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Article ; Online: Generalized Excess Spectroscopy.

Wang, Ya-Qian / Yu, Zhi-Wu

The journal of physical chemistry. A

2022 Volume 126, Issue 10, Page(s) 1775–1781

Abstract: With a clear enhancement of the apparent resolution of experimentally determined spectra, excess spectroscopy has been developed as a powerful tool to study solution structures and molecular interactions. In the standard procedure of the method, excess ... ...

Abstract	With a clear enhancement of the apparent resolution of experimentally determined spectra, excess spectroscopy has been developed as a powerful tool to study solution structures and molecular interactions. In the standard procedure of the method, excess spectra are calculated based on the ideal spectra constructed using two pure compounds. This limits the applications of the method when the pure compounds are unstable or their physical state is different from that of the mixtures. To overcome the problem or to extend the application, we propose generalized excess spectroscopy in this work, where the ideal spectrum is evaluated from the spectra of reference mixtures. After deducing the working equations, we performed digital simulation and then applied the novel approach to a binary system consisting of
Language	English
Publishing date	2022-03-08
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.2c00161
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Article: Role cognition of assigned nurses supporting Hubei Province in the fight against COVID-19 in China: a hermeneutic phenomenological study.

Zhang, Xu / Wang, Yaqian / Chen, Yuanyuan / Yang, Hailing / Luan, Xiaorong

Frontiers in psychology

2024 Volume 15, Page(s) 1287944

Abstract: Aims: During the COVID-19 epidemic, nurses played a crucial role in clinical treatment. As a special group, front-line nurses, especially those assigned to support Hubei Province in the fight against COVID-19 between February and April 2020, brought ... ...

Abstract	Aims: During the COVID-19 epidemic, nurses played a crucial role in clinical treatment. As a special group, front-line nurses, especially those assigned to support Hubei Province in the fight against COVID-19 between February and April 2020, brought diverse experiences from different provinces in China in taking care of COVID-19 patients and role cognition. Therefore, our purpose is to explore the real coping experience and role cognition of front-line nurses during the novel coronavirus outbreak to provide relevant experience references for society and managers in the face of such major public health emergencies in the future. Design: This qualitative study was performed using the phenomenological hermeneutics method. Method: This is a qualitative phenomenological study. Semi-structured in-depth interviews were used to collect data. The interviewees were 53 front-line nurses who assisted and supported the fight against COVID-19 in Hubei Province during the COVID-19 epidemic. Data were collected through individual online and telephone interviews using a semi-structured interview during March 2020. The COREQ guidance was used to report this study. Results: The findings revealed that front-line nurses assisting in the fight against COVID-19 developed a context-specific role cognition of their work and contribution to society. The qualitative analysis of the data revealed 15 sub-categories and 5 main categories. These five themes represented the different roles identified by nurses. The roles included expectations, conflicts, adaptation, emotions, and flow of blessing. Belief in getting better, a sense of honor, and training could help them to reduce feelings of conflict in this role and adapt more quickly. Discussion: This article discusses the real coping experience and role cognition of front-line nurses during the novel coronavirus epidemic. It provides relevant experience references for society and managers to face similar major public health emergencies in the future. This study makes a significant contribution to the literature because it demonstrates how non-local nurses sent to Hubei to work perceived their roles as part of a larger narrative of patriotism, duty, solidarity, and hope.
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2024.1287944
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Article: Predicting long-term prognosis after percutaneous coronary intervention in patients with acute coronary syndromes: a prospective nested case-control analysis for county-level health services.

Lu, Yue / Wang, Yaqian / Zhou, Bo

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1297527

Abstract: Purpose: We aimed to establish and authenticate a clinical prognostic nomogram for predicting long-term Major Adverse Cardiovascular Events (MACEs) among high-risk patients who have undergone Percutaneous Coronary Intervention (PCI) in county-level ... ...

