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  1. AU="Wang, Xiaozhong"
  2. AU="Suner, Asli"
  3. AU="Charles Thickstun"
  4. AU="Tatar, Emel Cadalli"
  5. AU="Shcherbakova Tatyana"
  6. AU="Coats, Brittany"
  7. AU="Monte, Natasha"
  8. AU="Sarma, D.K."
  9. AU=Deng Lisi AU=Deng Lisi
  10. AU=Deshmukh V
  11. AU="Gutiérrez-García, Carmen"
  12. AU="Johnson, Sally"
  13. AU="Sousa, Amanda Freire Tamburini"
  14. AU="Cronin, Chunxia"
  15. AU=Weder W
  16. AU="Nirja Thakur"
  17. AU="Jiang, Shimin"
  18. AU="Wu, Xue-Ying"
  19. AU="Carlos Augusto de Mattos"
  20. AU="Procopio, Francesco A"
  21. AU="Nagata, Kosei"
  22. AU="Kevin Pottie"
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  24. AU="Couto Souza, Paulo Henrique"
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  1. Artikel ; Online: Multiscale biophysical analysis of nucleolus disassembly during mitosis.

    Pham, An T / Mani, Madhav / Wang, Xiaozhong / Vafabakhsh, Reza

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Band 121, Heft 6, Seite(n) e2312250121

    Abstract: During cell division, precise and regulated distribution of cellular material between daughter cells is a critical step and is governed by complex biochemical and biophysical mechanisms. To achieve this, membraneless organelles and condensates often ... ...

    Abstract During cell division, precise and regulated distribution of cellular material between daughter cells is a critical step and is governed by complex biochemical and biophysical mechanisms. To achieve this, membraneless organelles and condensates often require complete disassembly during mitosis. The biophysical principles governing the disassembly of condensates remain poorly understood. Here, we used a physical biology approach to study how physical and material properties of the nucleolus, a prominent nuclear membraneless organelle in eukaryotic cells, change during mitosis and across different scales. We found that nucleolus disassembly proceeds continuously through two distinct phases with a slow and reversible preparatory phase followed by a rapid irreversible phase that was concurrent with the nuclear envelope breakdown. We measured microscopic properties of nucleolar material including effective diffusion rates and binding affinities as well as key macroscopic properties of surface tension and bending rigidity. By incorporating these measurements into the framework of critical phenomena, we found evidence that near mitosis surface tension displays a power-law behavior as a function of biochemically modulated interaction strength. This two-step disassembly mechanism maintains structural and functional stability of nucleolus while enabling its rapid and efficient disassembly in response to cell cycle cues.
    Mesh-Begriff(e) Mitosis ; Cell Nucleolus/metabolism
    Sprache Englisch
    Erscheinungsdatum 2024-01-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2312250121
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  2. Artikel: Direct-acting Antiviral Regimens for Patients with Chronic Infection of Hepatitis C Virus Genotype 3 in China.

    Wang, Xiaozhong / Wei, Lai

    Journal of clinical and translational hepatology

    2021  Band 9, Heft 3, Seite(n) 419–427

    Abstract: Hepatitis C virus (HCV) genotype (GT)3 infection is associated with a more rapid hepatic disease progression than the other genotypes. Hence, early HCV clearance slows down the disease progression and is important for improving prognosis in GT3-infected ... ...

