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Article ; Online: Function of autophagy genes in innate immune defense against mucosal pathogens.

Cui, Xiaoyan / Wang, Ya-Ting

2024 Volume 79, Page(s) 102456

Abstract: Mucosal immunity is posed to constantly interact with commensal microbes and invading pathogens. As a fundamental cell biological pathway affecting immune response, autophagy regulates the interaction between mucosal immunity and microbes through ... ...

Abstract	Mucosal immunity is posed to constantly interact with commensal microbes and invading pathogens. As a fundamental cell biological pathway affecting immune response, autophagy regulates the interaction between mucosal immunity and microbes through multiple mechanisms, including direct elimination of microbes, control of inflammation, antigen presentation and lymphocyte homeostasis, and secretion of immune mediators. Some of these physiologically important functions do not involve canonical degradative autophagy but rely on certain autophagy genes and their 'autophagy gene-specific functions.' Here, we review the relationship between autophagy and important mucosal pathogens, including influenza virus, Mycobacterium tuberculosis, Salmonella enterica, Citrobacter rodentium, norovirus, and herpes simplex virus, with a particular focus on distinguishing the canonical versus gene-specific mechanisms of autophagy genes.
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1418474-6
ISSN	1879-0364 ; 1369-5274
ISSN (online)	1879-0364
ISSN	1369-5274
DOI	10.1016/j.mib.2024.102456
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Article: Gastroduodenal strongyloidiasis infection causing protein-losing enteropathy: A case report and review of the literature.

Wang, Yating / Zhang, Xuequn

Heliyon

2023 Volume 9, Issue 7, Page(s) e18094

Abstract: Strongyloides stercoralis is an intestinal nematode in which adult worms in the host small intestine can cause strongyloidiasis. Symptoms in immunocompromised patients might range from diarrhea and bleeding to sepsis and even death. A 56-year-old patient ...

Abstract	Strongyloides stercoralis is an intestinal nematode in which adult worms in the host small intestine can cause strongyloidiasis. Symptoms in immunocompromised patients might range from diarrhea and bleeding to sepsis and even death. A 56-year-old patient presented with a 2-month history of weight loss, vomiting, and diarrhea. The patient had type 2 diabetes mellitus (T2DM) and was on long-term prednisone for chronic kidney disease. The results of the gastric emptying test and head magnetic resonance (MRI) were normal. A blood test revealed increased IgE levels, eosinophilia, and hypoalbuminemia. Parasitic larvae were not discovered during stool analysis. Gastroscopy revealed chronic nonatrophic gastritis with erosions and dilation of lymphatic vessels of the duodenum. Small-bowel capsule endoscopy suggested dilation of lymphatic vessels of the small intestine. Colonoscopy revealed no abnormalities. Finally, a histopathology examination identified
Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Case Reports
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e18094
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Article ; Online: Spatially Confined Nanoreactors Designed for Biological Applications.

Wang, Yating / Xie, Fengjuan / Zhao, Liang

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2310331

Abstract: The applications of nanoreactors in biology are becoming increasingly significant and prominent. Specifically, nanoreactors with spatially confined, due to their exquisite design that effectively limits the spatial range of biomolecules, attracted ... ...

Abstract	The applications of nanoreactors in biology are becoming increasingly significant and prominent. Specifically, nanoreactors with spatially confined, due to their exquisite design that effectively limits the spatial range of biomolecules, attracted widespread attention. The main advantage of this structure is designed to improve reaction selectivity and efficiency by accumulating reactants and catalysts within the chambers, thus increasing the frequency of collisions between reactants. Herein, the recent progress in the synthesis of spatially confined nanoreactors and their biological applications is summarized, covering various kinds of nanoreactors, including porous inorganic materials, porous crystalline materials with organic components and self-assembled polymers to construct nanoreactors. These design principles underscore how precise reaction control could be achieved by adjusting the structure and composition of the nanoreactors to create spatial confined. Furthermore, various applications of spatially confined nanoreactors are demonstrated in the biological fields, such as biocatalysis, molecular detection, drug delivery, and cancer therapy. These applications showcase the potential prospects of spatially confined nanoreactors, offering robust guidance for future research and innovation.
Language	English
Publishing date	2024-01-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202310331
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Article: Machine learning model based on enhanced CT radiomics for the preoperative prediction of lymphovascular invasion in esophageal squamous cell carcinoma.

Wang, Yating / Bai, Genji / Huang, Min / Chen, Wei

Frontiers in oncology

2024 Volume 14, Page(s) 1308317

Abstract: Objective: To evaluate the value of a machine learning model using enhanced CT radiomics features in the prediction of lymphovascular invasion (LVI) of esophageal squamous cell carcinoma (ESCC) before treatment.: Methods: We reviewed and analyzed the ...

