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  1. Article ; Online: From Translation to Treatment.

    Wang, Xuemin / Proud, Christopher G

    Faculty reviews

    2023  Volume 12, Page(s) 9

    Abstract: Protein synthesis (mRNA translation) plays a crucial role in cell function by shaping the proteome -making all the proteins each cell requires at the right time and in the right quantities and places. Proteins carry out almost every job in the cell. ... ...

    Abstract Protein synthesis (mRNA translation) plays a crucial role in cell function by shaping the proteome -making all the proteins each cell requires at the right time and in the right quantities and places. Proteins carry out almost every job in the cell. Protein synthesis is also a major component of the cellular economy, using large amounts of metabolic energy and resources, especially amino acids. Accordingly, it is tightly regulated through diverse mechanisms which respond, for example, to nutrients, growth factors, hormones, neurotransmitters and stressful situations.
    Language English
    Publishing date 2023-04-28
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/12-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Genome-wide analysis and expression of the aquaporin gene family in

    Zhou, Xinyue / Yi, Dengxia / Ma, Lin / Wang, Xuemin

    Frontiers in plant science

    2024  Volume 14, Page(s) 1305299

    Abstract: Background: Oat (: Methods: In this study, AQP genes (: Results: In this study, a total of 45 AQP genes (: Conclusion: The findings of this study provide a comprehensive list of members and their sequence characteristics of ... ...

    Abstract Background: Oat (
    Methods: In this study, AQP genes (
    Results: In this study, a total of 45 AQP genes (
    Conclusion: The findings of this study provide a comprehensive list of members and their sequence characteristics of the
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1305299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Identification of Arabidopsis phospholipase Ds involved in circadian clock alterations using CRISPR/Cas9-based multiplex editing.

    Kim, Sang-Chul / Nusinow, Dmitri A / Wang, Xuemin

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Reciprocal regulation between circadian clock and lipid metabolism is emerging, but its mechanistic details remain elusive in plants. We previously reported that a lipid metabolite phosphatidic acid (PA) bound to the core clock transcription factors LATE ...

    Abstract Reciprocal regulation between circadian clock and lipid metabolism is emerging, but its mechanistic details remain elusive in plants. We previously reported that a lipid metabolite phosphatidic acid (PA) bound to the core clock transcription factors LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and chemical suppression of phospholipase D (PLD)-catalyzed PA formation perturbed the clock in Arabidopsis. Here, we investigated to identify, among 12 isoforms, specific PLD(s) important to the regulation of clock function. We generated a library of Arabidopsis plants bearing
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.09.574824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors.

    Wang, Xuemin / Proud, Christopher G

    The Biochemical journal

    2022  Volume 479, Issue 10, Page(s) 1059–1082

    Abstract: Control of protein synthesis (mRNA translation) plays key roles in shaping the proteome and in many physiological, including homeostatic, responses. One long-known translational control mechanism involves phosphorylation of initiation factor, eIF2, which ...

    Abstract Control of protein synthesis (mRNA translation) plays key roles in shaping the proteome and in many physiological, including homeostatic, responses. One long-known translational control mechanism involves phosphorylation of initiation factor, eIF2, which is catalysed by any one of four protein kinases, which are generally activated in response to stresses. They form a key arm of the integrated stress response (ISR). Phosphorylated eIF2 inhibits eIF2B (the protein that promotes exchange of eIF2-bound GDP for GTP) and thus impairs general protein synthesis. However, this mechanism actually promotes translation of certain mRNAs by virtue of specific features they possess. Recent work has uncovered many previously unknown features of this regulatory system. Several studies have yielded crucial insights into the structure and control of eIF2, including that eIF2B is regulated by several metabolites. Recent studies also reveal that control of eIF2 and the ISR helps determine organismal lifespan and surprising roles in sensing mitochondrial stresses and in controlling the mammalian target of rapamycin (mTOR). The latter effect involves an unexpected role for one of the eIF2 kinases, HRI. Phosphoproteomic analysis identified new substrates for another eIF2 kinase, Gcn2, which senses the availability of amino acids. Several genetic disorders arise from mutations in genes for eIF2α kinases or eIF2B (i.e. vanishing white matter disease, VWM and microcephaly, epileptic seizures, microcephaly, hypogenitalism, diabetes and obesity, MEHMO). Furthermore, the eIF2-mediated ISR plays roles in cognitive decline associated with Alzheimer's disease. New findings suggest potential therapeutic value in interfering with the ISR in certain settings, including VWM, for example by using compounds that promote eIF2B activity.
    MeSH term(s) Eukaryotic Initiation Factor-2/metabolism ; Eukaryotic Initiation Factor-2B/chemistry ; Eukaryotic Initiation Factor-2B/genetics ; Eukaryotic Initiation Factor-2B/metabolism ; Humans ; Microcephaly ; Phosphorylation ; eIF-2 Kinase/metabolism
    Chemical Substances Eukaryotic Initiation Factor-2 ; Eukaryotic Initiation Factor-2B ; eIF-2 Kinase (EC 2.7.11.1)
    Language English
    Publishing date 2022-04-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20220068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Monitoring lipid-protein interactions in planta using Förster resonance energy transfer.

