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  1. Article ; Online: Efficacy of non-invasive brain stimulation for post-stroke dysphagia: a meta-analysis.

    Yao, Shan / Wang, Xuxia / Sun, Jie / Guo, Pengfei

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

    2024  Volume 24, Issue 2, Page(s) 433–442

    Abstract: Background: Given the potential harms of dysphagia after stroke, we noticed the possibility of non-invasive brain stimulation treatments in the management process.: Methods: The meta-analysis search for articles published before May 2023 in databases. ...

    Abstract Background: Given the potential harms of dysphagia after stroke, we noticed the possibility of non-invasive brain stimulation treatments in the management process.
    Methods: The meta-analysis search for articles published before May 2023 in databases. We used STATA 12.0 software to compute the standard mean difference (SMD) and 95% confidence intervals (CI).
    Results: The study showed a greater improvement in swallowing function in post-stroke dysphagia given transcranial direct current stimulation (tDCS) immediately after treatment, compared to those given sham tDCS (SMD = 2.99, 95% CI = 1.86-4.11). The study showed a greater improvement in swallowing function in post-stroke dysphagia given tDCS some days after treatment, compared to those given sham tDCS (SMD = 2.01, 95% CI = 0.87-3.16). The study showed a greater improvement in swallowing function in post-stroke dysphagia given repetitive transcranial magnetic stimulation (rTMS) immediately after treatment, compared to those given sham rTMS (SMD = 4.17, 95% CI = 3.11-5.23). The study showed a greater improvement in swallowing function in post-stroke dysphagia given rTMS some days after treatment, compared to those given sham rTMS (SMD = 1.77, 95% CI = 0.94-2.60).
    Conclusions: In conclusion, our study showed the beneficial effects of non-invasive brain stimulation on difficulty swallowing for stroke patients and speculated about the potential application of non-invasive brain stimulation on post-stroke dysphagia improvement.
    MeSH term(s) Humans ; Deglutition Disorders/etiology ; Deglutition Disorders/therapy ; Transcranial Direct Current Stimulation ; Stroke/complications ; Stroke/therapy ; Brain
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2213105-X
    ISSN 1479-8301 ; 1346-3500
    ISSN (online) 1479-8301
    ISSN 1346-3500
    DOI 10.1111/psyg.13090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Japanese encephalitis transmission trends in Gansu, China: A time series predictive model based on spatial dispersion.

    Wang, Xuxia / He, Aiwei / Zhang, Chunfang / Wang, Yongsheng / An, Jing / Zhang, Yu / Hu, Wenbiao

    One health (Amsterdam, Netherlands)

    2023  Volume 16, Page(s) 100554

    Abstract: Objective: This study serves to ascertain trends of space and time for Japanese encephalitis (JE) transmission at the township-level and develop an innovative time series predictive model to predict the geographical spread of JE in Gansu Province, China. ...

    Abstract Objective: This study serves to ascertain trends of space and time for Japanese encephalitis (JE) transmission at the township-level and develop an innovative time series predictive model to predict the geographical spread of JE in Gansu Province, China.
    Methods: We collected weekly data on JE from 2005 to 2019 at the township-level. Kriging interpolation maps were used to visualize the trend of the epidemic spread of JE, and linear regression models were used to calculate the monthly changes in minimum longitude and maximum latitude of emerging towns with JE to assess the speed of the epidemic's spread to the northwest. Additionally, we utilized a time series Seasonal Autoregressive Integrated Moving Average (SARIMA) model to dynamically predict the ongoing weekly number of JE emerging townships.
    Results: The Kriging difference map revealed a significant trend of JE spread towards the northwest. Our regression model indicated that the rate of decrease in minimum longitude was approximately 0.64 km per month, while the rate of increase in maximum latitude was approximately 1.00 km per month. Furthermore, the SARIMA pattern (2,0,0)(2,0,1)
    Conclusion: Our study highlights the expansion of JE cases towards the northwest of Gansu, indicating the need for ongoing surveillance and control efforts. The use of the SARIMA model provides a valuable tool for predicting the trend of JE spatial dispersion, thereby improving early warning systems. Our findings suggest that the number of emerging townships can be used to predict the trend of JE spatial dispersion, providing crucial insights for future research on JE incidence.
    Language English
    Publishing date 2023-04-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2023.100554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Effect of collagen sponge on the healing process of alveolar fossa after tooth extraction in rats].

