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Article ; Online: Pan-cancer analysis reveals a regulatory pattern of anoikis in human cancers.

Wang, Xiaoyun / Yang, Chao / Wang, Xingjian / Duan, Pengfei

Cellular and molecular biology (Noisy-le-Grand, France)

2024 Volume 70, Issue 2, Page(s) 51–61

Abstract: Anoikis emerges when a cell finds itself extricated from the appropriate extracellular matrix, leading to an interruption in integrin ligation and thus triggering programmed cellular demise. The cardinal role of Anoikis in the realms of tumor invasion ... ...

Abstract	Anoikis emerges when a cell finds itself extricated from the appropriate extracellular matrix, leading to an interruption in integrin ligation and thus triggering programmed cellular demise. The cardinal role of Anoikis in the realms of tumor invasion and metastasis is undeniable, although our grasp on its precise influence within the convoluted landscape of cancer biology remains somewhat circumscribed. Notably, both the immune milieu of the tumor and its inherent aggression are correlated with the fluctuating variables of Anoikis. We conducted a thorough evaluation of the genes associated with anoikis and studied the regulatory patterns of these genes as well as the prognostic impact of anoikis in 33 different types of tumors. We provided functional annotations for the regulatory patterns linked to Anoikis. Additionally, we described the associations between immunological factors and genes associated with Anoikis. By applying gene set variation analysis (GSVA), we utilized the inherent abilities of 34 basic genes to calculate the Anoikis index. The Anoikis index is closely related to prognosis, immune microenvironment, immunotherapy, and other aspects. Our functional research revealed a correlation between immune cell infiltration, EMT, and a regulatory gene that is synonymous with adverse survival outcomes. In addition, our observations revealed a direct relationship between the expression of CEACAM5 and CEACAM6,the amplification of epithelial mesenchymal transition (EMT) phenomenon, and a decrease in survival outcomes.The potential therapeutic utility of anoikis-related genes was highlighted by the possible links between TME, clinical samples, genetic mutations, drug resistance, and immunotherapy.
MeSH term(s)	Humans ; Anoikis/genetics ; Cell Line, Tumor ; Neoplasms/genetics
Language	English
Publishing date	2024-02-29
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2024.70.2.8
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Article ; Online: Low illumination fog noise image denoising method based on ACE-GPM.

Li, Wuyi / Zhou, Guanglu / Wang, Xingjian

PloS one

2024 Volume 19, Issue 5, Page(s) e0302492

Abstract: The Perona-Malik (P-M) model exhibits deficiencies such as noise amplification, new noise introduction, and significant gradient effects when processing noisy images. To address these issues, this paper proposes an image-denoising algorithm, ACE-GPM, ... ...

Abstract	The Perona-Malik (P-M) model exhibits deficiencies such as noise amplification, new noise introduction, and significant gradient effects when processing noisy images. To address these issues, this paper proposes an image-denoising algorithm, ACE-GPM, which integrates an Automatic Color Equalization (ACE) algorithm with a gradient-adjusted P-M model. Initially, the ACE algorithm is employed to enhance the contrast of low-light images obscured by fog and noise. Subsequently, the Otsu method, a technique to find the optimal threshold based on between-class variance, is applied for precise segmentation, enabling more accurate identification of different regions within the image. After that, distinct gradients enhance the image's foreground and background via an enhancement function that accentuates edge and detailed information. The denoising process is finalized by applying the gradient P-M model, employing a gradient descent approach to further emphasize image edges and details. Experimental evidence indicates that the proposed ACE-GPM algorithm not only elevates image contrast and eliminates noise more effectively than other denoising methods but also preserves image details and texture information, evidenced by an average increase of 0.42 in the information entropy value. Moreover, the proposed solution achieves these outcomes with reduced computational resource expenditures while maintaining high image quality.
MeSH term(s)	Algorithms ; Signal-To-Noise Ratio ; Image Processing, Computer-Assisted/methods ; Lighting/methods ; Humans ; Color ; Image Enhancement/methods
Language	English
Publishing date	2024-05-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0302492
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Article: Spatial distribution of Airbnb and its influencing factors: A case study of Suzhou, China

Sun, Shijie / Wang, Xingjian / Hu, Mingxing

Applied geography. 2022 Feb., v. 139

2022

Abstract: The homestay model represented by Airbnb has developed rapidly in China over the last several years. By taking the city of Suzhou in China as a case study, this paper analyzes the distribution characteristics and impact factors of Airbnb in a typical ... ...

