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  1. Article ; Online: Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?

    Iakunchykova, Olena / Leonardsen, Esten H / Wang, Yunpeng

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 63

    Abstract: The question of whether immune dysfunction contributes to risk of psychiatric disorders has long been a subject of interest. To assert this hypothesis a plethora of correlative evidence has been accumulated from the past decades; however, a variety of ... ...

    Abstract The question of whether immune dysfunction contributes to risk of psychiatric disorders has long been a subject of interest. To assert this hypothesis a plethora of correlative evidence has been accumulated from the past decades; however, a variety of technical and practical obstacles impeded on a cause-effect interpretation of these data. With the advent of large-scale omics technology and advanced statistical models, particularly Mendelian randomization, new studies testing this old hypothesis are accruing. Here we synthesize these new findings from genomics and genetic causal inference studies on the role of immune dysfunction in major psychiatric disorders and reconcile these new data with pre-omics findings. By reconciling these evidences, we aim to identify key gaps and propose directions for future studies in the field.
    MeSH term(s) Humans ; Mendelian Randomization Analysis ; Causality ; Mental Disorders/genetics ; Models, Statistical ; Genome-Wide Association Study
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-024-02778-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How Seasonality and Control Measures Jointly Determine the Multistage Waves of the COVID-19 Epidemic: A Modelling Study and Implications.

    Zheng, Yangcheng / Wang, Yunpeng

    International journal of environmental research and public health

    2022  Volume 19, Issue 11

    Abstract: The current novel Coronavirus Disease 2019 (COVID-19) is a multistage epidemic consisting of multiple rounds of alternating outbreak and containment periods that cannot be modeled with a conventional single-stage Suspected-Exposed-Infectious-Removed ( ... ...

    Abstract The current novel Coronavirus Disease 2019 (COVID-19) is a multistage epidemic consisting of multiple rounds of alternating outbreak and containment periods that cannot be modeled with a conventional single-stage Suspected-Exposed-Infectious-Removed (SEIR) model. Seasonality and control measures could be the two most important driving factors of the multistage epidemic. Our goal is to formulate and incorporate the influences of seasonality and control measures into an epidemic model and interpret how these two factors interact to shape the multistage epidemic curves. New confirmed cases will be collected daily from seven Northern Hemisphere countries and five Southern Hemisphere countries from March 2020 to March 2021 to fit and validate the modified model. Results show that COVID-19 is a seasonal epidemic and that epidemic curves can be clearly distinguished in the two hemispheres. Different levels of control measures between different countries during different seasonal periods have different influences on epidemic transmission. Seasonality alone cannot cause the baseline reproduction number
    MeSH term(s) COVID-19/epidemiology ; Disease Outbreaks ; Epidemics/prevention & control ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19116404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transmission Characteristics and Predictive Model for Recent Epidemic Waves of COVID-19 Associated With OMICRON Variant in Major Cities in China.

    Zheng, Yangcheng / Wang, Yunpeng

    International journal of public health

    2022  Volume 67, Page(s) 1605177

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Humans ; COVID-19/epidemiology ; Cities/epidemiology ; SARS-CoV-2 ; Epidemics ; China/epidemiology
    Language English
    Publishing date 2022-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.3389/ijph.2022.1605177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Role of TNFSF9 bidirectional signal transduction in antitumor immunotherapy.

    Wu, Jiao / Wang, Yunpeng

    European journal of pharmacology

    2022  Volume 928, Page(s) 175097

    Abstract: The complex structure of the tumor microenvironment leads to the poor efficacy of tumor immunotherapy. The therapeutic adjuvant designed to enhance the effect of T cells by acting on the costimulatory molecule tumor necrosis factor superfamily member 9 ( ... ...

    Abstract The complex structure of the tumor microenvironment leads to the poor efficacy of tumor immunotherapy. The therapeutic adjuvant designed to enhance the effect of T cells by acting on the costimulatory molecule tumor necrosis factor superfamily member 9 (TNFSF9) has achieved good results. However, because some tumors are characterized by reduced T-cell infiltration, adjuvants acting on T cells alone may have limitations. On the other hand, the blockade of TNFSF9 reverse signalling can have an antitumor effect by reshaping the tumor microenvironment. Therefore, this paper mainly discusses the current status and potential of TNFSF9 bidirectional signalling in antitumor immunotherapy to provide new ideas for tumor immunotherapy.
    MeSH term(s) 4-1BB Ligand/metabolism ; Factor IX/therapeutic use ; Humans ; Immunotherapy/methods ; Neoplasms/drug therapy ; Signal Transduction ; Tumor Microenvironment
    Chemical Substances 4-1BB Ligand ; TNFSF9 protein, human ; Factor IX (9001-28-9)
    Language English
    Publishing date 2022-06-14
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2022.175097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 522: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: SEM - based construction cost analysis of prefabricated building

    Yang Hongxiong / Wang Yunpeng

    E3S Web of Conferences, Vol 248, p

    2021  Volume 03002

    Abstract: Prefabricated buildings have comprehensive advantages over traditional buildings, but the reasons for the incremental cost in the construction stage are complex and need to be solved urgently. This paper takes the prefabricated components that have the ... ...