    Abstract Hepatitis C virus (HCV) genotype (GT)3 infection is associated with a more rapid hepatic disease progression than the other genotypes. Hence, early HCV clearance slows down the disease progression and is important for improving prognosis in GT3-infected patients. Nevertheless, compared with other genotypes, GT3 is difficult-to-treat with direct-acting antivirals, especially in the presence of cirrhosis. Current guidelines recommend several regimens which have been proven to be effective in GT3-infected patients from the Western world (North America, Europe, and Oceania). In China, GT3 infection comprises 8.7-11.7% of the 10 million patients infected with HCV and has strikingly different characteristics from that in Western countries. Unlike the Western countries, where GT3a is the predominant subtype, GT3a and 3b each affect roughly half of Chinese GT3-infected patients, with 94-96% of the GT3b-infected patients carrying A30K+L31M double NS5A resistance-associated substitutions. Phase 3 clinical trials including GT3b-infected patients have suggested that GT3b infection is difficult to cure, making the regimen choice for GT3b-infected patients an urgent clinical gap to be filled. This review includes discussions on the epidemiology of HCV GT3 in China, recommendations from guidelines, and clinical data from both Western countries and China. The aim is to provide knowledge that will elucidate the challenges in treating Chinese GT3-infected patients and propose potential solutions and future research directions.
    Sprache Englisch
    Erscheinungsdatum 2021-05-12
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2020.00097
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Analysis of HBV genotype distribution and its association with liver cirrhosis in Xinjiang Uygur Autonomous Region, China

    WANG Xiaozhong

    Journal of Clinical Hepatology, Vol 30, Iss 12, Pp 1307-

    2014  Band 1309

    Abstract: ObjectiveTo investigate the distribution of hepatitis B virus (HBV) genotypes among patients in Xinjiang Uygur Autonomous Region, China, and to explore its association with liver cirrhosis. MethodsHBV genotypes of 1018 hepatitis B patients were ... ...

    Abstract ObjectiveTo investigate the distribution of hepatitis B virus (HBV) genotypes among patients in Xinjiang Uygur Autonomous Region, China, and to explore its association with liver cirrhosis. MethodsHBV genotypes of 1018 hepatitis B patients were determined by PCR analysis. The relationship of HBV genotype with clinical outcomes and relevant chronic liver diseases was assessed by contingency chi-square test, Kruskal-Wallis test, and multivariate unconditional logistic regression analysis. ResultsAmong the 828 patients whose HBV genotyping was completed in this study, type C was the major genotype and the percentage was 54.11% (448/828), 25.15% (200/828) had type B, and 16.18% (134/828) had type D. Among the 116 patients with liver cirrhosis, 20.84% had type C, which was significantly more frequent than other genotypes (P＜0.00). The multivariate unconditional logistic regression model identified several risk factors for liver cirrhosis, including duration of hepatitis B≥10 years, C genotype, high HBV DNA viral load, and impaired liver function characterized by abnormal alanine aminotransferase test. Among all these factors, genotype C had the highest relevance to liver cirrhosis (OR=2819). ConclusionThe leading genotype of HBV in Xinjiang Uygur Autonomous Region is type C, followed by type B and type D. Genotype C is an independent risk factor for HBV-related liver cirrhosis.
    Schlagwörter hepatitis B ; chronic; genotype; liver cirrhosis ; Medicine (General) ; R5-920 ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Chinesisch
    Erscheinungsdatum 2014-12-01T00:00:00Z
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Nanotechnology-based non-viral vectors for gene delivery in cardiovascular diseases.

    Jiao, Liping / Sun, Zhuokai / Sun, Zhihong / Liu, Jie / Deng, Guanjun / Wang, Xiaozhong

    Frontiers in bioengineering and biotechnology

    2024  Band 12, Seite(n) 1349077

    Abstract: Gene therapy is a technique that rectifies defective or abnormal genes by introducing exogenous genes into target cells to cure the disease. Although gene therapy has gained some accomplishment for the diagnosis and therapy of inherited or acquired ... ...

    Abstract Gene therapy is a technique that rectifies defective or abnormal genes by introducing exogenous genes into target cells to cure the disease. Although gene therapy has gained some accomplishment for the diagnosis and therapy of inherited or acquired cardiovascular diseases, how to efficiently and specifically deliver targeted genes to the lesion sites without being cleared by the blood system remains challenging. Based on nanotechnology development, the non-viral vectors provide a promising strategy for overcoming the difficulties in gene therapy. At present, according to the physicochemical properties, nanotechnology-based non-viral vectors include polymers, liposomes, lipid nanoparticles, and inorganic nanoparticles. Non-viral vectors have an advantage in safety, efficiency, and easy production, possessing potential clinical application value when compared with viral vectors. Therefore, we summarized recent research progress of gene therapy for cardiovascular diseases based on commonly used non-viral vectors, hopefully providing guidance and orientation for future relevant research.
    Sprache Englisch
    Erscheinungsdatum 2024-01-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2024.1349077
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Identification and validation of hub genes and molecular classifications associated with chronic myeloid leukemia.

