenol in Du-Zhong. In the current study, chlorogenic acid was found to enhance osteoblast proliferation and differentiation. Chlorogenic acid also inhibits the RANKL-induced osteoclastogenesis. Notably, ovariectomy significantly decreased bone volume and mechanical properties in the ovariectomized (OVX) rats. Administration of chlorogenic acid antagonized OVX-induced bone loss. Taken together, chlorogenic acid seems to be a hopeful molecule for the development of novel anti-osteoporosis treatment.
    MeSH term(s) Humans ; Rats ; Female ; Animals ; Osteoclasts ; Chlorogenic Acid/pharmacology ; Chlorogenic Acid/therapeutic use ; Chlorogenic Acid/metabolism ; Osteogenesis ; Osteoporosis/metabolism ; Osteoblasts/metabolism ; Cell Differentiation
    Chemical Substances Chlorogenic Acid (318ADP12RI)
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Screening of Serum miRNAs as Diagnostic Biomarkers for Lung Cancer Using the Minimal-Redundancy-Maximal-Relevance Algorithm and Random Forest Classifier Based on a Public Database.

    Huang, Xiaoyan / Chen, Xiong / Chen, Xi / Wang, Wenling

    Public health genomics

    2022  , Page(s) 1–9

    Abstract: Background: Lung cancer is one of the deadliest cancers, early diagnosis of which can efficiently enhance patient's survival. We aimed to screening out the serum miRNAs as diagnostic biomarkers for patients with lung cancer.: Methods: A total of 416 ... ...

    Abstract Background: Lung cancer is one of the deadliest cancers, early diagnosis of which can efficiently enhance patient's survival. We aimed to screening out the serum miRNAs as diagnostic biomarkers for patients with lung cancer.
    Methods: A total of 416 remarkably differentially expressed miRNAs were acquired using the limma package, and next feature ranking was derived by the minimal-redundancy-maximal-relevance method. An incremental feature selection algorithm of a random forest (RF) classifier was utilized to choose the top 5 miRNA combination with the optimum predictive performance. The performance of the RF classifier of top 5 miRNAs was analyzed using the receiver operator characteristic (ROC) curve. Afterward, the classification effect of the 5-miRNA combination was validated through principal component analysis and hierarchical clustering analysis. Analysis of top 5 miRNA expressions between lung cancer patients and normal people was performed based on GSE137140 dataset, and their expression was validated by qPCR. The hierarchical clustering analysis was used to analyze the similarity of 5 miRNAs expression profiles. ROC analysis was undertaken on each miRNA.
    Results: We acquired top 5 miRNAs finally, with the Matthews correlation coefficient value as 0.988 and the area under the curve (AUC) value as 0.996. The 5 feature miRNAs were capable of distinguishing most cancer patients and normal people. Furthermore, except for the lowly expressed miR-6875-5p in lung cancer tissue, the other 4 miRNAs all expressed highly in cancer patients. Performance analysis revealed that their AUC values were 0.92, 0.96, 0.94, 0.95, and 0.93, respectively.
    Conclusion: By and large, the 5 feature miRNAs screened here were anticipated to be effective biomarkers for lung cancer.
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2457023-0
    ISSN 1662-8063 ; 1662-4246
    ISSN (online) 1662-8063
    ISSN 1662-4246
    DOI 10.1159/000525316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Research on the Theoretical Framework of Web Archiving Data Quality Assurance Strategies

    Wang Wenling / Qu Yunpeng

    Zhishi guanli luntan, Vol 3, Iss 2, Pp 106-

    2018  Volume 115

    Abstract: Purpose/significance] Quality assurance is one of the most important procedures in web archiving, it runs throughout the whole web archiving work and affects the success odds of web archiving work. [Method/process] In this article, we made an analysis ... ...

    Abstract [Purpose/significance] Quality assurance is one of the most important procedures in web archiving, it runs throughout the whole web archiving work and affects the success odds of web archiving work. [Method/process] In this article, we made an analysis and comparative study for the quality assurance strategies of domestic and foreign web archiving organizations, and proposed a strategic theoretical framework for data quality assurance. [Result/conclusion] The framework in this article is a data-centered design, it includes a series of criteria and operating specifications, carries out data quality inspection throughout the collecting procedure by using semi-automatic auxiliary tools. Meanwhile, to ensure access to high quality archive data, the framework also takes team building, running environment maintenance and authorized backup to the websites as supplementary means.
    Keywords web archiving ; Bibliography. Library science. Information resources ; Z
    Language Chinese
    Publishing date 2018-04-01T00:00:00Z
    Publisher LIS Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Lesion detection of chest X-Ray based on scalable attention residual CNN.

    Lin, Cong / Huang, Yiquan / Wang, Wenling / Feng, Siling

    Mathematical biosciences and engineering : MBE

    2022  Volume 20, Issue 2, Page(s) 1730–1749

    Abstract: Most of the research on disease recognition in chest X-rays is limited to segmentation and classification, but the problem of inaccurate recognition in edges and small parts makes doctors spend more time making judgments. In this paper, we propose a ... ...

