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Book ; Online: Nanotoxicology and Nanosafety 2.0

Wang, Ying-Jan

2020

Keywords	Medicine
Size	1 electronic resource (320 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021044531
ISBN	9783039367498 ; 3039367498
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Mechanisms of Nanotoxicology and the Important Role of Alternative Testing Strategies.

Wu, Yuan-Hua / Ho, Sheng-Yow / Wang, Bour-Jr / Wang, Ying-Jan

International journal of molecular sciences

2022 Volume 23, Issue 15

Abstract: Recently, rapid advances in nanotechnology have provided a lot of opportunities for the mass production of engineered nanomaterials of various types of chemicals, including metals and nonmetals, promoting the development of a new generation of industrial ...

Abstract	Recently, rapid advances in nanotechnology have provided a lot of opportunities for the mass production of engineered nanomaterials of various types of chemicals, including metals and nonmetals, promoting the development of a new generation of industrial and commercial products and the field of nanomedicine [...].
MeSH term(s)	Nanomedicine ; Nanostructures/toxicity ; Nanotechnology
Language	English
Publishing date	2022-07-26
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23158204
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury.

Wang, Bour-Jr / Chen, Yu-Ying / Chang, Hui-Hsuan / Chen, Rong-Jane / Wang, Ying-Jan / Lee, Yu-Hsuan

Particle and fibre toxicology

2024 Volume 21, Issue 1, Page(s) 9

Abstract: Background: Zinc oxide nanoparticles (ZnONPs) are common materials used in skin-related cosmetics and sunscreen products due to their whitening and strong UV light absorption properties. Although the protective effects of ZnONPs against UV light in ... ...

Abstract	Background: Zinc oxide nanoparticles (ZnONPs) are common materials used in skin-related cosmetics and sunscreen products due to their whitening and strong UV light absorption properties. Although the protective effects of ZnONPs against UV light in intact skin have been well demonstrated, the effects of using ZnONPs on damaged or sunburned skin are still unclear. In this study, we aimed to reveal the detailed underlying mechanisms related to keratinocytes and macrophages exposed to UVB and ZnONPs. Results: We demonstrated that ZnONPs exacerbated mouse skin damage after UVB exposure, followed by increased transepidermal water loss (TEWL) levels, cell death and epithelial thickness. In addition, ZnONPs could penetrate through the damaged epithelium, gain access to the dermis cells, and lead to severe inflammation by activation of M1 macrophage. Mechanistic studies indicated that co-exposure of keratinocytes to UVB and ZnONPs lysosomal impairment and autophagy dysfunction, which increased cell exosome release. However, these exosomes could be taken up by macrophages, which accelerated M1 macrophage polarization. Furthermore, ZnONPs also induced a lasting inflammatory response in M1 macrophages and affected epithelial cell repair by regulating the autophagy-mediated NLRP3 inflammasome and macrophage exosome secretion. Conclusions: Our findings propose a new concept for ZnONP-induced skin toxicity mechanisms and the safety issue of ZnONPs application on vulnerable skin. The process involved an interplay of lysosomal impairment, autophagy-mediated NLRP3 inflammasome and macrophage exosome secretion. The current finding is valuable for evaluating the effects of ZnONPs for cosmetics applications.
MeSH term(s)	Mice ; Animals ; Zinc Oxide/toxicity ; NLR Family, Pyrin Domain-Containing 3 Protein ; Ultraviolet Rays/adverse effects ; Cytokines ; Exosomes ; Inflammasomes ; Nanoparticles/toxicity ; Epithelial Cells
Chemical Substances	Zinc Oxide (SOI2LOH54Z) ; NLR Family, Pyrin Domain-Containing 3 Protein ; Cytokines ; Inflammasomes
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2170936-1
ISSN	1743-8977 ; 1743-8977
ISSN (online)	1743-8977
ISSN	1743-8977
DOI	10.1186/s12989-024-00571-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bioaccumulation and depuration of TiO

Lu, Hsin-Yi / Wang, Ying-Jan / Hou, Wen-Che

Journal of hazardous materials

2021 Volume 426, Page(s) 127801

Abstract: The bioaccumulation and depuration of ... ...

