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Article: [Some Problems and Risk Analysis of Infusion Pump Instructions].

Wang, Xiao-Yu

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

2022 Volume 46, Issue 3, Page(s) 323–325

Abstract: Objective: 10 instructions of infusion pumps were contrasted and analyzed in order to explore the problems of instructions, furthermore improve the product safety.: Methods: Analyzed the scopes of application, requirements of infusion apparatus, ... ...

Abstract	Objective: 10 instructions of infusion pumps were contrasted and analyzed in order to explore the problems of instructions, furthermore improve the product safety. Methods: Analyzed the scopes of application, requirements of infusion apparatus, maintenance methods and cycles, battery maintenance, and service life, etc. Results: There were 5 products in 10 which did not indicate contraindications. One product only provided the thickness range of the tube wall of the infusion apparatus instead of specific brands. The cleaning cycles of 9 products varied from 2 to 12 months. One product did not clarify the service life. Conclusions: It is recommended that manufactures should improve the product instructions to ensure the safety of infusion pumps.
MeSH term(s)	Electric Power Supplies ; Infusion Pumps ; Risk Assessment
Language	Chinese
Publishing date	2022-06-09
Publishing country	China
Document type	Journal Article
ISSN	1671-7104
ISSN	1671-7104
DOI	10.3969/j.issn.1671-7104.2022.03.018
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Article: Qntrolling the LncRNA HULC-Tregs-PD-1 axis inhibits immune escape in the tumor microenvironment.

Wang, XiaoYu / Mo, Xiaoyan / Yang, Zhuolin / Zhao, Changlin

Heliyon

2024 Volume 10, Issue 7, Page(s) e28386

Abstract: Background: Immune escape remains a major challenge in the treatment of malignant tumors. Here, we studied the mechanisms underlying immune escape in the tumor microenvironment and identified a potential therapeutic target.: Methods: Pathological ... ...

Abstract	Background: Immune escape remains a major challenge in the treatment of malignant tumors. Here, we studied the mechanisms underlying immune escape in the tumor microenvironment and identified a potential therapeutic target. Methods: Pathological specimens from patients with liver cancer, soft tissue sarcoma, and liver metastasis of colon cancer were subjected to immunohistochemistry analysis to detect the expression of programmed death-1 (PD-1) in the tumor microenvironment (TME). Additionally, the expression of regulatory T cells (Tregs) and long non-coding RNAs (lncRNAs), such as highly upregulated in liver cancer (HULC) was evaluated by fluorescence in situ hybridization, and the relationship between HULC, Treg cells, and PD-1 was determined. The animals were divided into H22 hepatic carcinoma and S180 sarcoma groups. Each group was divided into Results: High expression of lncRNA HULC promotes the proliferation of Treg cells and increases PD-1 expression in the tumor microenvironment. The HULC-Treg-PD-1 axis plays an immunosuppressive role and promotes the proliferation of malignant tumors. Knocking out the Conclusion: The lncRNA HULC-Treg-PD-1 axis promotes the growth of malignant tumors. This axis could be modulated to reduce PD-1, IL-10, and TGF-β1 expression and the subsequent immune escape. The inhibition of immune escape in the tumor microenvironment can be achieved by controlling the LncRNA HULC-Treg-PD-1 axis.
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28386
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Article: [Nutrition Plays a Vital Role in the Prevention and Treatment of COVID-19].

Wang, Xiao-Yu / Zhang, Ling-Li / Cheng, Guo

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2023 Volume 54, Issue 1, Page(s) 108–113

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic of coronavirus disease 2019 (COVID-19). Proper nutritional support helps boost the immunity of the human body, strengthen the high-risk populations' ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic of coronavirus disease 2019 (COVID-19). Proper nutritional support helps boost the immunity of the human body, strengthen the high-risk populations' defense against SARS-CoV-2, reduce the prevalence of COVID-19, prevent mild cases from developing into severe cases, and reduce the occurrence of adverse symptoms during recovery. Nutritional support is an important guarantee to provide protection against virus infection, promote patient recovery, and improve patient prognosis. Whole nutritional food formulas designed according to the characteristic clinical symptoms of COVID-19 provide patients with comprehensive nutritional support of appropriate nutritional content, which effectively improves the nutritional status of patients and provides strong technical support to improve their quality of survival. During the critical period of COVID-19 prevention and control, more emphasis should be placed on the essential role of nutritional support and the clinical efficacy of nutritional support should be given full play.
MeSH term(s)	Humans ; COVID-19/prevention & control ; Nutritional Status ; Risk Factors ; SARS-CoV-2 ; Treatment Outcome
Language	Chinese
Publishing date	2023-01-16
Publishing country	China
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20230160303
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Article: Long-term low-dose lamotrigine for paroxysmal kinesigenic dyskinesia: a two-year investigation of cognitive function in children.