Abstract	Purpose: We aimed to establish and authenticate a clinical prognostic nomogram for predicting long-term Major Adverse Cardiovascular Events (MACEs) among high-risk patients who have undergone Percutaneous Coronary Intervention (PCI) in county-level health service. Patients and methods: This prospective study included Acute Coronary Syndrome (ACS) patients treated with PCI at six county-level hospitals between September 2018 and August 2019, selected from both the original training set and external validation set. Least Absolute Shrinkage and Selection Operator (LASSO) regression techniques and logistic regression were used to assess potential risk factors and construct a risk predictive nomogram. Additionally, the potential non-linear relationships between continuous variables were tested using Restricted Cubic Splines (RCS). The performance of the nomogram was evaluated based on the Receiver Operating Characteristic (ROC) curve analysis, Calibration Curve, Decision Curve Analysis (DCA), and Clinical Impact Curve (CIC). Results: The original training set and external validation set comprised 520 and 1,061 patients, respectively. The final nomogram was developed using nine clinical variables: Age, Killip functional classification III-IV, Hypertension, Hyperhomocysteinemia, Heart failure, Number of stents, Multivessel disease, Low-density Lipoprotein Cholesterol, and Left Ventricular Ejection Fraction. The AUC of the nomogram was 0.79 and 0.75 in the training set and external validation set, respectively. The DCA and CIC validated the clinical value of the constructed prognostic nomogram. Conclusion: We developed and validated a prognostic nomogram for predicting the probability of 3-year MACEs in ACS patients who underwent PCI at county-level hospitals. The nomogram could provide a precise risk assessment for secondary prevention in ACS patients receiving PCI.
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1297527
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Article ; Online: Hierarchical energy management strategy based on adaptive dynamic programming for hybrid electric vehicles in car-following scenarios

Tang, Wenbin / Wang, Yaqian / Jiao, Xiaohong / Ren, Lina

Energy. 2023 Feb., v. 265 p.126264-

2023

Abstract: In order to improve the driving safety and fuel economy of hybrid electric vehicles (HEVs) in car-following scenarios, this paper proposes a hierarchical energy management strategy (EMS) based on adaptive dynamic programming (ADP). In the upper-layer ... ...

Abstract	In order to improve the driving safety and fuel economy of hybrid electric vehicles (HEVs) in car-following scenarios, this paper proposes a hierarchical energy management strategy (EMS) based on adaptive dynamic programming (ADP). In the upper-layer speed planning, the speed prediction model of the preceding vehicle is established utilizing a back-propagation neural network (BPNN), and the host vehicle speed is planned based on heuristic dynamic programming (HDP) real-time through the predicted preceding vehicle speed and the current state of the host vehicle. In the lower-layer energy management control, the EMS based on dual heuristic dynamic programming (DHP) is used to realize the power allocation of each power source according to the planned speed to reduce fuel consumption. In both HDP and DHP algorithms, BPNN is used to implement the critic network (CN) and action network (AN) to obtain a more accurate control variable and faster convergence speed. By comparing the results with various existing EMSs in the different driving cycles, the simulation results show that the proposed EMS ensures real-time planning speed and good following performance while reducing energy consumption.
Keywords	energy ; energy use and consumption ; fuels ; models ; Adaptive dynamic programming (ADP) ; Predictive cruise control (PCC) ; Back-propagation neural network (BPNN) ; Energy management strategy (EMS) ; Hybrid electric vehicle (HEV)
Language	English
Dates of publication	2023-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2022.126264
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Article ; Online: The role of ADRB2 gene polymorphisms in malignancies.

Wang, Yaqian / Jiang, Shujuan

Molecular biology reports

2021 Volume 48, Issue 3, Page(s) 2741–2749

Abstract: Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is increasing evidence showing that beta-2-adrenergic receptors are associated with carcinogenesis, proliferation, ...

