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  1. Article ; Online: Sub-100-micron calcium-alginate microspheres: Preparation by nitrogen flow focusing, dependence of spherical shape on gas streams and a drug carrier using acetaminophen as a model drug.

    Wang, Ying-Lin / Hu, Jin-Jia

    Carbohydrate polymers

    2021  Volume 269, Page(s) 118262

    Abstract: We developed a miniature gas-liquid coaxial flow device using glass capillaries, aiming to produce sub-100-μm Ca-alginate microspheres. Depending on collecting distance and the flow rates of nitrogen gas and alginate solution, however, Ca-alginate ... ...

    Abstract We developed a miniature gas-liquid coaxial flow device using glass capillaries, aiming to produce sub-100-μm Ca-alginate microspheres. Depending on collecting distance and the flow rates of nitrogen gas and alginate solution, however, Ca-alginate microparticles of different shapes were obtained. Spherical, monodisperse microparticles (microspheres) could only be obtained at certain gas flow rates and within a corresponding range of collecting distance. The result suggests that, for particles of this size, the gas flow rate and collecting distance are crucial for the formation of the spherical shape. We evaluated, as an example of its applications, the microsphere as a drug carrier using acetaminophen as a model drug. Large (~150 μm) and small (~70 μm) drug-loaded microspheres were prepared using two respective devices. Specifically, the drug-loaded microspheres were complexed with chitosan of different molecular weights. The dependence of in vitro drug release on the microsphere size and the chitosan molecular weight was examined. CHEMICAL COMPOUNDS STUDIED IN THIS ARTICLE: Alginic acid sodium salt (PubChem CID: 5102882); Chitosan (PubChem CID: 71853); Calcium chloride (PubChem CID: 5284359); Sodium chloride (PubChem CID: 5234); Acetaminophen (PubChem CID: 1983); Polydimethylsiloxane (PubChem CID: 24771); n-Octadecyltrimethoxysilane (PubChem CID: 76486).
    MeSH term(s) Acetaminophen/chemistry ; Alginates/chemistry ; Chitosan/chemistry ; Drug Carriers/chemistry ; Drug Liberation ; Microspheres ; Molecular Weight ; Nitrogen/chemistry
    Chemical Substances Alginates ; Drug Carriers ; Acetaminophen (362O9ITL9D) ; Chitosan (9012-76-4) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2021-05-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2021.118262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Air Pollution-Related Respiratory Diseases and Associated Environmental Factors in Chiang Mai, Thailand, in 2011-2020.

    Jainonthee, Chalita / Wang, Ying-Lin / Chen, Colin W K / Jainontee, Karuna

    Tropical medicine and infectious disease

    2022  Volume 7, Issue 11

    Abstract: The unfavorable effects of global climate change, which are mostly the result of human activities, have had a particularly negative effect on human health and the planet's ecosystems. This study attempted to determine the seasonality and association of ... ...

    Abstract The unfavorable effects of global climate change, which are mostly the result of human activities, have had a particularly negative effect on human health and the planet's ecosystems. This study attempted to determine the seasonality and association of air pollution, in addition to climate conditions, with two respiratory infections, influenza and pneumonia, in Chiang Mai, Thailand, which has been considered the most polluted city on Earth during the hot season. We used a seasonal-trend decomposition procedure based on loess regression (STL) and a seasonal cycle subseries (SCS) plot to determine the seasonality of the two diseases. In addition, multivariable negative binomial regression (NBR) models were used to assess the association between the diseases and environmental variables (temperature, precipitation, relative humidity, PM
    Language English
    Publishing date 2022-10-31
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed7110341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of shift work on sleep quality and cardiovascular function in Taiwanese police officers.

    Tseng, Yen-Ju / Leicht, Anthony S / Pagaduan, Jeffrey Cayaban / Chien, Ling-Chu / Wang, Ying-Lin / Kao, Chi-Sian / Lu, Wei-Szu / Chen, Yung-Sheng

    Chronobiology international

    2024  Volume 41, Issue 4, Page(s) 530–538

    Abstract: This study aimed to investigate the effects of shift work on sleep quality, cardiovascular function, and physical activity (PA) levels in Taiwanese police officers. Twenty-one male police officers aged 26.9 ± 4.1 years old located in Taipei voluntarily ... ...