You, Dong-Dong / Huang, Yu-Mei / Wang, Xiao-Yu / Li, Wei / Li, Feng

Frontiers in psychiatry

2024 Volume 15, Page(s) 1368289

Abstract: Objective: While low-dose lamotrigine has shown effectiveness in managing paroxysmal kinesigenic dyskinesia (PKD) in pediatric populations, the cognitive consequences of extended use are yet to be fully elucidated. This study seeks to assess the ... ...

Abstract	Objective: While low-dose lamotrigine has shown effectiveness in managing paroxysmal kinesigenic dyskinesia (PKD) in pediatric populations, the cognitive consequences of extended use are yet to be fully elucidated. This study seeks to assess the evolution of cognitive functions and the amelioration of attention deficit and hyperactivity disorder (ADHD) symptoms following a two-year lamotrigine treatment in children. Methods: This investigation employed an open-label, uncontrolled trial design. Between January 2008 and December 2021, thirty-one participants, ranging in age from 6.5 to 14.1 years, were enrolled upon receiving a new diagnosis of PKD, as defined by the clinical diagnostic criteria set by Bruno in 2004. Comprehensive evaluation of PRRT2 variants and 16p11.2 microdeletion was achieved using whole-exome sequencing (WES) and bioinformatics analysis of copy number variant (CNV) for all subjects. Immediately after diagnosis, participants commenced treatment with low-dose lamotrigine. Cognitive function was assessed using the Wechsler Intelligence Scale for Children-Chinese Revised (WISC-CR) at baseline and after 2 years, with ADHD diagnoses and symptom severity simultaneously assessed by experts in accordance with the DSM-IV diagnostic criteria for ADHD and the ADHD Rating Scale-IV (ADHD-RS-IV). Results: Initially, twelve out of 31 patients (38.7%) presented with comorbid ADHD. The latency to treatment initiation was notably longer in PKD patients with ADHD (30.75 ± 12.88 months) than in those without ADHD (11.66 ± 9.08 months), t = 4.856, p<0.001. Notably, patients with a latency exceeding 2 years exhibited a heightened risk for comorbid ADHD (OR = 4.671, P=0.015) in comparison to those with shorter latency. Out of the cohort, twenty-five patients saw the clinical trial to its completion. These individuals demonstrated a marked elevation in WISC-CR scores at the 2-year mark relative to the outset across FSIQ (baseline mean: 108.72 ± 10.45 vs 24 months: 110.56 ± 10.03, p=0.001), VIQ (baseline mean: 109.44 ± 11.15 vs 24 months: 110.80 ± 10.44, p=0.028), and PIQ domains (baseline mean: 106.52 ± 9.74 vs 24 months: 108.24 ± 9.38, p=0.012). Concurrently, a substantial mitigation was observed in ADHD inattention at 2 years compared to baseline (p<0.001), with an average total subscale scores decrement from 9.04 ± 4.99 to 6.24 ± 4.05. Conclusion: Prolonged duration of untreated PKD in children may elevate the risk of ADHD comorbidity. Notably, following a 2-year lamotrigine regimen, enhancements were observed in both cognitive test outcomes and ADHD symptomatology.
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2024.1368289
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Article: [Effects of Heavy Metal-immobilizing Bacteria on Reducing Wheat Uptake Cd by Regulation Soil Iron Oxides].

Wang, Xiao-Yu / Han, Hui

Huan jing ke xue= Huanjing kexue

2020 Volume 41, Issue 11, Page(s) 5160–5167

Abstract: Iron oxides are widely distributed in soils and have large specific surface areas and strong affinities with heavy metals, and thus play a significant role in the transformation of heavy metals in soils. Pot experiments were conducted to study the ... ...

Abstract	Iron oxides are widely distributed in soils and have large specific surface areas and strong affinities with heavy metals, and thus play a significant role in the transformation of heavy metals in soils. Pot experiments were conducted to study the effects of heavy metal-immobilizing bacteria
MeSH term(s)	Cadmium/analysis ; Ferric Compounds ; Iron ; Metals, Heavy/analysis ; Oxides ; Soil ; Soil Pollutants/analysis ; Triticum
Chemical Substances	Ferric Compounds ; Metals, Heavy ; Oxides ; Soil ; Soil Pollutants ; Cadmium (00BH33GNGH) ; ferric oxide (1K09F3G675) ; Iron (E1UOL152H7)
Language	Chinese
Publishing date	2020-10-29
Publishing country	China
Document type	Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202005235
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Article ; Online: Post-transcriptional Gene Silencing Using Virus-Induced Gene Silencing to Study Plant Gametogenesis in Tomato.

