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Article: [Comparative study of the effects of intramedullary nail fixation and minimally invasive percutaneous plate internal fixation technique on platelet activation and serum transforming growth factor-β1(TGF-β) 1 and bone morphogenetic protein-2 (BMP-2) in patients with tibial and fibular fracture].

Wen, Cheng / Wang, Xi-Jie / Han, Jun-Cheng / Wang, Han-Wei

Zhongguo gu shang = China journal of orthopaedics and traumatology

2023 Volume 36, Issue 11, Page(s) 1100–1106

Abstract: Objective: To investigate the effect of intramedullary nail fixation (IMN) and minimally invasive percutaneous plate internal fixation (MIPPO) techniques on tibiofibular fractures and their effect on platelet activation and serum transforming growth ... ...

Abstract	Objective: To investigate the effect of intramedullary nail fixation (IMN) and minimally invasive percutaneous plate internal fixation (MIPPO) techniques on tibiofibular fractures and their effect on platelet activation and serum transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-2 (BMP-2). Methods: Total of 105 patients with tibiofibular fractures from February 2019 to February 2020 were selected and divided into 53 cases in the MIPPO group and 52 cases in the IMN group. There were 29 males and 24 females with an average age of (41.74±6.05) years old in MIPPO group;in IMN group, 31 males and 21 females with an average age of (40.59±5.26) years old. The perioperative surgical indexes, postoperative complications, ankle function recovery at 12 months postoperatively, platelet activation indexes at 3 and 7 days preoperatively and postoperatively, and serum TGF-β1 and BMP-2 levels at 4 and 8 weeks preoperatively and postoperatively were compared between the two groups. Results: The operating time and fracture healing time in the MIPPO group were shorter than those in the IMN group( Conclusion: Both intramedullary nail fixation and MIPO technique for treatment of tibia and fibula fractures can improve ankle joint function, but the latter has the advantages of short operation time, fast fracture healing, fewer complications, and light platelet activation. Serum TGF-β1, BMP-2 level improves quickly.
MeSH term(s)	Male ; Female ; Humans ; Adult ; Middle Aged ; Tibia/surgery ; Tibia/injuries ; Transforming Growth Factor beta1 ; Fracture Fixation, Intramedullary/methods ; Tibial Fractures/surgery ; Fracture Fixation, Internal/methods ; Bone Plates ; Fracture Healing ; Postoperative Complications ; Fractures, Multiple ; Treatment Outcome ; Bone Morphogenetic Proteins ; Minimally Invasive Surgical Procedures/methods ; Retrospective Studies
Chemical Substances	Transforming Growth Factor beta1 ; Bone Morphogenetic Proteins
Language	Chinese
Publishing date	2023-11-28
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1003-0034
ISSN	1003-0034
DOI	10.12200/j.issn.1003-0034.2023.11.018
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Article ; Online: Wang et al. Respond.

Wang, Xijie / Dong, Bin / Wang, Zhiqiang / Ma, Jun

American journal of public health

2021 Volume 111, Issue 4, Page(s) e23

MeSH term(s)	Adolescent ; Asian People ; Body Mass Index ; Child ; China ; Cohort Studies ; Humans ; Hypertension
Language	English
Publishing date	2021-03-08
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2021.306164
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Article ; Online: Circulating prekallikrein levels are correlated with lipid levels in the chinese population: a cross-sectional study.

Shu, Yuanlu / Zhao, Xiang / Yang, Changshun / Yan, Yan / Zheng, Yao / Wang, Xijie / Qiu, Chengfeng

Lipids in health and disease

2023 Volume 22, Issue 1, Page(s) 79

Abstract: Background: Recent evidence has revealed that circulating coagulation factor prekallikrein (PK), an important part of the kallikrein-kinin system, regulates cholesterol metabolism, but the association between serum PK and lipid levels is unclear.: ... ...