    Zhong, Fangmin / Yao, Fangyi / Xu, Shuai / Zhang, Jing / Liu, Jing / Wang, Xiaozhong

    Frontiers in immunology

    2024  Band 14, Seite(n) 1297886

    Abstract: Background: Chronic myeloid leukemia (CML) is a kind of malignant blood tumor, which is prone to drug resistance and relapse. This study aimed to identify novel diagnostic and therapeutic targets for CML.: Methods: Differentially expressed genes ( ... ...

    Abstract Background: Chronic myeloid leukemia (CML) is a kind of malignant blood tumor, which is prone to drug resistance and relapse. This study aimed to identify novel diagnostic and therapeutic targets for CML.
    Methods: Differentially expressed genes (DEGs) were obtained by differential analysis of the CML cohort in the GEO database. Weighted gene co-expression network analysis (WGCNA) was used to identify CML-related co-expressed genes. Least absolute shrinkage and selection operator (LASSO) regression analysis was used to screen hub genes and construct a risk score model based on hub genes. Consensus clustering algorithm was used for the identification of molecular subtypes. Clinical samples and
    Results: A total of 378 DEGs were identified by differential analysis. 369 CML-related genes were identified by WGCNA analysis, which were mainly enriched in metabolism-related signaling pathways. In addition, CML-related genes are mainly involved in immune regulation and anti-tumor immunity, suggesting that CML has some immunodeficiency. Immune infiltration analysis confirmed the reduced infiltration of immune killer cells such as CD8+ T cells in CML samples. 6 hub genes (LINC01268, NME8, DMXL2, CXXC5, SCD and FBN1) were identified by LASSO regression analysis. The receiver operating characteristic (ROC) curve confirmed the high diagnostic value of the hub genes in the analysis and validation cohorts, and the risk score model further improved the diagnostic accuracy. hub genes were also associated with cell proliferation, cycle, and metabolic pathway activity. Two molecular subtypes, Cluster A and Cluster B, were identified based on hub gene expression. Cluster B has a lower risk score, higher levels of CD8+ T cell and activated dendritic cell infiltration, and immune checkpoint expression, and is more sensitive to commonly used tyrosine kinase inhibitors. Finally, our clinical samples validated the expression and diagnostic efficacy of hub genes, and the knockdown of LINC01268 inhibited the proliferation of CML cells, and promoted apoptosis.
    Conclusion: Through WGCNA analysis and LASSO regression analysis, our study provides a new target for CML diagnosis and treatment, and provides a basis for further CML research.
    Mesh-Begriff(e) Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myeloid ; Chronic Disease ; Algorithms ; Apoptosis ; DNA-Binding Proteins ; Transcription Factors
    Chemische Substanzen CXXC5 protein, human ; DNA-Binding Proteins ; Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2024-01-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1297886
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  6. Artikel ; Online: CD8 + T cell-based molecular subtypes with heterogeneous immune landscapes and clinical significance in acute myeloid leukemia.

    Zhong, Fangmin / Yao, Fangyi / Jiang, Junyao / Yu, Xiajing / Liu, Jing / Huang, Bo / Wang, Xiaozhong

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2024  Band 73, Heft 3, Seite(n) 329–344

    Abstract: Background: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy. Although high-dose chemotherapy is the primary treatment option, it cannot cure the disease, and new approaches need to be developed. The tumor microenvironment (TME) ... ...