    Yao, Shuaibing / Wang, Xuemin

    Methods in enzymology

    2022  Volume 683, Page(s) 243–252

    Abstract: Phospholipids are not only the major structural components of cellular membranes but also important signaling molecules regulating various cellular and physiological processes. One mode of action by lipid mediators is via lipid-protein interactions to ... ...

    Abstract Phospholipids are not only the major structural components of cellular membranes but also important signaling molecules regulating various cellular and physiological processes. One mode of action by lipid mediators is via lipid-protein interactions to modulate the downstream cellular events. An increasing number of lipid-binding proteins have been identified using in vitro lipid-protein binding assays, but it has been challenging to monitor lipid-protein interactions in vivo. Here we describe one Förster resonance energy transfer (FRET)-based method using the cyan fluorescence protein (CFP)-tagged protein cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPC) and TopFluor TMR-labeled lipid phosphatidic acid (PA) to monitor the lipid-protein interaction in planta. This approach permits detection of the subcellular localization of lipid-protein interactions and dynamics of the interactions in planta in response to different cues.
    MeSH term(s) Fluorescence Resonance Energy Transfer/methods ; Signal Transduction ; Protein Binding ; Cell Membrane/metabolism ; Lipids
    Chemical Substances Lipids
    Language English
    Publishing date 2022-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2022.08.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The "Hand as Foot" teaching method in the radiographic presentation and clinical treatment of bleeding for cirrhotic portal hypertension.

    Han, Xin-Qiang / Wang, Xue-Min

    Asian journal of surgery

    2022  Volume 46, Issue 2, Page(s) 1029–1030

    MeSH term(s) Humans ; Hypertension, Portal/complications ; Hypertension, Portal/diagnostic imaging ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnostic imaging ; Hemorrhage ; Gastrointestinal Hemorrhage
    Language English
    Publishing date 2022-08-08
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.07.099
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  7. Article ; Online: Lipid phosphorylation by a diacylglycerol kinase suppresses ABA biosynthesis to regulate plant stress responses.

    Li, Jianwu / Yao, Shuaibing / Kim, Sang-Chul / Wang, Xuemin

    Molecular plant

    2024  Volume 17, Issue 2, Page(s) 342–358

    Abstract: Lipid phosphorylation by diacylglycerol kinase (DGK) that produces phosphatidic acid (PA) plays important roles in various biological processes, including stress responses, but the underlying mechanisms remain elusive. Here, we show that DGK5 and its ... ...

    Abstract Lipid phosphorylation by diacylglycerol kinase (DGK) that produces phosphatidic acid (PA) plays important roles in various biological processes, including stress responses, but the underlying mechanisms remain elusive. Here, we show that DGK5 and its lipid product PA suppress ABA biosynthesis by interacting with ABA-DEFICIENT 2 (ABA2), a key ABA biosynthesis enzyme, to negatively modulate plant response to abiotic stress tested in Arabidopsis thaliana. Loss of DGK5 function rendered plants less damaged, whereas overexpression (OE) of DGK5 enhanced plant damage to water and salt stress. The dgk5 mutant plants exhibited decreased total cellular and nuclear levels of PA with increased levels of diacylglycerol, whereas DGK5-OE plants displayed the opposite effect. Interestingly, we found that both DGK5 and PA bind to the ABA-synthesizing enzyme ABA2 and suppress its enzymatic activity. Consistently, the dgk5 mutant plants exhibited increased levels of ABA, while DGK5-OE plants showed reduced ABA levels. In addition, we showed that both DGK5 and ABA2 are detected in and outside the nuclei, and loss of DGK5 function decreased the nuclear association of ABA2. We found that both DGK5 activity and PA promote nuclear association of ABA2. Taken together, these results indicate that both DGK5 and PA interact with ABA2 to inhibit its enzymatic activity and promote its nuclear sequestration, thereby suppressing ABA production in response to abiotic stress. Our study reveals a sophisticated mechanism by which DGK5 and PA regulate plant stress responses.
    MeSH term(s) Arabidopsis Proteins/metabolism ; Diacylglycerol Kinase/metabolism ; Abscisic Acid/metabolism ; Phosphorylation ; Arabidopsis/metabolism ; Lipids ; Gene Expression Regulation, Plant
    Chemical Substances Arabidopsis Proteins ; Diacylglycerol Kinase (EC 2.7.1.107) ; Abscisic Acid (72S9A8J5GW) ; Lipids
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2024.01.003
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  8. Article ; Online: MicroRNA-30b-5p inhibits autophagy in ovarian granulosa cells in polycystic ovary syndrome rats by targeting Atg5

    WANG Xuemin / WANG Yanan / NIU Aiqin / YE Ying / LI Fei

    Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 43, Iss 1, Pp 20-

    2023  Volume 28

    Abstract: Objective·To explore the expression of microRNA-30b-5p (miR-30b-5p) in polycystic ovary syndrome (PCOS) rats and the effect of miR-30b-5p overexpression on ovarian granulosa cell (GC) autophagy.Methods·Dehydroepiandrosterone (DHEA) was performed to ... ...

