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Article: Effects of exogenous melatonin on the osmotic regulation and antioxidant capacity of

Zhou, Dan / Li, Hai-Yan / Wang, Xiu-Jun / Li, Qing-Wei

Ying yong sheng tai xue bao = The journal of applied ecology

2024 Volume 35, Issue 2, Page(s) 431–438

Abstract: We investigated the effects of exogenous melatonin on the osmotic regulation and antioxidant capacity of 4-year- ... ...

Title translation	外源褪黑素对盐胁迫下银杏幼苗渗透调节和抗氧化能力的影响.
Abstract	We investigated the effects of exogenous melatonin on the osmotic regulation and antioxidant capacity of 4-year-old
MeSH term(s)	Antioxidants ; Melatonin/pharmacology ; Seedlings ; Ginkgo biloba ; Sodium Chloride/pharmacology ; Salt Tolerance ; Salt Stress ; Electrolytes/pharmacology ; Superoxide Dismutase ; Flavonoids/pharmacology
Chemical Substances	Antioxidants ; Melatonin (JL5DK93RCL) ; Sodium Chloride (451W47IQ8X) ; Electrolytes ; Superoxide Dismutase (EC 1.15.1.1) ; Flavonoids
Language	English
Publishing date	2024-03-24
Publishing country	China
Document type	Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202402.001
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Article ; Online: Dysfunction of Nrf2-regulated cellular defence system and JNK activation induced by high dose of fly Ash particles are associated with pulmonary injury in mouse lungs.

Zhang, Jingwen / Liu, Kaihua / Tang, Xiuwen / Wang, Xiu Jun

Ecotoxicology and environmental safety

2024 Volume 275, Page(s) 116239

Abstract: The mechanisms of the exposure to fine particulate matter (PM) as a risk factor for pulmonary injury are not fully understood. The transcription factor, NF-E2-related factor 2 (Nrf2), plays a key role in protection lung against PM insult and cancer ... ...

Abstract	The mechanisms of the exposure to fine particulate matter (PM) as a risk factor for pulmonary injury are not fully understood. The transcription factor, NF-E2-related factor 2 (Nrf2), plays a key role in protection lung against PM insult and cancer chemoprevention. In this study, F3-S fly ash particles from a municipal waste incinerator were evaluated as a PM model. We found that F3-S triggered hierarchical oxidative stress responses involving the prolonged activation of the cytoprotective Nrf2 transcriptional program via Keap1 Cys
MeSH term(s)	Animals ; Mice ; Coal Ash/toxicity ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; Lung Injury ; Oxidative Stress ; Lung/metabolism
Chemical Substances	Coal Ash ; NF-E2-Related Factor 2 ; Kelch-Like ECH-Associated Protein 1
Language	English
Publishing date	2024-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.116239
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Article ; Online: REPLY.

Tang, Xiuwen / Wang, Xiu Jun

Hepatology (Baltimore, Md.)

2020 Volume 73, Issue 1, Page(s) 468–469

MeSH term(s)	Carcinoma, Hepatocellular ; Guanine/analogs & derivatives ; Hepatitis B virus ; Humans ; Liver Neoplasms ; Neoplasm Recurrence, Local ; Tenofovir
Chemical Substances	entecavir (5968Y6H45M) ; Guanine (5Z93L87A1R) ; Tenofovir (99YXE507IL)
Language	English
Publishing date	2020-12-07
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.31441
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Article ; Online: Survey and analysis of willingness to use mobile medical services and influencing factors of TB patients treated at home.

Chen, Xiao-Feng / Nie, Fei-Fei / Jiao, Xiao-Ke / Lv, Chen / Sun, Juan / Wang, Xiu-Jun / Wang, Xiu-Hua / Zhang, Ning

Journal of infection in developing countries

2023 Volume 17, Issue 12, Page(s) 1761–1768

Abstract: Introduction: The objective of this study was to investigate the willingness of patients with tuberculosis (TB) to use mobile medical services (mHealth) and its influencing factors, so as to provide theoretical guidance for optimizing the TB mobile ... ...

