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Article ; Online: Determinants of ecological and carbon footprints to assess the framework of environmental sustainability in BRICS countries: A panel ARDL and causality estimation model.

Wang, XuGuang

2021 Volume 197, Page(s) 111111

Abstract: The purpose of the present study is to evaluate the effects of financial development, human capital, globalization, and renewable energy consumption on ecological and carbon footprint. For this purpose, the data was collected from four countries i.e. ... ...

Abstract	The purpose of the present study is to evaluate the effects of financial development, human capital, globalization, and renewable energy consumption on ecological and carbon footprint. For this purpose, the data was collected from four countries i.e. Brazil, Russia, India, and China for 20 years (1997-2016). The 20 years panel data collected for these countries was analyzed through "auto-regressive distributed lag" (ARDL). Findings of this study reveal that human capital is a significant positive determinant of environmental degradation in short run and long run while renewable energy consumption is a significant negative determinant of environmental degradation in short run and long run. Findings further reveal that globalization significantly reduces environmental degradation in short run and long run. Furthermore, findings show that the financial development significantly positively affects the environmental degradation in short run and long run. Therefore, renewable energy consumption and globalization are found to be negative predictors of ecological footprint and carbon footprint while human capital and financial development are found to be positive predictors of ecological footprint and carbon footprint. These findings are expected to be great contribution to the literature and practice, as they will help researchers and policymakers to realize the relative importance of energy, educational, economic, and trade policies in determining the environmental degradation.
MeSH term(s)	Brazil ; Carbon ; Carbon Dioxide/analysis ; Carbon Footprint ; China ; Economic Development ; Humans ; India ; Renewable Energy ; Russia
Chemical Substances	Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
Language	English
Publishing date	2021-04-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2021.111111
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Article ; Online: An integrating strategy for systematic profiling of Chinese patent drug's chemicalome and associated metabolome: Huanghou antidiarrhea dropping pills as a case study.

Li, Li / Wang, Xuguang / Ma, Ruiting / Hou, Mingxing

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2024 Volume 1234, Page(s) 124029

Abstract: Huanghou antidiarrhea dropping pills (HADP) is an efficient Chinese patent drug that is clinically used to treat diarrhea. However, its functional materials remain unclear due to the characteristics of traditional Chinese medicine, which is a multi- ... ...

Abstract	Huanghou antidiarrhea dropping pills (HADP) is an efficient Chinese patent drug that is clinically used to treat diarrhea. However, its functional materials remain unclear due to the characteristics of traditional Chinese medicine, which is a multi-component and multi-target complex system. In this study, we investigated the intrinsic chemical components and combined with in vivo metabolism to reveal the functional material basis of HADP. Spectral behavior (accurate molecular weight and secondary fragmentation) and chromatographic behavior (retention time) were key criterions that throughout the whole research of components identification, prototypes screening, and tissue distribution. Mass defect filter (MDF), characteristic product ion filter (PIF), and neutral loss filter (NLF) were other three criterions for metabolites searching. Consequently, a total of 102 components in HADP, including alkaloids, lignans, lactones, gingerols, and alkaloid complexes were identified or tentatively characterized. About 39 metabolites that related to 37 prototypes were calculated and matched in bio-samples. Among them, 14 prototypes and 18 metabolites were detected distribution in colon, liver, heart, spleen, lung or kidney. This study provides a systematic investigation into the metabolism of HADP and offers effective analytical strategies for the characterization of compounds and metabolites in Chinese patent drugs.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Metabolome ; Medicine, Chinese Traditional ; Liver/metabolism ; Drugs, Chinese Herbal/chemistry
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2024.124029
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Article: Determinants of ecological and carbon footprints to assess the framework of environmental sustainability in BRICS countries: A panel ARDL and causality estimation model

