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Article ; Online: Self-assembly of peptides in living cells for disease theranostics.

Mo, Xiaowei / Zhang, Zeyu / Song, Jinyan / Wang, Yushi / Yu, Zhilin

2024 Volume 12, Issue 18, Page(s) 4289–4306

Abstract: The past few decades have witnessed substantial progress in biomedical materials for addressing health concerns and improving disease therapeutic and diagnostic efficacy. Conventional biomedical materials are typically created through ... ...

Abstract	The past few decades have witnessed substantial progress in biomedical materials for addressing health concerns and improving disease therapeutic and diagnostic efficacy. Conventional biomedical materials are typically created through an
MeSH term(s)	Humans ; Peptides/chemistry ; Peptides/chemical synthesis ; Theranostic Nanomedicine ; Biocompatible Materials/chemistry ; Biocompatible Materials/chemical synthesis ; Biocompatible Materials/pharmacology ; Animals
Chemical Substances	Peptides ; Biocompatible Materials
Language	English
Publishing date	2024-05-08
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d4tb00365a
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Article ; Online: Technology spillover and incremental cost effects of carbon transfers on optimal carbon quotas in supply chains

Jiang, Xiaozhuang / Sun, Licheng / Wang, Yushi

Journal of Cleaner Production. 2023 Sept., v. 419 p.138171-

2023

Abstract: A fair and effective allocation of carbon quotas is crucial for China to achieve its “Double Carbon” goals and the effective operation of its carbon trading market. By constructing a differential game model, this study explored the effects of the ... ...

Abstract	A fair and effective allocation of carbon quotas is crucial for China to achieve its “Double Carbon” goals and the effective operation of its carbon trading market. By constructing a differential game model, this study explored the effects of the technology spillovers and incremental costs of carbon transfers on the allocation of carbon quotas under centralised and decentralised decision-making scenarios with the purpose of maximizing social welfare. This paper proposes a cost-sharing contract to coordinate a supply chain for the loss of social welfare under decentralised decision-making. The results show that the effects of spillovers and incremental costs on carbon quota allocation depend upon the enterprises' abatement costs. The suppliers' carbon quotas are negatively correlated with the spillover effects. The incremental cost effects will be more pronounced for suppliers when their abatement costs are high and they could obtain more carbon quotas accordingly. When the manufacturer's abatement costs are low (high), its carbon quotas decrease (increase) with the spillover effects but increase (decrease) with the incremental costs. The cost-sharing contract achieves Pareto improvements based on improved social welfare and increased carbon quotas for both the manufacturer and supplier. Given the effects of carbon transfer on enterprises with different abatement costs, this paper can provide the government with a reference for designing an allocation mechanism for carbon quotas.
Keywords	carbon ; decision making ; game theory ; markets ; models ; social welfare ; supply chain ; China ; Carbon transfer ; Technology spillover effects ; Incremental cost effects ; Carbon quotas ; Differential game
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
ISSN	0959-6526
DOI	10.1016/j.jclepro.2023.138171
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Causal relationship between immune cells and atrial fibrillation: A Mendelian randomization study.

Chu, Haoxuan / Guo, Xia / Xu, Hanchi / Wang, Shipeng / He, Jiahuan / Wang, Yushi

Medicine

2024 Volume 103, Issue 19, Page(s) e38079

Abstract: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia, with recent research indicating a correlation between immune system characteristics and the development of AF. However, it remains uncertain whether the immunological response is the primary ... ...

