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  1. Article ; Online: Cancer associated autoantibodies in idiopathic inflammatory myopathies: A retrospective cohort from a single center in China.

    Zhao, Yin / Su, Haiyuan / Yin, Xiaoyang / Hou, Hou / Wang, Ying'ai / Xu, Yong / Li, Xin / Zhang, Nang / Sun, Wenwen / Wei, Wei

    Medicina clinica

    2022  

    Abstract: Objectives: Idiopathic inflammatory myopathies (IIMs) are systemic, heterogeneous diseases, which mainly affect skeletal muscle. Myositis with cancer is often referred to as cancer-associated myositis (CAM), which is associated with poor prognosis. This ...

    Abstract Objectives: Idiopathic inflammatory myopathies (IIMs) are systemic, heterogeneous diseases, which mainly affect skeletal muscle. Myositis with cancer is often referred to as cancer-associated myositis (CAM), which is associated with poor prognosis. This study aimed to determine the cancer associated myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with IIMs.
    Methods: This retrospective study enrolled 312 patients with IIMs who were treated at Tianjin Medical University General Hospital, China, from January 2015 to December 2020. Clinical data were collected. Serum MSAs, including anti-Mi-2, anti-TIF1-γ, anti-NXP2, anti-SAE, anti-MDA5, anti-SRP, anti-Jo-1, anti-PL-7, anti-PL-12, anti-OJ, anti-EJ and anti-HMGCR antibodies were detected. Cancer-associated MSAs, their phenotypic and survival features were estimated through SPSS 20.0.
    Results: The results revealed that anti-TIF1-γ antibody and anti-SAE antibody were cancer-associated autoantibodies with odds ratios (95% CI) of 8.70 (3.35-22.64) and 22.31 (4.32-115.05), respectively. Skin lesions, proximal weakness, dysphagia and dysarthria were observed more frequently in patients carrying anti-TIF1-γ antibody. By contrast, patients with anti-TIF1-γ antibody had a lower frequencies of fever, arthritis/arthralgia and interstitial lung disease (ILD). Anti-TIF1-γ antibody positive CAM comprised about half of CAM entities and had the characteristic of close temporal association with cancer detection/recurrence. Female-dominant, common reproductive system tumors were other clinical features of this subset. Besides, patients with anti-TIF1-γ antibody positive had significantly lower survival rates than the anti-TIF1-γ antibody negative group.
    Conclusions: Anti-TIF1-γ antibody and anti-SAE antibody were cancer-associated autoantibodies. Anti-TIF1-γ antibody positive CAM was a subset that comprised about half of CAM entities and had the characteristic of poor prognosis.
    Language Spanish
    Publishing date 2022-07-13
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2022.03.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H

    Tang, Wen-Zhao / Wang, Ying-Ai / Gao, Tian-Yang / Wang, Xiao-Jing / Zhao, Yun-Xue

    Chinese journal of natural medicines

    2017  Volume 15, Issue 5, Page(s) 384–391

    Abstract: The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti- ... ...

    Abstract The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C (1) and five known C-geranylated flavanones (2-6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH
    MeSH term(s) Aging/drug effects ; Cell Line ; Chromatography, High Pressure Liquid ; Flavonoids/chemistry ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Fruit/chemistry ; Humans ; Hydrogen Peroxide/toxicity ; Magnoliopsida/chemistry ; Molecular Structure ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Tandem Mass Spectrometry
    Chemical Substances Flavonoids ; Plant Extracts ; Hydrogen Peroxide (BBX060AN9V)
    Keywords covid19
    Language English
    Publishing date 2017-05-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2192577-X
    ISSN 1875-5364 ; 2095-6975 ; 1672-3651
    ISSN (online) 1875-5364
    ISSN 2095-6975 ; 1672-3651
    DOI 10.1016/S1875-5364(17)30059-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Undescribed C-geranylflavonoids isolated from the fruit peel of Paulownia catalpifolia T. Gong ex D.Y. Hong with their protection on human umbilical vein endothelial cells injury induced by hydrogen peroxide

    Wang, Ying-Ai / Cheng-Lin Du / Hong-Fang Du / Jing Xue / Wen-Zhao Tang / Xian-Hui Jia / Xiao-Jing Wang / Xing Guo / Yun-Xue Zhao

    Phytochemistry. 2019 Feb., v. 158

    2019  

    Abstract: Six undescribed C-geranylated flavonoids, including five C-geranylflavanones named as paucatalinones F - J, one C-geranylflavonol named as paucatalinone K, along with seven known geranylated flavanones, were isolated from the fruit peel of Paulownia ... ...

