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  1. Article ; Online: Research on emotion classification technology of movie reviews based on topic attention mechanism and dual channel long short term memory.

    Wang, Yufei

    PeerJ. Computer science

    2023  Volume 9, Page(s) e1295

    Abstract: In recent years, with the popularity of the Internet, more and more people like to comment on movies they have watched on the film platform after watching them. These reviews hide the reviewers' feedback on films. Mining the emotional orientation ... ...

    Abstract In recent years, with the popularity of the Internet, more and more people like to comment on movies they have watched on the film platform after watching them. These reviews hide the reviewers' feedback on films. Mining the emotional orientation information in these reviews can provide consumers with shopping references and help businesses optimize film works and improve business strategies. Therefore, the emotional classification of film reviews has high research value because few emotion dictionaries and analysis tools are available for reference and use in film reviews. The accuracy of emotion classification still needs to be improved. This study introduces the attention mechanism and dual channel long short term memory (DC-LSTM) while building the emotion dictionary in the field of Chinese film review. It classifies Chinese film reviews in terms of topic-based fine-grained emotion. First, the emotion vector is constructed using the constructed movie review emotion lexicon. The semantic vector obtained by the Word2vector tool is input to LSTM to encode the comment text. Then, the topic attention module is used to decode. Finally, the final emotion classification result is obtained through the softmax function of the entire link layer and the output layer. The thematic attention modules constructed in this study are independent of each other for attention parameter adjustment and learning. One attention module corresponds to one film theme. In this study, eight themes, including "plot," "special effects," "original work," "music," "thought," "theme," "acting skills," and "joke," were extracted, and each theme was classified into three types of emotions: "positive," "neutral," and "negative." The experimental results on the crawled Chinese film review dataset show that the proposed algorithm is superior to some existing algorithms and models in accuracy, precision, recall and F1 measure. The DCLSTM based on the thematic attention mechanism (DCLSTM-TAM) model constructed in this study introduces the emotion vector into the network and adds the theme attention mechanism. It can not only classify the emotion for different topics of a film review but also effectively deal with film reviews with fuzzy emotional tendencies. It realizes the fine-grained emotion classification of film topics and improves the accuracy of emotion classification of film reviews. The emotion classification method and model proposed in this study have good transferability, and the change of training corpus is also applicable to other short text fields.
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 2376-5992
    ISSN (online) 2376-5992
    DOI 10.7717/peerj-cs.1295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multi-omics sequencing revealed endostar combined with cisplatin treated non small cell lung cancer via anti-angiogenesis.

    Wang, Yufei / Ren, Hong

    BMC cancer

    2024  Volume 24, Issue 1, Page(s) 187

    Abstract: Background: Endostar, an anti-angiogenic drug, has been approved for treating non-small cell lung cancer (NSCLC). At present, endostar combined with radiotherapy or chemotherapy has achieved ideal results in the treatment of some tumors, but there is a ... ...

    Abstract Background: Endostar, an anti-angiogenic drug, has been approved for treating non-small cell lung cancer (NSCLC). At present, endostar combined with radiotherapy or chemotherapy has achieved ideal results in the treatment of some tumors, but there is a lack of application and study in NSCLC. This study investigated the therapeutic effect and potential mechanism of endostar combined with cisplatin (EC) in NSCLC.
    Methods: HE staining, TUNEL staining, immunofluorescence, colony formation ability, and cell migration ability were used to evaluate the anti-tumor activity of EC. The expressions of FMOD, VEGF, FGF-2, and PDGF-B were detected by western blotting and qPCR. The target of combination therapy was analyzed by m6A sequencing and RNA sequencing. METTL3 knockdown and overexpressed A549 cells were constructed and co-cultured with HUVECs to further evaluate the effect of METLL3 on combination therapy.
    Results: Combination therapy significantly reduced the colony formation and migration ability of NSCLC cells, induced cell apoptosis, and inhibited the tube formation ability of HUVECs. The results of m6A sequencing and RNA sequencing showed that the EC could down-regulate the expression level of FMOD in tumor tissues, which might be related to the reduction of its m6A methylation modification regulatory enzyme METTL3. Restricting FMOD expression could reduce the expression of FGF2, TGF-β1, VEGF and PDGF-B. Moreover, overexpression of METTLE almost abolished the anti-tumor effect of EC and promoted angiogenesis.
    Conclusions: Endostar combined with cisplatin might exert anti-tumor effects by down-regulating the expression of METTL3 and FMOD.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Multiomics ; Vascular Endothelial Growth Factor A/metabolism ; Cell Line, Tumor ; Methyltransferases/genetics ; Recombinant Proteins ; Endostatins
    Chemical Substances endostar protein (GVG18ZDN65) ; Cisplatin (Q20Q21Q62J) ; Vascular Endothelial Growth Factor A ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-) ; Recombinant Proteins ; Endostatins
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11665-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A nonlinear relationship between systemic inflammation response index and short-term mortality in patients with acute myocardial infarction: a retrospective study from MIMIC-IV.