    Li, Jun-Fu / Zhu, Jia / Jiang, Juan / Wang, Xu-Xia / Chen, Dai-Yun / Zhao, Zuo-Qin

    Shanghai kou qiang yi xue = Shanghai journal of stomatology

    2023  Volume 32, Issue 3, Page(s) 241–245

    Abstract: Purpose: To investigate the effect of collagen sponge on early bone healing process of alveolar fossa after tooth extraction in rats.: Methods: A total of 16 healthy female SD rats were selected. Animal models with tooth extraction were established. ... ...

    Abstract Purpose: To investigate the effect of collagen sponge on early bone healing process of alveolar fossa after tooth extraction in rats.
    Methods: A total of 16 healthy female SD rats were selected. Animal models with tooth extraction were established. The right alveolar fossa inserted with collagen sponge was as the experimental group, and the left alveolar fossa was as the control group with treatment. The rats were sacrificed 1, 2, 4 and 8 weeks after tooth extraction, and the osteogenesis of alveolar fossa was observed. Real-time quantitative PCR (qt-PCR) was used to detect the changes of osteogenesis related gene expression. SPSS 19.0 software package was used for statistical analysis.
    Results: After surgery, alveolar cavity healing was significantly better in the experimental group than in the control group. Osterix, Runx2 and Vegf genes were expressed in the experimental group and the control group, and the expression levels of related genes in the experimental group were significantly higher than the control group 1, 2, 4 and 8 weeks after surgery(P<0.05).
    Conclusions: Collagen sponge could promote early alveolar bone healing, possibly related to the expression level of osteogenic genes regulated by collagen sponge.
    MeSH term(s) Rats ; Female ; Animals ; Rats, Sprague-Dawley ; Collagen/pharmacology ; Wound Healing ; Tooth Socket/surgery ; Tooth Extraction ; Osteogenesis
    Chemical Substances Collagen (9007-34-5)
    Language Chinese
    Publishing date 2023-10-06
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2269714-7
    ISSN 1006-7248
    ISSN 1006-7248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of repeated manganese treatment on proton magnetic resonance spectra of the globus pallidus in rat brain.

    Wang, Xuxia / Li, Ronghui / He, Rui / Fang, Fang

    NMR in biomedicine

    2021  Volume 35, Issue 1, Page(s) e4617

    Abstract: Excessive manganese is neurotoxic, which means that it can affect the concentrations of metabolite ... ...

    Abstract Excessive manganese is neurotoxic, which means that it can affect the concentrations of metabolite in
    MeSH term(s) Animals ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Choline/metabolism ; Creatine/metabolism ; Globus Pallidus/drug effects ; Globus Pallidus/metabolism ; Globus Pallidus/pathology ; Manganese/toxicity ; Proton Magnetic Resonance Spectroscopy/methods ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Aspartic Acid (30KYC7MIAI) ; Manganese (42Z2K6ZL8P) ; N-acetylaspartate (997-55-7) ; Creatine (MU72812GK0) ; Choline (N91BDP6H0X)
    Language English
    Publishing date 2021-09-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.4617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: miR-27b Suppresses Tongue Squamous Cell Carcinoma Epithelial-Mesenchymal Transition by Targeting ITGA5.

    Li, Tao / Wu, Qian / Liu, Duanqin / Wang, Xuxia

    OncoTargets and therapy

    2020  Volume 13, Page(s) 11855–11867

    Abstract: Background: MicroRNA27b-3p (miR-27b) has been reported to be dysregulated in multiple types of human cancer. However, the expression levels, biological roles, and underlying mechanism of miR-27b in tongue squamous cell carcinoma (TSCC) remain to be ... ...