Wang, Zhengming / Wang, Xiao Yu / Martinho, Claudia / Baulcombe, David C

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2484, Page(s) 201–212

Abstract: Loss-of-function analyses are essential to dissect the complex nature of biological processes, including gametogenesis. Virus-induced gene silencing (VIGS) has been widely used in crop species as an amenable and rapid way to generate gene knockdowns. As ... ...

Abstract	Loss-of-function analyses are essential to dissect the complex nature of biological processes, including gametogenesis. Virus-induced gene silencing (VIGS) has been widely used in crop species as an amenable and rapid way to generate gene knockdowns. As a transient assay, VIGS circumvents the generation of stable transgenic lines through laborious and time-consuming tissue culture techniques. VIGS involves inoculating plants during early development with genetically manipulated viral constructs carrying an endogenous gene target sequence. The viral infection triggers the host plant gene silencing machinery to process the viral genomic RNA into small RNAs (sRNAs) including the gene complementary region. The sRNAs with complementary sequences to the endogenous gene mediate posttranscriptional gene silencing of the targeted gene. Here, we provide a simple and reproducible VIGS protocol employing the tobacco rattle virus (TRV) in tomato (Solanum lycopersicum cv. M82). As it is stable at later developmental stages this approach is suitable for many traits in tomato including gametogenesis and it can be adapted to other crop species.
MeSH term(s)	Gametogenesis, Plant ; Gene Expression Regulation, Plant ; Gene Silencing ; Genetic Vectors ; Solanum lycopersicum/genetics ; Plant Viruses/genetics ; RNA Interference ; RNA, Viral ; Nicotiana/genetics
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2253-7_15
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Article ; Online: Defect Passivation in Quasi-2D Perovskite Light-Emitting Diodes by an Ibuprofen Additive.

Yang, Wei / He, XiaoLi / Huang, XinMei / Wang, XiaoYu / Zhang, Yong / Gao, Chun-Hong

ACS applied materials & interfaces

2023 Volume 16, Issue 1, Page(s) 1628–1637

Abstract: It is well known that the inferior film morphology and the excessive surface/interface defect states are two obstacles to achieving high electroluminescence performance of quasi-2D perovskite light-emitting diodes (PeLEDs). To solve these problems, ... ...

Abstract	It is well known that the inferior film morphology and the excessive surface/interface defect states are two obstacles to achieving high electroluminescence performance of quasi-2D perovskite light-emitting diodes (PeLEDs). To solve these problems, ibuprofen was introduced as an additive in the quasi-2D perovskite emitting layer. More efficient photoluminescence is demonstrated. Further, optimized quasi-2D PeLEDs with a current efficiency of 55.93 cd/A are confirmed and 5.7-fold enhancement in device stability is obtained. The physical mechanism of the remarkable improvement is investigated by kinds of measurements. Three aspects should be counted into it. First, the introduction of ibuprofen can passivate defects, thus making the quasi-2D perovskite emitting layer more dense and homogeneous. The reason should be that the C═O functional group and C═C bond in the benzene ring in ibuprofen can coordinate the unsaturated Pb
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c10337
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Article ; Online: Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.

Wang, ChongShu / Dong, MingMing / Zhang, XiaoYi / Wang, XiaoYu / Zhao, Yan / Cao, Yunpeng

Acta biochimica Polonica

2023 Volume 70, Issue 4, Page(s) 807–815

Abstract: Objective: Circular RNAs (circRNAs) are enriched in the brain and involved in various central nervous system diseases. The potential role of circCCDC6 in cerebral ischemia-reperfusion defects was partly elucidated in the work.: Methods: A middle ... ...