Abstract	The homestay model represented by Airbnb has developed rapidly in China over the last several years. By taking the city of Suzhou in China as a case study, this paper analyzes the distribution characteristics and impact factors of Airbnb in a typical historical and cultural tourism city and discusses the uniqueness of Suzhou. This paper identifies the explanatory variables of the spatial distribution of Airbnb through literature review and the analysis of local characteristics of Suzhou. The spatial Durbin model in the spatial econometric model was chosen to analyze the influencing factors of the spatial distribution of Airbnb in Suzhou. The results showed that the factors influencing the distribution of Airbnb in Suzhou include traditional folk dwellings, restaurants, shopping malls, and tourist attractions and also reveal the differences between the old city and the new city in influencing the spatial distribution of Airbnb. The study found that historical and cultural resources and local characteristics are the most important factors influencing the distribution of Airbnb in historic cities. Airbnb's rapid rise in urban historical districts may challenge the government by causing negative impacts on historic preservation, and the results of the study can help improve the management of B&B in cities.
Keywords	case studies ; econometric models ; geography ; historic preservation ; hospitality industry ; tourism ; tourists ; China
Language	English
Dates of publication	2022-02
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0143-6228
DOI	10.1016/j.apgeog.2022.102641
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Pandemic effect on corporate financial asset holdings: Precautionary or return-chasing?

Gao, Haoyu / Wen, Huiyu / Wang, Xingjian

Research in international business and finance

2022 Volume 62, Page(s) 101750

Abstract: This study empirically investigates whether and how the COVID-19 pandemic affects corporate financial asset holdings. We find that firms with higher pandemic exposure are less likely to hold financial assets. Mechanism analyses suggest that the return- ... ...

Abstract	This study empirically investigates whether and how the COVID-19 pandemic affects corporate financial asset holdings. We find that firms with higher pandemic exposure are less likely to hold financial assets. Mechanism analyses suggest that the return-chasing rationale dominates the precautionary motive concerning the pandemic effect on corporate financial asset holdings. Furthermore, firms prefer to liquidate highly liquid financial assets to fill the pandemic-induced liquidity shortage. This study contributes to the economic consequences of the COVID-19 pandemic regarding corporate portfolio choice, and sheds light on corporate resilience to crises.
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article
ISSN	1878-3384
ISSN (online)	1878-3384
DOI	10.1016/j.ribaf.2022.101750
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Article ; Online: Increased carotid intima-media thickness is independently associated with the occurrence of depressive disorders in patients with obstructive sleep apnea without cardiocerebrovascular disease.

Li, Xiaomeng / Wang, Xingjian / Li, Wenyang / Wang, Wei

Journal of psychiatric research

2022 Volume 150, Page(s) 122–129

Abstract: Study objectives: This study aimed to explore the relationship between carotid intima-media thickness (cIMT) and depression in patients with obstructive sleep apnea (OSA) without cardiocerebrovascular diseases.: Methods: This study evaluated self- ... ...