Wang, XuGuang

Environmental research. 2021 June, v. 197

2021

Abstract	The purpose of the present study is to evaluate the effects of financial development, human capital, globalization, and renewable energy consumption on ecological and carbon footprint. For this purpose, the data was collected from four countries i.e. Brazil, Russia, India, and China for 20 years (1997–2016). The 20 years panel data collected for these countries was analyzed through “auto-regressive distributed lag” (ARDL). Findings of this study reveal that human capital is a significant positive determinant of environmental degradation in short run and long run while renewable energy consumption is a significant negative determinant of environmental degradation in short run and long run. Findings further reveal that globalization significantly reduces environmental degradation in short run and long run. Furthermore, findings show that the financial development significantly positively affects the environmental degradation in short run and long run. Therefore, renewable energy consumption and globalization are found to be negative predictors of ecological footprint and carbon footprint while human capital and financial development are found to be positive predictors of ecological footprint and carbon footprint. These findings are expected to be great contribution to the literature and practice, as they will help researchers and policymakers to realize the relative importance of energy, educational, economic, and trade policies in determining the environmental degradation.
Keywords	Russia ; carbon ; carbon footprint ; economic development ; energy ; environmental degradation ; globalization ; human capital ; models ; renewable energy sources ; research ; Brazil ; China ; India
Language	English
Dates of publication	2021-06
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2021.111111
Database	NAL-Catalogue (AGRICOLA)

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Article: PIPER adult comfort: an open-source full body human body model for seating comfort assessment and its validation under static loading conditions.

Liu, Shenghui / Beillas, Philippe / Ding, Li / Wang, Xuguang

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1170768

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1170768
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Article ; Online: Research progress on the correlation between gut microbiota and preeclampsia: microbiome changes, mechanisms and treatments.

Zong, Yichi / Wang, Xuguang / Wang, Jun

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1256940

Abstract: Preeclampsia is a specific disease during pregnancy and is a significant factor in the increased mortality in perinatal women. Gut microbiota, an intricate and abundant microbial community in the digestive tract, is crucial for host metabolism, immunity, ...

Abstract	Preeclampsia is a specific disease during pregnancy and is a significant factor in the increased mortality in perinatal women. Gut microbiota, an intricate and abundant microbial community in the digestive tract, is crucial for host metabolism, immunity, and nutrient absorption. The onset and progression of preeclampsia are closely correlated with the changes in maternal gut microbiota. Research purpose was to compile the existing bits of present scientific data and to close the gap in the knowledge of changes in gut microbiota in preeclampsia and their association with preeclampsia. We searched studies from two electronic databases (PubMed and Web of Science) included from 2014 to 2023. This review is divided into three parts. In the first part, the author elaborates longitudinal differences of maternal gut microbiota during different gestation periods. In the second part, we discuss that gut microbiota can lead to the occurrence of preeclampsia by systemic immune response, influencing the release of active peptides, short-chain fatty acids, trimethylamine-N-oxide (TMAO) and other metabolites, vascular factors and Microorganism-immune axis. In the third part, we proposed that a high-fiber diet combined with drugs and microecological regulators may be therapeutic in enhancing or preventing the emergence and evolution of preeclampsia, which needs further exploration. Although the pathogenesis of preeclampsia is still nebulous and there is no clear and valid clinical treatment, our study provides new ideas for the pathogenesis, prevention and treatment of preeclampsia.
MeSH term(s)	Pregnancy ; Humans ; Female ; Gastrointestinal Microbiome/physiology ; Pre-Eclampsia/therapy ; Microbiota ; Fatty Acids, Volatile
Chemical Substances	Fatty Acids, Volatile
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1256940
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Article ; Online: Effect of seat back angle on preferred seat pan inclination for the development of highly automated vehicles.

Wang, Xuguang / Grébonval, Cyrille / Beillas, Philippe

Ergonomics

2023 Volume 67, Issue 5, Page(s) 619–627

Abstract: Recent studies on occupants' safety in reclined positions suggest that a more inclined seat pan could be needed to reduce the occurrence of submarining. This study aimed to investigate whether a more inclined seat pan would also be comfortable for ... ...