    Abstract Objective·To explore the expression of microRNA-30b-5p (miR-30b-5p) in polycystic ovary syndrome (PCOS) rats and the effect of miR-30b-5p overexpression on ovarian granulosa cell (GC) autophagy.Methods·Dehydroepiandrosterone (DHEA) was performed to establish a PCOS rat model, and real-time fluorescent quantitative PCR (qRT-PCR) and Western blotting were performed to measure the expression of miR-30b-5p and autophagy-associated protein 5 homologue (Atg5) in the ovarian tissues of the normal group and PCOS group. Primary PCOS rat ovarian GCs were isolated and cultured, and divided into control group, miR-NC group, miR-30b-5p overexpression group, miR-30b-5p overexpression+pcDNA3.1-NC group, and miR-30b-5p overexpression+pcDNA3.1-Atg5 group. In addition, the ovarian GC of the normal group was taken as the blank group. MiR-30b-5p mimic, pcDNA3.1-Atg5 and the corresponding negative control were transfected into the cells, and 48 h after transfection, qRT-PCR was performed to measure the expression of miR-30b-5p and Atg5 mRNA of cells in each group to verify the transfection effect. CCK-8 and flow cytometer were performed to measure cell viability and apoptosis rate, respectively; immunofluorescence staining was performed to measure the positive expression of microtubule-associated protein 1 light chain 3 (LC3) in each group. Western blotting was performed to measure the protein expression of autophagy-related proteins Atg5, p62, Beclin-1 and LC3.Results·The expression level of miR-30b-5p in the ovarian tissue of the PCOS group was significantly lower than that of the normal group, and the levels of Atg5 mRNA and protein were significantly higher than those of the normal group (all P=0.000). After transfection, compared with the blank group, the miR-30b-5p level, apoptosis rate, and p62 protein level in the ovarian GC of the control group were significantly reduced, the Atg5 mRNA and protein levels, cell proliferation activity, LC3 positive cell percentage, Beclin-1 protein level and LC3Ⅱ/LC3Ⅰ ratio were significantly ...
    Keywords polycystic ovary syndrome ; microrna-30b-5p ; autophagy ; autophagy-associated protein 5 homologue(atg5) ; proliferation ; apoptosis ; Medicine ; R
    Subject code 500 ; 571
    Language Chinese
    Publishing date 2023-01-01T00:00:00Z
    Publisher Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study.

    Wang, Xuemin / Glubb, Dylan M / O'Mara, Tracy A

    Nutrients

    2023  Volume 15, Issue 3

    Abstract: Given the strong association between obesity and endometrial cancer risk, dietary factors may play an important role in the development of this cancer. However, observational studies of micro- and macronutrients and their role in endometrial cancer risk ... ...

    Abstract Given the strong association between obesity and endometrial cancer risk, dietary factors may play an important role in the development of this cancer. However, observational studies of micro- and macronutrients and their role in endometrial cancer risk have been inconsistent. Clarifying these relationships are important to develop nutritional recommendations for cancer prevention. We performed two-sample Mendelian randomization (MR) to investigate the effects of circulating levels of 15 micronutrients (vitamin A (retinol), folate, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, β-carotene, calcium, copper, iron, magnesium, phosphorus, selenium, and zinc) as well as corrected relative macronutrient intake (protein, carbohydrate, sugar and fat) on risks of endometrial cancer and its subtypes (endometrioid and non-endometrioid histologies). Genetically predicted vitamin C levels were found to be strongly associated with endometrial cancer risk. There was some evidence that genetically predicted relative intake of macronutrients (carbohydrate, sugar and fat) affects endometrial cancer risk. No other significant association were observed. Conclusions: In summary, these findings suggest that vitamin C and macronutrients influence endometrial cancer risk but further investigation is required.
    MeSH term(s) Female ; Humans ; Mendelian Randomization Analysis ; Vitamins ; Ascorbic Acid ; Endometrial Neoplasms/etiology ; Endometrial Neoplasms/genetics ; Sugars ; Risk Factors
    Chemical Substances Vitamins ; Ascorbic Acid (PQ6CK8PD0R) ; Sugars
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15030603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Construction of core-shell CoSe

    Xie, Yuhan / Dong, Boyu / Wang, Xuemin / Wang, Siyuan / Chen, Jinxi / Lou, Yongbing

    Dalton transactions (Cambridge, England : 2003)

    2024  Volume 53, Issue 2, Page(s) 675–683

    Abstract: The use of photocatalysts based on semiconductor heterostructures for hydrogen evolution is a prospective tactic for converting solar energy. Herein, visible-light-responsive three-dimensional core-shell ... ...

    Abstract The use of photocatalysts based on semiconductor heterostructures for hydrogen evolution is a prospective tactic for converting solar energy. Herein, visible-light-responsive three-dimensional core-shell CoSe
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt03379a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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