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Article: The Association Between Mild Cognitive Impairment and Medication Non-adherence Among Elderly Patients With Chronic Diseases.

He, Xiaoqin / Wang, Xinguo / Wang, Bin / Zhu, Aiyong

2023 Volume 15, Issue 10, Page(s) e47756

Abstract: Background: Medication adherence is essential for optimizing treatment outcomes in elderly patients who frequently contend with multiple chronic diseases requiring pharmacological interventions. Mild cognitive impairment (MCI) is a prevalent cognitive ... ...

Abstract	Background: Medication adherence is essential for optimizing treatment outcomes in elderly patients who frequently contend with multiple chronic diseases requiring pharmacological interventions. Mild cognitive impairment (MCI) is a prevalent cognitive disorder among the elderly population, but its impact on medication adherence among elderly patients is still uncertain. This cross-sectional study aimed to investigate the impact of MCI on medication adherence among elderly patients. Methods: A cross-sectional study of 436 elderly patients with common chronic diseases aged 60 years and above was conducted. Medication adherence was measured using the Morisky Medication Adherence Scale-8 (MMAS-8). MCI was screened, and cognitive status was assessed using the Mini-Mental State Examination (MMSE) questionnaire. Multivariate logistic regression analysis was performed to identify independent risk factors of medication non-adherence. Results: Among these elderly patients, 212 (48.6%) had poor medication compliance, and 181 (41.5%) had MCI. Preliminary analyses showed a significant association between MCI and medication non-adherence among elderly patients (odds ratio (OR)=3.95, 95% confidence interval (95%CI)=2.63-5.92, P<0.001). Multivariate logistic regression analysis showed that MCI was independently associated with the risk of medication non-adherence among elderly patients (adjusted OR=2.64, 95%CI=1.64-4.24, P<0.001). Additionally, adverse drug reaction and poor evaluation of medication effects were also independently associated with medication non-adherence in elderly patients (P<0.05). Conclusion: Findings from this cross-sectional study proved the substantial adverse impact of MCI on medication adherence among elderly patients, and MCI was an independently influential factor of medication non-adherence. Identifying the MCI status early and providing interventions to enhance medication adherence are undoubtedly essential for optimizing healthcare outcomes in elderly patients.
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47756
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Article ; Online: MiR-22-3p facilitates bone marrow mesenchymal stem cell osteogenesis and fracture healing through the SOSTDC1-PI3K/AKT pathway.

Wang, Chunqiu / Wang, Xinguo / Cheng, Hui / Fang, Jiahu

International journal of experimental pathology

2023 Volume 105, Issue 2, Page(s) 52–63

Abstract: Bone fractures are the most common form of musculoskeletal trauma worldwide. Numerous microRNAs (miRNAs) have been suggested to be participants in regulating bone-related diseases. Recent studies revealed the regulatory role of miR-22-3p in osteogenic ... ...

Abstract	Bone fractures are the most common form of musculoskeletal trauma worldwide. Numerous microRNAs (miRNAs) have been suggested to be participants in regulating bone-related diseases. Recent studies revealed the regulatory role of miR-22-3p in osteogenic differentiation, but its role in fracture healing has not been investigated previously. Here, a rat femoral fracture model was established, Bone marrow mesenchymal stem cells (BMSCs) were isolated to detect the specific function and underlying mechanisms of miR-22-3p. MiR-22-3p and sclerostin domain-containing 1 (SOSTDC1) expression was determined by RT-qPCR and immunohistochemistry staining. The levels of proteins associated with osteogenic differentiation were assessed by western blotting. Flow cytometry was conducted to identify the isolated rat BMSCs. Alizarin red staining, alkaline phosphatase staining and Oil Red O staining were used to evaluate the osteogenic and adipogenic differentiation of rat BMSCs. The interaction between miR-22-3p and SOSTDC1 was verified using a luciferase reporter assay. Haematoxylin and Eosin (H&E) staining of the bone tissues was performed to analyse the effect of miR-22-3p on histopathological changes in vivo. MiR-22-3p was downregulated in the callus tissues of rat femoral fracture, while the expression of SOSTDC1 was upregulated. The isolated rat BMSCs had the capacity for both osteogenic and adipogenic differentiation. The differentiation capacity of BMSCs into osteoblasts was increased by miR-22-3p overexpression. MiR-22-3p activated the PI3K/AKT pathway by targeting SOSTDC1. SOSTDC1 overexpression and PI3K/AKT signalling inhibitor LY294002 abolished the enhancing effect of miR-22-3p overexpression on the osteogenesis of BMSCs. Thus MiR-22-3p facilitated the femoral fracture healing in rats. MiR-22-3p overexpression promoted fracture healing via the activation of PI3K/AKT pathway by targeting SOSTDC1.
MeSH term(s)	Animals ; Humans ; Rats ; Adaptor Proteins, Signal Transducing/genetics ; Cell Differentiation ; Cells, Cultured ; Femoral Fractures/genetics ; Femoral Fractures/metabolism ; Femoral Fractures/pathology ; Fracture Healing ; Mesenchymal Stem Cells ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Osteogenesis ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
Chemical Substances	Adaptor Proteins, Signal Transducing ; MicroRNAs ; MIRN22 microRNA, human ; MIRN22 microRNA, rat ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; SOSTDC1 protein, human ; Sostdc1 protein, rat
Language	English
Publishing date	2023-12-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1016006-1
ISSN	1365-2613 ; 0958-4625 ; 0007-1021 ; 0959-9673
ISSN (online)	1365-2613
ISSN	0958-4625 ; 0007-1021 ; 0959-9673
DOI	10.1111/iep.12500
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Article ; Online: Preparation, Characterization, and Gastrointestinal Digestion of Triterpenol‐Loaded Liposomes