Abstract	Background: Recent evidence has revealed that circulating coagulation factor prekallikrein (PK), an important part of the kallikrein-kinin system, regulates cholesterol metabolism, but the association between serum PK and lipid levels is unclear. Methods: This cross-sectional study included 256 subjects (aged from 1 month to 90 years) who underwent physical examinations at the First People's Hospital of Huaihua, China. After overnight fasting, serum was collected for PK and lipid testing. Spearman correlation analysis and multivariable logistic regression analysis were used to analyze the association of PK level with lipid levels and the likelihood risk of hyperlipidemia. The possible threshold value of PK was calculated according to the receiver operating characteristic (ROC) curve. Results: The median serum PK level was 280.9 µg/mL (IQR 168.0, 377.0), and this level changed with age but not sex. The serum PK level was positively correlated with the serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels. A nonlinear relationship was observed between serum PK and high-density lipoprotein cholesterol (HDL-C) levels. The serum PK level was positively correlated with HDL-C when its level was lower than 240 µg/mL and negatively correlated with HDL-C when its level was higher than 240 µg/mL. The regression analysis demonstrated that an elevated serum PK level was significantly associated with the likelihood risk of hypercholesterolemia and hypertriglyceridemia. The ROC curve showed that the possible threshold values of serum PK for hypercholesterolemia and hypertriglyceridemia occurrences were 344.9 µg/mL and 305.7 µg/mL, respectively. Conclusions: Elevated serum PK levels were significantly associated with the likelihood of hypercholesterolemia and hypertriglyceridemia, and the possible threshold values of PK levels were 344.9 µg/mL and 305.70 µg/mL, respectively, suggesting that higher PK levels may be a risk factor for cardiovascular diseases.
MeSH term(s)	Humans ; Cholesterol, HDL ; Cross-Sectional Studies ; East Asian People ; Hypercholesterolemia/blood ; Hyperlipidemias/blood ; Hypertriglyceridemia/blood ; Prekallikrein/analysis ; Triglycerides ; Infant ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over
Chemical Substances	Cholesterol, HDL ; Prekallikrein (9055-02-1) ; Triglycerides
Language	English
Publishing date	2023-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2091381-3
ISSN	1476-511X ; 1476-511X
ISSN (online)	1476-511X
ISSN	1476-511X
DOI	10.1186/s12944-023-01849-5
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Article ; Online: Screening of a short chain antimicrobial peptide-FWKFK and its application in wound healing.

Zhang, Runfeng / Yan, Han / Wang, Xijie / Cong, Hailin / Yu, Bing / Shen, Youqing

Biomaterials science

2023 Volume 11, Issue 5, Page(s) 1867–1875

Abstract: As a kind of basic polypeptide with antibacterial properties, antimicrobial peptides play an important role in resisting the invasion of foreign microorganisms. Antimicrobial peptides have a wide range of antimicrobial activities against bacteria, fungi, ...

Abstract	As a kind of basic polypeptide with antibacterial properties, antimicrobial peptides play an important role in resisting the invasion of foreign microorganisms. Antimicrobial peptides have a wide range of antimicrobial activities against bacteria, fungi, viruses and other microorganisms. They are active against traditional antibiotic-resistant strains and do not easily cause bacterial resistance. In this study, we synthesized an antibacterial peptide library by a Fmoc solid phase synthesis method, and screened the peptide chain FWKFK by modified cell membrane chromatography. The minimum inhibitory concentration of FWKFK against
MeSH term(s)	Mice ; Animals ; Staphylococcus aureus ; Antimicrobial Peptides ; Escherichia coli ; Wound Healing ; Peptides/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Microbial Sensitivity Tests
Chemical Substances	Antimicrobial Peptides ; Peptides ; Anti-Bacterial Agents
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d2bm01992b
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Article ; Online: ProBox: A Rigid yet Dynamic Cyclophane Capable of Adaptive and Redox-Switchable Host-Guest Binding.

Lu, Zonghuan / Lv, Wanqian / Liu, Hongyi / Liu, Yandie / Liao, Shuhua / Wang, Xijie / Zhu, Kelong

Organic letters

2023 Volume 25, Issue 19, Page(s) 3508–3511

Abstract: ... ...

Abstract	A
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c01092
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Article ; Online: Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery.

Wang, Xijie / Zhang, Min / Li, Yanan / Cong, Hailin / Yu, Bing / Shen, Youqing

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 50, Page(s) e2304006

Abstract: Dendrimers are a family of polymers with highly branched structure, well-defined composition, and extensive functional groups, which have attracted great attention in biomedical applications. Micelles formed by dendrimers are ideal nanocarriers for ... ...