    Abstract Background: MicroRNA27b-3p (miR-27b) has been reported to be dysregulated in multiple types of human cancer. However, the expression levels, biological roles, and underlying mechanism of miR-27b in tongue squamous cell carcinoma (TSCC) remain to be elucidated.
    Methods: Bioinformatics analyses and quantitative real-time PCR (qRT-PCR) were used to determine miR-27b expression in TSCC tissues and cell lines. The influence of miR-27b overexpression or inhibition on TSCC cell proliferation, migration, and invasion in vitro, and on tumor growth in vivo, was explored via CCK8, colony formation, wound healing, and transwell assays, and in xenograft tumors in nude mice, respectively. Luciferase reporter assays, qRT-PCR, and Western blotting were performed to clarify the potential mechanisms involving miR-27b in TSCC cells.
    Results: miR-27b was significantly downregulated in TSCC tissues and cell lines, and its expression was correlated with cancer status. Overexpression of miR-27b led to diminished proliferation, migration, and invasion, and notably reduced tumor growth in vivo. Bioinformatics analysis followed by luciferase reporter assays demonstrated that miR-27b expression was inversely correlated with that of integrin subunit α5 (ITGA5)and that miR-27b directly bound to the 3'-untranslated region of ITGA5 in TSCC cells. The bioinformatics analysis also indicated that ITGA5 was upregulated in TSCC and that its expression was correlated with epithelial-mesenchymal transition (EMT) and poor prognosis. Moreover, we found that miRNA-27b could reverse ITGA5-induced promotion of TSCC cell proliferation and migration. Finally, we demonstrated that regulation of miR-27b expression in TSCC may result in alterations in the expression of ITGA5 and EMT-related marker genes at the mRNA and protein levels.
    Conclusion: These results indicate that miR-27b hampers TSCC proliferation and migration via suppressing the EMT process by targeting ITGA5. These findings support consideration of miR-27b/ITGA5 as a valuable marker for the metastatic potential of TSCC, or as a therapeutic target for the treatment of TSCC.
    Language English
    Publishing date 2020-11-17
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495130-4
    ISSN 1178-6930
    ISSN 1178-6930
    DOI 10.2147/OTT.S281211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: [Advances of enzymes related to microbial cement].

    Wang, Lei / Wang, Xuxia / Li, Fei / Cui, Mingjuan / Yang, Xiaoxu / Yang, Min / Yan, Yunjun

    Sheng wu gong cheng xue bao = Chinese journal of biotechnology

    2022  Volume 38, Issue 2, Page(s) 506–517

    Abstract: Microbial induced calcium carbonate precipitation (MICP) refers to the natural biological process of calcium carbonate precipitation induced by microbial metabolism in its surrounding environment. Based on the principles of MICP, microbial cement has ... ...

    Abstract Microbial induced calcium carbonate precipitation (MICP) refers to the natural biological process of calcium carbonate precipitation induced by microbial metabolism in its surrounding environment. Based on the principles of MICP, microbial cement has been developed and has received widespread attention in the field of biology, civil engineering, and environment owing to the merits of environmental friendliness and economic competence. Urease and carbonic anhydrase are the key enzymes closely related to microbial cement. This review summarizes the genes, protein structures, regulatory mechanisms, engineering strains and mutual synergistic relationship of these two enzymes. The application of bioinformatics and synthetic biology is expected to develop biocement with a wide range of environmental adaptability and high performance, and will bring the MICP research to a new height.
    MeSH term(s) Calcium Carbonate/chemistry ; Calcium Carbonate/metabolism ; Chemical Precipitation ; Urease/genetics ; Urease/metabolism
    Chemical Substances Urease (EC 3.5.1.5) ; Calcium Carbonate (H0G9379FGK)
    Language Chinese
    Publishing date 2022-03-02
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 1042206-7
    ISSN 1872-2075 ; 1042-749X
    ISSN (online) 1872-2075
    ISSN 1042-749X
    DOI 10.13345/j.cjb.210127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comparative Transcriptome Analysis Reveals Mechanisms of Folate Accumulation in Maize Grains.

    Lian, Tong / Wang, Xuxia / Li, Sha / Jiang, Haiyang / Zhang, Chunyi / Wang, Huan / Jiang, Ling

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Previously, the complexity of folate accumulation in the early stages of maize kernel development has been reported, but the mechanisms of folate accumulation are unclear. Two maize inbred lines, DAN3130 and JI63, with different patterns of folate ... ...

