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Article: Modeling Hydrodynamic and Hydrological Processes in Tidal Wetlands

Wang, Yini / Zhang, Mingliang

Wetlands. 2022 Jan., v. 42, no. 1

2022

Abstract: Hydrologic processes in tidal wetlands are important regulators controlling the growth and productivity of salt marsh plants. Understanding hydrodynamic and hydrological processes is therefore critical to sustaining ecosystem functions and productivity ... ...

Abstract	Hydrologic processes in tidal wetlands are important regulators controlling the growth and productivity of salt marsh plants. Understanding hydrodynamic and hydrological processes is therefore critical to sustaining ecosystem functions and productivity in tidal wetlands. We used remote sensing and geographic information system to determine the spatial distributions of Suaeda heteroptera and Phragmites australis plants on the tidal-flats of Liao River Estuary (LRE), China. Next, hydrodynamic modelling was performed to characterize the water levels and tidal currents in these wetland waters. After extensive calibration and validation against field data, we proposed a 2D circulation structure for the LRE that can be used to calculate the hydrological parameters in different areas of the tidal wetlands. The simulation results showed that the hydrological characteristics of the tidal wetlands were primarily dependent on local topography and water level. The prevalent plant community in the LRE, dominated by Suaeda heteroptera, was abundant across a large range of flood times (0.79 ~ 3.22 h/day), inundation frequencies (11 ~ 52 times/month), and max flooding depths (0.42 ~ 0.81 m). However, certain hydrological conditions did appear to limit the spatial distributions of wetland plant communities. These findings have provided detailed methods of a novel approach to quantitatively assess habitat status in tidal-flat wetlands.
Keywords	Heteroptera ; Phragmites australis ; Suaeda ; ecosystems ; estuaries ; geographic information systems ; habitats ; hydrodynamics ; plant communities ; rivers ; salt marshes ; topography ; China
Language	English
Dates of publication	2022-01
Size	p. 1.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1097341-2
ISSN	1943-6246 ; 0277-5212
ISSN (online)	1943-6246
ISSN	0277-5212
DOI	10.1007/s13157-021-01519-1
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Article ; Online: Research progress on the role of PDGF/PDGFR in type 2 diabetes.

Cao, Zhanqi / Liu, Yijie / Wang, Yini / Leng, Ping

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 164, Page(s) 114983

Abstract: Platelet-derived growth factors (PDGFs) are basic proteins stored in the α granules of platelets. PDGFs and their receptors (PDGFRs) are widely expressed in platelets, fibroblasts, vascular endothelial cells, platelets, pericytes, smooth muscle cells and ...

Abstract	Platelet-derived growth factors (PDGFs) are basic proteins stored in the α granules of platelets. PDGFs and their receptors (PDGFRs) are widely expressed in platelets, fibroblasts, vascular endothelial cells, platelets, pericytes, smooth muscle cells and tumor cells. The activation of PDGFR plays a number of critical roles in physiological functions and diseases, including normal embryonic development, cellular differentiation, and responses to tissue damage. In recent years, emerging experimental evidence has shown that activation of the PDGF/PDGFR pathway is involved in the development of diabetes and its complications, such as atherosclerosis, diabetic foot ulcers, diabetic nephropathy, and retinopathy. Research on targeting PDGF/PDGFR as a treatment has also made great progress. In this mini-review, we summarized the role of PDGF in diabetes, as well as the research progress on targeted diabetes therapy, which provides a new strategy for the treatment of type 2 diabetes.
MeSH term(s)	Pregnancy ; Female ; Humans ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Endothelial Cells/metabolism ; Platelet-Derived Growth Factor/metabolism ; Receptor, Platelet-Derived Growth Factor beta/metabolism ; Diabetic Nephropathies/metabolism ; Receptors, Platelet-Derived Growth Factor/metabolism
Chemical Substances	Platelet-Derived Growth Factor ; Receptor, Platelet-Derived Growth Factor beta (EC 2.7.10.1) ; Receptors, Platelet-Derived Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2023-06-07
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114983
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Article ; Online: Biological therapies for hemophagocytic lymphohistiocytosis: current knowledge and future perspectives.

