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Article ; Online: Estrogen receptor-related receptor γ uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer.

Wang, Xiao-Xiao / Hua, Teng / Wang, Hong-Bo

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

2023 Volume 39, Issue 1, Page(s) 2264411

Abstract: Objective: Estrogen receptor-related receptor γ (ERRγ), is implicated in cancer cell proliferation and metastasis. The function of ERRγ in tumor angiogenesis, however, is to be revealed. This study was designed to elaborate the regulatory effect of ERRγ ...

Abstract	Objective: Estrogen receptor-related receptor γ (ERRγ), is implicated in cancer cell proliferation and metastasis. The function of ERRγ in tumor angiogenesis, however, is to be revealed. This study was designed to elaborate the regulatory effect of ERRγ on angiogenesis in endometrial cancer (EC). Methods: Immunohistochemistry (IHC) was adopted to determine the protein expression of ERRγ, VEGFA, CD31 and hypoxia-inducible factor-1 (HIF-1) in tumor tissues. HEC-1A cells stably expressing ERRγ were established bytransfection, and then an endothelial cell tube formation assay was performed. CCK-8 assay was employed for cell viability, and wound healing assay for cell migration ability. Besides, western blot, ELISA and qRT-PCR were used to examine the VEGFA expression. After hypoxia treatment of ERRγ overexpressing HEC-1A cells, the ERRγ expression and VEGFA expression were determined by western blot. Finally, EC xenografts in nude mice were constructed by subcutaneous injection of ERRγ stably expressing HEC-1A cells and control HEC-1A cells. Results: IHC results revealed a negative correlation between the expression of ERRγ and VEGFA in EC tissues. ERRγ overexpression significantly decreased the level of HIF-1 in tumor tissue of nude mice. ERRγ overexpression down-regulated inhibited angiogenesis capability and inhibited the proliferation and migration of HEC-1A cells. Furthermore, ERRγ expression was suppressed under the condition of hypoxia while restoration of ERRγ partially inhibited hypoxia-induced VEGFA expression in HEC-1A cells. Conclusions: ERRγ is an angiogenesis suppressor and involved in hypoxia-induced VEGFA expression in EC. Hence, ERRγ might be a promising antiangiogenic target for human EC.
MeSH term(s)	Animals ; Female ; Humans ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Endometrial Neoplasms/blood supply ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/metabolism ; Endometrial Neoplasms/pathology ; Hypoxia ; Mice, Nude ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/metabolism ; Receptors, Estrogen/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Hypoxia-Inducible Factor 1/metabolism
Chemical Substances	ESRRG protein, human ; Receptors, Estrogen ; Vascular Endothelial Growth Factor A ; VEGFA protein, human ; Hypoxia-Inducible Factor 1
Language	English
Publishing date	2023-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	639237-4
ISSN	1473-0766 ; 0951-3590
ISSN (online)	1473-0766
ISSN	0951-3590
DOI	10.1080/09513590.2023.2264411
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Article: Advances in the molecular pathogenesis and cell therapy of stress urinary incontinence.

Wang, Xiao-Xiao / Zhang, Lei / Lu, Ye

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1090386

Abstract: Stress urinary incontinence (SUI) is very common in women. It affects patients' mental and physical health, and imposed huge socioeconomic pressure. The therapeutic effect of conservative treatment is limited, and depends heavily on patient persistence ... ...

Abstract	Stress urinary incontinence (SUI) is very common in women. It affects patients' mental and physical health, and imposed huge socioeconomic pressure. The therapeutic effect of conservative treatment is limited, and depends heavily on patient persistence and compliance. Surgical treatment often brings procedure-related adverse complications and higher costs for patients. Therefore, it is necessary to better understand the potential molecular mechanisms underlying stress urinary incontinence and develop new treatment methods. Although some progress has been made in the basic research in recent years, the specific molecular pathogenic mechanisms of SUI are still unclear. Here, we reviewed the published studies on the molecular mechanisms associated with nerves, urethral muscles, periurethral connective tissue and hormones in the pathogenesis of SUI. In addition, we provide an update on the recent progresses in research on the use of cell therapy for treating SUI, including research on stem cells therapy, exosome differentiation and gene regulation.
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1090386
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Article ; Online: Effect of Orthodontic Treatment on the Outcomes of Endodontically Treated Teeth: a CBCT analysis.

