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Article ; Online: MALT1 Protease Regulates T-Cell Immunity via the mTOR Pathway in Oral Lichen Planus.

Wang, Xiao-Feng / Wang, Fang / Zhou, Gang

2023

Abstract: Oral lichen planus (OLP) is a T cell-mediated immune mucosal disease of unknown pathogenesis. Whether mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), an intracellular signaling protein, is involved in the T-cell immune ... ...

Abstract	Oral lichen planus (OLP) is a T cell-mediated immune mucosal disease of unknown pathogenesis. Whether mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), an intracellular signaling protein, is involved in the T-cell immune dysfunction of OLP remains elusive. MALT1 expression in local and peripheral T cells of OLP and controls was analyzed using immunohistochemistry, multiplex immunohistochemistry, and flow cytometry. The expression of MALT1 in activated Jurkat T cells incubated with either OLP plasma or interleukin (IL)-7/IL-15 was determined by flow cytometry. The effects of MALT1 and mechanistic target of rapamycin (mTOR) on T-cell immunity were investigated through western blot, CCK8 assay, and flow cytometry. The expression of MALT1 protein was elevated in local OLP T cells and mucosal-associated invariant T (MAIT) cells, while reduced in peripheral OLP T cells, MAIT cells, and follicular helper-like MAIT (MAITfh) cells. Stimulation with OLP plasma and IL-7/ IL-15 had no effect on MALT1 expression in activated Jurkat T cells. MALT1 protease-specific inhibitor (MI-2) induced mTOR phosphorylation, increased B-cell lymphoma 10 (BCL10) expression, inhibited T-cell proliferation, and promoted T-cell apoptosis. The combination of MI-2 and rapamycin increased MALT1 expression, further suppressed T-cell proliferation, and facilitated T-cell apoptosis. MALT1 expression is aberrant in both local lesions and peripheral blood of OLP. Inhibition of the mTOR pathway further enhances the suppression of T-cell proliferation and the promotion of apoptosis induced by the MALT1 inhibitor MI-2.
Language	English
Publishing date	2023-12-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	434408-x
ISSN	1573-2576 ; 0360-3997
ISSN (online)	1573-2576
ISSN	0360-3997
DOI	10.1007/s10753-023-01952-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1401: Show issues

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Article ; Online: The

Wang, Xiao-Feng / Liu, Dong-Li / Geng, Li

Genetic testing and molecular biomarkers

2023 Volume 27, Issue 2, Page(s) 44–55

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Male ; Humans ; Stomach Neoplasms/genetics ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder ; Membrane Proteins ; RNA, Messenger ; Antigens, Neoplasm/genetics ; Neoplasm Proteins ; GPI-Linked Proteins/genetics
Chemical Substances	Membrane Proteins ; RNA, Messenger ; PSCA protein, human ; Antigens, Neoplasm ; Neoplasm Proteins ; GPI-Linked Proteins
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2486664-7
ISSN	1945-0257 ; 1945-0265
ISSN (online)	1945-0257
ISSN	1945-0265
DOI	10.1089/gtmb.2022.0067
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Zs.A 5195: Show issues

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Article ; Online: Zwitterion Dual-Modification Strategy for High-Quality NiO

Wang, Xianzhao / Jiang, Jun / Liu, Ziyan / Li, Aijun / Miyasaka, Tsutomu / Wang, Xiao-Feng

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2400356

Abstract: Nickel oxide ( ... ...

Abstract	Nickel oxide (NiO
Language	English
Publishing date	2024-02-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202400356
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biohybrid Molecule-Based Photocatalysts for Water Splitting Hydrogen Evolution.

Zheng, Tianfang / Li, Aijun / Han, Jiahong / Wang, Xiao-Feng

ChemPlusChem

2023 Volume 88, Issue 2, Page(s) e202200424

Abstract: The problems of resource depletion and environmental pollution caused by the excessive use of fossil fuels greatly restrict the rapid development of human technology and industry, which has led to a high demand for the development of new and clean energy ...