Abstract	The bioaccumulation and depuration of TiO
MeSH term(s)	Animals ; Bioaccumulation ; Hydrogen Peroxide ; Nanoparticles ; Titanium ; Zebrafish
Chemical Substances	titanium dioxide (15FIX9V2JP) ; Hydrogen Peroxide (BBX060AN9V) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2021-11-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.127801
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bioaccumulation and depuration of TiO2 nanoparticles by zebrafish through dietary exposure: Size- and number concentration-resolved analysis using single-particle ICP-MS

Lu, Hsin-Yi / Wang, Ying-Jan / Hou, Wen-Che

Journal of hazardous materials. 2022 Mar. 15, v. 426

2022

Abstract: The bioaccumulation and depuration of TiO₂ nanoparticles (TiO₂NPs) by zebrafish via the dietary exposure following the OECD Test Guideline 305 (OECD TG305) was evaluated using particle size- and number concentration-resolved analysis based on single- ... ...

Abstract	The bioaccumulation and depuration of TiO₂ nanoparticles (TiO₂NPs) by zebrafish via the dietary exposure following the OECD Test Guideline 305 (OECD TG305) was evaluated using particle size- and number concentration-resolved analysis based on single-particle ICP-MS (spICP-MS). We found that using enzymatic digestion without H₂O₂ or excessive heating can recover 84.0 ± 4.0% and 94.5 ± 3.5% of TiO₂NP mass and number concentrations from fish tissue, respectively, without altering the size distribution of parent TiO₂NPs. OECD TG305 can allow for the evaluation of bioaccumulation and depuration of TiO₂NPs by fish based on the particle mass and number dose metrics. The toxicokinetic modeling can reasonably describe the mass- and number-based measurement data with the derived absorption efficiency α at ~0.2, depuration rate at ~0.5 d⁻¹, and kinetic biomagnification factor (BMFₖ) at ~0.007 comparable with available data. The mass concentration- and number concentration-based bioaccumulation metrics including body burdens are correlated for TiO₂NPs that remained nano-sized in vivo and exhibited marginal physicochemical alterations upon uptake by fish. The result indicates that the traditional mass concentration metric may be used to represent the fish bioaccumulation potential for chemically inert NPs like TiO₂.
Keywords	Danio rerio ; absorption ; bioaccumulation ; depuration ; dietary exposure ; fish ; guidelines ; heat ; titanium dioxide
Language	English
Dates of publication	2022-0315
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.127801
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Skin damage induced by zinc oxide nanoparticles combined with UVB is mediated by activating cell pyroptosis via the NLRP3 inflammasome-autophagy-exosomal pathway.

Chen, Yu-Ying / Lee, Yu-Hsuan / Wang, Bour-Jr / Chen, Rong-Jane / Wang, Ying-Jan

Particle and fibre toxicology

2022 Volume 19, Issue 1, Page(s) 2

Abstract: Background: Zinc oxide nanoparticles (ZnONPs) are widely used nanomaterial in personal cosmetics, such as skin creams and sunscreens, due to their whitening properties and strong UV light absorption. However, the safety issues and the hazards of ZnONPs, ...