    Wang, Yufei / Chen, Hua

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1208171

    Abstract: Background: This investigation aimed to evaluate the efficacy of the Systemic Inflammatory Response Index (SIRI) in prognosticating short-term all-cause mortality among patients diagnosed with acute myocardial infarction (AMI) in the intensive care unit ...

    Abstract Background: This investigation aimed to evaluate the efficacy of the Systemic Inflammatory Response Index (SIRI) in prognosticating short-term all-cause mortality among patients diagnosed with acute myocardial infarction (AMI) in the intensive care unit (ICU).
    Methods and results: Clinical data were obtained from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. A total of 4,291 patients were included in the cohort. Results from multivariate regression analyses showed that the quartile of the natural logarithm of SIRI (ln-SIRI) was independently associated with mortality. Compared to patients in the first quartile (Q1), patients in the second quartile (Q2) and fourth quartile (Q4) were significantly associated with an increased risk of 30-day (HR = 2.031, 95% CI: 1.604-2.571,
    Conclusion: SIRI is an independent risk factor for 30- and 90-day mortality, and length of stay in ICU for critical AMI patients.
    Language English
    Publishing date 2023-07-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1208171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Natural and synthetic compounds for glioma treatment based on ROS-mediated strategy.

    Wang, Yu-Fei / Hu, Jin-Yue

    European journal of pharmacology

    2023  Volume 953, Page(s) 175537

    Abstract: Glioma is the most frequent and most malignant tumor of the central nervous system (CNS),accounting for about 50% of all CNS tumor and approximately 80% of the malignant primary tumors in the CNS. Patients with glioma benefit from surgical resection, ... ...

    Abstract Glioma is the most frequent and most malignant tumor of the central nervous system (CNS),accounting for about 50% of all CNS tumor and approximately 80% of the malignant primary tumors in the CNS. Patients with glioma benefit from surgical resection, chemo- and radio-therapy. However these therapeutical strategies do not significantly improve the prognosis, nor increase survival rates owing to restricted drug contribution in the CNS and to the malignant characteristics of glioma. Reactive oxygen species (ROS) are important oxygen-containing molecules that regulate tumorigenesis and tumor progression. When ROS accumulates to cytotoxic levels, this can lead to anti-tumor effects. Multiple chemicals used as therapeutic strategies are based on this mechanism. They regulate intracellular ROS levels directly or indirectly, resulting in the inability of glioma cells to adapt to the damage induced by these substances. In the current review, we summarize the natural products, synthetic compounds and interdisciplinary techniques used for the treatment of glioma. Their possible molecular mechanisms are also presented. Some of them are also used as sensitizers: they modulate ROS levels to improve the outcomes of chemo- and radio-therapy. In addition, we summarize some new targets upstream or downstream of ROS to provide ideas for developing new anti-glioma therapies.
    MeSH term(s) Humans ; Reactive Oxygen Species ; Glioma/drug therapy ; Glioma/pathology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Central Nervous System ; Cell Line, Tumor ; Brain Neoplasms/drug therapy
    Chemical Substances Reactive Oxygen Species ; Antineoplastic Agents
    Language English
    Publishing date 2023-03-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2023.175537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CRISPR/Cas systems for in situ imaging of intracellular nucleic acids: Concepts and applications.