Abstract	Recent studies on occupants' safety in reclined positions suggest that a more inclined seat pan could be needed to reduce the occurrence of submarining. This study aimed to investigate whether a more inclined seat pan would also be comfortable for occupants. Eighteen volunteers participated in the experiment. They were asked to self-select seat pan inclination for seat back angles from 20 to 60 degrees using a reconfigurable experimental seat from two initial seat pan angles (10 and 40 degrees from the horizontal). On average, preferred seat pan angle varied from 11.3(±2.1, standard deviation) to 29.9(±6.8), 12.5(±3.8) to 37.4(±3.7), and 12.8(±4.8) to 38.6(±2.7) degrees for seat pan angles of 20, 40, and 60 degrees respectively. The shear force analysis suggests that the seat pan inclination might be self-selected to reduce the forward shear, while a high inclination angle with a noticeable backward shear was also preferred.
MeSH term(s)	Humans ; Autonomous Vehicles ; Sitting Position ; Data Collection
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1920-3
ISSN	1366-5847 ; 0014-0139
ISSN (online)	1366-5847
ISSN	0014-0139
DOI	10.1080/00140139.2023.2236818
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Article ; Online: Promoting effects of calponin 3 on the growth of diffuse large B‑cell lymphoma cells.

Xing, Xiaojing / Liu, Meichen / Wang, Xuguang / Guo, Qianxue / Wang, Hongyue

Oncology reports

2023 Volume 49, Issue 2

Abstract: Diffuse large B‑cell lymphoma (DLBCL) is one of the most common types of lymphoma. Calponin 3 (CNN3) is a thin filament‑associated protein previously known to regulate smooth muscle contraction. Recent evidence illustrates its involvement in ... ...

Abstract	Diffuse large B‑cell lymphoma (DLBCL) is one of the most common types of lymphoma. Calponin 3 (CNN3) is a thin filament‑associated protein previously known to regulate smooth muscle contraction. Recent evidence illustrates its involvement in carcinogenesis; however, its roles in DLBCL remain unknown. CNN3 was found to be highly expressed in DLBCL specimens according to the online Gene Expression Profiling Interactive Analysis data. The aim of the present study was to investigate the roles of CNN3 in the progression of DLBCL.
MeSH term(s)	Animals ; Mice ; Cell Line, Tumor ; Mice, Nude ; Cell Proliferation/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Gene Expression Regulation, Neoplastic ; Calponins
Language	English
Publishing date	2023-01-20
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2023.8483
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Article ; Online: Ras interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells.

Xing, Xiaojing / Wang, Xuguang / Liu, Meichen / Guo, Qianxue / Wang, Hongyue

Cancer biology & therapy

2023 Volume 24, Issue 1, Page(s) 2193114

Abstract: A GTPase binding protein, Ras interacting protein 1 (RASIP1), has been reported with a tumor-promoting role in lung cancer cells, and its role in lymphoma remains unknown. The analysis of medical databank shows that RASIP1 is upregulated in diffuse large ...

Abstract	A GTPase binding protein, Ras interacting protein 1 (RASIP1), has been reported with a tumor-promoting role in lung cancer cells, and its role in lymphoma remains unknown. The analysis of medical databank shows that RASIP1 is upregulated in diffuse large B-cell lymphoma (DLBCL) specimens. In this article, we demonstrated that RASIP1 is highly expressed in DLBCL cell lines, compared with primary B cells. The gain- and loss-of-function experiments were performed to investigate the effects of RASIP1 on DLBCL cells. CCK-8, flow cytometry, western blot, and transwell assays demonstrated that silence of RASIP1 inhibited proliferation, cell cycle transition, and invasion and induced significant apoptosis in DLBCL cells, and ectopic expression of RASIP1 played opposite roles. Xenograft results revealed that RASIP1 facilitated the growth of DLBCL cells
MeSH term(s)	Humans ; Apoptosis ; Carrier Proteins/metabolism ; Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Lymphoma, Large B-Cell, Diffuse/pathology ; Intracellular Signaling Peptides and Proteins/metabolism
Chemical Substances	Carrier Proteins ; RASIP1 protein, human ; Intracellular Signaling Peptides and Proteins
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146305-0
ISSN	1555-8576 ; 1538-4047
ISSN (online)	1555-8576
ISSN	1538-4047
DOI	10.1080/15384047.2023.2193114
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Article ; Online: ZNF655 mediated by LINC01210/miR-124-3p axis promotes the progression of gastric cancer.