Abstract	Introduction: The objective of this study was to investigate the willingness of patients with tuberculosis (TB) to use mobile medical services (mHealth) and its influencing factors, so as to provide theoretical guidance for optimizing the TB mobile medical platform and improve the willingness of patients to use mHealth. Methodology: In this cross-sectional study, convenience sampling method was used to investigate patients with TB from the outpatient clinics of two TB specialized hospitals (Beijing Thoracic Tumor and Tuberculosis Hospital and Tuberculosis Prevention and Treatment Hospital of Shaanxi Province) from January to June 2021 using a self-designed questionnaire. Results: Out of 231 patients, only 90 (38.96%) were aware of mHealth services, and 63 (27.27%) had used mHealth services. Among the 63 patients who had used mHealth services, the proportion of mobile medical forms based on WeChat platform was 74.89%. Patients' willingness to use mHealth was scored (11.49 ± 2.53). Univariate analysis showed that the scores of patients' willingness to use mHealth differed by gender and the different ways of affording healthcare (p < 0.05). Regression analysis showed that the influencing factors of willingness to use mHealth in patients with TB included attitude towards use (0.750), health beliefs (0.091) and social impact (0.169) (adjusted R2 = 0.781, p < 0.001). Conclusions: Patients' awareness of the advantages of the new medical model needs to be improved. Optimized design can improve the willingness of patients to use mHealth services and improve the role of mHealth in patient management.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Tuberculosis/drug therapy ; Tuberculosis/prevention & control ; Telemedicine ; Ambulatory Care Facilities ; Surveys and Questionnaires
Language	English
Publishing date	2023-12-31
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.17831
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Article ; Online: Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice.

Hammad, Ahmed / Zheng, Zhao-Hong / Namani, Akhileshwar / Elshaer, Mohamed / Wang, Xiu Jun / Tang, Xiuwen

BMC cancer

2021 Volume 21, Issue 1, Page(s) 607

Abstract: Background: The nuclear phosphatase mitogen-activate protein kinase phosphatase-1 (MKP-1) is a key negative regulator of the innate immune response through the regulation of the biosynthesis of proinflammatory cytokines. In colorectal cancer (CRC), ... ...

Abstract	Background: The nuclear phosphatase mitogen-activate protein kinase phosphatase-1 (MKP-1) is a key negative regulator of the innate immune response through the regulation of the biosynthesis of proinflammatory cytokines. In colorectal cancer (CRC), which is induced mainly by chronic inflammation, Mkp-1 overexpression was found in addition to disturbances in Mkp-1 functions, which may play a role in cancer development in different types of tumors. However, the potential molecular mechanisms by which Mkp-1 influences CRC development is not clear. Here, we performed global gene expression profiling of Mkp-1 KO mice using RNA sequencing (RNA-seq) to explore the role of Mkp-1 in CRC progression using transcriptome analysis. Methods: Azoxymethane/dextran sodium sulfate (AOM/DSS) mouse models were used to examine the most dramatic molecular and signaling changes that occur during different phases of CRC development in wild-type mice and Mkp-1 KO mice. Comprehensive bioinformatics analyses were used to elucidate the molecular processes regulated by Mkp-1. Differentially expressed genes (DEGs) were identified and functionally analyzed by Gene Ontology (GO), Kyoto Enrichment of Genes and Genomes (KEGG). Then, protein-protein interaction (PPI) network analysis was conducted using the STRING database and Cytoscape software. Results: Persistent DEGs were different in adenoma and carcinoma stage (238 & 251, respectively) and in WT and MKp-1 KO mice (221& 196, respectively). Mkp-1 KO modulated key molecular processes typically activated in cancer, in particular, cell adhesion, ion transport, extracellular matrix organization, response to drug, response to hypoxia, and response to toxic substance. It was obvious that these pathways are closely associated with cancer development and metastasis. From the PPI network analyses, nine hub genes associated with CRC were identified. Conclusion: These findings suggest that MKp-1 and its hub genes may play a critical role in cancer development, prognosis, and determining treatment outcomes. We provide clues to build a potential link between Mkp-1 and colitis-associated tumorigenesis and identify areas requiring further investigation.
MeSH term(s)	Animals ; Azoxymethane/administration & dosage ; Azoxymethane/toxicity ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinogenesis/genetics ; Colitis/chemically induced ; Colitis/complications ; Colitis/immunology ; Colitis/pathology ; Colitis-Associated Neoplasms/genetics ; Colitis-Associated Neoplasms/immunology ; Colitis-Associated Neoplasms/pathology ; Computational Biology ; Dextran Sulfate/administration & dosage ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Dual Specificity Phosphatase 1/genetics ; Dual Specificity Phosphatase 1/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Knockout ; Prognosis ; Protein Interaction Mapping ; Protein Interaction Maps/genetics ; RNA-Seq ; Signal Transduction/genetics
Chemical Substances	Biomarkers, Tumor ; Dextran Sulfate (9042-14-2) ; Dual Specificity Phosphatase 1 (EC 3.1.3.48) ; Dusp1 protein, mouse (EC 3.1.3.48) ; Azoxymethane (MO0N1J0SEN)
Language	English
Publishing date	2021-05-25
Publishing country	England
Document type	Journal Article
ISSN	1471-2407
ISSN (online)	1471-2407
DOI	10.1186/s12885-021-08200-0
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Article: Systematic Identification of Multi Omics-based Biomarkers in