Abstract	Objective: To evaluate the value of a machine learning model using enhanced CT radiomics features in the prediction of lymphovascular invasion (LVI) of esophageal squamous cell carcinoma (ESCC) before treatment. Methods: We reviewed and analyzed the enhanced CT images of 258 ESCC patients from June 2017 to December 2019. We randomly assigned the patients in a ratio of 7:3 to a training set (182 cases) and a validation (76 cases) set. Clinical risk factors and CT image characteristics were recorded, and multifactor logistic regression was used to screen independent risk factors of LVI of ESCC patients. We extracted the CT radiomics features using the FAE software and screened radiomics features using maximum relevance and minimum redundancy (MRMR) and least absolute shrinkage and selection operator (LASSO) algorithms, and finally, the radiomics labels of each patient were established. Five machine learning algorithms, namely, support vector machine (SVM), K-nearest neighbor (KNN), logistic regression (LR), Gauss naive Bayes (GNB), and multilayer perceptron (MLP), were used to construct the model of radiomics labels, and its clinical features were screened. The predictive efficacy of the machine learning model for LVI of ESCC was evaluated using the receiver operating characteristic (ROC) curve. Results: Tumor thickness [OR = 1.189, 95% confidence interval (CI) 1.060-1.351, Conclusion: Machine learning models can preoperatively predict the condition of LVI effectively in patients with ESCC based on enhanced CT radiomics features. The GNB and LR models exhibit good stability and may bring a new way for the non-invasive prediction of LVI condition in ESCC patients before treatment.
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1308317
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Article ; Online: Research progress of endogenous neural stem cells in spinal cord injury.

Wang, Ya-Ting / Yuan, Hao

Ibrain

2022 Volume 8, Issue 2, Page(s) 199–209

Abstract: Spinal cord injury (SCI) is a severe disabling disease, which mainly manifests as impairments of sensory and motor functions, sexual function, bladder and intestinal functions, respiratory and cardiac functions below the injury plane. In addition, the ... ...

Abstract	Spinal cord injury (SCI) is a severe disabling disease, which mainly manifests as impairments of sensory and motor functions, sexual function, bladder and intestinal functions, respiratory and cardiac functions below the injury plane. In addition, the condition has a profound effect on the mental health of patients, which often results in severe sequelae. Some patients may be paraplegic for life or even die, which places a huge burden on the family and society. There is still no effective treatment for SCI. Studies have confirmed that endogenous neural stem cells (ENSCs), as multipotent neural stem cells, which are located in the ependymal region of the central canal of the adult mammalian spinal cord, are activated after SCI and then differentiate into various nerve cells to promote endogenous repair and regeneration. However, the central canal of the spinal cord is often occluded to varying degrees in adults, and residual ependymal cells cannot be activated and do not proliferate after SCI. Besides, the destruction of the microenvironment after SCI is also an important factor that affects the proliferation and differentiation of ENSCs and spinal cord repair. Therefore, this review describes the role of ENSCs in SCI, in terms of the origin, transformation, treatment, and influencing factors, to provide new ideas for clinical treatment of SCI.
Language	English
Publishing date	2022-06-04
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2769-2795
ISSN (online)	2769-2795
DOI	10.1002/ibra.12048
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Article ; Online: Updates of cancer hallmarks in patients with inborn errors of immunity.

Wang, Yating / Abolhassani, Hassan

Current opinion in allergy and clinical immunology

2022 Volume 22, Issue 6, Page(s) 352–363

Abstract: Purpose of review: The development of cancer in patients with genetically determined inborn errors of immunity (IEI) is much higher than in the general population. The hallmarks of cancer are a conceptualization tool that can refine the complexities of ... ...

Abstract	Purpose of review: The development of cancer in patients with genetically determined inborn errors of immunity (IEI) is much higher than in the general population. The hallmarks of cancer are a conceptualization tool that can refine the complexities of cancer development and pathophysiology. Each genetic defect may impose a different pathological tumor predisposition, which needs to be identified and linked with known hallmarks of cancer. Recent findings: Four new hallmarks of cancer have been suggested, recently, including unlocking phenotypic plasticity, senescent cells, nonmutational epigenetic reprogramming, and polymorphic microbiomes. Moreover, more than 50 new IEI genes have been discovered during the last 2 years from which 15 monogenic defects perturb tumor immune surveillance in patients. Summary: This review provides a more comprehensive and updated overview of all 14 cancer hallmarks in IEI patients and covers aspects of cancer predisposition in novel genes in the ever-increasing field of IEI.
MeSH term(s)	Humans ; Neoplasms/genetics ; Disease Susceptibility ; Genotype
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2088710-3
ISSN	1473-6322 ; 1528-4050
ISSN (online)	1473-6322
ISSN	1528-4050
DOI	10.1097/ACI.0000000000000863
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Zs.A 5666: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: The race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options.

