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Article: Feature dependence: A method for reconstructing actual causes in engineering failure investigations.

Wang, Yafeng

Studies in history and philosophy of science

2022 Volume 96, Page(s) 100–111

Abstract: Engineering failure investigations seek to reconstruct the actual causes of major engineering failures. The investigators need to establish the existence of certain past events and the actual causal relationships that these events bear to the failures in ...

Abstract	Engineering failure investigations seek to reconstruct the actual causes of major engineering failures. The investigators need to establish the existence of certain past events and the actual causal relationships that these events bear to the failures in question. In this paper, I examine one method for reconstructing the actual causes of failure events, which I call "feature dependence". The basic idea of feature dependence is that some features of an event are informative about the features of its causes; therefore, the investigators can use the features of a known failure event to reconstruct details of its causes. I make explicit the structure of feature dependence and the evidential basis of its key premises, and show how feature dependence works in the investigation of the American Airlines Flight 191 accident.
MeSH term(s)	Causality ; Engineering
Language	English
Publishing date	2022-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	202358-1
ISSN	1879-2510 ; 0039-3681
ISSN (online)	1879-2510
ISSN	0039-3681
DOI	10.1016/j.shpsa.2022.09.005
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Article ; Online: Environmental fate and ecological impact of the potentially toxic elements from the geothermal springs.

Wang, Yafeng / Cheng, Hefa

Environmental geochemistry and health

2023 Volume 45, Issue 8, Page(s) 6287–6303

Abstract: Potentially toxic elements from geothermal springs can cause significant pollution of the surrounding environment and pose potential risk to the ecosystem. The fate of potentially toxic elements in the water-soil-plant system in the Yangbajain geothermal ...

Abstract	Potentially toxic elements from geothermal springs can cause significant pollution of the surrounding environment and pose potential risk to the ecosystem. The fate of potentially toxic elements in the water-soil-plant system in the Yangbajain geothermal field on the Tibetan Plateau, China was investigated to assess their impact on the eco-environment. The concentrations of Be, F, As, and Tl were highly elevated in the headwaters of the Yangbajain geothermal springs, and their concentrations in the local surface water impacted by the geothermal springs reached 8.1 μg/L (Be), 23.9 mg/L (F), 3.83 mg/L (As), and 8.4 μg/L (Tl), respectively, far exceeding the corresponding thresholds for surface and drinking water. The absence of As-Fe co-precipitation, undersaturated F
MeSH term(s)	Hot Springs ; Ecosystem ; Drinking Water ; China ; Environmental Pollution ; Environmental Monitoring
Chemical Substances	Drinking Water
Language	English
Publishing date	2023-06-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-023-01628-2
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Article ; Online: Soil heavy metal(loid) pollution and health risk assessment of farmlands developed on two different terrains on the Tibetan Plateau, China.

Wang, Yafeng / Cheng, Hefa

Chemosphere

2023 Volume 335, Page(s) 139148

Abstract: The quality of farmland soils on the Tibetan Plateau is important because of the region's ecological vulnerability and their close link with local food security. Investigation on the pollution status of heavy metal (loid)s (HMs) in the farmlands of Lhasa ...