Sun, Xiaotian / Guo, Xin / Liu, Ruijie / Chang, Ming / Wang, Xinguo

European Journal of Lipid Science and Technology. 2023 Feb., v. 125, no. 2 p.e2200048-

2023

Abstract: Triterpenol is an important phytochemical that is beneficial to humans. However, there are limitations of application due to its poor solubility. Liposomes are increasingly utilized as a delivery system for phytochemicals with poor solubility which is ... ...

Abstract	Triterpenol is an important phytochemical that is beneficial to humans. However, there are limitations of application due to its poor solubility. Liposomes are increasingly utilized as a delivery system for phytochemicals with poor solubility which is suitable for triterpenol. In the present study, the stability of triterpenol‐loaded liposomes (Tri‐LP) is demonstrated. Tri‐LP stability is observed when the mass ratio of phospholipids to triterpenol is 4:1. Sodium alginate (ALG) and chitosan showed different effects on Tri‐LP. Tri‐LP coated by ALG (Tri‐LP‐ALG) is stabilized by H‐bonding, while electrostatic interactions can stabilize Tri‐LP coated by chitosan (Tri‐LP‐CH). Tri‐LP‐ALG is more stable than Tri‐LP‐CH during storage. The bioaccessibility of Tri‐LP is 11%. ALG and chitosan show no influence on bioaccessibility of Tri‐LP, but reduce the release rate of triterpenol during digestion. Overall, the findings suggest that Tri‐LP showed good promise for future application in functional beverages. Practical Applications: Triterpenol has poor solubility both in oil and water, which greatly limits the functional utilization of triterpene in organisms. Liposomes offer a novel approach to triternenol oral delivery system. It meets the current demands for food health. Liposomes can improve the absorption and utilization of triterpenol in vivo digestion. Many studies and applications of liposomes has carried out in medical field while nutritional supplements with liposomes technology are not common in the market. Triterpenol‐loaded liposomes can not only increase applications in phytochemicals with poor absorption but also offer an interesting attempt of liposomes in food development.
Keywords	absorption ; bioavailability ; chitosan ; digestion ; gastrointestinal system ; hydrogen bonding ; markets ; oils ; phospholipids ; phytochemicals ; sodium alginate ; solubility ; technology ; triterpenoids
Language	English
Dates of publication	2023-02
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2003265-1
ISSN	1438-7697
ISSN	1438-7697
DOI	10.1002/ejlt.202200048
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Article: MIMU Optimal Redundant Structure and Signal Fusion Algorithm Based on a Non-Orthogonal MEMS Inertial Sensor Array.

Xue, Liang / Yang, Bo / Wang, Xinguo / Cai, Guangbin / Shan, Bin / Chang, Honglong

Micromachines

2023 Volume 14, Issue 4

Abstract: A micro-inertial measurement unit (MIMU) is usually used to sense the angular rate and acceleration of the flight carrier. In this study, multiple MEMS gyroscopes were used to form a spatial non-orthogonal array to construct a redundant MIMU system, and ... ...

