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Article ; Online: Study on carbon emission reduction countermeasures based on carbon emission influencing factors and trends.

Tang, Xinfa / Liu, Shuai / Wang, Yonghua / Wan, Youwei

Environmental science and pollution research international

2024 Volume 31, Issue 9, Page(s) 14003–14022

Abstract: The carbon mitigation response encompasses a variety of strategies aimed at mitigating greenhouse gas emissions resulting from human activities. These measures are crafted to address the challenges posed by climate change and facilitate the transition of ...

Abstract	The carbon mitigation response encompasses a variety of strategies aimed at mitigating greenhouse gas emissions resulting from human activities. These measures are crafted to address the challenges posed by climate change and facilitate the transition of businesses towards a low-carbon paradigm. Leveraging the analytical outcomes of the extended STIRPAT model and the PSO-BP prediction model, this paper suggests countermeasures for reducing carbon emissions in China's metal smelting industry. The overarching objective is to contribute to China's attainment of the "dual carbon objectives." The study identifies key factors influencing carbon emissions in the metal smelting industry, ranked in descending order of sensitivity: population, coal consumption, urbanization rate, total metal production, carbon intensity, proportion of secondary industry, and GDP per capita. Results from three established scenarios-namely, low carbon, standard, and high carbon-indicate a consistent decline in carbon emissions from China's metal smelting industry over the next 15 years. This research not only enhances the findings of existing studies on carbon emissions in the metal smelting sector but also introduces an innovative approach to carbon emission reduction within China's metal smelting industry.
MeSH term(s)	Humans ; Carbon/analysis ; Carbon Dioxide/analysis ; Greenhouse Gases ; Coal ; Climate Change ; Economic Development ; China
Chemical Substances	Carbon (7440-44-0) ; Carbon Dioxide (142M471B3J) ; Greenhouse Gases ; Coal
Language	English
Publishing date	2024-01-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-31962-6
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Article ; Online: Ferroptosis Biomarkers for Predicting Prognosis and Immunotherapy Efficacy in Adrenocortical Carcinoma.

Shen, Chengquan / Wang, Yonghua

Archives of medical research

2022 Volume 54, Issue 1, Page(s) 45–55

Abstract: Background: Numerous studies have suggested that ferroptosis plays an important regulatory role in cancer cell death. Nonetheless, the potential effects of ferroptosis regulators on the prognosis, the expression of immunomodulatory factors in the tumor ... ...

Abstract	Background: Numerous studies have suggested that ferroptosis plays an important regulatory role in cancer cell death. Nonetheless, the potential effects of ferroptosis regulators on the prognosis, the expression of immunomodulatory factors in the tumor microenvironment and on the efficacy of immunotherapy in adrenocortical carcinoma (ACC) remain largely unknown. Methods: Public ACC datasets were used to investigate the relationship between ferroptosis regulators and prognosis and clinical features. A ferroptosis scoring system was established for individual cases of ACC using principal component analysis algorithms. Hub ferroptosis-related genes involved in immunoregulation and immunotherapy efficacy in ACC were further identified. Results: Twenty ferroptosis regulators were differentially expressed in ACC and 17 ferroptosis regulators were closely related to prognosis in ACC. A ferroptosis scoring system was developed based on ACSL4, FANCD2, and SLC7A1 expression, and the ferroptosis regulators could serve as an independent prognostic factor for ACC. Further analyses indicated that the ferroptosis score integrated with the tumor mutation burden (TMB), and immune-checkpoint gene expression could predict prognosis in ACC. RNA isolation and reverse transcription‑quantitative polymerase chain reaction (RT-qPCR) demonstrated significant differences in the expression levels of ACSL4, FANCD2, and SLC7A1 between ACC and normal tissues. Furthermore, FANCD2 was significantly related to immunotherapy efficacy and prognosis in ACC. Conclusion: Our study demonstrated that ferroptosis was significantly associated with prognosis, clinical characteristics, immune-checkpoint gene expression, and tumor microenvironment immune cell infiltration in ACC. The current study provides comprehensive evidence for further research on ferroptosis regulators in ACC and provides new insight into the epigenetic regulation of the antitumor immune response.
MeSH term(s)	Humans ; Adrenocortical Carcinoma/genetics ; Adrenocortical Carcinoma/therapy ; Epigenesis, Genetic ; Ferroptosis/genetics ; Biomarkers ; Prognosis ; Immunotherapy ; Adrenal Cortex Neoplasms/genetics ; Adrenal Cortex Neoplasms/therapy ; Biomarkers, Tumor/genetics ; Tumor Microenvironment
Chemical Substances	Biomarkers ; Biomarkers, Tumor
Language	English
Publishing date	2022-12-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1156844-6
ISSN	1873-5487 ; 0188-4409 ; 0188-0128
ISSN (online)	1873-5487
ISSN	0188-4409 ; 0188-0128
DOI	10.1016/j.arcmed.2022.12.003
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Article: Integrated multiomics analysis and machine learning refine molecular subtypes and prognosis for muscle-invasive urothelial cancer.

