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Article ; Online: Identification of potential molecular mechanism related to craniofacial dysmorphism caused by FOXI3 deficiency.

Xing, Xiao-Liang / Zeng, Ziqiang / Wang, Yana / Pan, Bo / Huang, Xueshuang

2024 Volume 12, Issue 3, Page(s) e2411

Abstract: Background: Hemifacial macrosomia (HFM, OMIM 164210) is a complex and highly heterogeneous disease. FORKHEAD BOX I3 (FOXI3) is a susceptibility gene for HFM, and mice with loss of function of Foxi3 did exhibit a phenotype similar to craniofacial ... ...

Abstract	Background: Hemifacial macrosomia (HFM, OMIM 164210) is a complex and highly heterogeneous disease. FORKHEAD BOX I3 (FOXI3) is a susceptibility gene for HFM, and mice with loss of function of Foxi3 did exhibit a phenotype similar to craniofacial dysmorphism. However, the specific pathogenesis of HFM caused by FOXI3 deficiency remains unclear till now. Method: In this study, we first constructed a Foxi3 deficiency (Foxi3 Results: By observing the phenotype of Foxi3 Conclusion: The craniofacial dysmorphism caused by the deficiency of Foxi3 may be related to the expression of Akt2 and PI3K-Akt signaling pathway. This study laid a foundation for understanding the function of FOXI3 and the pathogenesis and treatment of related craniofacial dysmorphism caused by FOXI3 dysfunction.
MeSH term(s)	Animals ; Mice ; Computational Biology ; Craniofacial Abnormalities/genetics ; Musculoskeletal Abnormalities ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt/genetics
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Foxi1 protein, mouse
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.2411
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Article: The lemon genome and DNA methylome unveil epigenetic regulation of citric acid biosynthesis during fruit development.

Yu, Hang / Zhang, Chao / Lu, Chuang / Wang, Yana / Ge, Congcong / Huang, Guixiang / Wang, Haifeng

Horticulture research

2024 Volume 11, Issue 3, Page(s) uhae005

Abstract: Citric acid gives lemons their unique flavor, which impacts their sensory traits and market value. However, the intricate process of citric acid accumulation during lemon fruit growth remains incompletely understood. Here, we achieved a chromosomal-level ...

Abstract	Citric acid gives lemons their unique flavor, which impacts their sensory traits and market value. However, the intricate process of citric acid accumulation during lemon fruit growth remains incompletely understood. Here, we achieved a chromosomal-level genome assembly for the 'Xiangshui' lemon variety, spanning 364.85 Mb across nine chromosomes. This assembly revealed 27 945 genes and 51.37% repetitive sequences, tracing the divergence from citron 2.85 million years ago. DNA methylome analysis of lemon fruits across different developmental stages revealed significant variations in DNA methylation. We observed decreased CG and CHG methylation but increased CHH methylation. Notably, the expression of RdDM pathway-related genes increased with fruit development, suggesting a connection with elevated CHH methylation, which is potentially influenced by the canonical RdDM pathway. Furthermore, we observed that elevated CHH DNA methylation within promoters significantly influenced the expression of key genes, critically contributing to vital biological processes, such as citric acid accumulation. In particular, the pivotal gene
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ISSN	2662-6810
ISSN	2662-6810
DOI	10.1093/hr/uhae005
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Article: Micromechanics Modeling of Transverse Tensile Strength for Unidirectional CFRP Composite.

Liu, Liangbao / Zhang, Xiaohui / Wang, Zibiao / Wang, Yana / Guo, Jiangzhen

Materials (Basel, Switzerland)

2022 Volume 15, Issue 23

Abstract: Transverse tensile strength of unidirectional (UD) composites plays a key role in overall failure of fiber-reinforced composites. To predict this strength by micromechanics, calculation of actual stress in constituent matrix is essentially required. ... ...