Namani, Akhileshwar / Zheng, Zhaohong / Wang, Xiu Jun / Tang, Xiuwen

Journal of Cancer

2019 Volume 10, Issue 27, Page(s) 6813–6821

Abstract: Mutations ... ...

Abstract	Mutations in
Language	English
Publishing date	2019-11-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.35489
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Article ; Online: Integrated data analysis reveals significant associations of

Elshaer, Mohamed / ElManawy, Ahmed Islam / Hammad, Ahmed / Namani, Akhileshwar / Wang, Xiu Jun / Tang, Xiuwen

Aging

2020 Volume 12, Issue 8, Page(s) 7183–7206

Abstract: ... ...

Abstract	KEAP1
MeSH term(s)	Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/pathology ; Cell Line, Tumor ; DNA Methylation ; DNA Mutational Analysis ; DNA, Neoplasm/genetics ; DNA, Neoplasm/metabolism ; Female ; Humans ; Kelch-Like ECH-Associated Protein 1/biosynthesis ; Kelch-Like ECH-Associated Protein 1/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Mutation ; Prognosis ; Signal Transduction
Chemical Substances	DNA, Neoplasm ; KEAP1 protein, human ; Kelch-Like ECH-Associated Protein 1
Language	English
Publishing date	2020-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.103068
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Article ; Online: NRF2 has a splicing regulatory function involving the survival of motor neuron (SMN) in non-small cell lung cancer.

Cui, Qinqin / Wang, Wei / Namani, Akhileshwar / Wang, Hongyan / Hammad, Ahmed / Huang, Pu / Gao, Yang / Elshaer, Mohamed / Wu, Yihe / Wang, Xiu Jun / Tang, Xiuwen

Oncogene

2023 Volume 42, Issue 37, Page(s) 2751–2763

Abstract: The nuclear factor erythroid 2-like 2 (NFE2L2; NRF2) signaling pathway is frequently deregulated in human cancers. The critical functions of NRF2, other than its transcriptional activation, in cancers remain largely unknown. Here, we uncovered a ... ...

Abstract	The nuclear factor erythroid 2-like 2 (NFE2L2; NRF2) signaling pathway is frequently deregulated in human cancers. The critical functions of NRF2, other than its transcriptional activation, in cancers remain largely unknown. Here, we uncovered a previously unrecognized role of NRF2 in the regulation of RNA splicing. Global splicing analysis revealed that NRF2 knockdown in non-small cell lung cancer (NSCLC) A549 cells altered 839 alternative splicing (AS) events in 485 genes. Mechanistic studies demonstrated that NRF2 transcriptionally regulated SMN mRNA expression by binding to two antioxidant response elements in the SMN1 promoter. Post-transcriptionally, NRF2 was physically associated with the SMN protein. The Neh2 domain of NRF2, as well as the YG box and the region encoded by exon 7 of SMN, were required for their interaction. NRF2 formed a complex with SMN and Gemin2 in nuclear gems and Cajal bodies. Furthermore, the NRF2-SMN interaction regulated RNA splicing by expressing SMN in NRF2-knockout HeLa cells, reverting some of the altered RNA splicing. Moreover, SMN overexpression was significantly associated with alterations in the NRF2 pathway in patients with lung squamous cell carcinoma from The Cancer Genome Atlas. Taken together, our findings suggest a novel therapeutic strategy for cancers involving an aberrant NRF2 pathway.
MeSH term(s)	Humans ; HeLa Cells ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; SMN Complex Proteins/genetics ; SMN Complex Proteins/metabolism ; RNA-Binding Proteins/genetics ; Muscular Atrophy, Spinal/genetics ; Muscular Atrophy, Spinal/metabolism ; Muscular Atrophy, Spinal/therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Motor Neurons/metabolism ; RNA Splicing/genetics ; Cyclic AMP Response Element-Binding Protein/metabolism
Chemical Substances	NF-E2-Related Factor 2 ; SMN Complex Proteins ; RNA-Binding Proteins ; Cyclic AMP Response Element-Binding Protein
Language	English
Publishing date	2023-08-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-023-02799-z
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Zs.A 2218: Show issues

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Article ; Online: Resveratrol: An overview of its anti-cancer mechanisms.

