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Article: The role of anger rumination as a mediator in the relationship between driver moral disengagement and driving angry.

Lv, Renjie / Wang, Yusong / Zhang, Chao / Ma, Jinfei

2024 Volume 10, Issue 8, Page(s) e29112

Abstract: Background: Road rage is a common phenomenon during driving, which not only affects the psychological health of drivers but also may increase the risk of traffic accidents. This article explores the impact of moral disengagement and anger rumination on ... ...

Abstract	Background: Road rage is a common phenomenon during driving, which not only affects the psychological health of drivers but also may increase the risk of traffic accidents. This article explores the impact of moral disengagement and anger rumination on road rage through two studies. Method: This research combined experimental studies with survey questionnaires. Study one used a driving simulator to investigate whether moral disengagement and anger rumination are psychological triggers of road rage in real-time driving, and whether there are differences in the main psychological triggers of road rage under different road scenarios. Building on the first study, study two employed a survey questionnaire to analyze the relationship between moral disengagement, anger rumination, and road rage. Participants in both studies were drivers with certain driving ages and experience. Data were processed and analyzed using descriptive statistics, factor analysis, reliability and validity tests, and multiple regression analysis. Results: The findings indicated: (1) There were significant differences in the anger induction rate across different road scenarios, χ2 = 35.73, p < 0.01, effect size = 0.29. Significant differences in average anger levels were observed in scenarios involving oncoming vehicles, lane-cutting, sudden stops by the vehicle ahead, pedestrians crossing the road, and traffic congestion (F = 20.41, p < 0.01, ηp2 = 0.36), with anger rumination playing a major role in the formation of road rage; (2) Moral disengagement significantly predicted road rage (β = 0.25, t = 3.85, p < 0.01). The predictive effect of moral disengagement on anger rumination was significant (β = 0.39, t = 6.17, p < 0.01), as was the predictive effect of anger rumination on road rage (β = 0.43, t = 6.3, p < 0.01). The direct effect of moral disengagement on road rage included 0 in the bootstrap 95% confidence interval, while the mediating effect of anger rumination did not include 0 in the bootstrap 95% confidence interval, indicating that anger rumination fully mediated the relationship between moral disengagement and road rage.
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e29112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NMR methods to detect fluoride binding and transport by membrane proteins.

Zhang, Jin / Li, Juan / Wang, Yusong / Shi, Chaowei

Methods in enzymology

2024 Volume 696, Page(s) 25–42

Abstract: Solid-state nuclear magnetic resonance (NMR) methods can probe the motions of membrane proteins in liposomes at the atomic level, and propel the understanding of biomolecular processes for which static structures cannot provide a satisfactory description. ...

Abstract	Solid-state nuclear magnetic resonance (NMR) methods can probe the motions of membrane proteins in liposomes at the atomic level, and propel the understanding of biomolecular processes for which static structures cannot provide a satisfactory description. High-resolution crystallography snapshots have provided a structural basis for fluoride channels. NMR is a powerful tool to build upon these snapshots and depict a dynamic picture of fluoride channels in native-like lipid bilayers. In this contribution, we discuss solid-state and solution NMR experiments to detect fluoride binding and transport by fluoride channels. Ongoing developments in membrane protein sample preparation and ssNMR methodology, particularly in using
MeSH term(s)	Fluorides/chemistry ; Fluorides/metabolism ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Nuclear Magnetic Resonance, Biomolecular/methods ; Protein Binding ; Lipid Bilayers/chemistry ; Lipid Bilayers/metabolism ; Liposomes/chemistry ; Liposomes/metabolism ; Magnetic Resonance Spectroscopy/methods
Chemical Substances	Fluorides (Q80VPU408O) ; Membrane Proteins ; Lipid Bilayers ; Liposomes
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1557-7988
ISSN (online)	1557-7988
DOI	10.1016/bs.mie.2023.12.009
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Article ; Online: Is neoadjuvant chemotherapy the optimal treatment for primary resectable pancreatic cancer?

Wang, Yu-Song

HPB : the official journal of the International Hepato Pancreato Biliary Association

2020 Volume 22, Issue 5, Page(s) 790

MeSH term(s)	Humans ; Neoadjuvant Therapy/adverse effects ; Pancreatic Neoplasms/drug therapy
Language	English
Publishing date	2020-03-20
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2020.02.012
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Article: Application progress of single-cell sequencing technology in mesenchymal stem cells research.

Li, Hao / Wang, Yusong / Zhu, Gehua / Ma, Qimin / Huang, Shengyu / Guo, Guanghua / Zhu, Feng

Frontiers in cell and developmental biology

2024 Volume 11, Page(s) 1336482

Abstract: Single-Cell Sequencing (SCS) technology plays an important role in the field of Mesenchymal Stem Cells (MSCs) research. This paper comprehensively describes the application of SCS technology in the field of MSCs research, including (1) SCS enables more ... ...