Abstract	Transverse tensile strength of unidirectional (UD) composites plays a key role in overall failure of fiber-reinforced composites. To predict this strength by micromechanics, calculation of actual stress in constituent matrix is essentially required. However, traditional micromechanics models can only give the volume-averaged homogenized stress rather than an actual one for a matrix, which in practice will cause large errors. In this paper, considering the effect of stress concentration on a matrix, a novel micromechanics method was proposed to give an accurate calculation of the actual stress in the matrix for UD composite under transverse tension. A stress concentration factor for a matrix in transverse tensile direction is defined, using line-averaged pointwise stress (obtained from concentric cylinder assemblage model) divided by the homogenized quantity (obtained from a bridging model). The actual stress in matrix is then determined using applied external stress multiplied by the factor. Experimental validation on six UD carbon fiber-reinforced polymer (CFRP) specimens indicates that the predicted transverse tensile strength by the proposed method presents a minor deviation with an averaged relative error of 5.45% and thus is reasonable, contrary to the traditional method with an averaged relative error of 207.27%. Furthermore, the morphology of fracture section of the specimens was studied by scanning electron microscopy (SEM). It was observed that different scaled cracks appeared within the matrix, indicating that failure of a UD composite under transverse tension is mainly governed by matrix failure. Based on the proposed approach, the transverse tensile strength of a UD composite can be accurately predicted.
Language	English
Publishing date	2022-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15238577
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Article ; Online: Rheological Impact of Particle Size Gradation on GAP Propellant Slurries.

Wang, Yi / Wang, Yana / Song, Xiaolan / An, Chongwei / Li, Fengsheng

ACS omega

2022 Volume 7, Issue 43, Page(s) 38536–38542

Abstract: Over the years, widespread interest has been placed on rheological properties to reflect the processability of propellant slurries. Particle gradation technology plays an essential role in the improvement of the processability of propellant slurries. In ... ...

Abstract	Over the years, widespread interest has been placed on rheological properties to reflect the processability of propellant slurries. Particle gradation technology plays an essential role in the improvement of the processability of propellant slurries. In this article, rheological properties of glycidyl azide polymer (GAP) propellant slurries were measured by dynamic rheological measurements with a rheometer. Submicron-sized (
Language	English
Publishing date	2022-10-20
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c03872
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Article ; Online: Notch signaling pathway involved in

Wang, Mingxia / Shang, Zailing / Qiao, Fei / Hei, Junhu / Ma, Xueling / Wang, Yana

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1147025

Abstract: Introduction: The Notch signaling pathway is involved in the development of many diseases; it regulates the development of dendritic cells (DCs), and affects the immune response of DC-mediated T cells. We previously found that ferritin and malate ... ...

Abstract	Introduction: The Notch signaling pathway is involved in the development of many diseases; it regulates the development of dendritic cells (DCs), and affects the immune response of DC-mediated T cells. We previously found that ferritin and malate dehydrogenase (mMDH) in Echinococcus granulosus (E.granulosus) induced different immune responses through sensitized DCs. Therefore, in the study we explored whether the Notch signaling pathway affects the development and differentiation of DCs, causing changes in the immune response of DCs sensitized with E. granulosus antigens, and clarified whether it is involved in E.granulosus infection. Methods: We used the Notch signaling pathway inhibitor [N-[3,5-difluorophenace-tyl] -L-alanyl]-S-phenylglycinet-butyl ester (DAPT) or activator Jagged1 to construct in vitro cell models with blocked or activated Notch signaling respectively. We analyzed the effect of Notch signaling on the development and differentiation of DCs by detecting their morphology, migration function, capacity to promote T cell proliferation, and cytokine secretion. We observed the changes in DC response to E. granulosus antigens and the mediated immune response. Results: DAPT inhibited the development and maturation of DCs, which were in a non-responsive or incompetent state, reduced the sensitization of DCs to Eg.ferritin, weakened the migration ability of DCs, disrupted their ability to mediate T-cell proliferation, reduced DC expression of MHCII, CD80, CD60, and CD40 co-stimulatory molecules, prevented the secretion of cytokines and attenuated the expression of Notch1, Notch2, Notch3 receptors, Jagged1, Delta-like 4 (Delta4), and Hes1. Following Jagged1 addition, the function of DCs was restored to some extent, and the expression of Notch1, Delta4 and Hes1 was activated in response to the stimulation of Eg.ferritin. However, Eg.mMDH stimulated DCs to produce an immune response showing weak interference by DAPT and Jagged1. Discussion: The study suggests that the Notc h signaling pathway is involved in the Eg.ferritin-sensitized DC-mediated immune response, which may become a new target for treating E.granulosus infection.
MeSH term(s)	Humans ; Platelet Aggregation Inhibitors/pharmacology ; Echinococcosis ; Cell Differentiation ; Signal Transduction ; Dendritic Cells ; Ferritins
Chemical Substances	Platelet Aggregation Inhibitors ; Ferritins (9007-73-2)
Language	English
Publishing date	2023-05-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1147025
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Article ; Online: Perioperative Management Strategies for the COVID-19 Pandemic at a Facility in China.