Abstract	The quality of farmland soils on the Tibetan Plateau is important because of the region's ecological vulnerability and their close link with local food security. Investigation on the pollution status of heavy metal (loid)s (HMs) in the farmlands of Lhasa and Nyingchi on the Tibetan Plateau, China revealed that Cu, As, Cd, Tl, and Pb were apparently enriched, with the soil parent materials being the primary sources of the soil HMs. Overall, the farmlands in Lhasa had higher contents of HMs compared to those in Nyingchi, which could be attributed to the fact that the former were mainly developed on river terraces while the latter were mainly developed on the alluvial fans in mountainous areas. As displayed the most apparent enrichment, with the average contents in the vegetable field soils and grain field soils of Lhasa being 2.5 and 2.2 times higher compared to those of Nyingchi. The soils of vegetable fields were more heavily polluted than those of grain fields, probably due to the more intensive input of agrochemicals, particularly the use of commercial organic fertilizers. The overall ecological risk of the HMs in the Tibetan farmlands was low, while Cd posed medium ecological risk. Results of health risk assessment show that ingestion of the vegetable field soils could pose elevated health risk, with children facing greater risk than adults. Among all the HMs targeted, Cd had relatively high bioavailability of up to 36.2% and 24.9% in the vegetable field soils of Lhasa and Nyingchi, respectively. Cd also showed the most significant ecological and human health risk. Thus, attention should be paid to minimize further anthropogenic input of Cd to the farmland soils on the Tibetan Plateau.
MeSH term(s)	Adult ; Child ; Humans ; Soil/chemistry ; Farms ; Tibet ; Cadmium ; Soil Pollutants/analysis ; Environmental Monitoring/methods ; Metals, Heavy/analysis ; China ; Vegetables ; Risk Assessment
Chemical Substances	Soil ; Cadmium (00BH33GNGH) ; Soil Pollutants ; Metals, Heavy
Language	English
Publishing date	2023-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139148
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Article ; Online: Cohort studies have great potential in healthy ageing research.

Wang, Yafeng / Zhao, Yaohui

The lancet. Healthy longevity

2023 Volume 4, Issue 9, Page(s) e450–e451

MeSH term(s)	Humans ; Healthy Aging ; Cohort Studies
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article ; Comment
ISSN	2666-7568
ISSN (online)	2666-7568
DOI	10.1016/S2666-7568(23)00163-0
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Article ; Online: Case report: Cardiac arrest after radiofrequency ablation in a 76-year-old male.

Jin, Geya / Li, Shuyu / Wang, Yafeng / Pu, Jianyi

Medicine

2024 Volume 103, Issue 8, Page(s) e37191

Abstract: Rationale: Previous studies have found that the main treatment of sinus arrest is pacemaker treatment. It is rare to have 12 s of sinus arrest after radiofrequency ablation, and whether a permanent pacemaker is implanted immediately in this case is not ... ...

Abstract	Rationale: Previous studies have found that the main treatment of sinus arrest is pacemaker treatment. It is rare to have 12 s of sinus arrest after radiofrequency ablation, and whether a permanent pacemaker is implanted immediately in this case is not described in the guidelines. Patient concerns: A 76-year-old male patient with persistent atrial fibrillation (AF) developed sinus arrest lasting 12 s in the early morning of the fourth day after using radiofrequency ablation for pulmonary vein isolation. Diagnosis: The patient was diagnosed with AF and sinus arrest. Interventions: The patient received cardiopulmonary resuscitation, intravenous injection of atropine 1 mg, and intravenous infusion of isoproterenol 1mg and immediately recovered consciousness thereafter. Approximately, 1.5 h later, the patient underwent surgery to install a temporary pacemaker in the right femoral vein. Outcomes: The patient had repeated episodes of sinus arrest after the implantation of a temporary pacemaker. After 3 weeks, the patient stabilized and was discharged. The patient was followed up for 1 year and did not experience any recurrence of sinus arrest or AF. Lessons: We consider the potential for postoperative myocardial edema, injury to the sinoatrial node during the procedure, propafenone poisoning, and autonomic dysfunction as contributors to the occurrence of sinus arrest after radiofrequency ablation. When sinus arrest occurs after radiofrequency ablation, we can choose the appropriate treatment according to the patient's condition.
MeSH term(s)	Male ; Humans ; Aged ; Treatment Outcome ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Atrial Fibrillation/diagnosis ; Radiofrequency Ablation ; Heart Arrest/surgery ; Heart Atria/abnormalities ; Heart Block ; Cardiomyopathies ; Genetic Diseases, Inborn
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037191
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Article ; Online: Soil heavy metal(loid) pollution and health risk assessment of farmlands developed on two different terrains on the Tibetan Plateau, China