Abstract	Single-Cell Sequencing (SCS) technology plays an important role in the field of Mesenchymal Stem Cells (MSCs) research. This paper comprehensively describes the application of SCS technology in the field of MSCs research, including (1) SCS enables more precise MSCs characterization and biomarker definition. (2) SCS reveals the prevalent gene expression heterogeneity among different subclusters within MSCs, which contributes to a more comprehensive understanding of MSCs function and diversity in developmental, regenerative, and pathological contexts. (3) SCS provides insights into the dynamic transcriptional changes experienced by MSCs during differentiation and the complex web of important signaling pathways and regulatory factors controlling key processes within MSCs, including proliferation, differentiation and regulation, and interactions mechanisms. (4) The analytical methods underpinning SCS data are rapidly evolving and converging with the field of histological research to systematically deconstruct the functions and mechanisms of MSCs. This review provides new perspectives for unraveling the biological properties, heterogeneity, differentiation potential, biological functions, and clinical potential of MSCs at the single-cell level.
Language	English
Publishing date	2024-01-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1336482
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Article ; Online: Ameliorating Mitochondrial Dysfunction for the Therapy of Parkinson's Disease.

Zheng, Qing / Liu, Hanghang / Gao, Yifan / Cao, Guozhi / Wang, Yusong / Li, Zhen

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2311571

Abstract: Parkinson's disease (PD) is currently the second most incurable central neurodegenerative disease resulting from various pathogenesis. As the "energy factory" of cells, mitochondria play an extremely important role in supporting neuronal signal ... ...

Abstract	Parkinson's disease (PD) is currently the second most incurable central neurodegenerative disease resulting from various pathogenesis. As the "energy factory" of cells, mitochondria play an extremely important role in supporting neuronal signal transmission and other physiological activities. Mitochondrial dysfunction can cause and accelerate the occurrence and progression of PD. How to effectively prevent and suppress mitochondrial disorders is a key strategy for the treatment of PD from the root. Therefore, the emerging mitochondria-targeted therapy has attracted considerable interest. Herein, the relationship between mitochondrial dysfunction and PD, the causes and results of mitochondrial dysfunction, and major strategies for ameliorating mitochondrial dysfunction to treat PD are systematically reviewed. The study also prospects the main challenges for the treatment of PD.
Language	English
Publishing date	2024-02-22
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202311571
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Article ; Online: Development of an obesity-related multi-gene prognostic model incorporating clinical characteristics in luminal breast cancer.

Zhang, Hengjun / Ma, Shuai / Wang, Yusong / Chen, Xiuyun / Li, Yumeng / Wang, Mozhi / Xu, Yingying

iScience

2024 Volume 27, Issue 3, Page(s) 109133

Abstract: Despite adjuvant chemotherapy and endocrine therapy in luminal breast cancer (LBC), relapses are common. Addressing this, we aim to develop a prognostic model to refine adjuvant therapy strategies, particularly for patients at high recurrence risk. ... ...

Abstract	Despite adjuvant chemotherapy and endocrine therapy in luminal breast cancer (LBC), relapses are common. Addressing this, we aim to develop a prognostic model to refine adjuvant therapy strategies, particularly for patients at high recurrence risk. Notably, obesity profoundly affects the tumor microenvironment (TME) of LBC. However, it is unclear whether obesity-related biological features can effectively screen high-risk patients. Utilizing weighted gene coexpression network analysis (WGCNA) on RNA sequencing (RNAseq) data, we identified seven obese LBC genes (OLGs) closely associated with patient prognosis. Subsequently, we developed a luminal obesity-gene clinical prognostic index (LOG-CPI), combining a 7-gene signature, TNM staging, and age. Its predictive efficacy was confirmed across validation datasets and a clinical cohort (5-year accuracy = 0.828, 0.760, 0.751, and 0.792, respectively). LOG-CPI emerges as a promising predictor for clinical prognosis and treatment response, helping distinguish molecular and immunological features in LBC patients and guiding clinical practice by identifying varying prognoses.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109133
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Article ; Online: PFKFB3 knockdown attenuates Amyloid β-Induced microglial activation and retinal pigment epithelium disorders in mice.

Wang, Yusong / Han, Siyang / Chen, Jieqiong / Sun, Junran / Sun, Xiaodong

International immunopharmacology

2023 Volume 115, Page(s) 109691

Abstract: Age-related macular degeneration (AMD) is characterized by progressive accumulation of drusen deposits and retinal pigment epithelium (RPE) disorders. As the main component of drusen, amyloid β (Aβ) plays a critical role in activating microglia and ... ...

Abstract	Age-related macular degeneration (AMD) is characterized by progressive accumulation of drusen deposits and retinal pigment epithelium (RPE) disorders. As the main component of drusen, amyloid β (Aβ) plays a critical role in activating microglia and causing neuroinflammation in AMD pathogenesis. However, the role of activated microglia-mediated neuroinflammation in RPE senescence remains unclear. Recent evidence indicates that inflammatory microglia are glycolytic and driven by an increase in 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), an enzyme described as the master regulator of glycolysis. In this study, we mimicked the retinal inflammatory microenvironment of AMD by intravitreal injection of oligomeric Aβ
MeSH term(s)	Mice ; Animals ; Retinal Pigment Epithelium ; Microglia ; Amyloid beta-Peptides/metabolism ; Neuroinflammatory Diseases ; Retina/pathology ; Macular Degeneration/genetics
Chemical Substances	Amyloid beta-Peptides
Language	English
Publishing date	2023-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.109691
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Article: [Research progress of mesenchymal stem cells and their derivatives nebulization in the treatment of pulmonary diseases].