Abstract	The problems of resource depletion and environmental pollution caused by the excessive use of fossil fuels greatly restrict the rapid development of human technology and industry, which has led to a high demand for the development of new and clean energy sources. Hydrogen, due to its high calorific value and environmentally friendly combustion products, is undoubtedly a very promising energy carrier. The current methods of industrial hydrogen production are mainly water electrocatalytic decomposition or fossil fuels conversion, which also results in the waste of other energy sources. Since only one-step is involved during the conversion from solar to chemical energy and thus unnecessary energy waste is avoided, solar energy photocatalytic decomposition of water provides a more viable method for hydrogen production. The utilization of biohybrid molecules, which are widely available in nature and environmentally friendly, further reduce the cost of such photocatalytic systems. This Review discusses the research progress on hydrogen production using biohybrid molecules for photocatalytic hydrogen evolution. The basic reaction mechanism, general types and system structures about biohybrid molecule-based photocatalysts are summarized. The current challenges and prospects in the research of water splitting hydrogen evolution by biohybrid molecules photocatalysts are presented.
Language	English
Publishing date	2023-02-07
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	2192-6506
ISSN (online)	2192-6506
DOI	10.1002/cplu.202200424
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Preliminary results on the separation of the different parts of Ligustrum lucidum Ait fruit and the main bioactive compounds analysis

Dong, Xiao-Ning / Zhao, Qiang / Wang, Xiao-Feng

Heliyon. 2022 Dec., v. 8, no. 12 p.e12139-

2022

Abstract: Oleanolic acid (OA) and ursolic acid (UA) possess anti-inflammatory, antioxidative, antiprotozoal, antimutagenic and anticancer properties and are the main bioactive compounds in the fruit of Ligustrum lucidum Ait. The aim of this paper was to study the ... ...

Abstract	Oleanolic acid (OA) and ursolic acid (UA) possess anti-inflammatory, antioxidative, antiprotozoal, antimutagenic and anticancer properties and are the main bioactive compounds in the fruit of Ligustrum lucidum Ait. The aim of this paper was to study the method of separating the whole fruit into the main ingredients containing OA and UA for the later effective extraction with reduced organic solvents and easy separation and purification. In the present study, the sarcocarps and exocarps were separated from the whole fruits (designated exo-sarcocarps, the mass percentages (w/w, dry weight basis), 33.1%), testae (13.5%) and cores (48.7%) by using methods separated. The contents of OA and UA in whole fruits, exo-sarcocarps, testae and cores were analyzed. The OA and UA extraction yields were highest in exo-sarcocarps vs. yields from whole fruits, testae or cores. The spective yields of OA and UA from exo-sarcocarps were 24.34 ± 2.09 and 7.82 ± 0.09 mg/g; these yields were about 4 times higher than OA yields and about 4 times higher than UA yields from fruit.
Keywords	Ligustrum lucidum ; exocarp ; oleanolic acid ; ursolic acid ; Fruit of Ligustrum lucidum Ait ; Exo-sarcocarps ; Contents of OA and UA
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e12139
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Malla

Lin, Zilong / Cui, Jian / Liao, Xiaojing / Wang, XiaoFeng

Demystifying Real-world Large Language Model Integrated Malicious Services

2024

Abstract: The underground exploitation of large language models (LLMs) for malicious services (i.e., Malla) is witnessing an uptick, amplifying the cyber threat landscape and posing questions about the trustworthiness of LLM technologies. However, there has been ... ...