Wang, Yafeng / Cheng, Hefa

Chemosphere. 2023 Sept., v. 335 p.139148-

2023

Abstract	The quality of farmland soils on the Tibetan Plateau is important because of the region's ecological vulnerability and their close link with local food security. Investigation on the pollution status of heavy metal (loid)s (HMs) in the farmlands of Lhasa and Nyingchi on the Tibetan Plateau, China revealed that Cu, As, Cd, Tl, and Pb were apparently enriched, with the soil parent materials being the primary sources of the soil HMs. Overall, the farmlands in Lhasa had higher contents of HMs compared to those in Nyingchi, which could be attributed to the fact that the former were mainly developed on river terraces while the latter were mainly developed on the alluvial fans in mountainous areas. As displayed the most apparent enrichment, with the average contents in the vegetable field soils and grain field soils of Lhasa being 2.5 and 2.2 times higher compared to those of Nyingchi. The soils of vegetable fields were more heavily polluted than those of grain fields, probably due to the more intensive input of agrochemicals, particularly the use of commercial organic fertilizers. The overall ecological risk of the HMs in the Tibetan farmlands was low, while Cd posed medium ecological risk. Results of health risk assessment show that ingestion of the vegetable field soils could pose elevated health risk, with children facing greater risk than adults. Among all the HMs targeted, Cd had relatively high bioavailability of up to 36.2% and 24.9% in the vegetable field soils of Lhasa and Nyingchi, respectively. Cd also showed the most significant ecological and human health risk. Thus, attention should be paid to minimize further anthropogenic input of Cd to the farmland soils on the Tibetan Plateau.
Keywords	agricultural land ; agrochemicals ; bioavailability ; food security ; health effects assessments ; heavy metals ; human health ; ingestion ; mountains ; pollution ; risk ; rivers ; soil ; vegetables ; China ; Tibetan plateau ; Heavy metal(loid)s ; Farmland pollution ; Potential ecological risk ; Human health risk
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139148
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Article ; Online: Letter by Wang Regarding Article, "Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)".

Wang, Yafeng

Circulation

2018 Volume 137, Issue 19, Page(s) 2085–2086

MeSH term(s)	Atrial Fibrillation ; Biomarkers ; Cardiovascular Diseases ; Europe ; Female ; Humans ; Male ; Risk Assessment ; Risk Factors
Chemical Substances	Biomarkers
Language	English
Publishing date	2018-04-18
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.117.032835
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Article ; Online: An infant with congenital heart defects and proteinuria: a case report.

Liu, Dandan / Wang, Yafeng

BMC pediatrics

2022 Volume 22, Issue 1, Page(s) 636

Abstract: Background: Branchio-Oto-Renal (BOR) Syndrome is a rare autosomal disorder with a wide variety of clinical manifestations and a high degree of heterogeneity. Typical clinical manifestations of BOR syndrome include deafness, preauricular fistula, ... ...

Abstract	Background: Branchio-Oto-Renal (BOR) Syndrome is a rare autosomal disorder with a wide variety of clinical manifestations and a high degree of heterogeneity. Typical clinical manifestations of BOR syndrome include deafness, preauricular fistula, abnormal gill slits, and renal malformations. However, atypical phenotypes such as congenital hip dysplasia, congenital heart anomaly or facial nerve paresis are rare in BOR syndrome, and this might be easily misdiagnosed with other congenital disorders. Case presentation: We report a 5-month-old boy of BOR syndrome with "congenital heart defects and proteinuria" as clinical features. Initially, as this case mainly presented with symptoms of recurrent respiratory infections and was found to be with congenital heart disease and proteinuria at the local hospital, but he only was diagnosed with congenital heart disease combined with pulmonary infection and anti-infective and supportive treatment was given. Subsequently, during the physical examination at our hospital, left side preauricular pit and branchial fistulae on the right neck were found. Subsequent evaluation of auditory brainstem response and distortion product otoacoustic emission were revealed sensorineural hearing impairment. Results of renal ultrasonography showed small kidneys. Genetic analysis revealed a microdeletion at chromosome 8q13.2-q13.3 encompassing EYA1 gene, this patient was finally diagnosed with BOR syndrome. Then, this patient received transcatheter patent ductus arteriosus closure and hearing aid treatment. Proteinuria, renal function and hearing ability are monitoring by nephrologist and otologist. The patient is currently being followed up until 3 months after discharge and his condition is stable. Conclusion: Careful physical examination, detailed history and the implementation of diagnostic laboratory tests can reduce the incidence of misdiagnosis. Genetic sequencing analysis of patients is a key guide to the differential diagnosis of BOR syndrome.
MeSH term(s)	Male ; Humans ; Branchio-Oto-Renal Syndrome/complications ; Branchio-Oto-Renal Syndrome/diagnosis ; Branchio-Oto-Renal Syndrome/genetics ; Pedigree ; Phenotype ; Proteinuria ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/genetics
Language	English
Publishing date	2022-11-04
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-022-03705-4
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Article ; Online: The role of the ER stress sensor IRE1 in cardiovascular diseases.