Abstract	Background: Zinc oxide nanoparticles (ZnONPs) are widely used nanomaterial in personal cosmetics, such as skin creams and sunscreens, due to their whitening properties and strong UV light absorption. However, the safety issues and the hazards of ZnONPs, which can be taken up by the skin and cause skin toxicity, are still unclear. From a chemoprevention point of view, pterostilbene (PT) has been reported to prevent skin damage effectively by its anti-inflammatory and autophagy inducer effect. This study aims to determine the skin toxicity and the potential mechanisms of UVB and ZnONPs exposure and the preventive effect of PT. Results: The co-exposure of UVB and ZnONPs elicit NLRP3 inflammasome activation and pyroptosis in keratinocytes. Furthermore, exposure to both UVB and ZnONPs also disrupts cellular autophagy, which increases cell exosome release. In vivo UVB and ZnONPs exposure triggers skin toxicity, as indicated by increased histological injury, skin thickness and transepidermal water loss. Notably, the NLRP3 inflammasome-mediated pyroptosis are also activated during exposure. Topical application of pterostilbene attenuates NLRP3 inflammasome activation and pyroptosis by decreasing ROS generation and mitochondrial ROS (mtROS) levels. In addition to its antioxidant effect, PT also reversed autophagy abnormalities by restoring normal autophagic flux and decreasing NLRP3 inflammasome-loaded exosome release. Conclusions: Our findings reveal that ZnONPs induce skin damage in conjunction with UVB exposure. This process involves an interplay of inflammasomes, pyroptosis, autophagy dysfunction, and exosomes in skin toxicity. PT alleviates skin inflammation by regulating the inflammasome-autophagy-exosome pathway, a finding which could prove valuable when further evaluating ZnONPs effects for cosmetic applications.
MeSH term(s)	Autophagy ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nanoparticles ; Pyroptosis ; Zinc Oxide/toxicity
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2170936-1
ISSN	1743-8977 ; 1743-8977
ISSN (online)	1743-8977
ISSN	1743-8977
DOI	10.1186/s12989-021-00443-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Recent Progress in Nanotoxicology and Nanosafety from the Point of View of Both Toxicology and Ecotoxicology.

Wu, Yuan-Hua / Ho, Sheng-Yow / Wang, Bour-Jr / Wang, Ying-Jan

International journal of molecular sciences

2020 Volume 21, Issue 12

Abstract: This editorial aims to summarize the 14 scientific papers contributed to the Special Issue "Nanotoxicology and nanosafety 2.0 from the point of view of both toxicology and ecotoxicology". ...

Abstract	This editorial aims to summarize the 14 scientific papers contributed to the Special Issue "Nanotoxicology and nanosafety 2.0 from the point of view of both toxicology and ecotoxicology".
MeSH term(s)	Animals ; Ecotoxicology ; Environmental Pollution ; Humans ; Nanostructures/adverse effects ; Nanostructures/toxicity ; Nanotechnology
Language	English
Publishing date	2020-06-12
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21124209
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo.

Mao, Bin-Hsu / Luo, Yi-Kai / Wang, Bour-Jr / Chen, Chun-Wan / Cheng, Fong-Yu / Lee, Yu-Hsuan / Yan, Shian-Jang / Wang, Ying-Jan

Particle and fibre toxicology

2022 Volume 19, Issue 1, Page(s) 6

Abstract: Background: Silver nanoparticles (AgNPs) are considered a double-edged sword that demonstrates beneficial and harmful effects depending on their dimensions and surface coating types. However, mechanistic understanding of the size- and coating-dependent ... ...

Abstract	Background: Silver nanoparticles (AgNPs) are considered a double-edged sword that demonstrates beneficial and harmful effects depending on their dimensions and surface coating types. However, mechanistic understanding of the size- and coating-dependent effects of AgNPs in vitro and in vivo remains elusive. We adopted an in silico decision tree-based knowledge-discovery-in-databases process to prioritize the factors affecting the toxic potential of AgNPs, which included exposure dose, cell type and AgNP type (i.e., size and surface coating), and exposure time. This approach also contributed to effective knowledge integration between cell-based phenomenological observations and in vitro/in vivo mechanistic explorations. Results: The consolidated cell viability assessment results were used to create a tree model for generalizing cytotoxic behavior of the four AgNP types: SCS, LCS, SAS, and LAS. The model ranked the toxicity-related parameters in the following order of importance: exposure dose > cell type > particle size > exposure time ≥ surface coating. Mechanistically, larger AgNPs appeared to provoke greater levels of autophagy in vitro, which occurred during the earlier phase of both subcytotoxic and cytotoxic exposures. Furthermore, apoptosis rather than necrosis majorly accounted for compromised cell survival over the above dosage range. Intriguingly, exposure to non-cytotoxic doses of AgNPs induced G2/M cell cycle arrest and senescence instead. At the organismal level, SCS following a single intraperitoneal injection was found more toxic to BALB/c mice as compared to SAS. Both particles could be deposited in various target organs (e.g., spleen, liver, and kidneys). Morphological observation, along with serum biochemical and histological analyses, indicated that AgNPs could produce pancreatic toxicity, apart from leading to hepatic inflammation. Conclusions: Our integrated in vitro, in silico, and in vivo study revealed that AgNPs exerted toxicity in dose-, cell/organ type- and particle type-dependent manners. More importantly, a single injection of lethal-dose AgNPs (i.e., SCS and SAS) could incur severe damage to pancreas and raise blood glucose levels at the early phase of exposure.
MeSH term(s)	Animals ; Cell Survival ; Knowledge Discovery ; Metal Nanoparticles/toxicity ; Mice ; Particle Size ; Silver/toxicity
Chemical Substances	Silver (3M4G523W1G)
Language	English
Publishing date	2022-01-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2170936-1
ISSN	1743-8977 ; 1743-8977
ISSN (online)	1743-8977
ISSN	1743-8977
DOI	10.1186/s12989-022-00447-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cordycepin enhances radiosensitivity to induce apoptosis through cell cycle arrest, caspase pathway and ER stress in MA-10 mouse Leydig tumor cells.

