Article: Multi-lineage Differentiation from Hematopoietic Stem Cells.
Advances in experimental medicine and biology
2024 Volume 1442, Page(s) 159–175
Abstract: The hematopoietic stem cells (HSCs) have the ability to differentiate and give rise to all mature blood cells. Commitment to differentiation progressively limits the self-renewal potential of the original HSCs by regulating the level of lineage-specific ... ...
Abstract | The hematopoietic stem cells (HSCs) have the ability to differentiate and give rise to all mature blood cells. Commitment to differentiation progressively limits the self-renewal potential of the original HSCs by regulating the level of lineage-specific gene expression. In this review, we will summarize the current understanding of the molecular mechanisms underlying HSC differentiation toward erythroid, myeloid, and lymphocyte lineages. Moreover, we will decipher how the single-cell technologies advance the lineage-biased HSC subpopulations and their differentiation potential. |
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MeSH term(s) | Hematopoietic Stem Cells ; Cell Differentiation/physiology ; Cell Lineage/genetics |
Language | English |
Publishing date | 2024-01-16 |
Publishing country | United States |
Document type | Review ; Journal Article |
ZDB-ID | 410187-X |
ISSN | 0065-2598 |
ISSN | 0065-2598 |
DOI | 10.1007/978-981-99-7471-9_10 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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