He, Lingbo / Yang, Chun / Wang, Yini

Expert opinion on biological therapy

2023 Volume 23, Issue 10, Page(s) 1005–1013

Abstract: Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome with a dismal prognosis. The underlying causes of HLH are diverse. However, the overabundance of cytokines was shared by all forms of HLH. Cytokine-targeted ... ...

Abstract	Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome with a dismal prognosis. The underlying causes of HLH are diverse. However, the overabundance of cytokines was shared by all forms of HLH. Cytokine-targeted biotherapies have been increasingly used in HLH treatment. Areas covered: In this review, we aim to provide an overview of biological treatment options for HLH. Expert opinion: Biological therapies offer alternative treatment options for patients with refractory/relapsed HLH or who are intolerant to conventional chemotherapies. As a complement to traditional treatment, biological agents improve response rates, maintain more protracted periods of remission, and reduce treatment related toxicity. A combination of biological agents may be a promising direction for HLH treatment. However, they may induce HLH to deteriorate and even trigger HLH.
MeSH term(s)	Humans ; Lymphohistiocytosis, Hemophagocytic/drug therapy ; Lymphohistiocytosis, Hemophagocytic/etiology ; Cytokines/therapeutic use ; Biological Therapy/adverse effects
Chemical Substances	Cytokines
Language	English
Publishing date	2023-08-25
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2052501-1
ISSN	1744-7682 ; 1471-2598
ISSN (online)	1744-7682
ISSN	1471-2598
DOI	10.1080/14712598.2023.2251885
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Article ; Online: Prognostic value of Type D personality for post-stroke depression in ischemic stroke patients.

Yin, Shi / Li, Na / Wang, Yini

Journal of affective disorders

2023 Volume 333, Page(s) 172–176

Abstract: Background: Depression in patients with stroke has been a risk factor for adverse outcomes. Type D personality as a significant predictor of negative psychological status. However, the relationship with post-stroke depression (PSD) is still unclear.: ... ...

Abstract	Background: Depression in patients with stroke has been a risk factor for adverse outcomes. Type D personality as a significant predictor of negative psychological status. However, the relationship with post-stroke depression (PSD) is still unclear. Methods: A prospective observational study of 533 patients with first-ever ischemic stroke was conducted between November 2020 and March 2021. Type D personality was assessed at baseline. The presence of depression was measured 3-month after discharge. Results: During 3-month follow-up, a total of 141 patients developed PSD. On multivariate logistic analysis, the main effect of negative affectivity (OR = 1.28, 95%CI = 1.03-1.61, p = 0.030) and social inhibition (OR = 1.25, 95%CI = 1.01-1.54, p = 0.039) showed significant correlation with PSD when Type D analyzed as continuous variables. Furthermore, positive effects were found for the negative affectivity and social inhibition interaction (OR = 1.31, 95 % CI =1.11-1.55, p = 0.001) on PSD. Conclusions: Our findings suggest that Type D personality is high risk group of PSD. These findings highlight the importance of personalized interventions management in Type D individuals.
MeSH term(s)	Humans ; Prognosis ; Ischemic Stroke ; Depression/etiology ; Depression/psychology ; Type D Personality ; Stroke/complications ; Stroke/psychology ; Risk Factors
Language	English
Publishing date	2023-04-21
Publishing country	Netherlands
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2023.04.064
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Article ; Online: Bixafen causes hepatotoxicity and pancreas toxicity in zebrafish (Danio rerio).

Wang, Yini / Peng, Huihan / Yu, Hailing

Ecotoxicology (London, England)

2023 Volume 32, Issue 7, Page(s) 837–844

Abstract: Bixafen (BIX), a widely used succinate dehydrogenase inhibitor (SDHI) in agricultural disease control, has garnered significant attention due to its known hazardous effects on aquatic organisms. In this study, we exposed zebrafish embryos to 0.1, 0.2, ... ...