    Abstract Previously, the complexity of folate accumulation in the early stages of maize kernel development has been reported, but the mechanisms of folate accumulation are unclear. Two maize inbred lines, DAN3130 and JI63, with different patterns of folate accumulation and different total folate contents in mature kernels were used to investigate the transcriptional regulation of folate metabolism during late stages of kernel formation by comparative transcriptome analysis. The folate accumulation during DAP 24 to mature kernels could be controlled by circumjacent pathways of folate biosynthesis, such as pyruvate metabolism, glutamate metabolism, and serine/glycine metabolism. In addition, the folate variation between these two inbred lines was related to those genes among folate metabolism, such as genes in the pteridine branch, para-aminobenzoate branch, serine/tetrahydrofolate (THF)/5-methyltetrahydrofolate cycle, and the conversion of THF monoglutamate to THF polyglutamate. The findings provided insight into folate accumulation mechanisms during maize kernel formation to promote folate biofortification.
    MeSH term(s) Edible Grain/metabolism ; Folic Acid/metabolism ; Gene Expression Profiling ; Transcriptome ; Zea mays/genetics ; Zea mays/metabolism
    Chemical Substances Folic Acid (935E97BOY8)
    Language English
    Publishing date 2022-02-01
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Lower lip recurrent keratoacanthoma: A case report.

    Liu, Xian-Guang / Liu, Xing-Guang / Wang, Cai-Jiao / Wang, Han-Xi / Wang, Xu-Xia

    World journal of clinical cases

    2022  Volume 10, Issue 20, Page(s) 6960–6965

    Abstract: Background: This paper introduces a case of recurrent keratoacanthoma (KA). KA is a self-healing disease. Recurrence after surgical resection is rare. In this case, the local application of retinoic acid ointment after the second operation achieved a ... ...

    Abstract Background: This paper introduces a case of recurrent keratoacanthoma (KA). KA is a self-healing disease. Recurrence after surgical resection is rare. In this case, the local application of retinoic acid ointment after the second operation achieved a good prognosis after 2 years of follow-up.
    Case summary: A 76-year-old male patient was admitted to the hospital for "lower lip rupture and scab for 3 mo". Treatment: A rectangular incision was made in the healthy tissue about 3 mm outside the periphery of the lower lip mass, and a modified Bernard sliding flap was designed to completely remove the mass. Pathology showed (lower lip) KA. When the patient returned 6 mo after surgery, the middle mucosa of the lower lip had a bulge with a diameter of about 0.5 cm. The boundary was still clear, the surface was ulcerated. A recurrence of lower lip KA was suspected and a fan-shaped incision was performed in the healthy tissue about 5 mm outside the lesion to completely resect. Pathological showed lower lip KA had recurred. Topical application of tretinoin cream was applied once a day for 3 mo. The lower lip wounds were clean at the 2-year postoperative follow-up and the mucosa was normal.
    Conclusion: Adjuvant retinoic acid treatment after KA surgical resection can achieve good results.
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i20.6960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Different responses of Japanese encephalitis to weather variables among eight climate subtypes in Gansu, China, 2005-2019.

    Li, Ruifen / Zhao, Xiaohong / Tian, Yu / Shi, Yanjun / Gu, Xueyan / Wang, Shuang / Zhang, Rui / An, Jing / Su, Li / Wang, Xuxia

    BMC infectious diseases

    2023  Volume 23, Issue 1, Page(s) 114

    Abstract: This study evaluated epidemic temporal aspects of Japanese encephalitis (JE) and investigated the weather threshold of JE response across eight climate subtypes between 2005 and 2019 in Gansu Province, China. Epidemiological data were collected from the ... ...