Bo, Wei / Wang, Xu-Guang / Zhang, Min / Zhang, Zhong

The Kaohsiung journal of medical sciences

2022 Volume 39, Issue 3, Page(s) 200–208

Abstract: Gastric cancer (GC) is a common malignant tumor that usually originates from the epithelium of the gastric mucosa. ZNF655 was a suppressor gene of many cancers. However, the mechanism of ZNF655 in GC remains unknown. Quantitative polymerase chain ... ...

Abstract	Gastric cancer (GC) is a common malignant tumor that usually originates from the epithelium of the gastric mucosa. ZNF655 was a suppressor gene of many cancers. However, the mechanism of ZNF655 in GC remains unknown. Quantitative polymerase chain reaction was used to assess the expression of ZNF655, LINC01210, and miR-124-3p. Western blotting was used to monitor ZNF655 protein expression. MTT, clone formation, transwell, and flow cytometry were all used to investigate the functions of GC cells. The interactions between ZNF655, LINC01210, and miR-124-3p were confirmed using the dual-luciferase reporter gene assay and the RIP assay. ZNF655 was highly expressed in GC cells. ZNF655 knockdown reduced GC cell viability, proliferation, migration, invasion, and induced apoptosis. The level of miR-124-3p was significantly reduced in GC cells. Besides, miR-124-3p targeted ZNF655 and inhibited its expression. MiR-124-3p mimics inhibited GC cell progression, but ZNF655 overexpression reversed these effects. Moreover, LINC01210 was found to be highly expressed in GC cells and to be able to sponge miR-124-3p. Furthermore, inhibiting miR-124-3p or increasing ZNF655 could counteract the effects of LINC01210 knockdown on GC cell development. Finally, ZNF655 promoted GC cell progression and was regulated by the LINC01210/miR-124-3p axis.
MeSH term(s)	Humans ; Apoptosis/genetics ; Blotting, Western ; Cell Differentiation ; Cell Proliferation/genetics ; Kruppel-Like Transcription Factors ; MicroRNAs/genetics ; Stomach Neoplasms/genetics ; RNA, Long Noncoding/genetics
Chemical Substances	Kruppel-Like Transcription Factors ; MicroRNAs ; MIRN124 microRNA, human ; ZNF655 protein, human ; RNA, Long Noncoding
Language	English
Publishing date	2022-12-15
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12634
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Article: Mito-TEMPO Improves the Meiosis Resumption and Mitochondrial Function of Vitrified Sheep Oocytes via the Recovery of Respiratory Chain Activity.

Zhao, Xi / Dilixiati, Airixiati / Zhang, Luyao / Aihemaiti, Aikebaier / Song, Yukun / Zhao, Guodong / Fu, Xiangwei / Wang, Xuguang / Wusiman, Abulizi

Animals : an open access journal from MDPI

2024 Volume 14, Issue 1

Abstract: Vitrification is a crucial method for preserving animal germ cells. Considering the increased oxidative stress and organelle damage incurred, it is still necessary to make the process more efficient for oocytes. As the energy source of oocytes, ... ...

Abstract	Vitrification is a crucial method for preserving animal germ cells. Considering the increased oxidative stress and organelle damage incurred, it is still necessary to make the process more efficient for oocytes. As the energy source of oocytes, mitochondria are the most abundant organelle in oocytes and play a crucial role in their maturation. Here, we found that Mito-TEMPO, a mitochondria-targeted antioxidant, could efficaciously improve the oxidative stress injury of vitrified oocytes by recovering mitochondrial function via the mitochondrial respiratory chain. It was observed that Mito-TEMPO not only improves oocyte viability and meiosis but also maintains spindle structure. A subsequent study indicated that Mito-TEMPO effectively rescued mitochondrial dysfunction and attenuated vitrification-induced oxidative stress. Further investigation revealed that Mito-TEMPO regulates vitrified oocytes' intracellular Ca
Language	English
Publishing date	2024-01-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14010152
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