    Abstract This study aimed to investigate the effects of shift work on sleep quality, cardiovascular function, and physical activity (PA) levels in Taiwanese police officers. Twenty-one male police officers aged 26.9 ± 4.1 years old located in Taipei voluntarily participated in this study. The participants completed the resting heart rate (HR) and hemodynamic variables (e.g. blood pressure, BP) before and after day-time (DTW) and night-time (NTW) shift work phases (5 working days and 2 resting days for each phase). Additionally, an actigraphy was administered to measure PA and sleep patterns in the last 3 working days. The average total sleep time and sleep efficiency were 278.5 ± 79. 6 min and 72.9 ± 10%, respectively, in the NTW phases, which were significantly lower than that in the DTW phases. A comparison of the PA characteristics between the two phases revealed that a lower proportion of moderate-vigorous PA (1.2 ± 0.8%) and a greater proportion of sedentary behaviour PA (74.8 ± 6.4%) was found in the NTW phases. The results of hemodynamic measures demonstrated that the police officers have significantly elevated systolic BP by 3.3% and diastolic BP by 3.9% after the NTW phases. Furthermore, the NTW phases exhibited a significantly higher percentage change ratio of systolic BP and diastolic BP compared to the DTW phases. Compared with the DTW phases, the NTW phase was significantly more likely to report higher decreasing parasympathetic-related HR variability with a range of -5.9% to -7.8%. In conclusion, night-time shift work resulted in negative physiological changes leading to adverse effects on the health and well-being of Taiwanese police officers.
    MeSH term(s) Humans ; Male ; Police ; Adult ; Taiwan ; Heart Rate/physiology ; Blood Pressure/physiology ; Work Schedule Tolerance/physiology ; Circadian Rhythm/physiology ; Sleep Quality ; Sleep/physiology ; Exercise/physiology ; Young Adult ; Shift Work Schedule ; Actigraphy
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 998996-1
    ISSN 1525-6073 ; 0742-0528
    ISSN (online) 1525-6073
    ISSN 0742-0528
    DOI 10.1080/07420528.2024.2324023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Management of Ventilator-Associated Pneumonia: Quality Assessment of Clinical Practice Guidelines and Variations in Recommendations on Drug Therapy for Prevention and Treatment.

    Li, Hong-Yan / Wang, Hai-Shan / Wang, Ying-Lin / Wang, Jing / Huo, Xue-Chen / Zhao, Quan

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 903378

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.903378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Associations between parental and postnatal metal mixture exposure and developmental delays in a Taiwanese longitudinal birth cohort of preschool children.

    Kao, Chi-Sian / Fan, Yen-Tzu / Wang, Ying-Lin / Chen, Yi-Hua / Chao, Hsing-Jasmine / Lo, Yu-Chun / Jiang, Chuen-Bin / Chien, Ling-Chu

    Environmental science and pollution research international

    2023  Volume 30, Issue 55, Page(s) 117360–117372

    Abstract: Studies have evaluated the impact of environmental exposure to neurotoxic metals on developmental delays (DDs). However, comprehensive understanding regarding the associations between parental and postnatal exposure to metal mixtures and the occurrence ... ...