Bian, Dongmei / Jia, Weina / Wang, Yana / Ma, Na / Wang, Yu / Wang, Qian

AORN journal

2022 Volume 116, Issue 3, Page(s) 219–228

Abstract: The spread of coronavirus disease 2019 posed a public health crisis beginning in January 2020, affecting hospitals and health care personnel worldwide and disrupting perioperative services. Organization leaders at Xijing Hospital, Xi'an, China, developed ...

Abstract	The spread of coronavirus disease 2019 posed a public health crisis beginning in January 2020, affecting hospitals and health care personnel worldwide and disrupting perioperative services. Organization leaders at Xijing Hospital, Xi'an, China, developed a mitigation system for the OR that involved creating a pandemic response team to identify and implement appropriate infection control practices to prevent virus transmission. The leaders addressed managing the daily surgery schedule through patient screening and a focus on the urgency and volume of procedures. They required increased use of personal protective equipment and more stringent cleaning and disinfection protocols and ensured that the physical and mental health of staff members were monitored and prioritized. This article describes how leaders implemented these enhanced processes to protect personnel from infection as they continued to provide patient care. It also describes how high-risk procedures involving patients with confirmed or suspected infections were managed and discusses lessons learned.
MeSH term(s)	COVID-19 ; Humans ; Infection Control/methods ; Pandemics/prevention & control ; Personal Protective Equipment ; SARS-CoV-2
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	603972-8
ISSN	1878-0369 ; 0001-2092
ISSN (online)	1878-0369
ISSN	0001-2092
DOI	10.1002/aorn.13765
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Article ; Online: Impact of Echinococcus granulosus Antigens on Monocyte Development and Dendritic Cell Differentiation.

Wang, Mingxia / Qiao, Fei / Li, Zihua / Wang, Qiang / Shang, Zailing / Hei, Junhu / Ma, Xuelin / Wang, Yana

Iranian journal of immunology : IJI

2023 Volume 20, Issue 3, Page(s) 348–358

Abstract: Background: Different subtypes of dendritic cells (DCs) can induce different types of immune responses. Our previous study found that Echinococcus granulosus (E. granulosus) antigens (Eg.ferritin, Eg.mMDH and Eg.10) stimulated DC differentiation to ... ...

Abstract	Background: Different subtypes of dendritic cells (DCs) can induce different types of immune responses. Our previous study found that Echinococcus granulosus (E. granulosus) antigens (Eg.ferritin, Eg.mMDH and Eg.10) stimulated DC differentiation to different subtypes and produced different immune responses. Objective: To further understand whether Eg.ferritin, Eg.mMDH and Eg.10 affect the DC-mediated immune response by promoting the differentiation of monocytes to DCs. Methods: Bone marrow-derived monocytes were exposed to three antigens of E. granulosus on days 0, 3, 5, and 7. The percentage of monocyte-derived DCs (moDCs), DCs subsets, and the expression of surface molecules of DCs at different time points in different groups were assessed by flow cytometry. The levels of cytokines of IL-1β, IL-4, IL-6, IL-10, IL-13, IFN-γ, TNF-α, IL-12p70, IL-18, IL-23, and IL-27 in the cell culture supernatant were detected by multi-factorial detection technology. Results: The percentage of moDCs revealed that none of the three antigens blocked monocyte differentiation to DCs. The monocytes of 7-day-old cultures showed increased sensitivity to these antigens. The Eg.ferritin induced more mature DCs, which expressed high levels of MHC II and costimulatory molecules, and secreted Th1 cytokines. Eg10 and Eg.mMDH induced lower degrees of DC maturation, however differentiated DCs were in a semi-mature state due to low expression of MHC II and costimulatory molecules and secretion of higher Th2 and lower Th1 cytokines. Conclusion: Eg.ferritin promotes full maturation of DCs and induces Th1 immune response, whereas Eg.10 and Eg.mMDH induce semi-mature DCs producing higher levels of Th2 cytokines.
MeSH term(s)	Animals ; Monocytes ; Echinococcus granulosus ; Dendritic Cells ; Cytokines/metabolism ; Cell Differentiation ; Transcription Factors/metabolism ; Ferritins/metabolism
Chemical Substances	Cytokines ; Transcription Factors ; Ferritins (9007-73-2)
Language	English
Publishing date	2023-07-17
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2616647-1
ISSN	1735-367X ; 1735-367X
ISSN (online)	1735-367X
ISSN	1735-367X
DOI	10.22034/iji.2023.98163.2557
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Article ; Online: ASK1-K716R reduces neuroinflammation and white matter injury via preserving blood-brain barrier integrity after traumatic brain injury.