Abstract	Bixafen (BIX), a widely used succinate dehydrogenase inhibitor (SDHI) in agricultural disease control, has garnered significant attention due to its known hazardous effects on aquatic organisms. In this study, we exposed zebrafish embryos to 0.1, 0.2, and 0.3 μM BIX, to explore the impact of BIX on liver and pancreas. The results showed that BIX caused deformities and dysfunction in zebrafish embryos, including spinal curvature, pericardial edema, heart rate decrease, and hatching delay. Moreover, BIX significantly affected the development of the liver and pancreas in zebrafish and downregulated zebrafish fabp10a gene expression. Overall, this study presents strong evidence for BIX's potential toxicity to zebrafish liver and pancreas. The results may provide new insights into the evaluation of BIX'S impact on aquatic organisms.
MeSH term(s)	Animals ; Zebrafish/physiology ; Embryo, Nonmammalian ; Water Pollutants, Chemical/analysis ; Pancreas/chemistry ; Aquatic Organisms ; Chemical and Drug Induced Liver Injury/metabolism
Chemical Substances	Water Pollutants, Chemical
Language	English
Publishing date	2023-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	34042-x
ISSN	1573-3017 ; 0963-9292
ISSN (online)	1573-3017
ISSN	0963-9292
DOI	10.1007/s10646-023-02687-y
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Article ; Online: Methods for RPE Sheet Construction Using iPS-CM in Conjunction with Natural Scaffold of Corneal Lenticule Derived from SMILE.

Gu, Jianing / Wang, Yini / Ding, Chengcheng / Tang, Shibo / Chen, Jiansu

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2678, Page(s) 177–182

Abstract: In vitro generation of a functional retinal pigment epithelium (RPE) monolayer sheet is useful and promising for RPE cell therapy. Here, we outline a method to construct engineered RPE sheets treated by induced pluripotent stem cell-conditioned medium ( ... ...

Abstract	In vitro generation of a functional retinal pigment epithelium (RPE) monolayer sheet is useful and promising for RPE cell therapy. Here, we outline a method to construct engineered RPE sheets treated by induced pluripotent stem cell-conditioned medium (iPS-CM) in conjunction with femtosecond laser intrastromal lenticule (FLI-lenticule) scaffold to aid in enhanced RPE characteristics and cilium assembly. Such a strategy to construct RPE sheets is a promising avenue for developing RPE cell therapy, disease models, and drug screening tools.
MeSH term(s)	Retinal Pigment Epithelium ; Culture Media, Conditioned ; Induced Pluripotent Stem Cells ; Cells, Cultured
Chemical Substances	Culture Media, Conditioned
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3255-0_13
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Article ; Online: The diagnostic importance of multiple cytokines in adult hemophagocytic lymphohistiocytosis.

Jin, Zhili / Suolitiken, Dina / Wang, Yini / Wang, Zhao

Journal of clinical laboratory analysis

2022 Volume 37, Issue 6, Page(s) e24669

Abstract: Background: Hemophagocytic lymphohistiocytosis (HLH) is a category of immunological illnesses that cause out-of-control T cells and macrophages to release life-threatening cytokines. The HLH-2004 diagnostic criteria are the gold standard for HLH ... ...

