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Article: Complete Neuron Reconstruction Based on Branch Confidence.

Zeng, Ying / Wang, Yimin

2024 Volume 14, Issue 4

Abstract: In the past few years, significant advancements in microscopic imaging technology have led to the production of numerous high-resolution images capturing brain neurons at the micrometer scale. The reconstructed structure of neurons from neuronal images ... ...

Abstract	In the past few years, significant advancements in microscopic imaging technology have led to the production of numerous high-resolution images capturing brain neurons at the micrometer scale. The reconstructed structure of neurons from neuronal images can serve as a valuable reference for research in brain diseases and neuroscience. Currently, there lacks an accurate and efficient method for neuron reconstruction. Manual reconstruction remains the primary approach, offering high accuracy but requiring significant time investment. While some automatic reconstruction methods are faster, they often sacrifice accuracy and cannot be directly relied upon. Therefore, the primary goal of this paper is to develop a neuron reconstruction tool that is both efficient and accurate. The tool aids users in reconstructing complete neurons by calculating the confidence of branches during the reconstruction process. The method models the neuron reconstruction as multiple Markov chains, and calculates the confidence of the connections between branches by simulating the reconstruction artifacts in the results. Users iteratively modify low-confidence branches to ensure precise and efficient neuron reconstruction. Experiments on both the publicly accessible BigNeuron dataset and a self-created Whole-Brain dataset demonstrate that the tool achieves high accuracy similar to manual reconstruction, while significantly reducing reconstruction time.
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci14040396
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exosome-Transmitted miR-506-3p Inhibits Colorectal Cancer Cell Malignancy via Regulating GSTP1

Xuan, Bin / Wang, Yimin

Appl Biochem Biotechnol. 2023 Mar., v. 195, no. 3 p.2015-2027

2023

Abstract: Exosome-mediated microRNA transfer has been shown to regulate cancer progression. However, the involvement of exosomal-miR-506-3p in colorectal cancer (CRC) is unknown. The goal of the research was to study into the role of exosomal-miR-506-3p in CRC. ... ...

Abstract	Exosome-mediated microRNA transfer has been shown to regulate cancer progression. However, the involvement of exosomal-miR-506-3p in colorectal cancer (CRC) is unknown. The goal of the research was to study into the role of exosomal-miR-506-3p in CRC. Using a qRT-PCR experiment, it was observed that CRC tissues had lower levels of miR-506-3p than non-tumor tissues. It was observed that miR-506-3p inhibited the proliferation, regulates apoptosis, and cell cycle of HT29 and SW480 cells as compared to control groups. Dual luciferase reporter assay results showed that GSTP1 was the downstream target molecule of miR-506-3p, which was consistent with the database prediction. Furthermore, FHC cells transfected with miR-506-3p could transfer miR-506-3p to SW480 cells, limiting cell growth and inducing cell death. We discovered a unique regulatory mechanism in which exosome-mediated transfer of miR-506-3p reduces proliferation and induces apoptosis in CRC through negative regulation of GSTP1, implying that exosome-mediated delivery of miR-506-3p provides fresh insight into CRC diagnostics and treatment.
Keywords	apoptosis ; cell cycle ; cell growth ; colorectal neoplasms ; databases ; diagnostic techniques ; luciferase ; microRNA ; neoplasm cells ; neoplasm progression ; prediction
Language	English
Dates of publication	2023-03
Size	p. 2015-2027.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	392344-7
ISSN	0273-2289
ISSN	0273-2289
DOI	10.1007/s12010-022-04268-x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Key Strategies for Increasing Users’ Intention of Self-disclosure in Human-robot Interaction through Robotic Appearance Design

Zhu Xiaoling / Liang Wenrui / Xv Wenjun / Wang Yimin

SHS Web of Conferences, Vol 165, p

2023 Volume 01012

Abstract: Bridging the communication gap between humans and social robots constitutes a critical area of research in the field of human-robot interaction (HRI). However, inducing self-disclosure in HRI is a challenging task, primarily due to the unique ... ...

Abstract	Bridging the communication gap between humans and social robots constitutes a critical area of research in the field of human-robot interaction (HRI). However, inducing self-disclosure in HRI is a challenging task, primarily due to the unique characteristics of social robots. This study aims to address the following research question: Can the design expression dimensions that influence user disclosure depth in the HRI process be deconstructed? Do design strategies take precedence over appearance design? Firstly, we segmented the focus of appearance design into three dimensions: Artistic Expression, Featured Expression, and Identified Expression, hypothesizing their level of significance. Subsequently, we created a prototype with balanced degrees for experimentation and invited 52 users to participate in HRI, guiding them to self-disclose and record data. Bayesian statistics were utilized to model the data and obtain comprehensive user feedback regarding appearance design. Based on the experimental results, we reviewed the content and potential order of the three dimensions and proposed our design and research model. Currently, at the theoretical level, there is no significant emphasis on users’ willingness to self-disclose in HRI. Our proposed model serves as a valuable tool for researchers in the fields of human-computer interaction, communication, and user experience design to gain quick insights into this topic. At the practical level, our model has reference significance for industrial and visual designers, enabling them to better comprehend the design goals, situations, and output design methods.
Keywords	Social Sciences ; H
Subject code	700
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Towards a green world: the impact of the Belt and Road Initiative on the carbon intensity reduction of countries along the route.