Chen, Xue / Liu, Shao-Qing / Wang, Xiao-Xiao / Liu, Wei / Zhou, Xin / Wang, Xiao

Journal of endodontics

2024

Abstract: Introduction: Objective: Often there is the need of moving endodontically treated teeth. Orthodontic movement may have no effect on the prognosis of teeth with root canal treatment (RCT). To verify this subject, we evaluated the effect of orthodontic ... ...

Abstract	Introduction: Objective: Often there is the need of moving endodontically treated teeth. Orthodontic movement may have no effect on the prognosis of teeth with root canal treatment (RCT). To verify this subject, we evaluated the effect of orthodontic movement on the prognosis of RCT teeth using cone-beam computed tomography (CBCT) and further explored the influence of orthodontic movement on the prognosis of RCT teeth with and without apical periodontitis (AP). Materials and methods: This retrospective study was conducted by evaluating 169 RCT teeth of 100 patients who had undergone fixed orthodontic treatment. AP was assessed and classified using the CBCT periapical index. Univariate analysis of RCT outcome was performed for the total RCT group, RCT without AP group and RCT with AP group. Multivariate logistic regression was performed for the total RCT group and RCT without AP group, respectively, but not for the RCT with AP group. Variables related to the prognosis of RCT were included, such as age, gender, tooth position, RCT quality, coronal restoration quality, periodontal condition, orthodontic traction distance, and orthodontic rotation angle. Results: The orthodontic traction distance and rotation angle were not significantly correlated to the RCT outcomes, regardless of the presence of AP. Among the total RCT group, teeth with unqualified RCT (OR = 3.42, P = 0.004) and inadequate coronal restoration (OR = 4.40, P = 0.031) had a lower success rate. Of the 97 RCT teeth without AP, unqualified RCT was a risk factor for treatment failure (OR = 3.55, P = 0.041). Of the 72 RCT teeth with AP, the univariate analysis showed that RCT quality were significantly related to the outcome (p = 0.042). Conclusion: Orthodontic movement had no effect on the prognosis of RCT teeth regardless of the presence of AP.
Language	English
Publishing date	2024-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	752412-2
ISSN	1878-3554 ; 0099-2399
ISSN (online)	1878-3554
ISSN	0099-2399
DOI	10.1016/j.joen.2024.05.002
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Article: [Factors influencing the chronic post-surgical pain after laparoscopic surgery for elderly patients with urinary tract tumors].

Liu, Hui Li / Lv, Yan Han / Wang, Xiao Xiao / Li, Min

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2023 Volume 55, Issue 5, Page(s) 851–856

Abstract: Objective: To investigate the incidence and potential influence factors that contribute to chronic post-surgical pain (CPSP) in elderly patients with urinary tract tumors who underwent laparoscopic procedures.: Methods: A retrospective study was ... ...

