Article ; Online: Sub-100-micron calcium-alginate microspheres: Preparation by nitrogen flow focusing, dependence of spherical shape on gas streams and a drug carrier using acetaminophen as a model drug.
2021 Volume 269, Page(s) 118262
Abstract: We developed a miniature gas-liquid coaxial flow device using glass capillaries, aiming to produce sub-100-μm Ca-alginate microspheres. Depending on collecting distance and the flow rates of nitrogen gas and alginate solution, however, Ca-alginate ... ...
Abstract | We developed a miniature gas-liquid coaxial flow device using glass capillaries, aiming to produce sub-100-μm Ca-alginate microspheres. Depending on collecting distance and the flow rates of nitrogen gas and alginate solution, however, Ca-alginate microparticles of different shapes were obtained. Spherical, monodisperse microparticles (microspheres) could only be obtained at certain gas flow rates and within a corresponding range of collecting distance. The result suggests that, for particles of this size, the gas flow rate and collecting distance are crucial for the formation of the spherical shape. We evaluated, as an example of its applications, the microsphere as a drug carrier using acetaminophen as a model drug. Large (~150 μm) and small (~70 μm) drug-loaded microspheres were prepared using two respective devices. Specifically, the drug-loaded microspheres were complexed with chitosan of different molecular weights. The dependence of in vitro drug release on the microsphere size and the chitosan molecular weight was examined. CHEMICAL COMPOUNDS STUDIED IN THIS ARTICLE: Alginic acid sodium salt (PubChem CID: 5102882); Chitosan (PubChem CID: 71853); Calcium chloride (PubChem CID: 5284359); Sodium chloride (PubChem CID: 5234); Acetaminophen (PubChem CID: 1983); Polydimethylsiloxane (PubChem CID: 24771); n-Octadecyltrimethoxysilane (PubChem CID: 76486). |
---|---|
MeSH term(s) | Acetaminophen/chemistry ; Alginates/chemistry ; Chitosan/chemistry ; Drug Carriers/chemistry ; Drug Liberation ; Microspheres ; Molecular Weight ; Nitrogen/chemistry |
Chemical Substances | Alginates ; Drug Carriers ; Acetaminophen (362O9ITL9D) ; Chitosan (9012-76-4) ; Nitrogen (N762921K75) |
Language | English |
Publishing date | 2021-05-29 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1501516-6 |
ISSN | 1879-1344 ; 0144-8617 |
ISSN (online) | 1879-1344 |
ISSN | 0144-8617 |
DOI | 10.1016/j.carbpol.2021.118262 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.