Abstract	A micro-inertial measurement unit (MIMU) is usually used to sense the angular rate and acceleration of the flight carrier. In this study, multiple MEMS gyroscopes were used to form a spatial non-orthogonal array to construct a redundant MIMU system, and an optimal Kalman filter (KF) algorithm was established by a steady-state KF gain to combine array signals to improve the MIMU's accuracy. The noise correlation was used to optimize the geometric layout of the non-orthogonal array and reveal the mechanisms of influence of correlation and geometric layout on MIMU's performance improvement. Additionally, two different conical configuration structures of a non-orthogonal array for 4,5,6,8-gyro were designed and analyzed. Finally, a redundant 4-MIMU system was designed to verify the proposed structure and KF algorithm. The results demonstrate that the input signal rate can be accurately estimated and that the gyro's error can also be effectively reduced through fusion of non-orthogonal array. The results for the 4-MIMU system illustrate that the gyro's ARW and RRW noise can be decreased by factors of about 3.5 and 2.5, respectively. In particular, the estimated errors (1σ) on the axes of
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14040759
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Article ; Online: Coding RNA expression profile and transcription factor analysis of H.pylori-associated chronic atrophic gastritis.

Wang, Xinguo / Dong, Juan / Sheng, Hao / Ma, Xingting / Baheti, Lazati / Xu, Jie

Advances in medical sciences

2023 Volume 68, Issue 2, Page(s) 491–498

Abstract: Purpose: Atrophic gastritis, one of the processes leading to gastric cancer (GC), is closely related to Helicobacter pylori (HP) infection. This study aimed to understand how HP causes chronic inflammation that leads to ulcers and stomach problems.: ... ...

Abstract	Purpose: Atrophic gastritis, one of the processes leading to gastric cancer (GC), is closely related to Helicobacter pylori (HP) infection. This study aimed to understand how HP causes chronic inflammation that leads to ulcers and stomach problems. Methods: Twenty-eight CAG patients were included in the study (9 HP-infected and 19 HP-uninfected). Endoscopy, histopathology, and high-throughput mRNA sequencing were performed. Differentially expressed genes (DEGs) were validated via qRT-PCR. Results: Principal component analysis (PCA) results showed that more than 88.9 % of the samples were classified into the HP (+) group. A total of 157 DEGs were identified, of which 38 were up-regulated and 119 were down-regulated. The DEGs were mainly enriched in the biological process (BP) terms associated with immune system process, adaptive immune response, G protein-coupled receptor signaling pathway, as well as point to numerous key pathways, including fat digestion and absorption, retinol metabolism, steroid hormone biosynthesis, ascorbate and aldarate metabolism, and chemical carcinogenesis. APOA1, APOA4, FOXP3, NR1H4, ABCG5, ACTA1, CCL19, CCR7, CYP3A4, and PDCD had the highest degrees in protein-protein interaction network as the hub genes; they were also included into the transcription factor (TF)-target network except for PDCD. APOA1 and CYP3A4 were extremely significantly up-regulated in HP (+) CAG patients compared with the HP (-) CAG patients, while FOXP3, CCR7 and CCL19 were significantly down-regulated. Conclusion: The expression of APOA1, CYP3A4, FOXP3, CCR7, and CCL19 are the potential indicators for CAG to GC development, being the biomarkers to predict progression of CAG and poor prognosis of GC.
MeSH term(s)	Humans ; Gastritis, Atrophic/genetics ; Gastritis, Atrophic/complications ; Gastritis, Atrophic/metabolism ; Helicobacter pylori ; Cytochrome P-450 CYP3A ; Receptors, CCR7 ; Helicobacter Infections ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Forkhead Transcription Factors ; RNA
Chemical Substances	Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Receptors, CCR7 ; Forkhead Transcription Factors ; RNA (63231-63-0)
Language	English
Publishing date	2023-11-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273668-2
ISSN	1898-4002 ; 1896-1126
ISSN (online)	1898-4002
ISSN	1896-1126
DOI	10.1016/j.advms.2023.10.007
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Article ; Online: Quality evaluation of the classical prescription, Danggui Jianzhong decoction, using ultra‐high‐performance liquid chromatography fingerprint, chemical pattern recognition, and network pharmacology

Feng, Yu / Hu, Jingnan / Wang, Fengxia / Li, Baolin / Qian, Qi / Wang, Xinguo / Niu, Liying

Journal of Separation Science. 2022 Oct., v. 45, no. 20 p.3838-3851

2022

Abstract: Danggui Jianzhong decoction is a classical prescription that has been widely used for thousands of years. However, the quality of this formula is difficult to control owing to its complex chemical component system. In this study, a simple and efficient ... ...