Abstract	Atrial fibrillation (AF) is a prevalent cardiac arrhythmia, with recent research indicating a correlation between immune system characteristics and the development of AF. However, it remains uncertain whether the immunological response is the primary underlying component or a secondary consequence of AF. Initially, we investigated the effect of immune cells on AF by performing forward Mendelian randomization (MR) analyses with immune cells as the exposure variable and their associated genetic variants as instrumental variables. Subsequently, we performed reverse MR analyses with AF as the exposure variable and immune cells as the outcome variable to exclude the interference of reverse causality, to distinguish between primary and secondary effects, and to further elucidate the causal relationship between the immune system and AF. We discovered that membrane proteins on specific immune cells, such as CD25 on memory B cells-which functions as a part of the interleukin-2 receptor-may be risk factors for AF development, with odds ratios of 1.0233 (95% confidence interval: 1.0012-1.0458, P = .0383). In addition, certain immune cell counts, such as the CD4 regulatory T cell Absolute Count, play a protective factor in the development of AF (odds ratio: 0.9513, 95% confidence interval: 0.9165-0.9874; P = .0086). More detailed results are elaborated in the main text. Our MR study has yielded evidence that substantiates a genetically inferred causal association between the immune system and AF. Identifying the risk factors associated with AF is vital to facilitate the development of innovative pharmaceutical treatments.
MeSH term(s)	Atrial Fibrillation/genetics ; Atrial Fibrillation/immunology ; Atrial Fibrillation/epidemiology ; Mendelian Randomization Analysis ; Humans ; Interleukin-2 Receptor alpha Subunit/genetics ; Risk Factors ; B-Lymphocytes/immunology
Chemical Substances	Interleukin-2 Receptor alpha Subunit ; IL2RA protein, human
Language	English
Publishing date	2024-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000038079
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Article: A case report and literature review: pheochromocytoma-mediated takotsubo cardiomyopathy, which is similar to acute myocardial infarction.

Zhang, Zhiyu / Guo, Xia / Wang, Jingyue / Wang, Shipeng / Wang, Yushi

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1194814

Abstract: A 52-year-old Chinese woman was admitted to a cardiac intensive care unit (CCU) due to nausea, vomiting, and dyspnea, which began a day before her hospitalization. Metoprolol succinate and conventional treatment for acute myocardial infarction (AMI) were ...

Abstract	A 52-year-old Chinese woman was admitted to a cardiac intensive care unit (CCU) due to nausea, vomiting, and dyspnea, which began a day before her hospitalization. Metoprolol succinate and conventional treatment for acute myocardial infarction (AMI) were initially administered to the patient based on electrocardiogram (ECG) findings and elevated cardiac troponin I (cTnI). However, the following day, she developed aggravated nausea, vomiting, fever, sweating, a flushed face, a rapid heart rate, and a significant rise in blood pressure. Furthermore, ultrasonic cardiography (UCG) displayed takotsubo-like changes; nevertheless, ECG indicated inconsistent cTnI peaks with extensive infarction. After coronary computed tomography angiography (CTA) ruled out (AMI), and in conjunction with the uncommon findings, we strongly suspected that the patient had a secondary condition of pheochromocytoma-induced takotsubo cardiomyopathy (Pheo-TCM). In the meanwhile, the use of metoprolol succinate was promptly discontinued. This hypothesis was further supported by the subsequent plasma elevation of multiple catecholamines and contrast-enhanced computed tomography (CECT). After one month of treatment with high-dose Phenoxybenzamine in combination with metoprolol succinate, the patient met the criteria for surgical excision and successfully underwent the procedure. This case report demonstrated that pheochromocytoma could induce TCM and emphasized the significance of distinguishing it from AMI (in the context of beta-blocker usage and anticoagulant management).
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1194814
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Article ; Online: Biological analysis of the potential pathogenic mechanisms of Infectious COVID-19 and Guillain-Barré syndrome.

Gao, Hongyu / Wang, Shuning / Duan, Hanying / Wang, Yushi / Zhu, Hui

Frontiers in immunology

2023 Volume 14, Page(s) 1290578

Abstract: Background: Guillain-Barré syndrome (GBS) is a medical condition characterized by the immune system of the body attacking the peripheral nerves, including those in the spinal nerve roots, peripheral nerves, and cranial nerves. It can cause limb weakness, ...