Abstract	Background: Hemophagocytic lymphohistiocytosis (HLH) is a category of immunological illnesses that cause out-of-control T cells and macrophages to release life-threatening cytokines. The HLH-2004 diagnostic criteria are the gold standard for HLH diagnosis, but there is a need to investigate the usefulness of various cytokines for HLH diagnosis. Methods: Patients admitted to Beijing Friendship Hospital of Capital Medical University from January 2016 to December 2020 were included in this retrospective study, with 166 patients with confirmed HLH and 142 febrile patients requiring differential diagnosis completing the sum. Multiplex cytokine assays using multifactor liquid phase microarray technology-based multifactor liquid phase microarray technology were used to detect 33 cytokines. Twenty-eight cytokines detected using the Luminex analytical platform technology were ultimately included in the analysis. Results: Interleukin-1 receptor antagonist (IL-1 RA), IL-18, interferon-γ (IFN-γ), and interferon-induced protein 10 (IP-10) regulated upon activation normal T cell expressed and secreted (RANTES), eotaxin, growth-related oncogene α (GRO-α), and macrophage inflammatory protein-1 α (MIP-1α) were higher in the HLH group than in the non-HLH group, and the differences were statistically significant. Among them, the area under the curve (AUC) for IL-18 for HLH diagnosis was reported for the first time as 82.69%, with a sensitivity of 76.32% and a specificity of 79.61%; the AUC of IL-1 RA was 72.34%, with a sensitivity of 62.71% and a specificity of 75.97%; and the AUC of IP-10 was 71.73%, with a sensitivity of 60.14% and a specificity of 75.15%. Moreover, the AUC of the combined diagnostic tests for IL-1 RA, IL-18, IFN-γ, IP-10, and RANTES was 99.6%, with a sensitivity of 95.8% and a specificity of 98.6%. Conclusion: Our study concluded that multiple cytokines are valid biological markers for the diagnosis of HLH. The findings of this study remain to be validated in an external dataset.
MeSH term(s)	Humans ; Adult ; Cytokines/metabolism ; Interleukin-18 ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Retrospective Studies ; Chemokine CXCL10 ; Interferon-gamma/metabolism ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1
Chemical Substances	Cytokines ; Interleukin-18 ; Chemokine CXCL10 ; Interferon-gamma (82115-62-6) ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1
Language	English
Publishing date	2022-08-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.24669
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Article ; Online: EBV protection- and susceptibility-related HLA alleles and EBV status in the Chinese population: A single-center study.

Suolitiken, Dina / Wang, Yini / Jin, Zhili / Wang, Zhao

Immunity, inflammation and disease

2022 Volume 10, Issue 7, Page(s) e666

Abstract: Background: Although most adults are infected by Epstein-Barr virus (EBV), some patients develop highly lethal diseases associated with EBV infection, including EBV-hemophagocytic lymphohistiocytosis (EBV-HLH), chronic active EBV infections (CAEBV), and ...

Abstract	Background: Although most adults are infected by Epstein-Barr virus (EBV), some patients develop highly lethal diseases associated with EBV infection, including EBV-hemophagocytic lymphohistiocytosis (EBV-HLH), chronic active EBV infections (CAEBV), and lymphoma, the pathogeneses of which remain to be investigated. The human leukocyte antigen (HLA) complex may be associated with the viral infection pathway, and, therefore, HLA alleles may be associated with EBV-related diseases and subpopulations of infected cells, studies related to EBV-associated diseases, and subpopulations of infected cells that were conducted in China are scarce. Methods: In this study, we analyzed the high-resolution HLA genotypes of 269 patients with EBV-associated diseases and 213 EBV-seronegative hematopoietic stem cell donors using PCR-SBT assay and elucidated the associations of HLA-A, -B, -C, -DRB1, and -DQB1 alleles with EBV-associated diseases in the Chinese population, Benjamini-Hochberg correction to adjust for multiple testing. HLA genotypes were also analyzed in patients with EBV-associated diseases showing EBV-infected lymphocyte subpopulations. Results: We found that individuals carrying the following alleles showed the following levels of risks: HLA-DRB111 allele, reduced risk of EBV-related disease (OR [odds ratio]: 0.56; 95% confidence interval [95% CI]: 0.32-0.99; p < .05; Adjust p = .71); HLA-DQB106:02 allele, reduced risk (OR: 0.5699; 95% CI: 0.3486-0.9317; p < .05; Adjust p = .57); and HLA-B15:01 allele, increased risk (OR: 1.763; 95% CI: 0.3486-0.9317; p < .05; Adjust p = .57). Patients with EBV-associated diseases showing the B15:01 genotype had a higher risk of T-cell, NK-cell, and multicell infections than those with other genotype subgroups. Conclusions: These findings highlight the importance of HLA genotype for assessing EBV infectivity.
MeSH term(s)	Adult ; Alleles ; Epstein-Barr Virus Infections/genetics ; HLA-A Antigens/genetics ; HLA-B Antigens/genetics ; Herpesvirus 4, Human/genetics ; Humans
Chemical Substances	HLA-A Antigens ; HLA-B Antigens
Language	English
Publishing date	2022-06-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2740382-8
ISSN	2050-4527 ; 2050-4527
ISSN (online)	2050-4527
ISSN	2050-4527
DOI	10.1002/iid3.666
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Article ; Online: Age, formation mechanisms, spatial extent, and geodynamic effects of the eastern and northeastern Asian big mantle wedges