    Abstract Studies have evaluated the impact of environmental exposure to neurotoxic metals on developmental delays (DDs). However, comprehensive understanding regarding the associations between parental and postnatal exposure to metal mixtures and the occurrence of DDs in offspring is limited. In this study, we assessed the relationships between parental and postnatal exposure to three metals (arsenic [As], cadmium [Cd], and lead [Pb], levels of which were measured in toenails) and suspected DDs (SDDs) in preschool children within a Taiwanese longitudinal birth cohort. In total between 2017 and 2021, 154 pairs of parents and their children under the age of 6 years were recruited, and 462 toenail samples and 154 completed questionnaires were collected. Metal concentrations in toenails were quantified using inductively coupled plasma-mass spectrometry after acid digestion of the toenails. We applied multivariable logistic regression and Bayesian kernel machine regression to evaluate the overall effect and to identify key components of the metal mixture that were associated with the SDD risk. Higher concentrations of As, Cd, and Pb were found in the toenails of the parents of children with SDDs compared with the toenails of the parents of children without SDDs. Our examination of the combined effects of exposure to the metal mixture revealed that As concentration in the father's toenail and Cd concentration in the mother's toenail were positively correlated with the risk of SDDs in their offspring. Notably, the effect of exposure to the metal mixture on the risk of SDDs was stronger in boys than in girls. Our findings suggest that parents taking measures to minimize their exposure to metals might enhance their children's developmental outcomes.
    MeSH term(s) Male ; Female ; Humans ; Child, Preschool ; Child ; Cadmium/analysis ; Birth Cohort ; Bayes Theorem ; Lead ; Arsenic/analysis
    Chemical Substances Cadmium (00BH33GNGH) ; SDDS (17615-73-5) ; Lead (2P299V784P) ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2023-10-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-30435-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Oral and inhalation bioaccessibility of mercury in contaminated soils and potential health risk to the kidneys and neurodevelopment of children in Taiwan.

    Wang, Ying-Lin / Tsou, Ming-Chien Mark / Lai, Li-Chi / Hseu, Zeng-Yei / Hsi, Hsing-Cheng / Chien, Ling-Chu

    Environmental geochemistry and health

    2023  Volume 45, Issue 8, Page(s) 6267–6286

    Abstract: Health risk assessments of exposure to mercury (Hg) from soils via ingestion and inhalation are indispensable for Taiwanese people living in the vicinity of Hg-contaminated sites. In this study, anthropogenic soils were collected from various polluted ... ...

    Abstract Health risk assessments of exposure to mercury (Hg) from soils via ingestion and inhalation are indispensable for Taiwanese people living in the vicinity of Hg-contaminated sites. In this study, anthropogenic soils were collected from various polluted sources in Taiwan. In vitro oral and inhalation bioaccessible fractions of Hg were analyzed to avoid from overestimating the exposure risk. Discrepancies in oral and inhalation bioaccessible levels of Hg in soils were found using different in vitro assays with different pH levels and chemical compositions. The freshly contaminated soil (soil S7) polluted by chlor-alkali production activity sampled before the site was remediated had the highest total Hg concentration of 1346 mg/kg, with the highest oral bioaccessibility of 26.2% as analyzed by SW-846 Method 1340 and inhalation bioaccessibility of 30.5% as analyzed by modified Gamble's solution. The lesser extent of aging of Hg in soil S7 increased the Hg availability for humans, which was also found based on results of a sequential extraction procedure. Results of the hazard quotient showed that soil ingestion was the main pathway causing non-carcinogenic risks for children and adults. Children were also exposed to higher risks than were adults due to higher frequencies of hand-to-mouth behaviors and lower body weights. Furthermore, hazard index results adjusted for oral and inhalation bioaccessible Hg were lower than those obtained based on the total Hg content; however, an unacceptable value of the non-carcinogenic risk (> 1) for children living near soil S7 was still observed. This study suggests that children living near sites polluted for a short period of time may suffer potential renal effects regardless of the bioaccessibility. Our findings provide suggestions for decision makers on setting new strategies for managing risks of Hg-contaminated soils in Taiwan.
    MeSH term(s) Adult ; Child ; Humans ; Mercury/analysis ; Taiwan ; Environmental Pollution/analysis ; Soil/chemistry ; Risk Assessment ; Kidney ; Soil Pollutants/analysis ; Environmental Monitoring
    Chemical Substances Mercury (FXS1BY2PGL) ; Soil ; Soil Pollutants
    Language English
    Publishing date 2023-06-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 52039-1
    ISSN 1573-2983 ; 0142-7245 ; 0269-4042
    ISSN (online) 1573-2983
    ISSN 0142-7245 ; 0269-4042
    DOI 10.1007/s10653-023-01633-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Assessment of sources and health risks of heavy metals in metropolitan household dust among preschool children: The LEAPP-HIT study.