Abstract	Dendrimers are a family of polymers with highly branched structure, well-defined composition, and extensive functional groups, which have attracted great attention in biomedical applications. Micelles formed by dendrimers are ideal nanocarriers for delivering anticancer agents due to the explicit study of their characteristics of particle size, charge, and biological properties such as toxicity, blood circulation time, biodistribution, and cellular internalization. Here, the classification, preparation, and structure of dendrimer micelles are reviewed, and the specific functional groups modified on the surface of dendrimers for tumor active targeting, stimuli-responsive drug release, reduced toxicity, and prolonged blood circulation time are discussed. In addition, their applications are summarized as various platforms for biomedical applications related to cancer therapy including drug delivery, gene transfection, nano-contrast for imaging, and combined therapy. Other applications such as tissue engineering and biosensor are also involved. Finally, the possible challenges and perspectives of dendrimer micelles for their further applications are discussed.
MeSH term(s)	Humans ; Micelles ; Dendrimers/chemistry ; Tissue Distribution ; Drug Delivery Systems ; Neoplasms/drug therapy ; Neoplasms/pathology ; Drug Carriers/chemistry
Chemical Substances	Micelles ; Dendrimers ; Drug Carriers
Language	English
Publishing date	2023-08-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202304006
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Article ; Online: Polysaccharide-based nanocarriers for efficient transvascular drug delivery.

Zhang, Min / Ma, He / Wang, Xijie / Yu, Bing / Cong, Hailin / Shen, Youqing

Journal of controlled release : official journal of the Controlled Release Society

2023 Volume 354, Page(s) 167–187

Abstract: Polysaccharide-based nanocarriers (PBNs) are the focus of extensive investigation because of their biocompatibility, low cost, wide availability, and chemical versatility, which allow a wide range of anticancer agents to be loaded within the nanocarriers. ...

Abstract	Polysaccharide-based nanocarriers (PBNs) are the focus of extensive investigation because of their biocompatibility, low cost, wide availability, and chemical versatility, which allow a wide range of anticancer agents to be loaded within the nanocarriers. Similar to other nanocarriers, most PBNs are designed to extravasate out of tumor vessels, depending on the enhanced permeability and retention (EPR) effect. However, the EPR effect is compromised in some tumors due to the heterogeneity of tumor structures. Transvascular transport efficacy is decreased by complex blood vessels and condensed tumor stroma. The limited extravasation impedes efficient drug delivery into tumor parenchyma, and thus affects the subsequent tumor accumulation, which hinders the therapeutic effect of PBNs. Therefore, overcoming the biological barriers that restrict extravasation from tumor vessels is of great importance in PBN design. Many strategies have been developed to enhance the EPR effect that involve nanocarrier property regulation and tumor structure remodeling. Moreover, some researchers have proposed active transcytosis pathways that are complementary to the paracellular EPR effect to increase the transvascular extravasation efficiency of PBNs. In this review, we summarize the recent advances in the design of PBNs with enhanced transvascular transport to enable optimization of PBNs in the extravasation of the drug delivery process. We also discuss the obstacles and challenges that need to be addressed to clarify the transendothemial mechanism of PBNs and the potential interactions between extravasation and other drug delivery steps.
MeSH term(s)	Humans ; Drug Delivery Systems ; Antineoplastic Agents/therapeutic use ; Neoplasms/drug therapy ; Polysaccharides ; Nanoparticles/chemistry
Chemical Substances	Antineoplastic Agents ; Polysaccharides
Language	English
Publishing date	2023-01-09
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.12.051
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Article ; Online: Pathologic Diagnosis of a Pituicytoma in a Han-Wistar Rat

HOU Minbo / CUI Tiantian / SU Naying / ZHANG Miaomiao / JIAO Yongmin / YAN Jianyan / WANG Xijie / TOKO Ohira

Shiyan dongwu yu bijiao yixue, Vol 43, Iss 6, Pp 654-

2023 Volume 658

Abstract: A case of pituicytoma was observed in a Han-Wistar rat from the control group of a 2-year carcinogenicity study. No obvious abnormality were found in clinical observation and necropsy. Hematoxylin and Eosin (HE) staining results showed that nodular ... ...

Abstract	A case of pituicytoma was observed in a Han-Wistar rat from the control group of a 2-year carcinogenicity study. No obvious abnormality were found in clinical observation and necropsy. Hematoxylin and Eosin (HE) staining results showed that nodular hyperplasia in the pars nervosa of the pituitary, which was well demarcated and compressed the adjacent normal tissue. The tumor cells were similar to the glial cells with round or oval nuclei, cytoplasm rich in eosinophilic or vacuole. The tumor cells differentiated well, with no obvious cell pleomorphism and visible mitotic figures. Some tumor cells were arranged in a pseudorosette formation. Immunohistochemical staining (IHC) analysis confirmed positive expression of Glial fibrillary acidic protein (GFAP) and S-100 protein. The tumor was diagnosed as the spontaneous benign pituicytoma combining the HE and IHC staining results.
Keywords	pituicytoma ; han-wistar rat ; pathological diagnosis ; Medicine ; R
Language	Chinese
Publishing date	2023-12-01T00:00:00Z
Publisher	Editorial Office of Laboratory Animal and Comparative Medicine
Document type	Article ; Online
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Article ; Online: Change of weight status during school age and its association with late adolescent blood pressure: Results from a 15-year longitudinal study in China.