Elshaer, Mohamed / Chen, Yeru / Wang, Xiu Jun / Tang, Xiuwen

Life sciences

2018 Volume 207, Page(s) 340–349

Abstract: Cancer is one of the leading causes of death worldwide. Chemotherapy and radiotherapy are the conventional primary treatments for cancer patients. However, most of cancer cells develop resistance to both chemotherapy and radiotherapy after a period of ... ...

Abstract	Cancer is one of the leading causes of death worldwide. Chemotherapy and radiotherapy are the conventional primary treatments for cancer patients. However, most of cancer cells develop resistance to both chemotherapy and radiotherapy after a period of treatment, besides their lethal side-effects. This motivated investigators to seek more effective alternatives with fewer side-effects. In the last few years, resveratrol, a natural polyphenolic phytoalexin, has attracted much attention due to its wide biological effects. In this concise review, we highlight the role of resveratrol in the prevention and therapy of cancer with particular focus on colorectal and skin cancer. Also, we discuss the molecular mechanisms underlying its chemopreventive and therapeutic activity. Finally, we highlight the problems associated with the clinical application of resveratrol and how attempts have been made to overcome these drawbacks.
MeSH term(s)	Animals ; Anticarcinogenic Agents/pharmacokinetics ; Anticarcinogenic Agents/therapeutic use ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Autophagy ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/prevention & control ; Cyclooxygenase Inhibitors/pharmacokinetics ; Cyclooxygenase Inhibitors/therapeutic use ; Female ; Humans ; Inflammasomes ; Male ; Mice ; NF-E2-Related Factor 2/metabolism ; Neoplasm Metastasis ; Rats ; Sesquiterpenes ; Skin Neoplasms/drug therapy ; Skin Neoplasms/prevention & control ; Stilbenes/pharmacokinetics ; Stilbenes/therapeutic use
Chemical Substances	Anticarcinogenic Agents ; Antineoplastic Agents ; Cyclooxygenase Inhibitors ; Inflammasomes ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Sesquiterpenes ; Stilbenes ; phytoalexins (37297-20-4) ; resveratrol (Q369O8926L)
Language	English
Publishing date	2018-06-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2018.06.028
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Article ; Online: Synthetic Imine Resveratrol Analog 2-Methoxyl-3,6-Dihydroxyl-IRA Ameliorates Colitis by Activating Protective Nrf2 Pathway and Inhibiting NLRP3 Expression.

Chen, Yeru / Zheng, Zhaohong / Li, Chang / Pan, Yuanjiang / Tang, Xiuwen / Wang, Xiu Jun

Oxidative medicine and cellular longevity

2019 Volume 2019, Page(s) 7180284

Abstract: Resveratrol (RSV) is a naturally occurring polyphenol that exhibits pleiotropic health benefits, including anticolitis and colon cancer-protective activity. Recently, we identified the novel imine RSV analog (IRA), 2-methoxyl-3,6-dihydroxyl-IRA 3,4,5,4- ... ...

Abstract	Resveratrol (RSV) is a naturally occurring polyphenol that exhibits pleiotropic health benefits, including anticolitis and colon cancer-protective activity. Recently, we identified the novel imine RSV analog (IRA), 2-methoxyl-3,6-dihydroxyl-IRA 3,4,5,4-tetramethoxystilbene (C33), as a putative activator of nuclear factor erythroid 2-related factor 2 (Nrf2). The present study was designed to evaluate the ability of C33 to activate the Nrf2 signaling pathway and its anticolitis effect in comparison to RSV. The anticolitis action of C33 was assessed in a mouse model of colitis induced by dextran sulfate sodium (DSS). The effect of C33 on the Nrf2 signaling pathway was examined
MeSH term(s)	Animals ; Cell Line ; Colitis/chemically induced ; Dextran Sulfate ; Disease Models, Animal ; Down-Regulation ; Humans ; Imines/chemical synthesis ; Imines/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Resveratrol/analogs & derivatives ; Resveratrol/chemical synthesis ; Resveratrol/therapeutic use ; Signal Transduction
Chemical Substances	Imines ; NF-E2-Related Factor 2 ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nfe2l2 protein, mouse ; Nlrp3 protein, mouse ; Dextran Sulfate (9042-14-2) ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2019-11-21
Publishing country	United States
Document type	Journal Article
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2019/7180284
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