Abstract	Objective: To investigate the incidence and potential influence factors that contribute to chronic post-surgical pain (CPSP) in elderly patients with urinary tract tumors who underwent laparoscopic procedures. Methods: A retrospective study was conducted to collect the clinical data of 182 elderly patients with urinary tract tumors who were ≥65 years and underwent laparoscopic surgery from October 2021 to March 2022 in Peking University Third Hospital. The patients'demographic information, medical history and the severity of postoperative pain were collected. Telephone follow-ups were made 6 months after surgery, and the patients' CPSP conditions were recorded. The diagnostic criteria of CPSP were referred to the definition made by the International Association for the Study of Pain (IASP): (1) Pain that developed or increased in intensity after surgical procedure and persisted for at least 3 months after surgery; (2) Pain that localized to the surgical field or projected to the innervation territory of a nerve situated around the surgical area; (3) Pain due to pre-existing pain conditions or infections and malignancy was excluded. The patients were divided into two groups based on CPSP diagnosis. Risk factors that predisposed the patients to CPSP were identified using univariate analysis. A multivariate Logistic regression model using back-forward method was designed, including both variables that significantly associated with CPSP in the univariate analysis ( Results: Two hundred and sixteen patients with urinary tract tumors who had undergone laparoscopic surgery were included, of whom, 34 (15.7%) were excluded from the study. For the remaining 182 patients, the average age was (72.6±5.2) years, with 146 males and 36 females. The incidence of CPSP at the end of 6 months was 31.9% (58/182). Multiva-riate regression analysis revealed that age ≥75 years ( Conclusion: Age < 75 years, renal cancer and the 24 h postoperative moderate to severe pain are influence factors of the occurrence of CPSP after laparoscopic surgery in elderly patients with urinary tract tumors. Optimum postoperative multimodal analgesia strategies are suggested to prevent the occurrence of CPSP.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Retrospective Studies ; Chronic Pain/epidemiology ; Chronic Pain/etiology ; Chronic Pain/diagnosis ; Laparoscopy/adverse effects ; Pain, Postoperative/epidemiology ; Pain, Postoperative/etiology ; Kidney Neoplasms/complications ; Carcinoma, Renal Cell/complications ; Risk Factors
Language	Chinese
Publishing date	2023-10-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2452593-5
ISSN	1671-167X
ISSN	1671-167X
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Article ; Online: Mesoporous sol-gel silica supported vanadium oxide as effective catalysts in oxidative dehydrogenation of propane to propylene.

Guo, Xin-Peng / Wang, Xiao-Xiao / Lu, Hai-Qiang / Liu, Zhen-Min

RSC advances

2023 Volume 13, Issue 33, Page(s) 22815–22823

Abstract: Vanadium oxide incorporated mesoporous silica (V-m- ... ...

Abstract	Vanadium oxide incorporated mesoporous silica (V-m-SiO
Language	English
Publishing date	2023-07-28
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra04024k
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Article ; Online: CD1d-Dependent Natural Killer T Cells Mediate Hypertension and Vascular Injury Through Interleukin-17A.

Xiao, Xue / Hou, Cui-Liu / Zhang, Yun-Long / Yang, Hui / Wang, Xiao-Xiao / Wang, Hong-Xia

Journal of the American Heart Association

2023 Volume 12, Issue 13, Page(s) e029179

Abstract: Background Different T-lymphocyte subsets, including CD1d-dependent natural killer T (NKT) cells, play distinct roles in hypertension, highlighting the importance of identifying key immune cells for its treatment. This study aimed to determine the ... ...