    Abstract Most of the research on disease recognition in chest X-rays is limited to segmentation and classification, but the problem of inaccurate recognition in edges and small parts makes doctors spend more time making judgments. In this paper, we propose a lesion detection method based on a scalable attention residual CNN (SAR-CNN), which uses target detection to identify and locate diseases in chest X-rays and greatly improves work efficiency. We designed a multi-convolution feature fusion block (MFFB), tree-structured aggregation module (TSAM), and scalable channel and spatial attention (SCSA), which can effectively alleviate the difficulties in chest X-ray recognition caused by single resolution, weak communication of features of different layers, and lack of attention fusion, respectively. These three modules are embeddable and can be easily combined with other networks. Through a large number of experiments on the largest public lung chest radiograph detection dataset, VinDr-CXR, the mean average precision (mAP) of the proposed method was improved from 12.83% to 15.75% in the case of the PASCAL VOC 2010 standard, with IoU > 0.4, which exceeds the existing mainstream deep learning model. In addition, the proposed model has a lower complexity and faster reasoning speed, which is conducive to the implementation of computer-aided systems and provides referential solutions for relevant communities.
    MeSH term(s) Neural Networks, Computer ; Algorithms ; X-Rays ; Radiography, Thoracic/methods ; Lung
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Regarding "Comparison of High-intensity Focused Ultrasound and Conventional Surgery for Patients with Uterine Myomas: A Systematic Review and Meta-analysis".

    Cui, Hongmei / Wang, Wenling / Guan, Chongli

    Journal of minimally invasive gynecology

    2021  Volume 28, Issue 11, Page(s) 1954–1955

    MeSH term(s) Female ; Humans ; Leiomyoma/diagnostic imaging ; Leiomyoma/surgery ; Myoma ; Uterine Neoplasms/diagnostic imaging ; Uterine Neoplasms/surgery
    Language English
    Publishing date 2021-08-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2021.08.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Risk factors for fluoropyrimidine-induced cardiotoxicity in colorectal cancer: A retrospective cohort study and establishment of a prediction nomogram for 5-FU induced cardiotoxicity.

    Wang, Yan / Wang, Wenling / Dong, Hongming / Wang, Gang / Chen, Wanghua / Chen, Juan / Chen, Weiwei

    Frontiers in oncology

    2023  Volume 13, Page(s) 1017237

    Abstract: Background: Fluoropyrimidine is an important component of systemic chemotherapy for colorectal cancer (CRC). Fluoropyrimidine-induced cardiotoxicity (FIC) may result in delay and discontinuation of chemotherapy and, in severe cases, can even be life- ... ...

    Abstract Background: Fluoropyrimidine is an important component of systemic chemotherapy for colorectal cancer (CRC). Fluoropyrimidine-induced cardiotoxicity (FIC) may result in delay and discontinuation of chemotherapy and, in severe cases, can even be life-threatening. To date, risk factors for FIC have not been well identified. This cohort study aimed to identify the predictors of FIC in CRC patients and develop a risk prediction nomogram model.
    Methods: Between January 1, 2018 and December 31, 2020, colorectal cancer patients who received 5-fluoropyrimidine(5-Fu)/capecitabine-based chemotherapy in Affiliated Cancer Hospital of Guizhou Medical University were included. FIC was defined as an adverse cardiovascular event related to fluoropyrimidine that occurred during or within four weeks of completing chemotherapy. Risk factors were determined by LASSO algorithm and multivariate logistic regression analysis. Nomogram for predicting 5-Fu-induced cardiotoxicity was established and internally validated. The concordance index (C-index) and calibration curve were used to evaluate the nomogram's discrimination and accuracy.
    Results: A total of 916 patients were included for analysis, and 200 [21.8%,95% confidence interval (CI):19.12%-24.47%] experienced FIC. LASSO algorithm and multivariate logistic regression analysis determined that chemotherapy ≤3 cycles (OR=4.694, 95%CI=3.184-6.92), age≥ 60 (OR=1.678, 95%CI=1.143-2.464), BMI>22.97 (OR=1.77, 95%CI=1.202-2.606), and simultaneous use of bevacizumab (OR=2.922, 95%CI=1.835-4.653) were significant risk factors, and were included in the prediction model for 5-Fu induced cardiotoxicity. The C-index (95%CI) was 0.751 (0.706-0.795) by internal validation. For patients treated with capecitabine-based regimen, the incidence of FIC increased with the absolute value of neutrophils (OR=5.177, 95%CI=1.684-15.549) and eosinophils (OR=3.377,95% CI=1.237-9.22).
    Conclusions: Our study identified risk factors for FIC and established a prediction nomogram model based on chemotherapy cycle, age, BMI and use of target therapy for 5-FU induced Cardiotoxicity. The discriminative prediction model can be used for patient counselling and risk-stratification before undergoing chemotherapy in colorectal cancer.
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1017237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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