Abstract	The underground exploitation of large language models (LLMs) for malicious services (i.e., Malla) is witnessing an uptick, amplifying the cyber threat landscape and posing questions about the trustworthiness of LLM technologies. However, there has been little effort to understand this new cybercrime, in terms of its magnitude, impact, and techniques. In this paper, we conduct the first systematic study on 212 real-world Mallas, uncovering their proliferation in underground marketplaces and exposing their operational modalities. Our study discloses the Malla ecosystem, revealing its significant growth and impact on today's public LLM services. Through examining 212 Mallas, we uncovered eight backend LLMs used by Mallas, along with 182 prompts that circumvent the protective measures of public LLM APIs. We further demystify the tactics employed by Mallas, including the abuse of uncensored LLMs and the exploitation of public LLM APIs through jailbreak prompts. Our findings enable a better understanding of the real-world exploitation of LLMs by cybercriminals, offering insights into strategies to counteract this cybercrime.
Keywords	Computer Science - Cryptography and Security ; Computer Science - Artificial Intelligence
Subject code	306
Publishing date	2024-01-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficient Two-Dimensional Perovskite Solar Cells Realized by Incorporation of Ti

Jin, Xin / Yang, Lin / Wang, Xiao-Feng

Nano-micro letters

2021 Volume 13, Issue 1, Page(s) 68

Abstract: Two-dimensional (2D) perovskites solar cells (PSCs) have attracted considerable attention owing to their excellent stability against humidity; however, some imperfectness of 2D perovskites, such as poor crystallinity, disordered orientation, and inferior ...

Abstract	Two-dimensional (2D) perovskites solar cells (PSCs) have attracted considerable attention owing to their excellent stability against humidity; however, some imperfectness of 2D perovskites, such as poor crystallinity, disordered orientation, and inferior charge transport still limit the power conversion efficiency (PCE) of 2D PSCs. In this work, 2D Ti
Language	English
Publishing date	2021-02-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2642093-4
ISSN	2150-5551 ; 2150-5551
ISSN (online)	2150-5551
ISSN	2150-5551
DOI	10.1007/s40820-021-00602-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of Anti-

Yu, Jin-Han / Zhao, Ying / Wang, Xiao-Feng / Xu, Ying-Chun

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 5

Abstract: Serological testing (immunoassay) for Helicobacter pylori (H. pylori) is widely available and inexpensive, and does not require medication modifications before testing. It can also determine the type of infection, which helps with clinical diagnosis and ... ...

Abstract	Serological testing (immunoassay) for Helicobacter pylori (H. pylori) is widely available and inexpensive, and does not require medication modifications before testing. It can also determine the type of infection, which helps with clinical diagnosis and treatment, and guides the use of medication. However, the performance of immunoblotting for the detection of H. pylori infections in different populations has still not been fully evaluated. We performed a retrospective analysis of patients in the Health Examination Center and Outpatient Department, from November 2017 to September 2020, at Peking Union Medical College Hospital. All the subjects were tested with the 13C-urea breath test (13C-UBT) and for IgG antibodies. A total of 1678 participants, including 1377 individuals who had undergone physical examinations, were recruited. The results of the immunoassay were significantly different from those of the 13C-UBT for all the subjects and outpatients (p < 0.001). For the physical examinations of individuals, the agreement between the immunoassay and the 13C-UBT was 0.64 (95%CI: 0.59−0.68; p < 0.001), and the H. pylori immunoassay demonstrated a sensitivity and specificity of 74.24% and 90.45%, respectively, with a positive predictive value of 71.01% and negative predictive value of 91.76%. In addition, in patients with gastric mucosal atrophy or early gastric cancer, antibody typing tests can also detect infected patients with missed UBT. The prevalence of H. pylori in Beijing was 26.8%, and the serological positivity rate for H. pylori in the population of Beijing was about 31.7% (25.1% in the physical examination population). The rate of H. pylori antibody positivity among patients with allergic diseases was 73.5%, which is significantly higher than that of the non-allergic disease population (29.3%, p < 0.001). In conclusion, H. pylori antibody typing testing can be applied as a specific test in the healthy physical examination population, and the test can be performed with the remaining serum during the physical examination.
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12051214
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Article ; Online: Association between perceived stress and motoric cognitive risk syndrome in an elderly population: Rugao longevity and ageing study.