Abstract	Background: Guillain-Barré syndrome (GBS) is a medical condition characterized by the immune system of the body attacking the peripheral nerves, including those in the spinal nerve roots, peripheral nerves, and cranial nerves. It can cause limb weakness, abnormal sensations, and facial nerve paralysis. Some studies have reported clinical cases associated with the severe coronavirus disease 2019 (COVID-19) and GBS, but how COVID-19 affects GBS is unclear. Methods: We utilized bioinformatics techniques to explore the potential genetic connection between COVID-19 and GBS. Differential expression of genes (DEGs) related to COVID-19 and GBS was collected from the Gene Expression Omnibus (GEO) database. By taking the intersection, we obtained shared DEGs for COVID-19 and GBS. Subsequently, we utilized bioinformatics analysis tools to analyze common DEGs, conducting functional enrichment analysis and constructing Protein-protein interaction networks (PPI), Transcription factors (TF) -gene networks, and TF-miRNA networks. Finally, we validated our findings by constructing the Receiver Operating Characteristic (ROC) curves. Results: This study utilizes bioinformatics tools for the first time to investigate the close genetic relationship between COVID-19 and GBS. CAMP, LTF, DEFA1B, SAMD9, GBP1, DDX60, DEFA4, and OAS3 are identified as the most significant interacting genes between COVID-19 and GBS. In addition, the signaling pathway of NOD-like receptors is believed to be essential in the link between COVID-19 and GBS.
MeSH term(s)	Humans ; COVID-19/genetics ; COVID-19/complications ; Guillain-Barre Syndrome/etiology ; Muscle Weakness ; Communicable Diseases/complications ; Protein Interaction Maps ; Intracellular Signaling Peptides and Proteins
Chemical Substances	SAMD9 protein, human ; Intracellular Signaling Peptides and Proteins
Language	English
Publishing date	2023-12-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1290578
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Article: A double-edged sword: The effects of R&D intensity and capitalization on institutional investment in entrepreneurial firms.

Feng, Yuan / Ma, Chenyang / Wang, Yushi / Ma, Jiangshui

Frontiers in psychology

2022 Volume 13, Page(s) 942931

Abstract: Studies show that research and development (R&D) may not always benefit entrepreneurial firms. This paper focuses on the double-edged effect of R&D activities on attracting institutional investment in entrepreneurial firms. Based on a panel dataset of ... ...

Abstract	Studies show that research and development (R&D) may not always benefit entrepreneurial firms. This paper focuses on the double-edged effect of R&D activities on attracting institutional investment in entrepreneurial firms. Based on a panel dataset of 700 listed entrepreneurial firms in ChiNext, we document: (1) an inverted-U relationship between R&D intensity and future institutional investment, which we argue is evidence that institutional investors are concerned about R&D overinvestment; (2) an inverted-U relationship between R&D capitalization and future institutional investment, which we argue shows suspicion of the institutional investors towards high R&D capitalization. Furthermore, by splitting institutional investors into venture capitals (VCs) and non-venture capitals (non-VCs), we confirm that VCs have higher acceptance of both R&D intensity and capitalization as VCs have more expertise to alleviate a certain level of risks.
Language	English
Publishing date	2022-09-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.942931
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Article ; Online: Miniature Hierarchical DNA Hybridization Circuit for Amplified Multiplexed MicroRNA Imaging

Li, Ruomeng / Li, Fengzhe / Zhang, Yanping / He, Yuqiu / Wang, Yushi / Wang, Fuan

Analytical Chemistry. 2023 Feb. 06, v. 95, no. 7 p.3848-3855

2023

Abstract: Accurate diagnosis requires the development of multiple-guaranteed DNA circuits. Nevertheless, for reliable multiplexed molecular imaging, existing DNA circuits are limited by poor cell-delivering homogeneity due to their cumbersome and dispersive ... ...