    Abstract Background: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy. Although high-dose chemotherapy is the primary treatment option, it cannot cure the disease, and new approaches need to be developed. The tumor microenvironment (TME) plays a crucial role in tumor biology and immunotherapy. CD8 + T cells are the main anti-tumor immune effector cells, and it is essential to understand their relationship with the TME and the clinicopathological characteristics of AML.
    Methods: In this study, we conducted a systematic analysis of CD8 + T cell infiltration through multi-omics data and identified molecular subtypes with significant differences in CD8 + T cell infiltration and prognosis. We aimed to provide a comprehensive evaluation of the pathological factors affecting the prognosis of AML patients and to offer theoretical support for the precise treatment of AML.
    Results: Our results indicate that CD8 + T cell infiltration is accompanied by immunosuppression, and that there are two molecular subtypes, with the C2 subtype having a significantly worse prognosis than the C1 subtype, as well as less CD8 + T cell infiltration. We developed a signature to distinguish molecular subtypes using multiple machine learning algorithms and validated the prognostic predictive power of molecular subtypes in nine AML cohorts including 2059 AML patients. Our findings suggest that there are different immunosuppressive characteristics between the two subtypes. The C1 subtype has up-regulated expression of immune checkpoints such as CTLA4, PD-1, LAG3, and TIGITD, while the C2 subtype infiltrates more immunosuppressive cells such as Tregs and M2 macrophages. The C1 subtype is more responsive to anti-PD-1 immunotherapy and induction chemotherapy, as well as having higher immune and cancer-promoting variant-related pathway activity. Patients with the C2 subtype had a higher FLT3 mutation rate, higher WBC counts, and a higher percentage of blasts, as indicated by increased activity of signaling pathways involved in energy metabolism and cell proliferation. Analysis of data from ex vivo AML cell drug assays has identified a group of drugs that differ in therapeutic sensitivity between molecular subtypes.
    Conclusions: Our results suggest that the molecular subtypes we constructed have potential application value in the prognosis evaluation and treatment guidance of AML patients.
    Mesh-Begriff(e) Humans ; Clinical Relevance ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; CD8-Positive T-Lymphocytes ; Immunosuppression Therapy ; Immunotherapy ; Immunosuppressive Agents ; Prognosis ; Tumor Microenvironment
    Chemische Substanzen Immunosuppressive Agents
    Sprache Englisch
    Erscheinungsdatum 2024-01-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-023-01839-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: The Physical Biology of Nucleolus Disassembly.

    Pham, An T / Mani, Madhav / Wang, Xiaozhong A / Vafabakhsh, Reza

    bioRxiv : the preprint server for biology

    2023  

    Abstract: During cell division, precise and regulated distribution of cellular material between daughter cells is a critical step and is governed by complex biochemical and biophysical mechanisms. To achieve this, membraneless organelles and condensates often ... ...

    Abstract During cell division, precise and regulated distribution of cellular material between daughter cells is a critical step and is governed by complex biochemical and biophysical mechanisms. To achieve this, membraneless organelles and condensates often require complete disassembly during mitosis. The biophysical principles governing the disassembly of condensates remain poorly understood. Here, we used a physical biology approach to study how physical and material properties of the nucleolus, a prominent nuclear membraneless organelle in eukaryotic cells, change during mitosis and across different scales. We found that nucleolus disassembly proceeds continuously through two distinct phases with a slow and reversible preparatory phase followed by a rapid irreversible phase that was concurrent with the nuclear envelope breakdown. We measured microscopic properties of nucleolar material including effective diffusion rates and binding affinities as well as key macroscopic properties of surface tension and bending rigidity. By incorporating these measurements into the framework of critical phenomena, we found evidence that near mitosis surface tension displays a power-law behavior as a function of biochemically modulated interaction strength. This two-step disassembly mechanism, which maintains structural and functional stability of nucleolus while allowing for its rapid and efficient disassembly in response to cell cycle cues, may be a universal design principle for the disassembly of other biomolecular condensates.
    Sprache Englisch
    Erscheinungsdatum 2023-09-29
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.09.27.559731
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Extreme detectable vibration frequency limited by rolling shutter camera imaging of laser speckles.