Abstract	Background Different T-lymphocyte subsets, including CD1d-dependent natural killer T (NKT) cells, play distinct roles in hypertension, highlighting the importance of identifying key immune cells for its treatment. This study aimed to determine the unknown effects of CD1d-dependent NKT cells on hypertension and vascular injury. Methods and Results Hypertension models were induced in male CD1d knockout (CD1dko), wild-type, and adoptive bone marrow transfer mice by angiotensin II (Ang II) or deoxycorticosterone acetate salt. Blood pressure was measured by the tail-cuff system and radiotelemetry. Vascular injury was assessed by histologic studies or aortic ring assay. Inflammation was detected by flow cytometry, quantitative real-time polymerase chain reaction, or ELISA. Results showed that Ang II infusion significantly reduced CD1d expression and NKT cell numbers in the aorta of mice. CD1dko mice exhibited worsened blood pressure elevation, vascular injury, and inflammatory response induced by Ang II or deoxycorticosterone acetate salt. However, these effects were markedly reversed in wild-type mice treated with NKT cell-specific activator. Adoptive transfer of CD1dko bone marrow cells to wild-type mice also significantly worsened Ang II-induced responses. Mechanistically, CD1dko increased Ang II-induced interleukin-6 production and activated signal transducer and activator of transcription 3 and orphan nuclear receptor γ, subsequently inducing interleukin-17A production. Neutralizing interleukin-17A partially reversed Ang II-induced hypertension and vascular injury in CD1dko mice. In addition, levels of NKT cells were lower in the blood of patients with hypertension (n=57) compared with normotensive individuals (n=87). Conclusions These findings reveal a previously unknown role for CD1d-dependent NKT cells in hypertension and vascular injury, indicating that NKT cell activation could be a promising therapeutic target for hypertension.
MeSH term(s)	Animals ; Male ; Mice ; Acetates/adverse effects ; Acetates/metabolism ; Desoxycorticosterone/adverse effects ; Desoxycorticosterone/metabolism ; Hypertension/chemically induced ; Hypertension/metabolism ; Interleukin-17/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Natural Killer T-Cells/metabolism ; Vascular System Injuries/metabolism
Chemical Substances	Acetates ; Desoxycorticosterone (40GP35YQ49) ; Interleukin-17 ; Il17a protein, mouse ; CD1d antigen, mouse
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.029179
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Article ; Online: Association between odontogenic conditions and maxillary sinus abnormalities: a retrospective cone-beam computed-tomographic study.

Liu, Shaoqing / Chen, Xue / Wang, Xiao-Xiao / Li, Yuangao / Feng, Junliang / Wang, Xiao

Annals of palliative medicine

2023 Volume 12, Issue 2, Page(s) 365–375

Abstract: Background: In this study, we investigated the correlation between odontogenic conditions and the presence of maxillary sinus (MS) abnormalities using cone-beam computed tomography (CBCT) imaging.: Methods: The study unit was defined as the ... ...

Abstract	Background: In this study, we investigated the correlation between odontogenic conditions and the presence of maxillary sinus (MS) abnormalities using cone-beam computed tomography (CBCT) imaging. Methods: The study unit was defined as the ipsilateral MS, maxillary alveolar bone, and posterior teeth. The study included 1,140 study units from 570 patients visualized with CBCT. MS abnormalities, MS septal walls, the anatomical relationship between the MS and the teeth, and missing teeth were recorded. Adjacent odontogenic infections, including periapical lesions, periodontal bone loss, and combined periodontal-endodontic lesions, were documented, and the shortest distance between the infection and the MS floor was measured. The possible correlations between odontogenic conditions and MS abnormalities were analyzed. Whether the anatomical relationship between the MS and the teeth was related to age or sex was analyzed. The chi-squared test, Fisher's exact test, Mann-Whitney U test, Kruskal-Wallis H test, and logistic regression were used for the statistical analyses. Results: MS abnormalities were detected in 57.54% of patients and 42.89% of MSs. Male sex (OR =1.653; P<0.001) and a MS adjacent to teeth with periapical lesions (OR =5.771; P<0.001), periodontal bone loss (OR =2.778; P<0.001), or combined periodontal-endodontic lesions (OR =13.818; P<0.001) increased the probability of MS abnormalities. In MSs with a single infected tooth, male sex (OR =2.413; P=0.045), infected molar (OR =3.431; P=0.008), and a smaller distance between the infection and the MS floor (OR =0.871; P=0.021) increased the probability of MS abnormality. The maxillary root apices of older subjects tended to be farther from the MS (P<0.001). Conclusions: Adjacent odontogenic infection increased the probability of MS abnormalities. The likelihood of MS abnormality was related to the distance between the infection and the MS, not to the type of infection.
MeSH term(s)	Humans ; Male ; Maxillary Sinus ; Alveolar Bone Loss/pathology ; Retrospective Studies ; Cone-Beam Computed Tomography/methods
Language	English
Publishing date	2023-02-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-22-950
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Article ; Online: The effect of pelvic floor muscle training and perineal massage in late pregnancy on postpartum pelvic floor function in nulliparas: A randomised controlled clinical trial.