    Chen, Kun / Wang, Yufei

    Biotechnology and bioengineering

    2023  Volume 120, Issue 12, Page(s) 3446–3464

    Abstract: Accurate and precise localization of intracellular nucleic acids is crucial for regulating genetic information transcription and diagnosing diseases. Although intracellular nucleic acid imaging methods are available for various cell types, their ... ...

    Abstract Accurate and precise localization of intracellular nucleic acids is crucial for regulating genetic information transcription and diagnosing diseases. Although intracellular nucleic acid imaging methods are available for various cell types, their widespread utilization is impeded by the intricate nature of the process and its exorbitant cost. Recently, numerous intracellular nucleic acid labeling techniques based on clustered regularly interspaced short palindromic repeats (CRISPR) have been established due to their modularity, flexibility, and specificity. In this work, we present various CRISPR methods that are currently employed for visualizing intracellular genomic sequences and RNA, based on their detection principles and application scenarios. Furthermore, we discuss the advantages and drawbacks of the existing CRISPR imaging methods, as well as future research directions. We anticipate that with continued refinement, more advanced CRISPR-based imaging techniques can be developed to better elucidate the localization and dynamics of intracellular nucleic acids, thereby providing a powerful tool for molecular biology research and clinical molecular pathology diagnosis.
    MeSH term(s) CRISPR-Cas Systems ; Nucleic Acids/genetics ; RNA ; Genomics
    Chemical Substances Nucleic Acids ; RNA (63231-63-0)
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.28543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Vaginal microbiota: Potential targets for vulvovaginal candidiasis infection.

    Wang, Yufei / Liu, Zhaoxia / Chen, Tingtao

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e27239

    Abstract: Vulvovaginal candidiasis (VVC) is the second most common cause of vaginal infection globally after bacterial vaginosis (BV) and associated with adverse reproductive and obstetric outcomes, including preterm delivery, sexually transmitted infections and ... ...

    Abstract Vulvovaginal candidiasis (VVC) is the second most common cause of vaginal infection globally after bacterial vaginosis (BV) and associated with adverse reproductive and obstetric outcomes, including preterm delivery, sexually transmitted infections and pelvic inflammatory disease. Although effective control of VVC is achievable with the use of traditional treatment strategies (i.e., antifungals), the possibility of drug intolerance, treatment failure and recurrence, as well as the appearance of antifungal-resistant
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intelligent medical IoT health monitoring system based on VR and wearable devices

    Wang Yufei / An Xiaofeng / Xu Weiwei

    Journal of Intelligent Systems, Vol 32, Iss 1, Pp 1751-

    2023  Volume 6

    Abstract: In order to improve the shortcomings of the traditional monitoring equipment that is difficult to measure the daily physical parameters of the elderly and improve the accuracy of parameter measurement, this article designs wearable devices through the ... ...

    Abstract In order to improve the shortcomings of the traditional monitoring equipment that is difficult to measure the daily physical parameters of the elderly and improve the accuracy of parameter measurement, this article designs wearable devices through the Internet of Things technology and virtual reality technology. With this device, four daily physical parameters of the elderly, such as exercise heart rate, blood pressure, plantar health, and sleep function, are measured. The feasibility of the measurement method and equipment is verified by experiments. The experimental results showed that the accuracy of the measurement method based on the reflective photoplethysmography signal was high, with the mean and difference values of the subjects’ heart rate basically lying around 0 BPM and in good agreement between the estimated heart rate and the reference value. In the blood pressure measurements, the correlation coefficient between the Prs{P}_{rs} estimate and the reference value was 0.81. The estimation accuracy of the device used in the article was high, with the highest correlation coefficient of 0.96 ± 0.02 for subjects’ heart rate at rest, and its estimation error rate was 0.02 ± 0.01. The Pnth{P}_{{n}th} value for subject B8 exceeded the threshold of 0.5 before subject B21, and subject B8 had more severe symptoms, which was consistent with the actual situation. The wearable device was able to identify the subject’s eye features and provide appropriate videos to help subjects with poor sleep quality to fall asleep. The article provides a method and device that facilitates healthcare professionals to make real-time enquiries and receive user health advice.
    Keywords vr ; wearable devices ; internet of things ; health monitoring ; physical parameters ; Science ; Q ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 600
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Development of a human leukocyte antigen-based HIV vaccine.