Abstract	Objective: Circular RNAs (circRNAs) are enriched in the brain and involved in various central nervous system diseases. The potential role of circCCDC6 in cerebral ischemia-reperfusion defects was partly elucidated in the work. Methods: A middle cerebral artery occlusion/reperfusion (MCAO/R) rat model and an oxygen-glucose deprivation and re-oxygenation (OGD/R)-treated SH-SY5Y cell model were constructed. CircCCDC6 expression in the two models was examined, and circCCDC6-involved mechanisms in neuronal pyroptosis and inflammation were analyzed through loss- and gain-of-function assays. Results: MCAO/R rat brain tissues and OGD/R-treated SH-SY5Y cells exhibited upregulated circCCDC6. Silencing circCCDC6 attenuated neuronal pyroptosis and inflammation in the brain tissue of MCAO/R rats. Overexpressing circCCDC6 or inhibiting miR-128-3p stimulated OGD/R-induced pyroptosis and inflammation in SH-SY5Y cells, while upregulating miR-128-3p attenuated OGD/R injury. CircCCDC6 silencing-induced effects on SH-SY5Y cells were antagonized by TXNIP overexpression. Conclusion: Mechanistically, circCCDC6 mediates miR-128-3p and activates TXNIP/NLRP3, thereby promoting OGD/R-induced neuronal pyroptosis and inflammation. CircCCDC6 may provide a new strategy for the treatment of MCAO/R.
MeSH term(s)	Animals ; Humans ; Rats ; Apoptosis ; Binding, Competitive ; Brain Ischemia/genetics ; Brain Ischemia/metabolism ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Glucose/pharmacology ; Infarction, Middle Cerebral Artery/genetics ; Infarction, Middle Cerebral Artery/metabolism ; Inflammation ; MicroRNAs/metabolism ; Neuroblastoma ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Reperfusion ; Reperfusion Injury/genetics ; Reperfusion Injury/metabolism
Chemical Substances	Carrier Proteins ; Glucose (IY9XDZ35W2) ; MicroRNAs ; MIRN128 microRNA, human ; MIRN128 microRNA, rat ; NLR Family, Pyrin Domain-Containing 3 Protein ; TXNIP protein, human ; TXNIP protein, rat ; CCDC6 protein, human
Language	English
Publishing date	2023-12-25
Publishing country	Poland
Document type	Journal Article
ZDB-ID	595762-x
ISSN	1734-154X ; 0001-527X
ISSN (online)	1734-154X
ISSN	0001-527X
DOI	10.18388/abp.2020_6552
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Article ; Online: Analysis of Radioactive Iodine Trapping Mechanism by Zinc-Based Metal-Organic Frameworks with Various N-Containing Carboxylate Ligands.

Yu, Rui-Li / Li, Qian-Fan / Li, Zhen-Le / Wang, Xiao-Yu / Xia, Liang-Zhi

ACS applied materials & interfaces

2023 Volume 15, Issue 29, Page(s) 35082–35091

Abstract: This study aimed to develop effective adsorbents for capturing radioactive iodine in nuclear power waste gas. Two zinc metal-organic frameworks (Zn-MOFs) were synthesized and found to have favorable properties such as a large surface area, thermal ... ...

Abstract	This study aimed to develop effective adsorbents for capturing radioactive iodine in nuclear power waste gas. Two zinc metal-organic frameworks (Zn-MOFs) were synthesized and found to have favorable properties such as a large surface area, thermal stability, surface rich in π-electron-containing nitrogen, and redox potential. Adsorption experiments revealed maximum capacities of 1.25 and 1.96 g g
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c07032
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Article ; Online: Less common phenotypes of myelin oligodendrocyte glycoprotein antibody-related diseases in children deserve more attention.

Wang, Xiao-Yu / Jiang, Yan / Wu, Peng / Ma, Jian-Nan / Yuan, Ping / Li, Xiu-Juan / Jiang, Li

Pediatric research

2024

Abstract: Background: To facilitate the identification of less common clinical phenotypes of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in children.: Methods: We retrospectively reviewed medical records of 236 patients with MOGAD. ... ...

Abstract	Background: To facilitate the identification of less common clinical phenotypes of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in children. Methods: We retrospectively reviewed medical records of 236 patients with MOGAD. The following phenotypes were considered to be typical for MOGAD: ADEM, ON, TM, and NMOSD. Less common onset clinical phenotypes were screened out; their clinical and magnetic resonance imaging (MRI), diagnosis, treatment, and prognosis were summarized and analyzed. Results: 16 cases (6.8%) presented as cortical encephalitis, with convulsions, headache, and fever as the main symptoms. 15 cases were misdiagnosed in the early period. 13 cases (5.5%) showed the overlapping syndrome of MOGAD and anti-N-methyl-D aspartate receptor encephalitis (MNOS), with seizures (92.3%) being the most common clinical symptom. 11 cases (84.6%) showed relapses. The cerebral leukodystrophy-like phenotype was present in seven cases (3.0%), with a recurrence rate of 50%. Isolated seizures without any findings on MRI phenotype was present in three cases (1.3%), with the only clinical symptom being seizures of focal origin. Three cases (1.3%) of aseptic meningitis phenotype presented with prolonged fever. Conclusion: 40/236 (16.9%) of children with MOGAD had less common phenotypes. Less common clinical phenotypes of pediatric MOGAD are susceptible to misdiagnosis and deserve more attention. Impact: This is the first comprehensive analysis and summary of all less commonl clinical phenotypes of MOGAD in children, while previous studies have only focused on a specific phenotype or case reports. We analyzed the characteristics of MOGAD in children and further revealed the reasons why these less common clinical phenotypes are prone to misdiagnosis and deserve more attention. Our research on treatment has shown that early detection of MOG antibodies and early treatment are of great significance for improving the prognosis of these patients.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-024-03058-x
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