Chu, Guangdi / Ji, Xiaoyu / Wang, Yonghua / Niu, Haitao

Molecular therapy. Nucleic acids

2023 Volume 33, Page(s) 110–126

Abstract: Muscle-invasive urothelial cancer (MUC), characterized by high aggressiveness and significant heterogeneity, is currently lacking highly precise individualized treatment options. We used a computational pipeline to synthesize multiomics data from MUC ... ...

Abstract	Muscle-invasive urothelial cancer (MUC), characterized by high aggressiveness and significant heterogeneity, is currently lacking highly precise individualized treatment options. We used a computational pipeline to synthesize multiomics data from MUC patients using 10 clustering algorithms, which were then combined with 10 machine learning algorithms to identify molecular subgroups of high resolution and develop a robust consensus machine learning-driven signature (CMLS). Through multiomics clustering, we identified three cancer subtypes (CSs) that are related to prognosis, with CS2 exhibiting the most favorable prognostic outcome. Subsequent screening enabled identification of 12 hub genes that constitute a CMLS with robust predictive power for prognosis. The low-CMLS group exhibited a more favorable prognosis and greater responsiveness to immunotherapy and was more likely to exhibit the "hot tumor" phenotype. The high-CMLS group had a poor prognosis and lower likelihood of benefitting from immunotherapy, but dasatinib and romidepsin may serve as promising treatments for them. Comprehensive analysis of multiomics data can offer important insights and further refine the molecular classification of MUC. Identification of CMLS represents a valuable tool for early prediction of patient prognosis and for screening potential candidates likely to benefit from immunotherapy, with broad implications for clinical practice.
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2662631-7
ISSN	2162-2531
ISSN	2162-2531
DOI	10.1016/j.omtn.2023.06.001
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Article ; Online: Integral Reinforcement-Learning-Based Optimal Containment Control for Partially Unknown Nonlinear Multiagent Systems.

Wu, Qiuye / Wu, Yongheng / Wang, Yonghua

Entropy (Basel, Switzerland)

2023 Volume 25, Issue 2

Abstract: This paper focuses on the optimal containment control problem for the nonlinear multiagent systems with partially unknown dynamics via an integral reinforcement learning algorithm. By employing integral reinforcement learning, the requirement of the ... ...

Abstract	This paper focuses on the optimal containment control problem for the nonlinear multiagent systems with partially unknown dynamics via an integral reinforcement learning algorithm. By employing integral reinforcement learning, the requirement of the drift dynamics is relaxed. The integral reinforcement learning method is proved to be equivalent to the model-based policy iteration, which guarantees the convergence of the proposed control algorithm. For each follower, the Hamilton-Jacobi-Bellman equation is solved by a single critic neural network with a modified updating law which guarantees the weight error dynamic to be asymptotically stable. Through using input-output data, the approximate optimal containment control protocol of each follower is obtained by applying the critic neural network. The closed-loop containment error system is guaranteed to be stable under the proposed optimal containment control scheme. Simulation results demonstrate the effectiveness of the presented control scheme.
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25020221
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Article ; Online: An Efficient Impulsive Adaptive Dynamic Programming Algorithm for Stochastic Systems.