Wang, Yating / Tang, Shou-Ching

Cancer metastasis reviews

2022 Volume 41, Issue 4, Page(s) 975–990

Abstract: Hormonal therapy plays a vital part in the treatment of estrogen receptor-positive (ER +) breast cancer. ER can be activated in a ligand-dependent and independent manner. Currently available ER-targeting agents include selective estrogen receptor ... ...

Abstract	Hormonal therapy plays a vital part in the treatment of estrogen receptor-positive (ER +) breast cancer. ER can be activated in a ligand-dependent and independent manner. Currently available ER-targeting agents include selective estrogen receptor modulators (SERMs), selective estrogen receptor degraders (SERDs), and aromatase inhibitors (AIs). Estrogen receptor mutation (ESR1 mutation) is one of the common mechanisms by which breast cancer becomes resistant to additional therapies from SERMs or AIs. These tumors remain sensitive to SERDs such as fulvestrant. Fulvestrant is limited in clinical utilization by its intramuscular formulation and once-monthly injection in large volumes. Oral SERDs are being rapidly developed to replace fulvestrant with the potential of higher efficacy and lower toxicities. Elacestrant is the first oral SERD that went through a randomized phase III trial showing increased efficacy, especially in tumors bearing ESR1 mutation, and good tolerability. Two other oral SERDs recently failed to achieve the primary endpoints of longer progression-free survival (PFS). They targeted tumors previously treated with several lines of prior therapies untested for ESR1 mutation. Initial clinical trial data demonstrated that tumors without the ESR1 mutation are less likely to benefit from the SERDs and may still respond to SERMs or AIs, including tumors previously exposed to hormonal therapy. Testing for ESR1 mutation in ongoing clinical trials and in hormonal therapy for breast cancer is highly recommended. Novel protein degradation technologies such as proteolysis-targeting chimera (PROTACS), molecular glue degrader (MGD), and lysosome-targeting chimeras (LYTACS) may result in more efficient ER degradation, while ribonuclease-targeting chimeras (RIBOTAC) and small interfering RNA (siRNA) may inhibit the production of ER protein.
MeSH term(s)	Humans ; Female ; Selective Estrogen Receptor Modulators/pharmacology ; Selective Estrogen Receptor Modulators/therapeutic use ; Fulvestrant/therapeutic use ; Receptors, Estrogen/metabolism ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Clinical Trials, Phase III as Topic ; Randomized Controlled Trials as Topic
Chemical Substances	Selective Estrogen Receptor Modulators ; Fulvestrant (22X328QOC4) ; Receptors, Estrogen ; Estrogen Receptor alpha
Language	English
Publishing date	2022-10-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	604857-2
ISSN	1573-7233 ; 0167-7659
ISSN (online)	1573-7233
ISSN	0167-7659
DOI	10.1007/s10555-022-10066-y
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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Regulatory mechanisms underlying yeast chemical stress response and development of robust strains for bioproduction.

Yuan, Bing / Wang, Wei-Bin / Wang, Ya-Ting / Zhao, Xin-Qing

Current opinion in biotechnology

2024 Volume 86, Page(s) 103072

Abstract: Yeast is widely studied in producing biofuels and biochemicals using renewable biomass. Among various yeasts, Saccharomyces cerevisiae has been particularly recognized as an important yeast cell factory. However, economic bioproduction using S. ... ...

Abstract	Yeast is widely studied in producing biofuels and biochemicals using renewable biomass. Among various yeasts, Saccharomyces cerevisiae has been particularly recognized as an important yeast cell factory. However, economic bioproduction using S. cerevisiae is challenged by harsh environments during fermentation, among which inhibitory chemicals in the culture media or toxic products are common experiences. Understanding the stress-responsive mechanisms is conducive to developing robust yeast strains. Here, we review recent progress in mechanisms underlying yeast stress response, including regulation of cell wall integrity, membrane transport, antioxidative system, and gene transcription. We highlight epigenetic regulation of stress response and summarize manipulation of yeast stress tolerance for improved bioproduction. Prospects in the application of machine learning to improve production efficiency are also discussed.
MeSH term(s)	Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Epigenesis, Genetic ; Ethanol/metabolism ; Fermentation ; Biofuels
Chemical Substances	Ethanol (3K9958V90M) ; Biofuels
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1052045-4
ISSN	1879-0429 ; 0958-1669
ISSN (online)	1879-0429
ISSN	0958-1669
DOI	10.1016/j.copbio.2024.103072
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Article: Rap1 Activation Protects Against Fatty Liver and Non-Alcoholic Steatohepatitis Development.

