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  1. Book: RNA structure and dynamics

    Ding, Jienyu / Stagno, Jason R. / Wang, Yun-Xing

    (Methods in molecular biology ; 2568 ; Springer protocols)

    2023  

    Author's details edited by Jienyu Ding, Jason R. Stagno and Yun-Xing Wang (Protein-Nucleic Acid Interaction Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA)
    Series title Methods in molecular biology ; 2568
    Springer protocols
    Collection
    Keywords RNA. ; RNA/Structure
    Subject code 572.88
    Language English
    Size xi, 254 Seiten, Illustrationen, 26 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT021570058
    ISBN 978-1-0716-2686-3 ; 9781071626870 ; 1-0716-2686-8 ; 1071626876
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2568- not available for loan Lesesaal EG

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  2. Article ; Online: Sink Node Placement and Partial Connectivity in Wireless Sensor Networks.

    Wang, Yun

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 22

    Abstract: This research delves into the aspects of communication and connectivity problems within random Wireless Sensor Networks (WSNs). It takes into account the distinctive role of the sink node, its placement, and application-specific requirements for ... ...

    Abstract This research delves into the aspects of communication and connectivity problems within random Wireless Sensor Networks (WSNs). It takes into account the distinctive role of the sink node, its placement, and application-specific requirements for effective communication while conserving valuable network resources. Through mathematical modeling, theoretical analysis, and simulation evaluations, we derive, compare, and contrast the probabilities of partial and full connectivity within a random WSN, factoring in network parameters and the maximum allowable hop distance/count hmax. hmax captures the diverse range of delay-sensitive requirements encountered in practical scenarios. Our research underscores the significant impact of the sink node and its placement on network connectivity and the sensor connection rate. The results exemplify a noteworthy decline in the sensor connection rate, dropping from 98.8% to 72.5%, upon relocating the sink node from the network center to the periphery. Moreover, as compared with full connectivity, partial connectivity and the sensor connection rate are more suitable metrics for assessing the communication capability of random WSNs. The results illustrate that 1.367 times
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23229058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Low-calorie Diets for Remission of Type 2 Diabetes-Do the Benefits Outweigh the Risks?

    Wang, Yun Cathy

    Canadian journal of diabetes

    2023  Volume 47, Issue 7, Page(s) 544

    Language English
    Publishing date 2023-02-24
    Publishing country Canada
    Document type Letter
    ISSN 2352-3840
    ISSN (online) 2352-3840
    DOI 10.1016/j.jcjd.2023.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Transient Receptor Potential Channels: Multiple Modulators of Peripheral Neuropathic Pain in Several Rodent Models.

    Xu, Songchao / Wang, Yun

    Neurochemical research

    2024  Volume 49, Issue 4, Page(s) 872–886

    Abstract: Neuropathic pain, a prevalent chronic condition in clinical settings, has attracted widespread societal attention. This condition is characterized by a persistent pain state accompanied by affective and cognitive disruptions, significantly impacting ... ...

    Abstract Neuropathic pain, a prevalent chronic condition in clinical settings, has attracted widespread societal attention. This condition is characterized by a persistent pain state accompanied by affective and cognitive disruptions, significantly impacting patients' quality of life. However, current clinical therapies fall short of addressing its complexity. Thus, exploring the underlying molecular mechanism of neuropathic pain and identifying potential targets for intervention is highly warranted. The transient receptor potential (TRP) receptors, a class of widely distributed channel proteins, in the nervous system, play a crucial role in sensory signaling, cellular calcium regulation, and developmental influences. TRP ion channels are also responsible for various sensory responses including heat, cold, pain, and stress. This review highlights recent advances in understanding TRPs in various rodent models of neuropathic pain, aiming to uncover potential therapeutic targets for clinical management.
    MeSH term(s) Animals ; Humans ; Transient Receptor Potential Channels/metabolism ; Transient Receptor Potential Channels/therapeutic use ; Rodentia/metabolism ; Quality of Life ; Neuralgia/metabolism ; Signal Transduction
    Chemical Substances Transient Receptor Potential Channels
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1007/s11064-023-04087-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Dynamics-Entropy Relationship in Metallic Glasses.

    Cao, Lin-Li / Wang, Yun-Jiang

    The journal of physical chemistry letters

    2024  Volume 15, Issue 3, Page(s) 811–816

    Abstract: Establishing a robust quantitative correlation between thermodynamics and dynamics in amorphous matter remains a significant challenge in condensed matter physics. Although the classical Adam-Gibbs relationship represents a pivotal step in this direction ...