    Abstract This study evaluated epidemic temporal aspects of Japanese encephalitis (JE) and investigated the weather threshold of JE response across eight climate subtypes between 2005 and 2019 in Gansu Province, China. Epidemiological data were collected from the China Information System for Disease Control and Prevention (CISDCP). Three epidemic temporal indices [frequency index (α), duration index (β), and intensity index (γ)] were adopted for the comparison of epidemic features among different climate subtypes. In addition, the local indicators of spatial association (LISA) technique was used to detect the hot-spot areas. The category and regression tree (CART) model was used to detect the response threshold of weather variables in hot-spot areas across climate subtypes. Among eight climate subtypes in Gansu, in most hot-spot areas (i.e., high-high clusters), α, β, and γ were detected in the climate subtypes of subtropical winter dry (Cwa), temperate oceanic continental (Cwb), and continental winter dry (Dwa and Dwb). According to the CART analysis, a minimum monthly temperature is required for Japanese encephalitis virus (JEV) transmission, with different threshold values among the climatic subtypes. In temperate climate zones (Cwa and Cwb), this threshold is 19 °C at a 1-month lag. It is lower in continental winter dry climate zones: 18 °C in Dwa (snow climate, dry winter, and hot summer) and 16 °C in Dwb (snow climate, dry winter, and warm summer). Additionally, some areas of the areas with temperate arid (BWk and BSk) had the first JE cases. Further studies to detect whether the climate change influence the JEV's distribution in Gansu Province are needed.
    MeSH term(s) Humans ; Encephalitis, Japanese/epidemiology ; Incidence ; Weather ; Seasons ; Encephalitis Virus, Japanese ; China/epidemiology ; Dermatitis ; Fever
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08074-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fatty acid modification of antimicrobial peptide CGA-N9 and the combats against Candida albicans infection.

    Li, Ruifang / Wang, Xuxia / Yin, Kedong / Xu, Qingpeng / Ren, Shiming / Wang, Xueqin / Wang, Zichao / Yi, Yanjie

    Biochemical pharmacology

    2023  Volume 211, Page(s) 115535

    Abstract: High-efficiency and low-toxic antimicrobial peptides (AMPs) are supposed to be the future candidates to solve the increasingly prominent problems of Candida albicans infection and drug resistance. Generally, introduction of hydrophobic moieties on AMPs ... ...

    Abstract High-efficiency and low-toxic antimicrobial peptides (AMPs) are supposed to be the future candidates to solve the increasingly prominent problems of Candida albicans infection and drug resistance. Generally, introduction of hydrophobic moieties on AMPs resulted in analogues with remarkably increased activity against pathogens. CGA-N9, an antifungal peptide found in our lab, is a Candida-selective antimicrobial peptide capable of preferentially killing Candida spp. relative to benign microorganisms with low toxicities. We speculate that fatty acid modification could improve the anti-Candida activity of CGA-N9. In the present investigation, a set of CGA-N9 analogues with fatty acid conjugations at N-terminus were obtained. The biological activities of CGA-N9 analogues were determined. The results showed that the n-octanoic acid conjugation of CGA-N9 (CGA-N9-C8) was the optimal CGA-N9 analogue with the highest anti-Candida activity and biosafety; exhibited the strongest biofilm inhibition activity and biofilm eradication ability; and the highest stability against protease hydrolysis in serum. Furthermore, CGA-N9-C8 is less prone to develop resistance for C. albicans in reference with fluconazole; CGA-N9-C8 also exhibited Candidacidal activity to the planktonic cells and the persister cells of C. albicans; reduced C. albicans susceptibility in a systemic candidiasis mouse model. In conclusion, fatty acid modification is an effective method to enhance the antimicrobial activity of CGA-N9, and CGA-N9-C8 is a promising candidate to defend C. albicans infection and resolve C. albicans drug resistance.
    MeSH term(s) Animals ; Mice ; Candida albicans ; Antimicrobial Peptides ; Fatty Acids/pharmacology ; Antimicrobial Cationic Peptides/pharmacology ; Antimicrobial Cationic Peptides/therapeutic use ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Antifungal Agents/chemistry ; Chromogranin A/pharmacology ; Biofilms ; Microbial Sensitivity Tests
    Chemical Substances Antimicrobial Peptides ; Fatty Acids ; Antimicrobial Cationic Peptides ; Antifungal Agents ; Chromogranin A
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2023.115535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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