Lee, Yi-Ping / Huang, Wei-Ru / Wu, Wun-Syuan / Wu, Yuan-Hua / Ho, Sheng-Yow / Wang, Ying-Jan / Huang, Bu-Miin

American journal of cancer research

2022 Volume 12, Issue 8, Page(s) 3601–3624

Abstract: Radiotherapy is a localized treatment commonly used in various types of cancer. However, major limitation of radiotherapy is the development of resistance of tumor cells to radiosensitivity. Cordycepin, a predominant functional component of ... ...

Abstract	Radiotherapy is a localized treatment commonly used in various types of cancer. However, major limitation of radiotherapy is the development of resistance of tumor cells to radiosensitivity. Cordycepin, a predominant functional component of the
Language	English
Publishing date	2022-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Toxic Effects and Mechanisms of Silver and Zinc Oxide Nanoparticles on Zebrafish Embryos in Aquatic Ecosystems.

Lee, Yen-Ling / Shih, Yung-Sheng / Chen, Zi-Yu / Cheng, Fong-Yu / Lu, Jing-Yu / Wu, Yuan-Hua / Wang, Ying-Jan

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: The global application of engineered nanomaterials and nanoparticles (ENPs) in commercial products, industry, and medical fields has raised some concerns about their safety. These nanoparticles may gain access into rivers and marine environments through ... ...

Abstract	The global application of engineered nanomaterials and nanoparticles (ENPs) in commercial products, industry, and medical fields has raised some concerns about their safety. These nanoparticles may gain access into rivers and marine environments through industrial or household wastewater discharge and thereby affect the ecosystem. In this study, we investigated the effects of silver nanoparticles (AgNPs) and zinc oxide nanoparticles (ZnONPs) on zebrafish embryos in aquatic environments. We aimed to characterize the AgNP and ZnONP aggregates in natural waters, such as lakes, reservoirs, and rivers, and to determine whether they are toxic to developing zebrafish embryos. Different toxic effects and mechanisms were investigated by measuring the survival rate, hatching rate, body length, reactive oxidative stress (ROS) level, apoptosis, and autophagy. Spiking AgNPs or ZnONPs into natural water samples led to significant acute toxicity to zebrafish embryos, whereas the level of acute toxicity was relatively low when compared to Milli-Q (MQ) water, indicating the interaction and transformation of AgNPs or ZnONPs with complex components in a water environment that led to reduced toxicity. ZnONPs, but not AgNPs, triggered a significant delay of embryo hatching. Zebrafish embryos exposed to filtered natural water spiked with AgNPs or ZnONPs exhibited increased ROS levels, apoptosis, and lysosomal activity, an indicator of autophagy. Since autophagy is considered as an early indicator of ENP interactions with cells and has been recognized as an important mechanism of ENP-induced toxicity, developing a transgenic zebrafish system to detect ENP-induced autophagy may be an ideal strategy for predicting possible ecotoxicity that can be applied in the future for the risk assessment of ENPs.
Language	English
Publishing date	2022-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12040717
Database	MEDical Literature Analysis and Retrieval System OnLINE

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