    Abstract Establishing a robust quantitative correlation between thermodynamics and dynamics in amorphous matter remains a significant challenge in condensed matter physics. Although the classical Adam-Gibbs relationship represents a pivotal step in this direction and the correlation between relaxation time and configurational entropy has been partially verified in simple liquids, this quantitative link has yet to be tested in realistic glass-forming systems where complex many-body interactions are present. Here we conduct free energy samplings and lattice dynamics analysis to distinguish vibrational entropy from configurational entropy in a realistic Cu-Zr model of a metallic glass. Our calculations unveil a power-law relationship (with a substantial exponent of ∼3) between the logarithmic relaxation time and configurational entropy, surpassing the linear prediction of the original Adam-Gibbs relationship. This nonlinear entropy driven relaxation time variation likely originates from anisotropic nature of atomic many-body interactions, suggesting that factors beyond thermodynamics contribute to the glass transition phenomenon.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c03530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Risk assessment for commercial crime and legal protection based on modularity-optimized LM and SCA-optimized CNN.

    Wang, YunZhe / Su, FengLan

    PeerJ. Computer science

    2023  Volume 9, Page(s) e1683

    Abstract: With the Internet of Things (IoT) making significant strides in recent years, the challenges associated with data collection and analysis have emerged as a pressing concern in public security. When employed to tackle extensive criminal networks, the ... ...

    Abstract With the Internet of Things (IoT) making significant strides in recent years, the challenges associated with data collection and analysis have emerged as a pressing concern in public security. When employed to tackle extensive criminal networks, the conventional deep learning model encounters issues such as heightened computational complexity, sluggish operational efficiency, and even system failures. Consequently, this research article introduces an intricately devised framework for detecting commercial offenses, employing a modularity-optimized Louvain-Method (LM) algorithm. Additionally, a convolutional neural networks (CNN)-based model is formulated to determine the feasibility of extending legal aid, wherein feature transformation is facilitated by utilizing TFIDF and Word2vec algorithms aligned with diverse legal text corpora. Furthermore, the hyper-parameter optimization is accomplished using the sine cosine algorithm (SCA), ultimately enabling the classification of relevant legal guidance. The experimental outcomes comprehensively affirm the exceptional training effectiveness of this model. The commercial crime identification model, grounded in modular optimization as proposed in this article, adeptly discerns criminal syndicates within the commercial trading network, achieving an accuracy rate exceeding 90%. This empowers the identification of such syndicates and bestows the judicial sphere with pertinent legal insights.
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ISSN 2376-5992
    ISSN (online) 2376-5992
    DOI 10.7717/peerj-cs.1683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Palmitic Acid Upregulates CD96 Expression to Mediate Maternal-Foetal Interface Immune Tolerance by Inhibiting Cytotoxic Activity and Promoting Adhesion Function in Human Decidual Natural Killer Cells.

    Wang, Yingjie / Wang, Yun

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 9

    Abstract: Decidual natural killer cells (dNK cells) are an essential component of the immune cells present at the maternal-foetal interface during early pregnancy, and they play a vital role in various physiological processes. Abnormalities in the ratio or ... ...

    Abstract Decidual natural killer cells (dNK cells) are an essential component of the immune cells present at the maternal-foetal interface during early pregnancy, and they play a vital role in various physiological processes. Abnormalities in the ratio or function of dNK cells have been linked to recurrent miscarriages. CD96 has been previously shown to regulate NK cell function in the tumour microenvironment; however, its role and mechanism at the maternal-foetal interface remains unclear. The present study aimed to investigate the immunomodulatory role of CD96 in dNK cells and its function at the maternal-foetal interface. Immunofluorescence staining and flow cytometry were used to detect the expression of cellular markers such as CD96. Furthermore, the secretory function, adhesion-function-related molecules, and cell proliferation markers of CD96+ and CD96- dNK cells were detected using flow cytometry. In addition, we performed cell culture experiments via the magnetic bead sorting of NK cells to detect changes in the expression of the aforementioned functional molecules in dNK cells after the CD96 blockade. Furthermore, we examined the functional characteristics of dNK cells after palmitic acid treatment at a concentration of 10 μM. We also examined the changes in dNK cell function when subjected to the combined effect of palmitic acid and CD96 antagonists. The results indicated that CD96, TIGIT, CD155, and CD112 were highly expressed at the maternal-foetal interface, with dNK cells predominantly expressing CD96, whereas TIGIT was mainly expressed on T cells, and CD155 and CD112 were mainly present in metaphase stromal and trophoblast cells. CD96+ dNK cells displayed low cytotoxic activity and a high adhesion phenotype, which mediated the immunosuppressive effect on dNK cells at the maternal-foetal interface. Palmitic acid upregulated CD96 expression on the surface of dNK cells in the coculture system, inhibiting dNK cell activity and increasing their adhesion molecule expression. CD96 antagonist treatment blocked the inhibitory effect of trophoblasts on dNK cells, resulting in enhanced cytokine secretion and reduced adhesion. The results of this study provide valuable insight into the immunomodulatory role of CD96 in dNK cells and its mechanism at the maternal-foetal interface, particularly in metaphase NK cells. This study sheds light on the mechanisms of immune regulation at the maternal-foetal interface and their implications for the study of recurrent miscarriages of unknown origin.
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10091008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Amphetamines abuse and depression: Focus on TRPC channels.