    Abstract Six undescribed C-geranylated flavonoids, including five C-geranylflavanones named as paucatalinones F - J, one C-geranylflavonol named as paucatalinone K, along with seven known geranylated flavanones, were isolated from the fruit peel of Paulownia catalpifolia T. Gong ex D.Y. Hong. Their structures were elucidated distinctly according to their UV, IR, MS, NMR, and CD data. Among them, two compounds were substituted with unusual modified geranyl groups, namely paucatalinone F with an oxygenated cyclogeranyl substituent and paucatalinone H with a terminal pyranoid geranyl substituent. Furthermore, the protective effects on human umbilical vein endothelial cells (HUVECs) injury induced by H2O2 were evaluated, and paucatalinone F showed the most potential activity. The bioactive results suggested that the geranyl substituent may be an important factor for restraining oxidative HUVECs damage and Paulownia C-geranylated flavonoids might have the potential for preventing cardiovascular complications.
    Keywords flavanones ; fruit peels ; human umbilical vein endothelial cells ; hydrogen peroxide ; moieties ; nuclear magnetic resonance spectroscopy ; Paulownia ; protective effect
    Language English
    Dates of publication 2019-02
    Size p. 126-134.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2018.11.010
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2

    TANG, Wen-Zhao / WANG, Ying-Ai / GAO, Tian-Yang / Wang, Xiao-Jing / ZHAO, Yun-Xue

    Chinese journal of natural medicines. 2017 May, v. 15, no. 5 p.384-391

    2017  

    Abstract: The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti- ... ...

    Abstract The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C (1) and five known C-geranylated flavanones (2–6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH2Cl2 extract of P. catalpifolia. Futhermore, anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by H2O2. Phytochemical results indicated that P. catalpifolia was a natural resource of abundant C-geranylated flavonoids. Diplacone (3) and paucatalinone A (5) were the potent anti-aging agents in the premature senescent 2BS cells induced by H2O2 and the C-geranyl substituent may be an important factor because of its lipophilic character.
    Keywords Oriental traditional medicine ; Paulownia ; anti-aging properties ; bronchitis ; dysentery ; enteritis ; flavanones ; flavones ; fruits ; herbal medicines ; hydrogen peroxide ; lipophilicity ; lung neoplasms ; methylene chloride ; tandem mass spectrometry ; Paulownia catalpifolia Gong Tong ; C-geranylated flavonoids ; Paucatalinone C ; HPLC-DAD-ESI-MS/MS ; Anti-aging effects ; 2BS cells ; covid19
    Language English
    Dates of publication 2017-05
    Size p. 384-391.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Resource is Open Access
    ZDB-ID 2192577-X
    ISSN 1875-5364 ; 2095-6975 ; 1672-3651
    ISSN (online) 1875-5364
    ISSN 2095-6975 ; 1672-3651
    DOI 10.1016/S1875-5364(17)30059-6
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: New antioxidant C-geranylated flavonoids from the fruit peels of Paulownia catalpifolia T. Gong ex D.Y. Hong

    Wang, Ying-ai / Xue, Jing / Jia, Xian-hui / Du, Cheng-lin / Tang, Wen-zhao / Wang, Xiao-Jing

    Phytochemical Society of Europe Phytochemistry letters. 2017 Sept., v. 21 p.169-173

    2017  

    Abstract: Three new geranylated flavonoids, including two geranylflavones (1, 2) and one geranylflavonol (3), named as paucatalinone C–E, were isolated from the fruit peel of P. catalpifolia T. Gong ex D.Y. Hong. Their structures were determined by means of UV, IR, ...

    Abstract Three new geranylated flavonoids, including two geranylflavones (1, 2) and one geranylflavonol (3), named as paucatalinone C–E, were isolated from the fruit peel of P. catalpifolia T. Gong ex D.Y. Hong. Their structures were determined by means of UV, IR, MS, and NMR techniques. To our known, geranylflavone or geranylflavonol was the first isolation from the genus Paulownia. These isolated geranylated flavonoids displayed good antioxidant effects on DPPH and the senescent human embryonic lung diploid fibroblasts cells (2BS cells) induced by H2O2. The geranyl substituent may be an important factor for the cellular radical-scavenging effect because of its lipophilic character.
    Keywords 2,2-diphenyl-1-picrylhydrazyl ; Paulownia ; antioxidant activity ; diploidy ; fibroblasts ; flavonoids ; fruit peels ; humans ; hydrogen peroxide ; nuclear magnetic resonance spectroscopy ; Paulownia catalpifolia T. gong ex D.Y. hong ; Geranylated flavonoids ; Antioxidant effects ; DPPH ; 2BS cells
    Language English
    Dates of publication 2017-09
    Size p. 169-173.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2017.06.025
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Undescribed C-geranylflavonoids isolated from the fruit peel of Paulownia catalpifolia T. Gong ex D.Y. Hong with their protection on human umbilical vein endothelial cells injury induced by hydrogen peroxide.