    Wang, Yufei

    F1000Research

    2018  Volume 7

    Abstract: Human immunodeficiency virus (HIV) carries abundant human cell proteins, particularly human leukocyte antigen (HLA) molecules when the virus leaves host cells. Immunization in macaques with HLAs protects the animals from simian immunodeficiency virus ... ...

    Abstract Human immunodeficiency virus (HIV) carries abundant human cell proteins, particularly human leukocyte antigen (HLA) molecules when the virus leaves host cells. Immunization in macaques with HLAs protects the animals from simian immunodeficiency virus infection. This finding offers an alternative approach to the development of HLA molecule-based HIV vaccines. Decades of studies have enhanced a great deal of our understanding of the mechanisms of allo-immune response-mediated anti-HIV immunity. These include cell-mediated immunity, innate immunity, and antibody response. These studies provided a rationale for the future design of effective HIV vaccines.
    Language English
    Publishing date 2018
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.13759.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Physical activity and mental health in sports university students during the COVID-19 school confinement in Shanghai.

    Wang, Yufei / Li, Youqiang

    Frontiers in public health

    2022  Volume 10, Page(s) 977072

    Abstract: Background: In 2022, Shanghai was seriously affected by the coronavirus disease 2019 (COVID-19) pandemic. The government implemented citywide static management for 2 months, as well as all universities in Shanghai, which changed the normal learning and ... ...

    Abstract Background: In 2022, Shanghai was seriously affected by the coronavirus disease 2019 (COVID-19) pandemic. The government implemented citywide static management for 2 months, as well as all universities in Shanghai, which changed the normal learning and living style of sports students and led to a decline in physical activity level. As the physical activity has a strong correlation with mental health, this study aimed to investigate the current state of physical activity (PA) and mental health of the students in Shanghai University of Sport. It will try to reveal the correlation between PA and depressive symptoms, anxiety symptoms, fear of COVID-19 and smartphone addiction.
    Methods: A cross-sectional survey was conducted on a random sample of 400 students who came from six different majors in May 2022 at the Shanghai University of Sport. Respondents completed the International Physical Activity Questionnaire Short Form (IPAQ-SF), the Chinese version of the 9-item Patient Health Questionnaire (PHQ-9), the Chinese version of the Generalized Anxiety Disorder Scale (GAD-7), the Chinese version of the COVID-19 Fear Scale (FCV- 19S), and the Smartphone Addiction Scale (SAS-SV). Demographics, PA, depressive symptoms, anxiety symptoms, fear of COVID-19, and smartphone addiction were compared. A binary logistic regression model was used for the further analysis.
    Results: A total of 376 college students were included in the final analysis. Binary logistics analysis showed that moderate physical activity (MPA) was negatively correlated with depression (OR = 0.95, 95%CI = 0.93-0.98), anxiety (OR = 0.97, 95%CI = 0.95-0.99), fear of COVID 19(OR = 0.99, 95%CI = 0.98-0.99)and smartphone addiction (OR = 0.94, 95%CI = 0.9-0.98) (all
    Conclusion: There was an association between the presence of MPA and depressive symptoms, anxiety symptoms, fear of COVID-19, smartphone addiction, and sedentary behavior associated with smartphone addiction levels. Clarifying the causal relationship between PA and mental health will require further research.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Mental Health ; Universities ; Cross-Sectional Studies ; China/epidemiology ; Students/psychology ; Exercise
    Language English
    Publishing date 2022-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.977072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Faculty Opinions recommendation of Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19.

    Wang, Yufei

    Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

    2020  

    Keywords covid19
    Publisher Faculty Opinions Ltd
    Publishing country uk
    Document type Book ; Online
    DOI 10.3410/f.738305284.793576755
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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