He, RuiJu / Wang, XiaoXiao / Nian, SongWen / Wang, XiaoQing / Zhang, Lei / Lu, Ye

Complementary therapies in medicine

2023 Volume 77, Page(s) 102982

Abstract: Objective: To evaluate the effects of pelvic floor muscle training (PFMT) and perineal massage during late pregnancy on postpartum pelvic floor function in nulliparas.: Design: Randomised controlled trial.: Setting: The Peking University First ... ...

Abstract	Objective: To evaluate the effects of pelvic floor muscle training (PFMT) and perineal massage during late pregnancy on postpartum pelvic floor function in nulliparas. Design: Randomised controlled trial. Setting: The Peking University First Hospital, a teaching hospital in China. Participants: Two-hundred nulliparas were included. Interventions: Nulliparas were randomised into four groups in a 1:1:1:1 ratio. Group A, control; group B, perineal massage; group C, pelvic floor muscle training (PFMT); group D, perineal massage and PFMT. The intervention group received the corresponding intervention from 34 weeks of gestation until delivery. Measurements: Changes in pelvic floor function from 34 weeks of gestation to 6 weeks postpartum were assessed using pelvic floor electromyography (EMG), pelvic organ prolapse quantitation (POP-Q), and pelvic floor distress inventory-20 (PFDI-20). Results: Those with PFMT (groups C and D) had a smaller decline in pelvic floor EMG of fibre II than those without PFMT (groups A and B) [- 0.2 (- 7.1, 11.3) µV vs 6.1 (- 0.2, 15.2) µV, P = 0.040]. The same scenario was observed in the pelvic floor EMG of fibre I. The Aa point measurement differences of those with PFMT (groups C and D) were smaller than those without PFMT (groups A and B) [0.0 (0.0, 2.0) cm vs 1.0 (0.0, 3.0) cm, P = 0.006]. The same result was observed for point Ba. No difference was observed in EMG and POP-Q in nulliparas with (groups B and D) or without perineal massage (groups A and C). No differences were observed in PFDI-20 scores. Key conclusions: PFMT during late pregnancy enhanced pelvic floor EMG, while perineal massage alone or PFMT combined with perineal massage did not. Implications for practice: PFMT in late pregnancy enhances pelvic floor function.
MeSH term(s)	Female ; Pregnancy ; Humans ; Pelvic Floor ; Postpartum Period ; Massage ; China ; Hospitals, Teaching
Language	English
Publishing date	2023-08-30
Publishing country	Scotland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1155895-7
ISSN	1873-6963 ; 0965-2299
ISSN (online)	1873-6963
ISSN	0965-2299
DOI	10.1016/j.ctim.2023.102982
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Article ; Online: CD1d-dependent natural killer T-cells inactivation aggravates sepsis-induced myocardial injury via T lymphocytes infiltration and IL-6 production in mice.

Chen, Li-Rui / Hui-Yang / Lu-Liu / Wang, Xiao-Xiao / Zhang, Xiao-Man / Wang, Hong-Xia

International immunopharmacology

2023 Volume 120, Page(s) 110256

Abstract: Myocardial edema mediated by endothelial dysfunction plays an important role in sepsis-induced cardiomyopathy (SIC); however, its mechanism is unclear. The current study aimed to provide evidence on the cardioprotection of CD1d-dependent natural killer T ...