    Fu, You-Peng / Wang, Yun

    Experimental neurology

    2023  Volume 364, Page(s) 114391

    Abstract: Amphetamines, such as amphetamine (AMPH), methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA), are the psychotropic substances widely abused in the world. Amphetamines abuse can damage dopaminergic and serotonin neurons and cause ... ...

    Abstract Amphetamines, such as amphetamine (AMPH), methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA), are the psychotropic substances widely abused in the world. Amphetamines abuse can damage dopaminergic and serotonin neurons and cause neuroinflammation and neurotoxicity. Neuropsychiatric disorders induced by amphetamines abuse include depression, anxiety, auditory hallucinations, mania, and cognitive disorders, of which depression has a higher incidence. Transient receptor potential (TRP) channels can regulate the inflow and outflow of Ca
    MeSH term(s) Transient Receptor Potential Channels ; Depression/chemically induced ; Amphetamines/adverse effects ; Methamphetamine ; Central Nervous System Stimulants/toxicity ; Amphetamine
    Chemical Substances Transient Receptor Potential Channels ; Amphetamines ; Methamphetamine (44RAL3456C) ; Central Nervous System Stimulants ; Amphetamine (CK833KGX7E)
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2023.114391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Overview of blood-brain barrier dysfunction in methamphetamine abuse.

    Pang, Lu / Wang, Yun

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 161, Page(s) 114478

    Abstract: Methamphetamine (METH) is one of the psychostimulants most widely abused in the world. METH abuse can lead to severe neurotoxicity. The blood-brain barrier (BBB) is a natural barrier separating the central nervous system (CNS) from the peripheral blood ... ...

    Abstract Methamphetamine (METH) is one of the psychostimulants most widely abused in the world. METH abuse can lead to severe neurotoxicity. The blood-brain barrier (BBB) is a natural barrier separating the central nervous system (CNS) from the peripheral blood circulation, which can limit or regulate the exchange of toxic substances, molecules, ions, etc., to maintain the homeostasis of CNS. Long-term or high dose abuse of METH can cause structural or functional abnormalities of the BBB and increase the risk of neurodegenerative diseases. In this review, we discussed the mechanisms of METH-induced BBB dysfunction, summarized the risk factors that could exacerbate METH-induced BBB dysfunction, and introduced some potential therapeutic agents. It would provide an important basis and direction for the prevention and treatment of BBB dysfunction induced by METH.
    MeSH term(s) Humans ; Blood-Brain Barrier ; Central Nervous System Stimulants/toxicity ; Methamphetamine/adverse effects ; Amphetamine-Related Disorders ; Neurotoxicity Syndromes
    Chemical Substances Central Nervous System Stimulants ; Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2023-03-14
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: A Novel Ultrasound-Guided "Three in One" Approach Plus Interfascial Plane Blocks for the Treatment of Cervicogenic Headache.

    Ma, Danxu / Maimaitimin, Abulaihaiti / Wang, Yun

    Local and regional anesthesia

    2024  Volume 17, Page(s) 1–8

    Abstract: Objective: Cervicogenic headache (CEH) is a condition resulting from upper cervical spine dysfunction and associated structural and soft tissue abnormalities, significantly impacting patients' quality of life. To acquire better therapeutic results, we ... ...

    Abstract Objective: Cervicogenic headache (CEH) is a condition resulting from upper cervical spine dysfunction and associated structural and soft tissue abnormalities, significantly impacting patients' quality of life. To acquire better therapeutic results, we presented a novel ultrasound-guided "three in one" approach plus interfascial plane (IFP) blocks for the treatment of CEH. This approach allows for the modulation of C2 dorsal root ganglion (DRG), third occipital nerve (TON), and C3 medial branch with one-point puncture. Additionally, it allows for IFP blocks between the upper neck and occipital muscles within the same scanning plane.
    Patients and methods: We evaluated patients diagnosed with CEH from July 2021 to December 2022 in our pain clinic. We included those who did not respond to conservative treatment and single occipital nerve block, therefore received nerve block or pulsed radiofrequency (PRF) using the "Three in One" approach plus IFP blocks. The accuracy of the ultrasound-guided C2 DRG puncture procedures was confirmed through fluoroscopy with C-arm and the sensory testing of PRF. The therapeutic effect of these interventions was assessed using the numerical rating scale (NRS) scores during telephone follow-ups at 1, 3, and 6 months.
    Results: Utilizing the "Three in One" approach, a total of 5 patients diagnosed with CEH underwent nerve block plus IFP blocks, while 2 patients underwent PRF plus IFP blocks. Employing ultrasound-guided C2 DRG puncture procedures, the needle tip's correct placement was confirmed through both fluoroscopy and sensory testing of PRF. Notably, none of the cases experienced any complications associated with the approach. Subsequent follow-up assessments revealed an improvement in the NRS scores for CEH in all patients.
    Conclusion: The ultrasound-guided "Three in One" approach plus IFP blocks may be a potential effective method for the treatment of CEH.
    Language English
    Publishing date 2024-02-01
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520725-8
    ISSN 1178-7112
    ISSN 1178-7112
    DOI 10.2147/LRA.S446667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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