    Wang, Ying-Ai / Guo, Xing / Jia, Xian-Hui / Xue, Jing / Du, Hong-Fang / Du, Cheng-Lin / Tang, Wen-Zhao / Wang, Xiao-Jing / Zhao, Yun-Xue

    Phytochemistry

    2018  Volume 158, Page(s) 126–134

    Abstract: Six undescribed C-geranylated flavonoids, including five C-geranylflavanones named as paucatalinones F - J, one C-geranylflavonol named as paucatalinone K, along with seven known geranylated flavanones, were isolated from the fruit peel of Paulownia ... ...

    Abstract Six undescribed C-geranylated flavonoids, including five C-geranylflavanones named as paucatalinones F - J, one C-geranylflavonol named as paucatalinone K, along with seven known geranylated flavanones, were isolated from the fruit peel of Paulownia catalpifolia T. Gong ex D.Y. Hong. Their structures were elucidated distinctly according to their UV, IR, MS, NMR, and CD data. Among them, two compounds were substituted with unusual modified geranyl groups, namely paucatalinone F with an oxygenated cyclogeranyl substituent and paucatalinone H with a terminal pyranoid geranyl substituent. Furthermore, the protective effects on human umbilical vein endothelial cells (HUVECs) injury induced by H
    MeSH term(s) Apoptosis/drug effects ; Circular Dichroism ; Drug Evaluation, Preclinical/methods ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Fruit/chemistry ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Hydrogen Peroxide/toxicity ; Lamiales/chemistry ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Spectrometry, Mass, Electrospray Ionization ; Spectrophotometry, Ultraviolet
    Chemical Substances Flavonoids ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2018-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2018.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Inhibiting TGFβ1 has a protective effect on mouse bone marrow suppression following ionizing radiation exposure in vitro.

    Zhang, Heng / Wang, Ying-Ai / Meng, Aimin / Yan, Hao / Wang, Xinzhuo / Niu, Jingxiu / Li, Jin / Wang, Hui

    Journal of radiation research

    2013  Volume 54, Issue 4, Page(s) 630–636

    Abstract: Ionizing radiation (IR) causes not only acute tissue damage but also residual bone marrow (BM) suppression. The induction of residual BM injury is primarily attributable to the induction of reactive oxygen species (ROS) pressure in hematopoietic cells. ... ...

    Abstract Ionizing radiation (IR) causes not only acute tissue damage but also residual bone marrow (BM) suppression. The induction of residual BM injury is primarily attributable to the induction of reactive oxygen species (ROS) pressure in hematopoietic cells. In this study, we examined if SB431542, a transforming growth factor β1 (TGFβ1) inhibitor, can mitigate IR-induced BM suppression in vitro. Our results showed that treatment with SB431542 protected mice bone marrow mononuclear cells (BMMNCs), hematopoietic progenitor cells (HPCs) and hematopoietic stem cells (HSCs) from IR-induced suppression using cell viability assays, clonogenic assays and competitive repopulation assays. Moreover, expression of gene-related ROS production in hematopoietic cells was analyzed. The expression of NOX1, NOX2 and NOX4 was increased in irradiated BMMNCs, and that of NOX2 and NOX4 was reduced by SB431542 treatment. Therefore, the results from this study suggest that SB431542, a TGFβ1 inhibitor, alleviates IR-induced BM suppression at least in part via inhibiting IR-induced NOX2 and NOX4 expression.
    MeSH term(s) Animals ; Benzamides/pharmacology ; Bone Marrow/drug effects ; Bone Marrow/radiation effects ; Cell Survival ; Dioxoles/pharmacology ; Hematopoietic Stem Cells/drug effects ; Hematopoietic Stem Cells/radiation effects ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/radiation effects ; Male ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; NADH, NADPH Oxidoreductases/metabolism ; NADPH Oxidase 1 ; NADPH Oxidase 2 ; NADPH Oxidase 4 ; NADPH Oxidases/metabolism ; Radiation Injuries/prevention & control ; Radiation, Ionizing ; Transforming Growth Factor beta1/antagonists & inhibitors
    Chemical Substances 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide ; Benzamides ; Dioxoles ; Membrane Glycoproteins ; Transforming Growth Factor beta1 ; NADH, NADPH Oxidoreductases (EC 1.6.-) ; Cybb protein, mouse (EC 1.6.3.-) ; NADPH Oxidase 1 (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-) ; NADPH Oxidase 4 (EC 1.6.3.-) ; NADPH Oxidases (EC 1.6.3.-) ; NOX1 protein, mouse (EC 1.6.3.-) ; Nox4 protein, mouse (EC 1.6.3.-)
    Language English
    Publishing date 2013-01-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603983-2
    ISSN 1349-9157 ; 0449-3060
    ISSN (online) 1349-9157
    ISSN 0449-3060
    DOI 10.1093/jrr/rrs142
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    Zs.B 388: Show issues Location:
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