Liang, Mingming / Wang, Yonghua / Liu, Derong

IEEE transactions on cybernetics

2023 Volume 53, Issue 9, Page(s) 5545–5559

Abstract: In this study, a novel general impulsive transition matrix is defined, which can reveal the transition dynamics and probability distribution evolution patterns for all system states between two impulsive "events," instead of two regular time indexes. ... ...

Abstract	In this study, a novel general impulsive transition matrix is defined, which can reveal the transition dynamics and probability distribution evolution patterns for all system states between two impulsive "events," instead of two regular time indexes. Based on this general matrix, the policy iteration-based impulsive adaptive dynamic programming (IADP) algorithm along with its variant, which is a more efficient IADP (EIADP) algorithm, are developed in order to solve the optimal impulsive control problems of discrete stochastic systems. Through analyzing the monotonicity, stability, and convergency properties of the obtained iterative value functions and control laws, it is proved that the IADP and EIADP algorithms both converge to the optimal impulsive performance index function. By dividing the whole impulsive policy into smaller pieces, the proposed EIADP algorithm updates the iterative policies in a "piece-by-piece" manner according to the actual hardware constraints. This feature of the EIADP method enables these ADP-based algorithms to be fully optimized to run on all "sizes" of computing devices including the ones with low memory spaces. A simulation experiment is conducted to validate the effectiveness of the present methods.
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2022.3158898
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Article ; Online: Exploring Diacylglycerol Oil-Based Oleogels as Effective Stabilizers in Peanut Butter: Performance, Structural Insights, and Sensory Evaluation.

Ding, Siliang / Chen, Xiaohan / Ouyang, Bo / Yang, Bo / Wang, Weifei / Wang, Yonghua

Journal of oleo science

2024 Volume 73, Issue 2, Page(s) 135–145

Abstract: In the pursuit of reducing oil separation in peanut butter, oleogels synthesized from diacylglycerol (DAG)-rich peanut oils, using glycerol monostearate (GMS) as the gelator, were examined as alternative stabilizers. In comparison to triacylglycerol (TAG) ...

Abstract	In the pursuit of reducing oil separation in peanut butter, oleogels synthesized from diacylglycerol (DAG)-rich peanut oils, using glycerol monostearate (GMS) as the gelator, were examined as alternative stabilizers. In comparison to triacylglycerol (TAG)-rich peanut oils, the DAG oil-based oleogels exhibited better oil-binding capacities across increasing GMS concentrations. Intriguingly, thermal and rheological assessments pointed to a weaker network structure in DAG oil oleogels, as evidenced by their lower crystallization temperatures and reduced viscoelastic parameters (G' and G''). Insight from infrared spectroscopy revealed that this could stem from heightened intermolecular hydrogen bonding between the DAG oil and the gelator. When applied to peanut butter, DAG oil oleogels demonstrated efficacy in minimizing oil separation. Extended storage trials affirmed the long-term stability of peanut butter formulations incorporating these oleogels. Furthermore, sensory evaluations by panelists underscored favorable impressions, suggesting potential consumer acceptance. Overall, this study illuminates the promising role of DAG oleogels as effective, alternative stabilizers in peanut butter formulations.
MeSH term(s)	Diglycerides ; Arachis ; Oils ; Organic Chemicals/chemistry
Chemical Substances	oleogels ; Diglycerides ; Oils ; Organic Chemicals
Language	English
Publishing date	2024-02-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2218264-0
ISSN	1347-3352 ; 1345-8957
ISSN (online)	1347-3352
ISSN	1345-8957
DOI	10.5650/jos.ess23122
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Article ; Online: Streamlined enzymatic synthesis of human milk fat substitutes.