Meng, Shan / Cao, Hui / Huang, Yichen / Shi, Ziyu / Li, Jiaying / Wang, Yana / Zhang, Yue / Chen, Shuning / Shi, Hong / Gao, Yanqin

Journal of neuroinflammation

2023 Volume 20, Issue 1, Page(s) 244

Abstract: Background: Traumatic brain injury (TBI) is a significant worldwide public health concern that necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), a key player in various central nervous system (CNS) diseases, has garnered interest for ... ...

Abstract	Background: Traumatic brain injury (TBI) is a significant worldwide public health concern that necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), a key player in various central nervous system (CNS) diseases, has garnered interest for its potential neuroprotective effects against ischemic stroke and epilepsy when deleted. Nonetheless, the specific impact of ASK1 on TBI and its underlying mechanisms remain elusive. Notably, mutation of ATP-binding sites, such as lysine residues, can lead to catalytic inactivation of ASK1. To address these knowledge gaps, we generated transgenic mice harboring a site-specific mutant ASK1 Map3k5-e (K716R), enabling us to assess its effects and elucidate potential underlying mechanisms following TBI. Methods: We employed the CRIPR/Cas9 system to generate a transgenic mouse model carrying the ASK1-K716R mutation, aming to investigate the functional implications of this specific mutant. The controlled cortical impact method was utilized to induce TBI. Expression and distribution of ASK1 were detected through Western blotting and immunofluorescence staining, respectively. The ASK1 kinase activity after TBI was detected by a specific ASK1 kinase activity kit. Cerebral microvessels were isolated by gradient centrifugation using dextran. Immunofluorescence staining was performed to evaluate blood-brain barrier (BBB) damage. BBB ultrastructure was visualized using transmission electron microscopy, while the expression levels of endothelial tight junction proteins and ASK1 signaling pathway proteins was detected by Western blotting. To investigate TBI-induced neuroinflammation, we conducted immunofluorescence staining, quantitative real-time polymerase chain reaction (qRT-PCR) and flow cytometry analyses. Additionally, immunofluorescence staining and electrophysiological compound action potentials were conducted to evaluate gray and white matter injury. Finally, sensorimotor function and cognitive function were assessed by a battery of behavioral tests. Results: The activity of ASK1-K716R was significantly decreased following TBI. Western blotting confirmed that ASK1-K716R effectively inhibited the phosphorylation of ASK1, JNKs, and p38 in response to TBI. Additionally, ASK1-K716R demonstrated a protective function in maintaining BBB integrity by suppressing ASK1/JNKs activity in endothelial cells, thereby reducing the degradation of tight junction proteins following TBI. Besides, ASK1-K716R effectively suppressed the infiltration of peripheral immune cells into the brain parenchyma, decreased the number of proinflammatory-like microglia/macrophages, increased the number of anti-inflammatory-like microglia/macrophages, and downregulated expression of several proinflammatory factors. Furthermore, ASK1-K716R attenuated white matter injury and improved the nerve conduction function of both myelinated and unmyelinated fibers after TBI. Finally, our findings demonstrated that ASK1-K716R exhibited favorable long-term functional and histological outcomes in the aftermath of TBI. Conclusion: ASK1-K716R preserves BBB integrity by inhibiting ASK1/JNKs pathway in endothelial cells, consequently reducing the degradation of tight junction proteins. Additionally, it alleviates early neuroinflammation by inhibiting the infiltration of peripheral immune cells into the brain parenchyma and modulating the polarization of microglia/macrophages. These beneficial effects of ASK1-K716R subsequently result in a reduction in white matter injury and promote the long-term recovery of neurological function following TBI.
MeSH term(s)	Mice ; Animals ; Blood-Brain Barrier/metabolism ; Neuroinflammatory Diseases ; White Matter/pathology ; Endothelial Cells/metabolism ; MAP Kinase Kinase Kinase 5/metabolism ; Brain Injuries, Traumatic/pathology ; Brain Injuries/metabolism ; Tight Junction Proteins/metabolism ; Mice, Inbred C57BL
Chemical Substances	MAP Kinase Kinase Kinase 5 (EC 2.7.11.25) ; Tight Junction Proteins
Language	English
Publishing date	2023-10-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-023-02923-6
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Article ; Online: Scaling strategy for cell and gene therapy bioreactors based on turbulent parameters.