Abstract	Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is increasing evidence showing that beta-2-adrenergic receptors are associated with carcinogenesis, proliferation, immune regulation, invasion, angiogenesis, clinical prognosis and treatment resistance in malignancies. Polymorphisms of the ADRB2 gene have been confirmed to be associated with transcriptional activity, mRNA translation, and beta-2-adrenergic receptor expression and sensitivity. This review discusses clinically relevant examples of single nucleotide polymorphisms of ADRB2 in malignancies and the effects of these polymorphisms on cancer susceptibility, prognosis and treatment response of cancer patients.
MeSH term(s)	Animals ; Genetic Predisposition to Disease ; Humans ; Neoplasms/genetics ; Polymorphism, Genetic ; Receptors, Adrenergic, beta-2/genetics ; Risk Factors ; Signal Transduction
Chemical Substances	Receptors, Adrenergic, beta-2
Language	English
Publishing date	2021-03-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06250-y
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Article ; Online: Combinatorial expression of γ-protocadherins regulates synaptic connectivity in the mouse neocortex.

Zhu, Yi-Jun / Deng, Cai-Yun / Fan, Liu / Wang, Ya-Qian / Zhou, Hui / Xu, Hua-Tai

eLife

2024 Volume 12

Abstract: In the process of synaptic formation, neurons must not only adhere to specific principles when selecting synaptic partners but also possess mechanisms to avoid undesirable connections. Yet, the strategies employed to prevent unwarranted associations have ...

Abstract	In the process of synaptic formation, neurons must not only adhere to specific principles when selecting synaptic partners but also possess mechanisms to avoid undesirable connections. Yet, the strategies employed to prevent unwarranted associations have remained largely unknown. In our study, we have identified the pivotal role of combinatorial clustered protocadherin gamma (γ-PCDH) expression in orchestrating synaptic connectivity in the mouse neocortex. Through 5' end single-cell sequencing, we unveiled the intricate combinatorial expression patterns of γ-PCDH variable isoforms within neocortical neurons. Furthermore, our whole-cell patch-clamp recordings demonstrated that as the similarity in this combinatorial pattern among neurons increased, their synaptic connectivity decreased. Our findings elucidate a sophisticated molecular mechanism governing the construction of neural networks in the mouse neocortex.
MeSH term(s)	Animals ; Mice ; Cadherin Related Proteins ; Cadherins/genetics ; Neocortex ; Neural Networks, Computer
Chemical Substances	Gamma-protocadherins ; Cadherin Related Proteins ; Cadherins
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.89532
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Article: The role of ADRB2 gene polymorphisms in malignancies

Wang, Yaqian / Jiang, Shujuan

Molecular biology reports. 2021 Mar., v. 48, no. 3

2021

Abstract	Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is increasing evidence showing that beta-2-adrenergic receptors are associated with carcinogenesis, proliferation, immune regulation, invasion, angiogenesis, clinical prognosis and treatment resistance in malignancies. Polymorphisms of the ADRB2 gene have been confirmed to be associated with transcriptional activity, mRNA translation, and beta-2-adrenergic receptor expression and sensitivity. This review discusses clinically relevant examples of single nucleotide polymorphisms of ADRB2 in malignancies and the effects of these polymorphisms on cancer susceptibility, prognosis and treatment response of cancer patients.
Keywords	angiogenesis ; carcinogenesis ; genes ; molecular biology ; prognosis ; transcription (genetics)
Language	English
Dates of publication	2021-03
Size	p. 2741-2749.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06250-y
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Article ; Online: The "Hand as Foot" teaching method for salivary gland imaging in nuclear medicine.

Wang, Yaqian / Chen, Na / Chang, Peiye / Li, Jianbo

Asian journal of surgery

2022 Volume 45, Issue 12, Page(s) 2842–2843

MeSH term(s)	Humans ; Nuclear Medicine ; Salivary Glands/diagnostic imaging ; Radionuclide Imaging ; Diagnostic Imaging ; Hand/diagnostic imaging ; Lower Extremity
Language	English
Publishing date	2022-06-21
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.06.060
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Article ; Online: Gender differences in trace element exposures with cognitive abilities of school-aged children: a cohort study in Wujiang city, China.

Wang, Yihong / Wang, Yaqian / Yan, Chonghuai

Environmental science and pollution research international

2022 Volume 29, Issue 43, Page(s) 64807–64821

Abstract: Trace elements persist in the environment, and their early exposure may adversely affect children's intellectual development. To clarify the influence of blood trace element levels in newborns and school-aged children, we used Wechsler Intelligence Scale ...