    Abstract Prefabricated buildings have comprehensive advantages over traditional buildings, but the reasons for the incremental cost in the construction stage are complex and need to be solved urgently. This paper takes the prefabricated components that have the greatest impact on the construction cost of prefabricated buildings as the research object, divides the construction process of prefabricated components into three stages: production, transportation and site installation of prefabricated components, studies the interrelation of each stage in combination with the application of information technology system of prefabricated components, and establishes a model by using structural equation. The results show that the production cost of prefabricated parts has a positive influence on the transportation and installation cost. Transportation and the application of information technology have the greatest impact on construction costs; the production and assembly of prefabricated parts have relatively little influence on the construction cost.
    Keywords Environmental sciences ; GE1-350
    Subject code 690
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Monitoring coastline variations in the Pearl River Estuary from 1978 to 2018 by integrating Canny edge detection and Otsu methods using long time series Landsat dataset

    Hu, Xinyi / Wang, Yunpeng

    Catena. 2022 Feb., v. 209

    2022  

    Abstract: The coastline of the Pearl River Estuary (PRE) experienced significant changes due to the increasing demand for land. Previous studies have focused on coastline changes of the mainland in China; thus changes of island coastlines have not been well ... ...

    Abstract The coastline of the Pearl River Estuary (PRE) experienced significant changes due to the increasing demand for land. Previous studies have focused on coastline changes of the mainland in China; thus changes of island coastlines have not been well investigated. In this study, the coastlines of the continent and islands of the Pearl River Estuary from 1978 to 2018 were extracted and analyzed by integrating Canny edge detection and Otsu methods based on Landsat data, and the coastline was classified into six types including biological, sandy, muddy, estuarine, rocky, and artificial via visual interpretation. The coastline length, coastline change rate and change area were calculated and analyzed for the 40 years period. The precision test showed that the coastline extraction methods presented in this paper meet the accuracy standard. The coastline length of the Pearl River Estuary was found to have increased rapidly from 789 km in 1978 to 979 km in 2018. During the past four decades, a large proportion of natural coastline converted into artificial one (66% in 2018), while 577 km² land increased in this area. The coastline of the western PRE demonstrates more rapid change rates than that of the eastern part, and more land reclamation has occurred in the western area. Between 1988 and 1997, the coastline length and area of reclamation experienced the most extensive changes. Both natural factors, including sediment transport, sea-level rise, wind, tide, as well as anthropogenic factors, such as land reclamation and dam construction, have impacted coastline variation of the Pearl River Estuary in the past four decades. In general, the western part of the study area showed more remarkable coastline change and experienced the enormous influence of land reclamation, dam construction and sediment transport, compared with the eastern part.
    Keywords Landsat ; catenas ; coasts ; data collection ; estuaries ; land restoration ; rivers ; sea level ; sediment transport ; time series analysis ; wind ; China
    Language English
    Dates of publication 2022-02
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 519608-5
    ISSN 1872-6887 ; 0008-7769 ; 0341-8162
    ISSN (online) 1872-6887 ; 0008-7769
    ISSN 0341-8162
    DOI 10.1016/j.catena.2021.105840
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3389: Show issues

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  7. Article: Effect of Cs

    Duan, Menghan / Wang, Yunpeng / Zhang, Pingli / Du, Luchao

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 17

    Abstract: Organic inorganic perovskite materials have received increasing attention in the optoelectronic field because of their unique properties. The ultrafast dynamics of photogenerated carriers determine photoelectric conversion efficiency, thus, it is ... ...

    Abstract Organic inorganic perovskite materials have received increasing attention in the optoelectronic field because of their unique properties. The ultrafast dynamics of photogenerated carriers determine photoelectric conversion efficiency, thus, it is feasible to influence the dynamics behavior of photogenerated carriers by regulating A-site cations. This paper mainly used transient absorption spectra (TAS) technology to study the photogenerated carriers relaxation processes of organic-inorganic perovskite Cs
    Language English
    Publishing date 2023-09-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16176064
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  8. Article ; Online: Theoretical Study on the Raman Effect Due to Magnons in Two-Dimensional Magnets.