Tang, Jie / Wang, Feng / Wang, Yi-Ni / Long, Xin-Yu / Xu, Wen-Liang

Earth-Science Reviews. 2023 Feb., v. 237 p.104324-

2023

Abstract: A big mantle wedge (BMW) is an important deep Earth structure that has implications for our understanding of geodynamic processes. The eastern and northeastern Asian BMWs have been extensively studied in the past two decades. This paper reviews evidence ... ...

Abstract	A big mantle wedge (BMW) is an important deep Earth structure that has implications for our understanding of geodynamic processes. The eastern and northeastern Asian BMWs have been extensively studied in the past two decades. This paper reviews evidence for the age, formation, spatial extent, and geodynamic effects of BMWs, with the aim of distinguishing between two BMWs. The eastern Asian BMW initially formed in the late Early Cretaceous and was active from 110 to 55 Ma due to rollback of the subducted Paleo-Pacific Plate and eastward-directed deep mantle flow. This BMW affected the entire eastern Asian continental margin and controlled the late Mesozoic–early Paleogene tectonic evolution of the margin, including destruction of the North China Craton and reworking of continental crust in South China. The northeastern Asian BMW has been active from 20 Ma to the present-day due to rollback of the subducted Pacific Plate and eastward mantle flow. It has mainly affected northeast Asia and resulted in different types of Cenozoic intraplate volcanism and occurrence of earthquakes with deep epicenters.
Keywords	Cenozoic era ; Early Cretaceous epoch ; tectonics ; volcanic activity ; China ; Eastern Asia ; Northeastern Asia ; Big mantle wedge ; Age ; Formation mechanism ; Spatial extent ; Geodynamic effect
Language	English
Dates of publication	2023-02
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1792-9
ISSN	0012-8252
ISSN	0012-8252
DOI	10.1016/j.earscirev.2023.104324
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Article: Cross-Coupling Reactions between Alkenes by C–H Cyclometalation

Lu, Xi / Wang, Yini / Xie, Kailin / Zhang, Jian

Synlett

2023 Volume 34, Issue 19, Page(s) 2262–2292

Abstract: Alkenes are one of the most abundant raw feedstocks and are utilized to construct complex chemicals, whilst cross-coupling reactions using alkenes represents a powerful method toward valuable chemicals. In the past decade, cross-coupling reactions of ... ...

Abstract	Alkenes are one of the most abundant raw feedstocks and are utilized to construct complex chemicals, whilst cross-coupling reactions using alkenes represents a powerful method toward valuable chemicals. In the past decade, cross-coupling reactions of simple alkenes by chelation-assisted alkenyl C–H functionalization has attracted significant attention due to its atom/step efficiency and excellent Z E selectivity, proceeding by C–H exo -cyclometalation and endo -cyclometalation. In this account, we summarize transition-metal-catalyzed cross-coupling reactions between alkenes to generate 1,3-dienes via C–H alkenylation,1,4-dienes through C–H allylation, multisubstituted alkenes via hydroalkenylation, and heterocycles by way of tandem alkenyl C–H functionalization/annulation. Asymmetric alkenyl C–H alkenylation to prepare axially chiral aryl 1,3-dienes is also discussed. 1 Introduction 2 Alkenyl C–H Alkenylation 2.1 By endo -Cyclometalation 2.2 By exo -Cyclometalation 3 Alkenyl C–H Allylation 3.1 By endo -Cyclometalation 3.2 By exo -Cyclometalation 4 Alkenyl C–H Alkylation via Hydroalkenylation 5 Cascade Reactions 6 Conclusion
Keywords	alkenes ; C–H functionalization ; cross-coupling ; chelation assistance ; transition-metal catalysis
Language	English
Publishing date	2023-04-04
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/a-2068-6215
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