Xu, Qingqing / Wang, Shushu / Zou, Qian / Chen, Wen / Lan, Dongming / Wang, Yonghua

Food chemistry

2024 Volume 443, Page(s) 138476

Abstract: The positional distribution of palmitic acid (PA) in human milk fat substitutes (HMFSs) plays a pivotal role in mimicking the nutritional profile of human milk fat for nourishing non-breastfed infants. This study innovatively introduced a streamlined ... ...

Abstract	The positional distribution of palmitic acid (PA) in human milk fat substitutes (HMFSs) plays a pivotal role in mimicking the nutritional profile of human milk fat for nourishing non-breastfed infants. This study innovatively introduced a streamlined enzymatic process for preparing HMFSs rich in sn-2 PA using palm stearin, a PA-rich source without the necessity for positional distribution of PA. The initial step involved enhancing the sn-2 PA concentration through enzymatic interesterification using Lipase UM1, which exhibited superior catalytic efficiency than Novozym 435. This process increased the sn-2 PA level from 40.98 % to 64.51 %. Subsequently, acidolysis was employed to reduce PA levels by replacing PA at sn-1,3 positions using sn-1,3-regioselective lipases. The PA content decreased from 60.64 % to 26.73 %, simultaneously raising the relative sn-2 PA concentration to 71.57 %, meeting the benchmarks for HMFSs. This study establishes a robust conceptual framework for the prospective industrial synthesis of HMFSs.
MeSH term(s)	Infant ; Humans ; Animals ; Milk, Human ; Fat Substitutes ; Prospective Studies ; Triglycerides ; Palmitic Acid ; Catalysis ; Fatty Acids ; Milk
Chemical Substances	Fat Substitutes ; Triglycerides ; Palmitic Acid (2V16EO95H1) ; Fatty Acids
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138476
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Article ; Online: Toxicity comparison of benzophenone-3 and its metabolite benzophenone-8 in different tissues of zebrafish.

Wang, Yonghua / Shang, Yujia / Liu, Xiaodan / Chen, Xi / Xu, Guanhua / Lu, Guanghua

Aquatic toxicology (Amsterdam, Netherlands)

2024 Volume 268, Page(s) 106852

Abstract: Benzophenone-3 (BP-3) is a commonly used ultraviolet absorber that has the potential to accumulate in organisms, leading to toxicity. Benzophenone-8 (BP-8) is one of the major metabolites of BP-3. In this study, zebrafish were exposed to different ... ...

Abstract	Benzophenone-3 (BP-3) is a commonly used ultraviolet absorber that has the potential to accumulate in organisms, leading to toxicity. Benzophenone-8 (BP-8) is one of the major metabolites of BP-3. In this study, zebrafish were exposed to different concentrations of BP-3 and BP-8 (1 μg/L, 30 μg/L, and 300 μg/L) to investigate their accumulation and toxic effects in various tissues, including zebrafish brain, gut, and liver. The analysis focused on neurotoxicity, oxidative damage, inflammation, and gene expressions. The results showed that both BP-3 and BP-8 accumulated in the tissues, with the highest concentration observed in the gut, followed by the liver and brain. BP-8 exhibited a stronger ability to accumulate. In the brain, exposure to 1 μg/L of BP-3 and BP-8 promoted cortisol production, while higher exposures (30 μg/L and 300 μg/L) inhibited acetylcholinesterase activity and suppressed cortisol production. In the gut, both BP-3 and BP-8 exposures disrupted oxidative stress, inflammatory immunity, and apoptosis functions. In the liver, BP-3 and BP-8 affected hepatic metabolism, oxidative stress, apoptosis, and inflammatory immunity. Comparing gene expression in the brain, gut, and liver, it was found that BP-3 and BP-8 had a lower effect on gene expression in the brain, while the effect on the gut and liver was significantly higher. BP-8 generally had a higher effect than BP-3, which aligns with the observed accumulation pattern. These findings provide valuable insights for the risk assessment of BP-3 and BP-8 in the aquatic environment.
MeSH term(s)	Animals ; Zebrafish/metabolism ; Acetylcholinesterase/metabolism ; Hydrocortisone ; Water Pollutants, Chemical/toxicity ; Benzophenones/toxicity
Chemical Substances	oxybenzone (95OOS7VE0Y) ; Acetylcholinesterase (EC 3.1.1.7) ; Hydrocortisone (WI4X0X7BPJ) ; Water Pollutants, Chemical ; benzophenone (701M4TTV9O) ; Benzophenones
Language	English
Publishing date	2024-01-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782699-0
ISSN	1879-1514 ; 0166-445X
ISSN (online)	1879-1514
ISSN	0166-445X
DOI	10.1016/j.aquatox.2024.106852
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Article: Testicular metastasis from urothelial carcinoma: case report and literature review.