Zhou, Lu / Zhu, Xizi / Lei, Shaoqing / Wang, Yafeng / Xia, Zhongyuan

Molecular and cellular biochemistry

2024

Abstract: Despite enormous advances in the treatment of cardiovascular diseases, including I/R injury and heart failure, heart diseases remain a leading cause of mortality worldwide. Inositol-requiring enzyme 1 (IRE1) is an evolutionarily conserved sensor ... ...

Abstract	Despite enormous advances in the treatment of cardiovascular diseases, including I/R injury and heart failure, heart diseases remain a leading cause of mortality worldwide. Inositol-requiring enzyme 1 (IRE1) is an evolutionarily conserved sensor endoplasmic reticulum (ER) transmembrane protein that senses ER stress. It manages ER stress induced by the accumulation of unfolded/misfolded proteins via the unfolded protein response (UPR). However, if the stress still persists, the UPR pathways are activated and induce cell death. Emerging evidence shows that, beyond the UPR, IRE1 participates in the progression of cardiovascular diseases by regulating inflammation levels, immunity, and lipid metabolism. Here, we summarize the recent findings and discuss the potential therapeutic effects of IRE1 in the treatment of cardiovascular diseases.
Language	English
Publishing date	2024-05-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-024-05014-z
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Article ; Online: A de novo ANK1 mutation in a childhood hereditary spherocytosis: a case report.

Wang, Yafeng / Liu, Linlin / Liu, Dandan / Liu, Wei

BMC pediatrics

2023 Volume 23, Issue 1, Page(s) 267

Abstract: Background: Due to the heterogeneity of the phenotype of Hereditary spherocytosis (HS) patients, some patients may have rare clinical complications such as biliary obstruction and ultra-high bilirubinemia.: Case presentation: A 8-y-old boy presented ... ...

Abstract	Background: Due to the heterogeneity of the phenotype of Hereditary spherocytosis (HS) patients, some patients may have rare clinical complications such as biliary obstruction and ultra-high bilirubinemia. Case presentation: A 8-y-old boy presented to the emergency with complaints of anemia for 6 years and worsened abdominal pain and scleral yellowing of the skin for 2 days. Physical examination showed tenderness in the middle and upper abdomen and splenomegaly. Abdominal CT revealed biliary obstruction. Genetic analysis revealed a de novo mutation in the gene ANK1, HS with biliary obstruction was diagnosed. The surgery of bile duct exploration and T-tube drainage, and splenectomy were performed successively. This patient was followed up for 13 months after splenectomy, and his condition was stable. Conclusion: The diagnosis of HS is not clinically difficult, and once a patient with HS is diagnosed, regular follow-up management and standardized treatment are required. Genetic testing is also needed to screen for other genetic disorders that may co-exist in patients with HS who do not have a good efficacy or who have a long-term chronic onset of jaundice.
MeSH term(s)	Humans ; Child ; Mutation ; Ankyrins/genetics ; Spherocytosis, Hereditary/complications ; Spherocytosis, Hereditary/diagnosis ; Spherocytosis, Hereditary/genetics ; Phenotype ; Cholestasis
Chemical Substances	Ankyrins ; ANK1 protein, human
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-023-04092-0
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