Abstract	Accurate diagnosis requires the development of multiple-guaranteed DNA circuits. Nevertheless, for reliable multiplexed molecular imaging, existing DNA circuits are limited by poor cell-delivering homogeneity due to their cumbersome and dispersive reactants. Herein, we developed a compact-yet-efficient hierarchical DNA hybridization (HDH) circuit for in situ simultaneous analysis of multiple miRNAs, which could be further exploited for specifically discriminating cancer cells from normal ones. By integrating the traditional hybridization chain reaction and catalytic hairpin assembly reactants into two highly organized hairpins, the HDH circuit is fitted with condensed components and multiple response domains, thus permitting the programmable multiple microRNA-guaranteed sequential activations and the localized cascaded signal amplification. The synergistic multi-recognition and amplification features of the HDH circuit facilitate the magnified detection of multiplex endogenous miRNAs in living cells. The in vitro and cellular imaging experimental results revealed that the HDH circuit displayed a reliable sensing performance with high selective cell-identification capacity. We anticipate that this compact design can provide a powerful toolkit for accurate diagnostics and pathological evolution.
Keywords	DNA ; analytical chemistry ; diagnostic techniques ; evolution ; hybridization chain reaction ; microRNA
Language	English
Dates of publication	2023-0206
Size	p. 3848-3855.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c05373
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Article: Improvement of multi‐layer soil moisture prediction using support vector machines and ensemble Kalman filter coupled with remote sensing soil moisture datasets over an agriculture dominant basin in China

Zhu, Qian / Wang, Yushi / Luo, Yulin

Hydrological processes. 2021 Apr., v. 35, no. 4

2021

Abstract: Soil moisture prediction is of great importance in crop yield forecasting and drought monitoring. In this study, the multi‐layer root zone soil moisture (0‐5, 0‐10, 10‐40 and 40‐100 cm) prediction is conducted over an agriculture dominant basin, namely ... ...

Abstract	Soil moisture prediction is of great importance in crop yield forecasting and drought monitoring. In this study, the multi‐layer root zone soil moisture (0‐5, 0‐10, 10‐40 and 40‐100 cm) prediction is conducted over an agriculture dominant basin, namely the Xiang River Basin, in southern China. The support vector machines (SVM) coupled with dual ensemble Kalman filter (EnKF) technique (SVM‐EnKF) is compared with SVM for its potential capability to improve the efficiency of soil moisture prediction. Three remote sensing soil moisture products, namely SMAP, ASCAT and AMSR2, are evaluated for their performance in multi‐layer soil moisture prediction with SVM and SVM‐EnKF, respectively. Multiple cases are designed to investigate the performance of SVM, the effectiveness of coupling dual EnKF technique and the applicability of the remote sensing products in soil moisture prediction. The main results are as follows: (a) The efficiency of soil moisture prediction with SVM using meteorological variables as inputs is satisfactory for the surface layers (0‐5 and 0‐10 cm), while poor for the root zone layers (10‐40 and 40‐100 cm). Adding SMAP as input to SVM can improve its performance in soil moisture prediction, with more than 47% increase in the R‐value and at least 11% reduction in RMSE for all layers. However, adding ASCAT or AMSR2 has no improvement for its performance. (b) Coupling dual EnKF can significantly improve the performance of SVM in the soil moisture prediction of both surface and the root zone layers. The increase in R‐value is above 80%, while the reduction in BIAS and RMSE is respectively more than 90% and 63%. However, adding remote sensing soil moisture products as inputs can no further improve the performance of SVM‐EnKF. (c) The SVM‐EnKF can eliminate the influence of remote sensing soil moisture extreme values in soil moisture prediction, therefore, improve its accuracy.
Keywords	basins ; crop yield ; data collection ; drought ; prediction ; rhizosphere ; soil water ; watersheds ; China
Language	English
Dates of publication	2021-04
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1479953-4
ISSN	1099-1085 ; 0885-6087
ISSN (online)	1099-1085
ISSN	0885-6087
DOI	10.1002/hyp.14154
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Article ; Online: Myocarditis combined with hypertrophic cardiomyopathy: a case report.

Wang, Jing-Yue / Wang, Yu-Shi / Shen, Bo-Tao

Annals of palliative medicine

2021 Volume 10, Issue 10, Page(s) 11203–11208

Abstract: Myocarditis can cause ventricular wall thickening due to myocardial edema. If the condition improves, the ventricular wall thickening should gradually decrease; a persistent thickening of the patient's ventricular wall indicates the coexistence of ... ...