    Hong, Huanhuan / Liang, Jiajia / Deng, Liza / Guo, Wei / Wang, Xiaozhong

    Optics letters

    2023  Band 48, Heft 15, Seite(n) 3837–3840

    Abstract: The row scanning mechanism of a rolling shutter camera can be used to infer high-frequency information from a low-frame-rate video. Combining the high intensity of laser speckle and high row-sampling rate of a rolling shutter, extreme detectable ... ...

    Abstract The row scanning mechanism of a rolling shutter camera can be used to infer high-frequency information from a low-frame-rate video. Combining the high intensity of laser speckle and high row-sampling rate of a rolling shutter, extreme detectable vibration frequency limited by rolling shutter camera imaging is experimentally demonstrated. Using a commercially available industrial camera at a frame rate of 70 fps, a vibration signal with a frequency of 14.285 kHz is extracted that corresponds to an inter-row sampling period of 35 µs and a sampling frequency of 28.57 kHz. Connected component and centroid alignment algorithms are used to extract the inter-row vibration displacement. The parameters that limit the highest and lowest detectable frequencies are discussed.
    Sprache Englisch
    Erscheinungsdatum 2023-08-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.495048
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  9. Artikel ; Online: RNA-binding proteins as drivers of AML and novel therapeutic targets.

    Qin, Tingyu / Cheng, Ying / Wang, Xiaozhong

    Leukemia & lymphoma

    2022  Band 63, Heft 5, Seite(n) 1045–1057

    Abstract: Acute myeloid leukemia (AML) is a group of genetically complex and heterogeneous invasive hematological malignancies with a low 5-year overall survival rate of 30%, which highlights the urgent need for improved treatment measures. RNA-binding proteins ( ... ...

    Abstract Acute myeloid leukemia (AML) is a group of genetically complex and heterogeneous invasive hematological malignancies with a low 5-year overall survival rate of 30%, which highlights the urgent need for improved treatment measures. RNA-binding proteins (RBPs) regulate the abundance of isoforms of related proteins by regulating RNA splicing, translation, stability, and localization, thereby affecting cell differentiation and self-renewal. It is increasingly believed that RBPs are essential for normal hematopoiesis, and RBPs play a key role in hematological tumors, especially AML, by acting as oncogenes or tumor suppressors. In addition, targeting an RBP that is significantly related to AML can trigger the apoptosis of leukemic stem cells or promote the proliferation of stem and progenitor cells by modulating the expression of important pathway regulatory factors such as HOXA9, MYC, and CDKN1A. Accordingly, RBPs involved in normal myeloid differentiation and the occurrence of AML may represent promising therapeutic targets.
    Mesh-Begriff(e) Cell Differentiation ; Hematopoiesis/genetics ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Oncogenes ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemische Substanzen RNA-Binding Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-01-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.2008381
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  10. Artikel ; Online: A Single Strain of

    Wang, Yuying / Wang, Xiaozhong / Xiao, Xinzhu / Yu, Shufang / Huang, Wennan / Rao, Benqiang / Chen, Fenglin

    Nutrients

    2023  Band 15, Heft 3

    Abstract: Type 2 diabetes (T2D) is usually accompanied by obesity and nonalcoholic fatty-liver-related insulin resistance. The link between T2D and dysbiosis has been receiving increasing attention. Probiotics can improve insulin sensitivity by regulating ... ...

    Abstract Type 2 diabetes (T2D) is usually accompanied by obesity and nonalcoholic fatty-liver-related insulin resistance. The link between T2D and dysbiosis has been receiving increasing attention. Probiotics can improve insulin sensitivity by regulating imbalances in microbiota, but efficacy varies based on the probiotic used. This study screened the main strain in the feces of healthy adult mice and found it to be a new
    Mesh-Begriff(e) Mice ; Animals ; Lactobacillus ; Glucose/pharmacology ; Gastrointestinal Microbiome ; Diabetes Mellitus, Type 2/therapy ; Dysbiosis/therapy ; Lipids/pharmacology ; Cholesterol, LDL ; Probiotics
    Chemische Substanzen Glucose (IY9XDZ35W2) ; Lipids ; Cholesterol, LDL
    Sprache Englisch
    Erscheinungsdatum 2023-01-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15030670
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