Abstract	Study objectives: This study aimed to explore the relationship between carotid intima-media thickness (cIMT) and depression in patients with obstructive sleep apnea (OSA) without cardiocerebrovascular diseases. Methods: This study evaluated self-rating depression scale (SDS) scores, night sleep, and cIMT in 114 patients with OSA without cardiocerebrovascular diseases. Results: Among the 114 patients, 79.8% were male (mean age: 46.7 ± 11.58 years; range: 22-72 years). Moreover, 46.5%, 44.7%, and 7.89% of the patients presented with depressive disorders (8, 24, and 21 with severe, moderate, and mild degrees of depression, respectively), cIMT increase, and carotid plaques, respectively. Logistic regression with adjustment for age, sex, and other confounding factors revealed that, compared with patients with OSA without depressive disorders, those with depressive disorders had higher cIMT (odds ratio [OR] = 1.839; 95% confidence interval [CI]: 1.210-2.795), D-value (the difference between nocturnal mean blood oxygen saturation and the lowest blood oxygen saturation; OR = 1.434; 95% CI: 1.259-1.633]), and time spent at O Conclusions: cIMT and D-value are independently associated with depression in patients with OSA, which provides clinical evidence regarding the involvement of vascular damage in OSA-induced depression.
MeSH term(s)	Adult ; Carotid Intima-Media Thickness ; Depressive Disorder/complications ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Sleep Apnea, Obstructive/complications
Language	English
Publishing date	2022-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2022.03.043
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Article: The Impact of COVID-19 on Cancer.

Li, Yue / Wang, Xingjian / Wang, Wei

Infection and drug resistance

2021 Volume 14, Page(s) 3809–3816

Abstract: Since late December 2019, the 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid international spread have posed a global health threat. The World Health Organization has declared the ... ...

Abstract	Since late December 2019, the 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid international spread have posed a global health threat. The World Health Organization has declared the outbreak of COVID-19 as "public health emergency of international concern". COVID-19 not only brings tremendous pressure to the medical system but also brings new challenges to the global economy. The occurrence and development of cancer has always been an area of active research, and COVID-19 also has a long-lasting impact on the diagnosis, treatment, and research of cancer. In the context, we review the adverse effects of COVID-19 on the screening, diagnosis, treatment and prognosis of cancer patients and the countermeasures in this situation, and provide solutions for improving the quality of life of cancer patients in the normalized prevention and control of COVID-19.
Language	English
Publishing date	2021-09-17
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S324569
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Article ; Online: Accuracy of portable spirometers in the diagnosis of chronic obstructive pulmonary disease A meta-analysis.

Zhou, Jiawei / Li, Xiaomeng / Wang, Xingjian / Yu, Na / Wang, Wei

NPJ primary care respiratory medicine

2022 Volume 32, Issue 1, Page(s) 15

Abstract: Portable spirometers has been approved for diagnosing chronic obstructive pulmonary disease (COPD). However, their diagnostic accuracy has not been reviewed. Therefore, the purpose of this study was to systematically evaluate the diagnostic value of ... ...

Abstract	Portable spirometers has been approved for diagnosing chronic obstructive pulmonary disease (COPD). However, their diagnostic accuracy has not been reviewed. Therefore, the purpose of this study was to systematically evaluate the diagnostic value of portable spirometers in detecting COPD. A comprehensive literature search for relevant studies was conducted in PubMed, Embase, CNKI, Wan Fang, and Web of Science databases. Pooled sensitivity, specificity, summary receiver operating characteristic (SROC), area under the curve (AUC), and other related indices were calculated using the bivariate mixed-effect model. Subgroup analysis was performed to explore the source of heterogeneity. Thirty one studies were included in the meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic ratio (DOR), SROC, and AUC of the SROC of portable spirometers were 0.85 (0.81-0.88), 0.85 (0.81-0.88), 5.6 (4.4-7.3), 0.18 (0.15-0.22), 31 (21-46) and 0.91 (0.89-0.94), respectively. Among the three commonly used types of portable spirometers, the accuracy of PIKO-6 was higher (0.95) than that of COPD-6 (0.91) and PEF (0.82). Subgroup analysis indicated that the accuracy of a multi-indices portable spirometer was higher than that of a single-index one (P < 0.05). In addition, portable spirometry performed by professional technicians in tertiary hospitals was more accurate than for those conducted by trained technicians in primary care facilities and communities (P < 0.05). Moreover, the accuracy of studies conducted in developing country was superior to developed country (P < 0.05). Portable spirometers have high accuracy in the diagnosis of COPD. Multi-index COPD-6 and PIKO-6 displayed higher accuracy than others. Standardized training of instrument operators should be considered to achieve reliable results.
MeSH term(s)	Area Under Curve ; Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; ROC Curve ; Sensitivity and Specificity ; Spirometry
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2780812-9
ISSN	2055-1010 ; 2055-1010
ISSN (online)	2055-1010
ISSN	2055-1010
DOI	10.1038/s41533-022-00275-x
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Article: Malnutrition and Venous Thromboembolism are Specific Issues in Elderly Patients with Coronavirus Disease 2019.