Agarwal, Heena / Wang, Yating / Ozcan, Lale

bioRxiv : the preprint server for biology

2023

Abstract: We previously demonstrated that hepatic activation of a small G protein of the Ras family, Rap1a, is suppressed in obesity, which results in increased hepatic glucose production and glucose intolerance in obese mice. Here, we show that Rap1a inhibition ... ...

Abstract	We previously demonstrated that hepatic activation of a small G protein of the Ras family, Rap1a, is suppressed in obesity, which results in increased hepatic glucose production and glucose intolerance in obese mice. Here, we show that Rap1a inhibition in obese mice liver also results in fatty liver formation, which is characteristic of the diabetic liver. Specifically, we report that Rap1a activity is decreased in the livers of patients with non-alcoholic steatohepatitis (NASH) and mouse models of non-alcoholic fatty liver disease (NAFLD) and NASH. Restoring hepatic Rap1a activity by overexpressing a constitutively active mutant form of Rap1a lowered the mature, processed form of lipogenic transcription factor, Srebp1, without an effect on the unprocessed Srebp1 and suppressed hepatic TG accumulation, whereas liver Rap1a deficiency increased Srebp1 processing and exacerbated steatosis. Mechanistically, we show that mTORC1, which promotes Srebp1 cleavage, is hyperactivated upon Rap1a deficiency despite disturbed insulin signaling. In proof-of-principle studies, we found that treatment of obese mice with a small molecule activator of Rap1a (8-pCPT) or inhibiting Rap1a's endogenous inhibitor, Rap1Gap, recapitulated our hepatic gain-of-function model and resulted in improved hepatic steatosis and lowered lipogenic genes. Thus, hepatic Rap1a serves as a signaling molecule that suppresses both hepatic gluconeogenesis and steatosis, and inhibition of its activity in the liver contributes to the pathogenesis of glucose intolerance and NAFLD/NASH development.
Language	English
Publishing date	2023-10-24
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.24.563728
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Article ; Online: Analysis of Spatiotemporal Changes of Ecological Environment Quality and Its Coupling Coordination with Urbanization in the Yangtze River Delta Urban Agglomeration, China.

Shi, Zhiyu / Wang, Yating / Zhao, Qing

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: It is inevitable that urban agglomeration will have a coercive impact on the regional Ecological Environment Quality (EEQ) as a consequence of high-speed urbanization. Balancing the EEQ and urbanization development has become a problem worthy of ... ...

Abstract	It is inevitable that urban agglomeration will have a coercive impact on the regional Ecological Environment Quality (EEQ) as a consequence of high-speed urbanization. Balancing the EEQ and urbanization development has become a problem worthy of attention. In order to objectively evaluate the EEQ of the Yangtze River Delta Urban Agglomeration (YRDUA) and explore the impact of the urbanization process on it, this paper is based on the Modified Remote Sensing Ecological Index (MRSEI) and the Comprehensive Night Light Index (CNLI), respectively, and conducts a quantitative assessment of the YRDUA in China from 2000 to 2020. The results show that: (1) From 2000 to 2020, the MRSEI of the YRDUA first decreased and then increased, and the ecological environment quality degraded first and then improved; however, there were significant differences between regions. The ecological environment quality in the south is obviously better than that in the north, and the ecological environment quality in the north changes more drastically, and the low value area of MRSEI will gradually move downstream as time changes; (2) During the study period, the YRDUA formed a hierarchical and progressive urbanization pattern. The inland urbanization process expanded from east to west along the Yangtze River, and the urbanization process of coastal cities expanded from Shanghai as the center to the north and south with high-intensity urbanization cities concentrated in Shanghai and its surrounding cities and low-intensity urbanization cities distributed in the western part of the urban agglomeration; (3) The Coupling Coordination Degree (CCD) between urbanization and EEQ in the YRDUA has continuously improved with an increase of 28.57% in the past 21 years, and the number of cities with high level coupling continues to rise, while the number of medium level coupling cities and low level coupling cities has declined. As a large-scale and long-term analysis of changes in the EEQ and the urbanization process, this study can provide theoretical support for policymakers to formulate mesoscale development planning, EEQ monitoring, and environmental protection policies.
MeSH term(s)	Urbanization ; China ; Cities ; Conservation of Natural Resources ; Rivers ; Economic Development
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021627
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