Iurashev, Dmytro / Jones, Peter Anthony / Andreev, Nadejda / Wang, Yana / Iwata-Kajihara, Tomoko / Kraus, Barbara / Hernandez Bort, Juan A

Biotechnology journal

2023 Volume 19, Issue 1, Page(s) e2300235

Abstract: So far, power input has been used as the main parameter for bioreactor scale-up/-down in upstream process development and manufacturing. The rationale is that maintaining a consistent power input per unit volume should result in comparable mixing times ... ...

Abstract	So far, power input has been used as the main parameter for bioreactor scale-up/-down in upstream process development and manufacturing. The rationale is that maintaining a consistent power input per unit volume should result in comparable mixing times at different scales. However, shear generated from turbulent flow may compromise the integrity of non-robust cells such as those used during the production of cell and gene therapies, which may lead to low product quality and yield. Of particular interest is the Kolmogorov length parameter that characterizes the smallest turbulent eddies in a mixture. To understand its impact on scale-up/-down decisions, the distribution of Kolmogorov length along the trajectory flow of individual particles in bioreactors was estimated in silico with the help of computational fluid dynamics simulations. Specifically, in this study the scalability of iPSC-derived lymphocyte production and the impact of shear stress across various differentiation stages were investigated. The study used bioreactors of volumes from 0.1 to 10 L, which correspond to the scales most used for parameter optimization. Our findings, which align with in vitro runs, help determine optimal agitation speed and shear stress adjustments for process transfer between scales and bioreactor types, using vertically-oriented wheel and pitched-blade impellers. In addition, empirical models specific to the bioreactors used in this study were developed. The provided computational analysis in combination with experimental data supports selection of appropriate bioreactors and operating conditions for various cell and gene therapy process steps.
MeSH term(s)	Cell Culture Techniques ; Bioreactors ; Hydrodynamics ; Stress, Mechanical
Language	English
Publishing date	2023-11-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2221885-3
ISSN	1860-7314 ; 1860-6768
ISSN (online)	1860-7314
ISSN	1860-6768
DOI	10.1002/biot.202300235
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Article ; Online: Recombinant antigen P29 of

Yang, Jihui / Zhao, Yinqi / Fu, Yong / Lv, Yongxue / Zhu, Yazhou / Zhu, Mingxing / Zhao, Jiaqing / Wang, Yana / Wu, Changyou / Zhao, Wei

Frontiers in immunology

2023 Volume 14, Page(s) 1243204

Abstract: ... ...

Abstract	Echinococcosis
MeSH term(s)	Humans ; Animals ; Mice ; Sheep ; Echinococcus granulosus ; Interleukin-17 ; CD8-Positive T-Lymphocytes ; Leukocytes, Mononuclear ; Th17 Cells ; Myeloblastin ; Echinococcosis/prevention & control ; Cytokines ; Enzyme-Linked Immunospot Assay ; Vaccines ; Immunity
Chemical Substances	Interleukin-17 ; Myeloblastin (EC 3.4.21.76) ; Cytokines ; Vaccines
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1243204
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