Wang, Xijie / Dong, Yanhui / Huang, Sizhe / Dong, Bin / Ma, Jun / Liang, Wannian

Frontiers in public health

2022 Volume 10, Page(s) 980973

Abstract: Background: Change in obesity risk could be related to shift in high blood pressure (HBP) risk, while individualized influence of weight change on high blood pressure is in need of exploration.: Methods: A total of 16,446 children (53.47% boys) and ... ...

Abstract	Background: Change in obesity risk could be related to shift in high blood pressure (HBP) risk, while individualized influence of weight change on high blood pressure is in need of exploration. Methods: A total of 16,446 children (53.47% boys) and 13,9021 effective annual measurements from 2006 to 2020 were recruited. Children's weight status, both at baseline and endpoint, was categorized as underweight, normal, overweight, and obese according to the age and sex-specific Body Mass Index z scores. HBP at late adolescence was defined with the last two measurements for each child. Populational attributable risk (PAR) of weight trait on HBP risk was calculated. Results: Compared to children who maintained normal weight during follow-up, staying obese was associated with the highest HBP risk with OR of 6.39 (95% CI: 4.46, 9.15; Conclusion: Weight loss program could be effective to reduce HBP risk during school age, while the underlying mechanism needs further exploration.
MeSH term(s)	Adolescent ; Blood Pressure/physiology ; Child ; China/epidemiology ; Female ; Humans ; Hypertension/epidemiology ; Longitudinal Studies ; Male ; Obesity/epidemiology
Language	English
Publishing date	2022-08-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.980973
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Article ; Online: Effects of intravenous infusion, vest wearing and repeated intravenous blood collection on clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis).

Zhao, Qi / Li, Caiyun / Chen, Yan / Liu, Yongtao / Wang, Shuyan / Wang, Xijie

Experimental animals

2022 Volume 72, Issue 2, Page(s) 262–273

Abstract: Nonhuman primates are used extensively in a variety of nonclinical safety evaluation studies of new drugs. In those studies, intravenous infusion is a common treatment method, a noninvasive telemetry system is usually used for cardiovascular safety and ... ...

Abstract	Nonhuman primates are used extensively in a variety of nonclinical safety evaluation studies of new drugs. In those studies, intravenous infusion is a common treatment method, a noninvasive telemetry system is usually used for cardiovascular safety and pharmacology evaluation, and blood samples are repeatedly collected for various analysis. Intravenous infusion, vest wearing, and repeated intravenous blood collection can caused a stress response in cynomolgus monkeys, which may lead to changes in clinical pathology parameters in them. Here, we aimed to test the effects of the above operations on clinical pathology parameters in cynomolgus monkeys. Twenty monkeys (10 male/10 female) were administered 0.9% sodium chloride injections via intravenous infusions on Days 1 and 10. Each animal wore a vest before each dosing, and the vest was removed at 24 h after each dosing. Blood samples were collected before the first dose and at 2 min, 24 h, 48 h, 72 h, and 168 h after each dosing. As compared to values before the first dose (D-1) increases in reticulocytes (percentage and absolute count) and decreases in erythrocytes (red blood cells, hemoglobin, and hematocrit) were noted after dosing. The decrease in erythrocytes and increase in reticulocytes were considered to the related to the repeated intravenous blood collection. Increases in leukocytes (white blood cells and absolute count and percentage of neutrophils) and platelets (mean platelet volume and platelet distribution width) were noted at 2 min or 24 h post dose. Increases in aspartate aminotransferase, direct bilirubin, creatine kinase, C-reactive protein, and human cardiac troponin I and decreases in inorganic phosphate were noted at 2 min to 72 h post dose.
MeSH term(s)	Male ; Female ; Humans ; Animals ; Infusions, Intravenous ; Macaca fascicularis
Language	English
Publishing date	2022-12-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2088228-2
ISSN	1881-7122 ; 1341-1357 ; 0007-5124
ISSN (online)	1881-7122
ISSN	1341-1357 ; 0007-5124
DOI	10.1538/expanim.22-0106
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