Cao, Yuan-Fei / Shi, Guo-Ping / Zhang, Hui / Sun, Meng-Zhen / Wang, Zheng-Dong / Chu, Xue-Feng / Guo, Jiang-Hong / Wang, Xiao-Feng

Dementia and geriatric cognitive disorders

2024

Abstract: Introduction Previous studies have indicated a correlation between perceived stress and cognitive decline. However, it remains unknown whether high levels of perceived stress can result in motoric cognitive risk (MCR) syndrome. This study investigated ... ...

Abstract	Introduction Previous studies have indicated a correlation between perceived stress and cognitive decline. However, it remains unknown whether high levels of perceived stress can result in motoric cognitive risk (MCR) syndrome. This study investigated the relationship between perceived stress and MCR in a community-based population. Methods The study cohort comprised 852 elderly individuals from the Rugao Longitudinal Aging Cohort. Perceived stress was assessed using the 10-item Perceived Stress Scale (PSS-10), while MCR was defined as the coexistence of subjective memory complaints (SMCs) and slow gait speed. Results The average age of the study participants is 79.84 ± 4.34 years. The mean score of PSS-10 among participants is 10.32 (range = 0-33; [SD] = 5.71), with a median score of 10.00 (6.00, 14.00). The prevalence of MCR is 9.3%. In the logistic regression analysis, for each 1-SD (5.71) increase in the global PSS-10 score, the risk of MCR increased by 40% (95% CI 1.09-1.80). Additionally, in the aspect of two components of MCR, with a 1-SD increase (5.71) in the global PSS-10 score, there was a 50% (95% CI 1.29-1.75) increase in the risk of SMCs and a 27% (95% CI 1.04-1.55) increase in the risk of slow gait speed. In terms of specific walking speed, there was a reverse correlation between the global PSS-10 score and walking speed (r = -0.14, p < 0.001). Conclusions This study provided preliminary evidence that high levels of perceived stress were associated with the risk of MCR in a community-dwelling population.
Language	English
Publishing date	2024-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1026007-9
ISSN	1421-9824 ; 1013-7424
ISSN (online)	1421-9824
ISSN	1013-7424
DOI	10.1159/000537937
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2866: Show issues

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Article: Comparison of fungal

Khan, Sarah / Hong, Hanna / Bass, Stephanie / Wang, Yifan / Wang, Xiao-Feng / Sims, Omar T / Koval, Christine E / Kapoor, Aanchal / Lindenmeyer, Christina C

World journal of hepatology

2024 Volume 16, Issue 3, Page(s) 379–392

Abstract: Background: Due to development of an immune-dysregulated phenotype, advanced liver disease in all forms predisposes patients to sepsis acquisition, including by opportunistic pathogens such as fungi. Little data exists on fungal infection within a ... ...

Abstract	Background: Due to development of an immune-dysregulated phenotype, advanced liver disease in all forms predisposes patients to sepsis acquisition, including by opportunistic pathogens such as fungi. Little data exists on fungal infection within a medical intensive liver unit (MILU), particularly in relation to acute on chronic liver failure. Aim: To investigate the impact of fungal infections among critically ill patients with advanced liver disease, and compare outcomes to those of patients with bacterial infections. Methods: From our prospective registry of MILU patients from 2018-2022, we included 27 patients with culture-positive fungal infections and 183 with bacterial infections. We compared outcomes between patients admitted to the MILU with fungal infections to bacterial counterparts. Data was extracted through chart review. Results: All fungal infections were due to Conclusion: Mortality was worse among patients with fungal infections, likely attributable to severe ACLF development. Prospective studies examining empiric antifungals in severe ACLF and associations between fungal infections and transplant outcomes are critical.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573703-X
ISSN	1948-5182
ISSN	1948-5182
DOI	10.4254/wjh.v16.i3.379
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