Liu, Changxue / Liu, Jing / Yang, Qingbo / Song, Leilei / Ma, Xiaocheng / Wang, Yonghua

Frontiers in oncology

2024 Volume 14, Page(s) 1308399

Abstract: Urothelial carcinoma (UC) with testicular metastasis is extremely rare, and its modes of metastasis, prognosis, and treatment are unclear. In this report, we present an extraordinarily rare case of testicular metastasis arising from UC 8 years after ... ...

Abstract	Urothelial carcinoma (UC) with testicular metastasis is extremely rare, and its modes of metastasis, prognosis, and treatment are unclear. In this report, we present an extraordinarily rare case of testicular metastasis arising from UC 8 years after surgery. The patient underwent left orchiepididymectomy and received immunotherapy postoperatively. After a 6-month follow-up, there were no signs of recurrence. Moreover, the clinical characteristics, metastasis pattern, and treatment plan were also summarized based on 14 earlier reported cases of UC with testicular metastasis.
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1308399
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Article ; Online: Lipidomics analysis unveils the dynamic alterations of lipid degradation in rice bran during storage.

Liu, Xuan / Wang, Weifei / Li, Zhong / Xu, Long / Lan, Dongming / Wang, Yonghua

Food research international (Ottawa, Ont.)

2024 Volume 184, Page(s) 114243

Abstract: Recent explorations into rice bran oil (RBO) have highlighted its potential, owing to an advantageous fatty acid profile in the context of health and nutrition. Despite this, the susceptibility of rice bran lipids to oxidative degradation during storage ... ...

Abstract	Recent explorations into rice bran oil (RBO) have highlighted its potential, owing to an advantageous fatty acid profile in the context of health and nutrition. Despite this, the susceptibility of rice bran lipids to oxidative degradation during storage remains a critical concern. This study focuses on the evolution of lipid degradation in RBO during storage, examining the increase in free fatty acids (FFAs), the formation of oxylipids, and the generation of volatile secondary oxidation products. Our findings reveal a substantial rise in FFA levels, from 109.55 to 354.06 mg/g, after 14 days of storage, highlighting significant lipid deterioration. Notably, key oxylipids, including 9,10-EpOME, 12,13(9,10)-DiHOME, and 13-oxoODE, were identified, with a demonstrated positive correlation between total oxylipids and free polyunsaturated fatty acids (PUFAs), specifically linoleic acid (LA) and α-linolenic acid (ALA). Furthermore, the study provides a detailed analysis of primary volatile secondary oxidation products. The insights gained from this study not only sheds light on the underlying mechanisms of lipid rancidity in rice bran but also offers significant implications for extending the shelf life and preserving the nutritional quality of RBO, aligning with the increasing global interest in this high-quality oil.
MeSH term(s)	Lipidomics ; Lipolysis ; Fatty Acids ; Fatty Acids, Nonesterified ; Linoleic Acid ; Rice Bran Oil
Chemical Substances	Fatty Acids ; Fatty Acids, Nonesterified ; Linoleic Acid (9KJL21T0QJ) ; Rice Bran Oil (LZO6K1506A)
Language	English
Publishing date	2024-03-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2024.114243
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