Abstract	Trace elements persist in the environment, and their early exposure may adversely affect children's intellectual development. To clarify the influence of blood trace element levels in newborns and school-aged children, we used Wechsler Intelligence Scale for children (WISC-CR) to explore intellectual development level of 148 school-aged children based on a population cohort study. Lead (Pb), selenium (Se), arsenic (As), copper (Cu), manganese (Mn) and chromium (Cr) in cord blood and Pb, As, Cu in venous blood were determined by inductively coupled plasma mass spectrometry (ICP-MS) and atomic absorption spectrometer (AAS). Our analysis of the correlation between children's mental development and trace element content found children's cognitive abilities negatively correlate with Pb (PIQ: β=-0.109, P=0.03737) and Cu (PIQ: β=-0.031, P=0.04431; FISQ: β=-0.031, P=0.02137) levels in cord blood. Prenatal low-level As exposure may negatively affect girls' performance intelligence quotient (PIQ) and verbal intelligence quotient (VIQ). There were differences in Se levels in cord blood and venous blood between boys and girls (P=0.010; P=0.073). High Se levels were associated with a lower VIQ in boys and a higher VIQ in girls. Prenatal exposure to Pb, As and Cu may weaken children's cognitive abilities at school age. Se exposure may have opposite effects on cognitive abilities affected by dose and gender.
MeSH term(s)	Arsenic ; Child ; Chromium/pharmacology ; Cognition ; Cohort Studies ; Copper/pharmacology ; Female ; Humans ; Infant, Newborn ; Lead/pharmacology ; Male ; Manganese ; Pregnancy ; Selenium/pharmacology ; Sex Factors ; Trace Elements
Chemical Substances	Trace Elements ; Chromium (0R0008Q3JB) ; Lead (2P299V784P) ; Manganese (42Z2K6ZL8P) ; Copper (789U1901C5) ; Selenium (H6241UJ22B) ; Arsenic (N712M78A8G)
Language	English
Publishing date	2022-04-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-20353-4
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Article: Gender differences in trace element exposures with cognitive abilities of school-aged children: a cohort study in Wujiang city, China

Wang, Yihong / Wang, Yaqian / Yan, Chonghuai

Environmental science and pollution research. 2022 Sept., v. 29, no. 43

2022

Abstract	Trace elements persist in the environment, and their early exposure may adversely affect children's intellectual development. To clarify the influence of blood trace element levels in newborns and school-aged children, we used Wechsler Intelligence Scale for children (WISC-CR) to explore intellectual development level of 148 school-aged children based on a population cohort study. Lead (Pb), selenium (Se), arsenic (As), copper (Cu), manganese (Mn) and chromium (Cr) in cord blood and Pb, As, Cu in venous blood were determined by inductively coupled plasma mass spectrometry (ICP-MS) and atomic absorption spectrometer (AAS). Our analysis of the correlation between children's mental development and trace element content found children’s cognitive abilities negatively correlate with Pb (PIQ: β=-0.109, P=0.03737) and Cu (PIQ: β=-0.031, P=0.04431; FISQ: β=-0.031, P=0.02137) levels in cord blood. Prenatal low-level As exposure may negatively affect girls’ performance intelligence quotient (PIQ) and verbal intelligence quotient (VIQ). There were differences in Se levels in cord blood and venous blood between boys and girls (P=0.010; P=0.073). High Se levels were associated with a lower VIQ in boys and a higher VIQ in girls. Prenatal exposure to Pb, As and Cu may weaken children’s cognitive abilities at school age. Se exposure may have opposite effects on cognitive abilities affected by dose and gender.
Keywords	arsenic ; atomic absorption spectrometry ; blood ; chromium ; cognition ; cohort studies ; copper ; gender ; manganese ; maternal exposure ; pollution ; research ; selenium ; China
Language	English
Dates of publication	2022-09
Size	p. 64807-64821.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-20353-4
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