Abstract	Myocardial edema mediated by endothelial dysfunction plays an important role in sepsis-induced cardiomyopathy (SIC); however, its mechanism is unclear. The current study aimed to provide evidence on the cardioprotection of CD1d-dependent natural killer T (NKT) cells and clarify the possible mechanism in a mouse model of sepsis. Wild-type (WT) and CD1d-dependent NKT-cells inactivation (CD1dko) mice were subjected to sepsis induced by intraperitoneal injection of lipopolysaccharide (LPS). The NKT-cells number and CD1d expression were both increased in the hearts and blood of WT mice after LPS treatment. Compared with WT mice, CD1dko mice exhibited remarkably accelerated LPS-induced mortality, cardiac dysfunction, myocardial injury, endothelial apoptosis, microvascular damage, microvascular permeability and cardiac edema. Mechanistically, CD1d deficiency further increased LPS-induced accumulation of T lymphocytes in the myocardium and upregulation of IL-6 protein levels. Administration of an IL-6 neutralizing antibody to CD1dko mice improved cardiac dysfunction, myocardial injury and edema induced by LPS. Our study identified that CD1d-dependent NKT-cells inactivation exacerbated SIC via T lymphocytes infiltration and IL-6 production. Hence, activation of CD1d-dependent NKT cells may be a potential candidate strategy for SIC treatment.
MeSH term(s)	Mice ; Animals ; Natural Killer T-Cells ; Interleukin-6/metabolism ; Lipopolysaccharides/metabolism ; Antigens, CD1d/genetics ; Sepsis/metabolism ; Heart Diseases/metabolism ; Mice, Inbred C57BL ; Mice, Knockout
Chemical Substances	Interleukin-6 ; Lipopolysaccharides ; Antigens, CD1d
Language	English
Publishing date	2023-05-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110256
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Article ; Online: The burden of hepatitis C virus in the world, China, India, and the United States from 1990 to 2019.

Yang, Jia / Qi, Jin-Lei / Wang, Xiao-Xiao / Li, Xiao-He / Jin, Rui / Liu, Bai-Yi / Liu, Hui-Xin / Rao, Hui-Ying

Frontiers in public health

2023 Volume 11, Page(s) 1041201

Abstract: Background and aim: Hepatitis C virus infection can lead to an enormous health burden worldwide. Investigating the changes in HCV-related burden between different countries could provide inferences for disease management. Hence, we aim to explore the ... ...

Abstract	Background and aim: Hepatitis C virus infection can lead to an enormous health burden worldwide. Investigating the changes in HCV-related burden between different countries could provide inferences for disease management. Hence, we aim to explore the temporal tendency of the disease burden associated with HCV infection in China, India, the United States, and the world. Methods: Detailed data on the total burden of disease related to HCV infection were collected from the Global Burden of Disease (GBD) 2019 database. Joinpoint regression models were used to simulate the optimal joinpoints of annual percent changes (APCs). Further analysis of the age composition of each index over time and the relationship between ASRs and the socio-demographic Index (SDI) were explored. Finally, three factors (population growth, population aging, and age-specific changes) were deconstructed for the changes in the number of incidences, deaths, and DALYs. Results: It was estimated that 6.2 million new HCV infections, 0.54 million HCV-related deaths, and 15.3 million DALYs worldwide in 2019, with an increase of 25.4, 59.1, and 43.6%, respectively, from 1990, are mainly due to population growth and aging. China experienced a sharp drop in age-standardized rates in 2019, the United States showed an upward trend, and India exhibited a fluctuating tendency in the burden of disease. The incidence was increasing in all locations recently. Conclusion: HCV remains a global health concern despite tremendous progress being made. The disease burden in China improved significantly, while the burden in the United States was deteriorating, with new infections increasing recently, suggesting more targeted interventions to be established to realize the 2030 elimination goals.
MeSH term(s)	Humans ; United States/epidemiology ; Hepacivirus ; Quality-Adjusted Life Years ; Hepatitis C/epidemiology ; India/epidemiology ; China/epidemiology
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1041201
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