Qin, Zheng / Wang, Xingjian / Wang, Wei

Journal of translational internal medicine

2021 Volume 9, Issue 3, Page(s) 223–224

Language	English
Publishing date	2021-09-28
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2861892-0
ISSN	2224-4018 ; 2450-131X
ISSN (online)	2224-4018
ISSN	2450-131X
DOI	10.2478/jtim-2021-0027
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Article ; Online: Characteristics and influencing factors of Airbnb spatial distribution in China's rapid urbanization process: A case study of Nanjing.

Sun, Shijie / Zhang, Shengyue / Wang, Xingjian

PloS one

2021 Volume 16, Issue 3, Page(s) e0248647

Abstract: As in other countries, short-term rentals for tourism services are growing rapidly in China's tourist cities, which are mainly operated through Airbnb. This paper explores whether the spatial distribution of Airbnb in China's rapid urbanization process ... ...

Abstract	As in other countries, short-term rentals for tourism services are growing rapidly in China's tourist cities, which are mainly operated through Airbnb. This paper explores whether the spatial distribution of Airbnb in China's rapid urbanization process exhibits characteristics, paths, and drivers that are different from those of cities in other countries. Airbnb is a model for the global sharing economy, but it is increasingly influenced by other functions and facilities in cities as it grows. In this paper, the zero-expansion negative binomial regression was used to study the factors affecting the spatial distribution of Airbnb in Nanjing, China. The results showed that the spatial distribution of Airbnb listings was correlated with the distribution of cultural attractions, universities, public transport accessibility, shopping centers, and business apartments. By analyzing the driving forces of Airbnb's development in Nanjing, this paper found that a large number of business apartments developed in cities were essential providers of Airbnb listings, and affected its spatial distribution. The gap between short-term and long-term rentals was also correlated with the distribution of Airbnb. In addition, similar to the previous literature findings, the increase in the proportion of professional hosts changes the original intention of Airbnb for sharing and communication. Our empirical results applies to the current situation of Airbnb in Chinese cities, which is conducive to the government's more intelligent management and effective promotion of the Airbnb market. Our findings also provide positive references for urban renewal policies and public participation methods in China.
MeSH term(s)	China ; Cities/statistics & numerical data ; Geography ; Housing/statistics & numerical data ; Housing/trends ; Humans ; Internet/statistics & numerical data ; Internet/trends ; Spatial Analysis ; Tourism ; Urbanization/trends
Language	English
Publishing date	2021-03-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0248647
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Article ; Online: Phase Transformation Behavior of the Aluminosilicate Phase During High-Pressure Hydrothermal Reduction of High-Iron Red Mud.

Wang, Xingjian / Wang, Yiyong / Jin, Hui / Li, Jidong / Wang, Xiaomin

Bulletin of environmental contamination and toxicology

2022 Volume 109, Issue 1, Page(s) 186–193

Abstract: One-step separation and recovery of sodium, aluminum and iron in high-iron red mud in a high-calcium alkaline hydrothermal system is realized by a high-pressure hydrothermal reduction process. The transformation behavior of the aluminasilica phase in ... ...

Abstract	One-step separation and recovery of sodium, aluminum and iron in high-iron red mud in a high-calcium alkaline hydrothermal system is realized by a high-pressure hydrothermal reduction process. The transformation behavior of the aluminasilica phase in high-iron red mud is mainly investigated. The results show that under the optimized conditions, a temperature of 290℃, a Na
Language	English
Publishing date	2022-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	6895-0
ISSN	1432-0800 ; 0007-4861
ISSN (online)	1432-0800
ISSN	0007-4861
DOI	10.1007/s00128-022-03492-9
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