Xin, Li / Wang, Yimin

Environmental science and pollution research international

2022 Volume 29, Issue 19, Page(s) 28510–28526

Abstract: The Belt and Road Initiative (BRI) has attracted widespread attention since its implementation, especially the ecological effect. However, the net environmental impact of the BRI on countries along the route has rarely been directly assessed, though ... ...

Abstract	The Belt and Road Initiative (BRI) has attracted widespread attention since its implementation, especially the ecological effect. However, the net environmental impact of the BRI on countries along the route has rarely been directly assessed, though nearly 8 years after the BRI was proposed. This study quantitatively estimates the net effect, impact mechanism, and impact heterogeneity of the BRI on the carbon intensity reduction of countries along the route by adopting the difference-in-differences estimator based on propensity score matching, which enables a more convincing causal relationship between the BRI and the countries' ecological improvement. Research indicates that the BRI has significantly promoted the carbon intensity reduction of countries along the route, which is mainly achieved by boosting the growth of green economy (scale effect), the progress of green technology (technique effect), and the upgrading of industrial structure (composition effect). Moreover, the impact reveals obvious heterogeneity, manifested as the BRI has significantly promoted the carbon intensity reduction of countries with high institutional quality, high-income countries, and countries along the Silk Road Economic Belt, while its impacts on countries with low institutional quality, low-income countries, and countries along the 21st Century Maritime Silk Road are not significant. A series of validity tests further demonstrate the robustness of the estimation.
MeSH term(s)	Carbon ; Carbon Dioxide/analysis ; China ; Economic Development ; Environment ; Silk
Chemical Substances	Silk ; Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
Language	English
Publishing date	2022-01-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17575-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exosome-Transmitted miR-506-3p Inhibits Colorectal Cancer Cell Malignancy via Regulating GSTP1.

Xuan, Bin / Wang, Yimin

Applied biochemistry and biotechnology

2022 Volume 195, Issue 3, Page(s) 2015–2027

Abstract	Exosome-mediated microRNA transfer has been shown to regulate cancer progression. However, the involvement of exosomal-miR-506-3p in colorectal cancer (CRC) is unknown. The goal of the research was to study into the role of exosomal-miR-506-3p in CRC. Using a qRT-PCR experiment, it was observed that CRC tissues had lower levels of miR-506-3p than non-tumor tissues. It was observed that miR-506-3p inhibited the proliferation, regulates apoptosis, and cell cycle of HT29 and SW480 cells as compared to control groups. Dual luciferase reporter assay results showed that GSTP1 was the downstream target molecule of miR-506-3p, which was consistent with the database prediction. Furthermore, FHC cells transfected with miR-506-3p could transfer miR-506-3p to SW480 cells, limiting cell growth and inducing cell death. We discovered a unique regulatory mechanism in which exosome-mediated transfer of miR-506-3p reduces proliferation and induces apoptosis in CRC through negative regulation of GSTP1, implying that exosome-mediated delivery of miR-506-3p provides fresh insight into CRC diagnostics and treatment.
MeSH term(s)	Humans ; Exosomes/genetics ; Exosomes/metabolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cell Proliferation/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Gene Expression Regulation, Neoplastic ; Glutathione S-Transferase pi/genetics
Chemical Substances	MicroRNAs ; GSTP1 protein, human (EC 2.5.1.18) ; Glutathione S-Transferase pi (EC 2.5.1.18) ; MIRN506 microRNA, human
Language	English
Publishing date	2022-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	392344-7
ISSN	1559-0291 ; 0273-2289
ISSN (online)	1559-0291
ISSN	0273-2289
DOI	10.1007/s12010-022-04268-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SORBS1 inhibits epithelial to mesenchymal transition (EMT) of breast cancer cells by regulating PI3K/AKT signaling and macrophage phenotypic polarization.

Feng, Kai / Di, Ya / Han, Meng / Yan, Weitao / Wang, Yimin

Aging

2024 Volume 16, Issue 5, Page(s) 4789–4810

Abstract: This study aimed to explore the regulatory role of SORBS1 in macrophage polarization and the PI3K/AKT signaling pathway, as well as analyze its mechanism in epithelial-mesenchymal transition (EMT) of breast cancer cells. We established SORBS1- ... ...