Abstract	Danggui Jianzhong decoction is a classical prescription that has been widely used for thousands of years. However, the quality of this formula is difficult to control owing to its complex chemical component system. In this study, a simple and efficient method comprising ultra‐high‐performance liquid chromatography fingerprint, chemical pattern recognition, and network pharmacology was established to evaluate the quality of this decoction. A total of 20 common peaks were obtained by fingerprint analysis and 19 chemicals were identified. The fingerprint similarity of 15 batch samples ranged from 0.963 to 0.991. Chemical pattern recognition analysis could clearly classify 15 batches of Danggui Jianzhong decoction into three groups. Further, seven chemical markers were screened out. A herbs‐active components‐targets‐disease network was constructed and enrichment analyses were performed, which indicated that these 19 chemical components are the medicinal substances of Danggui Jianzhong decoction. Further, the mechanism employed by this formula to treat primary dysmenorrhea may be related to the regulation of inflammatory response. In conclusion, this combination approach enables accurate evaluation and prediction of the quality of Danggui Jianzhong decoction, and lays the foundation for studies on the material basis and exploration of the mechanism of Danggui Jianzhong decoction in the treatment of primary dysmenorrhea.
Keywords	inflammation ; pharmacology ; separation ; ultra-performance liquid chromatography
Language	English
Dates of publication	2022-10
Size	p. 3838-3851.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202200327
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Article: Data for “joint modeling of lithosphere and mantle dynamics: Sensitivity to viscosities within the lithosphere, asthenosphere, transition zone, and D″ layers”

Wang, Xinguo / Holt, William E. / Ghosh, Attreyee

Data in Brief. 2020 Feb., v. 28

2020

Abstract: The article presents the data calculated from four different viscosity structures V1, V2 [1], SH08 [2], and GHW13 [3], as well as two tomography models S40RTS [4] and SAW642AN [5], using the joint modeling of lithosphere and mantle dynamics technique [3, ...

Abstract	The article presents the data calculated from four different viscosity structures V1, V2 [1], SH08 [2], and GHW13 [3], as well as two tomography models S40RTS [4] and SAW642AN [5], using the joint modeling of lithosphere and mantle dynamics technique [3, 6–9]. Besides, the data contain the information on the viscosity variations of the lithosphere, asthenosphere, transition zone, and D″ layer based on the viscosity structure SH08.
Keywords	models ; tomography ; viscosity
Language	English
Dates of publication	2020-02
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2019.104935
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Article ; Online: Quality evaluation of the classical prescription, Danggui Jianzhong decoction, using ultra-high-performance liquid chromatography fingerprint, chemical pattern recognition, and network pharmacology.

Feng, Yu / Hu, Jingnan / Wang, Fengxia / Li, Baolin / Qian, Qi / Wang, Xinguo / Niu, Liying

Journal of separation science

2022 Volume 45, Issue 20, Page(s) 3838–3851

Abstract	Danggui Jianzhong decoction is a classical prescription that has been widely used for thousands of years. However, the quality of this formula is difficult to control owing to its complex chemical component system. In this study, a simple and efficient method comprising ultra-high-performance liquid chromatography fingerprint, chemical pattern recognition, and network pharmacology was established to evaluate the quality of this decoction. A total of 20 common peaks were obtained by fingerprint analysis and 19 chemicals were identified. The fingerprint similarity of 15 batch samples ranged from 0.963 to 0.991. Chemical pattern recognition analysis could clearly classify 15 batches of Danggui Jianzhong decoction into three groups. Further, seven chemical markers were screened out. A herbs-active components-targets-disease network was constructed and enrichment analyses were performed, which indicated that these 19 chemical components are the medicinal substances of Danggui Jianzhong decoction. Further, the mechanism employed by this formula to treat primary dysmenorrhea may be related to the regulation of inflammatory response. In conclusion, this combination approach enables accurate evaluation and prediction of the quality of Danggui Jianzhong decoction, and lays the foundation for studies on the material basis and exploration of the mechanism of Danggui Jianzhong decoction in the treatment of primary dysmenorrhea.
MeSH term(s)	Female ; Humans ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/chemistry ; Dysmenorrhea ; Network Pharmacology ; Prescriptions
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-08-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202200327
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Article ; Online: Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation.