    Kao, Chi-Sian / Wang, Ying-Lin / Jiang, Chuen-Bin / Tai, Pei-Ju / Chen, Yi-Hua / Chao, Hsing-Jasmine / Lo, Yu-Chun / Hseu, Zeng-Yei / Hsi, Hsing-Cheng / Chien, Ling-Chu

    Journal of environmental management

    2024  Volume 352, Page(s) 120015

    Abstract: The most common construction material used in Taiwan is concrete, potentially contaminated by geologic heavy metals (HMs). Younger children spend much time indoors, increasing HM exposure risks from household dust owing to their behaviors. We evaluated ... ...

    Abstract The most common construction material used in Taiwan is concrete, potentially contaminated by geologic heavy metals (HMs). Younger children spend much time indoors, increasing HM exposure risks from household dust owing to their behaviors. We evaluated arsenic (As), cadmium (Cd), and lead (Pb) concentrations in fingernails among 280 preschoolers between 2017 and 2023. We also analyzed HM concentrations, including As, Cd, Pb, chromium (Cr), nickel (Ni), copper (Cu), zinc (Zn), iron (Fe), and manganese (Mn), in 90 household dust and 50 road dust samples from a residential area where children lived between 2019 and 2021 to deepen the understanding of sources and health risks of exposure to HMs from household dust. The average As, Cd, and Pb concentrations in fingernails were 0.12 ± 0.06, 0.05 ± 0.05, and 0.95 ± 0.77 μg/g, respectively. Soil parent materials, indoor construction activities, vehicle emissions, and mixed indoor combustion were the pollution sources of HMs in household dust. Higher Cr and Pb levels in household dust may pose non-carcinogenic risks to preschoolers. Addressing indoor construction and soil parent materials sources is vital for children's health. The finding of the present survey can be used for indoor environmental management to reduce the risks of HM exposure and avoid potential adverse health effects for younger children.
    MeSH term(s) Humans ; Child, Preschool ; Cadmium ; Environmental Monitoring ; Dust/analysis ; Lead ; Metals, Heavy/analysis ; Chromium ; Arsenic ; Risk Assessment ; Soil ; China ; Cities
    Chemical Substances Cadmium (00BH33GNGH) ; Dust ; Lead (2P299V784P) ; Metals, Heavy ; Chromium (0R0008Q3JB) ; Arsenic (N712M78A8G) ; Soil
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Associations of maternal food safety-related risk perceptions and protective behaviors with daily mercury intake and internal doses of Taiwanese women and their preschool children.

    Kao, Chi-Sian / Wang, Ying-Lin / Jiang, Chuen-Bin / Chuang, Ying-Chih / Chen, Yi-Hua / Hsi, Hsing-Cheng / Chien, Ling-Chu

    Environmental research

    2022  Volume 212, Issue Pt B, Page(s) 113344

    Abstract: Mercury (Hg) is a well-known toxicant that can affect children's neurodevelopment. This study attempted to evaluate the internal dose of Hg in hair and fingernails and external Hg exposure from dietary consumption in 283 pairs of mothers and their ... ...