Abstract	This study aimed to explore the regulatory role of SORBS1 in macrophage polarization and the PI3K/AKT signaling pathway, as well as analyze its mechanism in epithelial-mesenchymal transition (EMT) of breast cancer cells. We established SORBS1-overexpressing and knockout cell lines and verified the effects of SORBS1 on cell viability, invasion, and migration by phenotyping experiments and assaying the expression of associated proteins. Furthermore, we established a breast cancer cell and macrophage co-culture system to validate the effect of SORBS1 expression on macrophage polarization and killing of breast cancer cells. Bioinformatics analysis showed that SORBS1 was lowly expressed in breast cancer (BRCA) samples and highly expressed in healthy tissues. Decreased SORBS1 expression was associated with poor prognosis, and the PI3K/AKT signaling pathway was the most significantly enriched pathway.
MeSH term(s)	Humans ; Female ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Breast Neoplasms/genetics ; Cell Line, Tumor ; Signal Transduction ; Macrophages/metabolism ; Cell Movement/genetics ; Cell Proliferation ; Microfilament Proteins/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; SORBS1 protein, human ; Microfilament Proteins
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205632
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Towards a green world: the impact of the Belt and Road Initiative on the carbon intensity reduction of countries along the route

Xin, Li / Wang, Yimin

Environ Sci Pollut Res. 2022 Apr., v. 29, no. 19 p.28510-28526

2022

Abstract	The Belt and Road Initiative (BRI) has attracted widespread attention since its implementation, especially the ecological effect. However, the net environmental impact of the BRI on countries along the route has rarely been directly assessed, though nearly 8 years after the BRI was proposed. This study quantitatively estimates the net effect, impact mechanism, and impact heterogeneity of the BRI on the carbon intensity reduction of countries along the route by adopting the difference-in-differences estimator based on propensity score matching, which enables a more convincing causal relationship between the BRI and the countries’ ecological improvement. Research indicates that the BRI has significantly promoted the carbon intensity reduction of countries along the route, which is mainly achieved by boosting the growth of green economy (scale effect), the progress of green technology (technique effect), and the upgrading of industrial structure (composition effect). Moreover, the impact reveals obvious heterogeneity, manifested as the BRI has significantly promoted the carbon intensity reduction of countries with high institutional quality, high-income countries, and countries along the Silk Road Economic Belt, while its impacts on countries with low institutional quality, low-income countries, and countries along the 21st Century Maritime Silk Road are not significant. A series of validity tests further demonstrate the robustness of the estimation.
Keywords	carbon ; economic sustainability ; environmental impact ; sustainable technology
Language	English
Dates of publication	2022-04
Size	p. 28510-28526.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17575-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: PSO-MCKD-MFFResnet based fault diagnosis algorithm for hydropower units.

Li, Xu / Xu, Zhuofei / Wang, Yimin

Mathematical biosciences and engineering : MBE

2023 Volume 20, Issue 8, Page(s) 14117–14135

Abstract: Due to the coupling effect of external environmental noise and vibration noise, the feature rate of the original hydroelectric unit fault signal is not prominent, which will affect the performance of fault diagnosis algorithms. To solve the above ... ...

Abstract	Due to the coupling effect of external environmental noise and vibration noise, the feature rate of the original hydroelectric unit fault signal is not prominent, which will affect the performance of fault diagnosis algorithms. To solve the above problems, this paper proposes a PSO-MCKD-MFFResnet algorithm for fault diagnosis of hydropower units (Particle swarm optimization, PSO; Maximum correlation kurtosis deconvolution, MCKD; Multi-scale feature fusion residual network, MFFResnet). In practical applications, the selection of key parameters in the traditional MCKD method is heavily dependent on prior knowledge. First, this paper proposes a PSO-MCKD enhancement algorithm for fault features, which uses the PSO algorithm to search for the influencing parameters of MCKD to enhance the features from the original fault signal. Second, a fault feature diagnosis algorithm based on MFFResnet is proposed to improve the utilization of local features. The multi-scale residual module is used to extract features at different scales and then put the enhanced signal into MFFResnet for training and classification. The experimental results show that our approach can accurately and effectively classify the fault types of hydropower units, with an accuracy rate of 98.85. It is superior to other representative algorithms in different indicators and has a good stability.
Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1551-0018
ISSN (online)	1551-0018
ISSN	1551-0018
DOI	10.3934/mbe.2023631
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biosynthesis of Au/CuO catalyst with

Yuan, Zhen / Liu, Hai / Wang, Yimin / Ke, Yihu

Nanotechnology

2023 Volume 34, Issue 36

Abstract: Efficient conversion of glycerol to 1,3-dihydroxyacetone (DHA) is the affirmation and guarantee of the feasible development of biodiesel industry, but the biocompatibility of catalyst must be considered due to the wide application of DHA in food and ... ...

Abstract	Efficient conversion of glycerol to 1,3-dihydroxyacetone (DHA) is the affirmation and guarantee of the feasible development of biodiesel industry, but the biocompatibility of catalyst must be considered due to the wide application of DHA in food and medicine industries. In this work, an environmentally benign biosynthesis approach with
MeSH term(s)	Glycerol ; Dihydroxyacetone ; Oxidation-Reduction ; Plant Extracts
Chemical Substances	Glycerol (PDC6A3C0OX) ; Dihydroxyacetone (O10DDW6JOO) ; cupric oxide (V1XJQ704R4) ; Plant Extracts
Language	English
Publishing date	2023-06-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/acdd7c
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: Image and geometry analysis for brain informatics.

Wang, Yimin / Zhou, Zhi / Liu, Min

Frontiers in neuroinformatics

2023 Volume 17, Page(s) 1174531

Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2452979-5
ISSN	1662-5196
ISSN	1662-5196
DOI	10.3389/fninf.2023.1174531
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