Han, Jun / Kan, Jie / Wang, Xinguo / Yuan, Qingling / Song, Xiaoyan / Huang, Min / Wu, Hao

Translational cancer research

2022 Volume 9, Issue 8, Page(s) 4715–4725

Abstract: Background: Polyphyllin I, a bioactive phytochemical extracted from : Methods: Dual-luciferase reporter assay was performed to test the bioactivity of Polyphyllin I on inhibiting JAK2/STAT3 signaling pathway. The anti-proliferation activity of ... ...

Abstract	Background: Polyphyllin I, a bioactive phytochemical extracted from Methods: Dual-luciferase reporter assay was performed to test the bioactivity of Polyphyllin I on inhibiting JAK2/STAT3 signaling pathway. The anti-proliferation activity of Polyphyllin I was tested using cell clone formation assay. The effect of Polyphyllin I on cell cycle and apoptosis were confirmed by flow cytometry and TUNEL assay. Western blot was used to test the effect of Polyphyllin I on JAK/STAT3 pathway and apoptosis related proteins. The subcutaneous GC mouse model was established to examine whether polyphyllin I could inhibit GC growth Results: A dual-luciferase reporter assay showed that polyphyllin I could inhibit the activity of Bcl-2 which is downstream of JAK2/STA3. Polyphyllin I significantly inhibited GC cell proliferation and induced cell apoptosis in a dose-dependent manner. The western blot results indicated that polyphyllin I mainly inhibited the phosphorylation of STAT3 by the way which is different from AG490. It was inferred that polyphyllin I may inhibit the JAK2/STAT3 pathway and affect the expression level of apoptosis related genes. Finally, in the tumor xenograft experiment proved that polyphyllin I significantly inhibited the growth of GC Conclusions: Polyphyllin I may play its anticancer activity by inhibiting phosphorylation of STAT3 in GC cells.
Language	English
Publishing date	2022-01-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-20-66
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Article ; Online: CHCHD2 Regulates Mitochondrial Function and Apoptosis of Ectopic Endometrial Stromal Cells in the Pathogenesis of Endometriosis.

Ren, Yanqing / Wang, Xinru / Guo, Jinyu / Wang, Di / Li, Xinhua / Cheng, Xiumei / Wang, Xinguo

Reproductive sciences (Thousand Oaks, Calif.)

2022 Volume 29, Issue 8, Page(s) 2152–2164

Abstract: Endometriosis is a disease that involves dysfunction of mitochondria, imbalance of proliferation, and apoptosis. Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) is a major mitochondrial protein which could regulate the mitochondrial ... ...

Abstract	Endometriosis is a disease that involves dysfunction of mitochondria, imbalance of proliferation, and apoptosis. Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) is a major mitochondrial protein which could regulate the mitochondrial function and apoptosis in various tumor cells, promote migration and then lead to tumor progression. This study aimed to explore the role of CHCHD2 on endometriosis. We investigated the expression of CHCHD2 in ectopic and eutopic endometrium tissues of patients with endometriosis and normal endometrium tissues. Furthermore, CHCHD2 was downregulated to explore the corresponding change of mitochondrial function and morphology, mitochondrial-mediated apoptosis pathway, and proliferation and migration of ectopic endometrial stromal cells. Our results demonstrated that the mRNA and protein expression levels of CHCHD2 were significantly increased in eutopic and ectopic endometrium tissues compared with the normal endometrium tissues. The knockdown of CHCHD2 could cause mitochondrial dysfunction, including the opening of mitochondrial permeability transition pore, loss of mitochondrial membrane potential and the release of cytochrome c, and morphological damage. In addition, CHCHD2 down-expression could also lead to inhibition of cell proliferation, decrease of migration ability, and aggravation of mitochondrial-mediated apoptosis. Together, these findings suggest that increased expression of CHCHD2 in endometriotic tissues may contribute to the pathogenesis of endometriosis via regulating mitochondrial function and apoptosis, and CHCHD2 may be a potential target for interrupting the development of endometriosis.
MeSH term(s)	Apoptosis/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Endometriosis/metabolism ; Endometrium/metabolism ; Female ; Humans ; Mitochondria/metabolism ; Stromal Cells/metabolism ; Transcription Factors/metabolism
Chemical Substances	CHCHD2 protein, human ; DNA-Binding Proteins ; Transcription Factors
Language	English
Publishing date	2022-02-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-021-00831-9
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