    Abstract Mercury (Hg) is a well-known toxicant that can affect children's neurodevelopment. This study attempted to evaluate the internal dose of Hg in hair and fingernails and external Hg exposure from dietary consumption in 283 pairs of mothers and their children aged under 6 years in Taiwan. Mean Hg levels in hair and fingernail samples were 1.07 ± 0.67 and 0.42 ± 0.34 μg/g for mothers, and 1.11 ± 1.22 and 0.36 ± 0.26 μg/g for children, respectively. Our results showed that 42% of mothers and 41% of children had hair Hg levels exceeding the US Environmental Protection Agency recommended value of 1 μg/g. Hg exposure in children was greater than that of their mothers. Estimated daily intake (EDI) levels of Hg among preschool children were 3.3-times higher than those of their mothers. A sensitivity analysis indicated that fish consumption was the main potential factor of Hg exposure among both mothers and their children. External Hg exposure using estimated daily dietary ingestion by mothers was a surrogate for internal hair Hg concentrations. However, poor correlations were found between EDI Hg levels and hair Hg levels among children aged 4-6 years. Exposure sources from food and other media, such as soil and dust, need to be considered to arrive at more-valid risk assessments for younger children's exposure to Hg. Children of mothers who did not have food safety-related risk perceptions or protective behaviors had significantly higher hair Hg concentrations compared to children whose mothers had risk perceptions and protective behaviors. Hg exposure of women of childbearing age and preschool children in Taiwan is still an area of great concern. Providing food safety information and risk-benefits of fish consumption for mothers may avoid harm to the developing nervous systems of their children.
    MeSH term(s) Animals ; Child, Preschool ; Environmental Exposure/analysis ; Environmental Monitoring ; Female ; Fishes ; Food Contamination/analysis ; Food Safety ; Hair/chemistry ; Humans ; Mercury/analysis
    Chemical Substances Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2022-04-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.113344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Associations of maternal food safety-related risk perceptions and protective behaviors with daily mercury intake and internal doses of Taiwanese women and their preschool children

    Kao, Chi Sian / Wang, Ying Lin / Jiang, Chuen Bin / Chuang, Ying Chih / Chen, Yi Hua / Hsi, Hsing Cheng / Chien, Ling Chu

    Environmental research. 2022 Apr. 18,

    2022  

    Abstract: Mercury (Hg) is a well-known toxicant that can affect children's neurodevelopment. This study attempted to evaluate the internal dose of Hg in hair and fingernails and external Hg exposure from dietary consumption in 283 pairs of mothers and their ... ...

    Abstract Mercury (Hg) is a well-known toxicant that can affect children's neurodevelopment. This study attempted to evaluate the internal dose of Hg in hair and fingernails and external Hg exposure from dietary consumption in 283 pairs of mothers and their children aged under 6 years in Taiwan. Mean Hg levels in hair and fingernail samples were 1.07 ± 0.67 and 0.42 ± 0.34 μg/g for mothers, and 1.11 ± 1.22 and 0.36 ± 0.26 μg/g for children, respectively. Our results showed that 42% of mothers and 41% of children had hair Hg levels exceeding the US Environmental Protection Agency recommended value of 1 μg/g. Hg exposure in children was greater than that of their mothers. Estimated daily intake (EDI) levels of Hg among preschool children were 3.3-times higher than those of their mothers. A sensitivity analysis indicated that fish consumption was the main potential factor of Hg exposure among both mothers and their children. External Hg exposure using estimated daily dietary ingestion by mothers was a surrogate for internal hair Hg concentrations. However, poor correlations were found between EDI Hg levels and hair Hg levels among children aged 4–6 years. Exposure sources from food and other media, such as soil and dust, need to be considered to arrive at more-valid risk assessments for younger children's exposure to Hg. Children of mothers who did not have food safety-related risk perceptions or protective behaviors had significantly higher hair Hg concentrations compared to children whose mothers had risk perceptions and protective behaviors. Hg exposure of women of childbearing age and preschool children in Taiwan is still an area of great concern. Providing food safety information and risk-benefits of fish consumption for mothers may avoid harm to the developing nervous systems of their children.
    Keywords United States Environmental Protection Agency ; absorbed dose ; average daily intake ; dust ; fish consumption ; food safety ; neurodevelopment ; research ; soil ; Taiwan
    Language English
    Dates of publication 2022-0418
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.113344
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Effect of high-dose ulinastatin on the cardiopulmonary bypass-induced inflammatory response in patients undergoing open-heart surgery.

    Liu, Yu / Wang, Ying-Lin / Zou, Shao-Hua / Sun, Peng-Fei / Zhao, Quan

    Chinese medical journal

    2020  Volume 133, Issue 12, Page(s) 1476–1478

    MeSH term(s) Cardiac Surgical Procedures/adverse effects ; Cardiopulmonary Bypass/adverse effects ; Glycoproteins ; Humans
    Chemical Substances Glycoproteins ; urinastatin (OR3S9IF86U)
    Language English
    Publishing date 2020-06-04
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000000832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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