    Liu, Shuang / Long, Mengqiu / Wang, Yun-Peng

    Nano letters

    2023  Volume 23, Issue 16, Page(s) 7427–7433

    Abstract: Raman spectroscopy is one of the most useful experimental tools for studying elementary excitations in two-dimensional (2D) materials. The Raman scattering due to phonons was widely employed for detecting structural evolutions, especially those caused by ...

    Abstract Raman spectroscopy is one of the most useful experimental tools for studying elementary excitations in two-dimensional (2D) materials. The Raman scattering due to phonons was widely employed for detecting structural evolutions, especially those caused by magnetic phase transitions in 2D magnets. A first-principles theory of the Raman scattering effect caused by magnons is still lacking. We theoretically study the magnon Raman effect in 2D magnet CrI
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c01851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Efficient expression of fusion human epidermal growth factor in tobacco chloroplasts.

    Wang, Yunpeng / Fan, Jieying / Wei, Zhengyi / Xing, Shaochen

    BMC biotechnology

    2023  Volume 23, Issue 1, Page(s) 1

    Abstract: Background: Chloroplast transformation is a robust technology for the expression of recombinant proteins. Various types of pharmaceutical proteins including growth factors have been reported in chloroplasts via chloroplast transformation approach at ... ...

    Abstract Background: Chloroplast transformation is a robust technology for the expression of recombinant proteins. Various types of pharmaceutical proteins including growth factors have been reported in chloroplasts via chloroplast transformation approach at high expression levels. However, high expression of epidermal growth factor (EGF) in chloroplasts with the technology is still unavailable.
    Results: The present work explored the high-level expression of recombinant EGF, a protein widely applied in many clinical therapies, in tobacco chloroplasts. In this work, homoplastic transgenic plants expressing fusion protein GFP-EGF, which was composed of GFP and EGF via a linker, were generated. The expression of GFP-EGF was confirmed by the combination of green fluorescent observation and Western blotting. The achieved accumulation of the recombinant fusion GFP-EGF was 10.21 ± 0.27% of total soluble proteins (1.57 ± 0.05 g kg
    Conclusion: The expression of recombinant EGF in tobacco chloroplasts via chloroplast transformation method was achieved at considerable accumulation level. The attempt gives a good example for the application of chloroplast transformation technology in recombinant pharmaceutical protein production.
    MeSH term(s) Humans ; Epidermal Growth Factor/genetics ; Epidermal Growth Factor/metabolism ; Nicotiana/genetics ; Nicotiana/metabolism ; Chloroplasts/genetics ; Chloroplasts/metabolism ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism ; Recombinant Proteins/metabolism ; Pharmaceutical Preparations/metabolism
    Chemical Substances Epidermal Growth Factor (62229-50-9) ; Recombinant Proteins ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-01-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052746-9
    ISSN 1472-6750 ; 1472-6750
    ISSN (online) 1472-6750
    ISSN 1472-6750
    DOI 10.1186/s12896-022-00771-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Thermal-Responsive Liquid Crystal Elastomer Foam-based Compressible and Omnidirectional Gripper.

    Zhang, Xinyuhang / Liao, Wei / Wang, Yunpeng / Yang, Zhongqiang

    Chemistry, an Asian journal

    2023  Volume 18, Issue 15, Page(s) e202300340

    Abstract: Liquid crystal elastomers (LCEs) are considered to be a promising material for the fabrication of soft grippers because of their large and reversible deformations, an LCE gripper with suitable compressibility and omnidirectionality has not yet been ... ...

    Abstract Liquid crystal elastomers (LCEs) are considered to be a promising material for the fabrication of soft grippers because of their large and reversible deformations, an LCE gripper with suitable compressibility and omnidirectionality has not yet been developed. To overcome these obstacles, this study utilizes salt template method to fabricate a rod-like LCE foam as gripper. The thickness of the compressible foam can be reduced by up to 77%, temporarily maintaining the deformation and enabling the gripper to pass through slits. The foam was aligned along the long axis and the length of the foam exhibits reversible thermal responsiveness and contract up to 57% along its alignment. Additionally, when the foam approaches a heat source, the generated temperature gradient results in a contraction gradient owing to the low thermal conductivity of the LCE foam. This in turn causes the foam to reversibly bend with a bending angle up to 93° and follow the movement of a heat source omnidirectionally. The developed gripper successfully grasps, moves, and releases hot objects in a cold and safe place, demonstrating its potential for emergency disposal. Thus, LCE foams can be considered suitable materials for novel gripper design and construction.
    Language English
    Publishing date 2023-06-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202300340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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