Abstract	Myocarditis can cause ventricular wall thickening due to myocardial edema. If the condition improves, the ventricular wall thickening should gradually decrease; a persistent thickening of the patient's ventricular wall indicates the coexistence of hypertrophic cardiomyopathy (HCM) and myocarditis. A 30-year-old man was referred to our hospital with continuous chest pain accompanied by profuse sweating. He suffered from fever for two days (the maximum body temperature: 38 °C) and the conditions improved following the use of antipyretics as self-administered medication before admission. Electrocardiogram exhibited ST-segment elevation in leads I and avL, and ST-T wave changes in leads II, III, avF, and V1-V6. Marked elevation of cardiac troponin I was found on laboratory testing. Respiratory tract infection testing showed negative results. A TORCH screen revealed positive herpes simplex virus (HSV), rubella virus (RV), and cytomegalovirus (CMV) IgG but all with negative IgM titer. Ultrasonic echocardiography showed thickness of the interventricular septum (17 mm) and diffuse left ventricular (LV) hypokinesia, without LV outflow tract obstruction. After consultation with the cardiology team, a diagnosis of myocarditis with HCM was made. Patients with myocarditis should be alerted to the possibility of HCM when there is persistent ventricular wall thickening.
MeSH term(s)	Adult ; Cardiomyopathy, Hypertrophic/diagnosis ; Echocardiography ; Heart Ventricles ; Humans ; Male ; Myocarditis/diagnosis ; Myocardium
Language	English
Publishing date	2021-05-17
Publishing country	China
Document type	Case Reports
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-21-359
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Article: Eugenol Inhibits Ox-LDL-Induced Proliferation and Migration of Human Vascular Smooth Muscle Cells by Inhibiting the Ang II/MFG-E8/MCP-1 Signaling Cascade.

He, Jia-Huan / Li, Xiang-Jun / Wang, Shi-Peng / Guo, Xia / Chu, Hao-Xuan / Xu, Han-Chi / Wang, Yu-Shi

Journal of inflammation research

2024 Volume 17, Page(s) 641–653

Abstract: Objective: In this study, we investigated the effect and mechanism of action of eugenol on oxidized low-density lipoprotein (ox-LDL)-induced abnormal proliferation and migration of human vascular smooth muscle cells (HVSMCs).: Methods: HVSMCs were ... ...

Abstract	Objective: In this study, we investigated the effect and mechanism of action of eugenol on oxidized low-density lipoprotein (ox-LDL)-induced abnormal proliferation and migration of human vascular smooth muscle cells (HVSMCs). Methods: HVSMCs were treated with 100 ug/mL ox-LDL for 24 hours to establish a cell model. After 1-hour pretreatment, eugenol at concentrations of 5, 25, and 50 uM was added. Cell viability was assessed using an MTT assay, PCNA expression was detected using Western blot, cell cycle distribution was analyzed using flow cytometry, and cell migration ability was evaluated using wound healing and Transwell migration assays. To investigate the mechanisms, Ang II receptors were inhibited by 1000 nM valsartan, MFG-E8 was knocked down by shRNA, MCP-1 was inhibited by siRNA, and MFG-E8 was overexpressed using plasmids. Results: The findings from this study elucidated the stimulatory impact of ox-LDL on the proliferation and functionality of HVSMCs. Different concentrations of eugenol effectively mitigated the enhanced activity of HVSMCs induced by ox-LDL, with 50 uM eugenol exhibiting the most pronounced inhibitory effect. Flow cytometry and Western blot results showed ox-LDL reduced G1 phase cells and increased PCNA expression, while 50 uM eugenol inhibited ox-LDL-induced HVSMC proliferation. In wound healing and Transwell migration experiments, the ox-LDL group showed larger cell scratch filling and migration than the control group, both of which were inhibited by 50 uM eugenol. Inhibiting the Ang II/MFG-E8/MCP-1 signaling cascade mimicked eugenol's effects, while MFG-E8 overexpression reversed eugenol's inhibitory effect. Conclusion: Eugenol can inhibit the proliferation and migration of ox-LDL-induced HVSMCs by inhibiting Ang II/MFG-E8/MCP-1 signaling cascade, making it a potential therapeutic drug for atherosclerosis.
Language	English
Publishing date	2024-02-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S446960
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