Wang, Yusong / Ma, Qimin / Zhu, Feng / Xia, Zhaofan

Zhonghua wei zhong bing ji jiu yi xue

2022 Volume 34, Issue 8, Page(s) 881–885

Abstract: In acute or chronic lung diseases, inappropriate immune response and abnormal repair process can lead to irreversible damage to lung tissue, which in turn leads to decreased lung function and even respiratory failure or death. Mesenchymal stem cells ( ... ...

Abstract	In acute or chronic lung diseases, inappropriate immune response and abnormal repair process can lead to irreversible damage to lung tissue, which in turn leads to decreased lung function and even respiratory failure or death. Mesenchymal stem cells (MSCs) and their derivatives have shown wide application prospects in cell therapy and acellular therapy of lung diseases and are entering the clinical transformation stage because of their unique physiological functions and characteristics, but the safety and efficacy of MSCs and their derivatives are still controversial. Nebulization therapy provides new opportunities and challenges for the innovative treatment of MSCs and their derivatives in lung diseases. In a number of preclinical studies and clinical trials, there have been evidence that atomization therapy of MSCs and their derivatives is safe and effective. This method could be an optimal solution for the treatment of various complex lung diseases. However, extensive research should be carried out on various strategies and their compatibility with different nebulizers before this method can be used in clinical setting. In this paper, we review the research progress of MSCs and their derivatives by nebulization in the treatment of pulmonary diseases.
MeSH term(s)	Humans ; Lung ; Lung Diseases/therapy ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells
Language	Chinese
Publishing date	2022-09-30
Publishing country	China
Document type	Journal Article ; Review
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.cn121430-20220706-00636
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Article ; Online: An in situ stretching instrument combined with low field nuclear magnetic resonance (NMR): Rheo-Spin NMR.

Xia, Zhijie / Wang, Yusong / Gong, Ke / Chen, Wei

The Review of scientific instruments

2022 Volume 93, Issue 3, Page(s) 33905

Abstract: An in situ stretching instrument combined with low field nuclear magnetic resonance (LF-NMR) was designed and developed, namely, Rheo-Spin NMR. The time resolved stress-strain curve together with the corresponding NMR signal can be simultaneously ... ...

Abstract	An in situ stretching instrument combined with low field nuclear magnetic resonance (LF-NMR) was designed and developed, namely, Rheo-Spin NMR. The time resolved stress-strain curve together with the corresponding NMR signal can be simultaneously obtained. The Rheo-Spin NMR contains the functional modules, including (1) the in situ stretching module, (2) the NMR signal acquisition module, and (3) the cavity of the NMR positioning module. The unique ring-like shape of the sample is used to replace the traditional dumbbell sample due to limited space in the NMR probe, and the whole ring-like sample will be deformed during the uniaxial stretching process, which avoids the generation of interference signals from the undeformed sample. The designed stretching assembly made by zirconia ceramics is manufactured to match and stretch the ring-like samples. The strain rate can be tuned within the range of 10
MeSH term(s)	Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Polymers
Chemical Substances	Polymers
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0080767
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Article ; Online: Adaptively Regularized Bases-Expansion Subspace Optimization Methods for Electrical Impedance Tomography.

Zong, Zheng / Wang, Yusong / He, Siyuan / Wei, Zhun

IEEE transactions on bio-medical engineering

2022 Volume 69, Issue 10, Page(s) 3098–3108

Abstract: Objective: In this work, to deal with the difficulties in choosing regularization weighting parameters and low spatial resolution problems in difference electrical impedance tomography (EIT), we propose two adaptively regularized bases-expansion ... ...

Abstract	Objective: In this work, to deal with the difficulties in choosing regularization weighting parameters and low spatial resolution problems in difference electrical impedance tomography (EIT), we propose two adaptively regularized bases-expansion subspace optimization methods (AR-BE-SOMs). Methods: Firstly, an adaptive L Conclusion: Both numerical and experimental tests are conducted to validate the proposed methods, where AR-BE-SOMs show better edge-preserving, anti-noise performance, lower relative errors, and higher structure similarity indexes than BE-SOM. Significance: Unlike the common regularization techniques in EIT, the proposed regularization factors can be obtained adaptively during the optimization process. More importantly, AR-BE-SOMs perform well in reconstructions of some challenging geometry with sharp corners such as the "heart and lung" phantoms, deformation phantoms, triangles and even rectangles. It is expected that the proposed AR-BE-SOMs will find their applications for high-quality lung health monitoring and other clinical applications.
MeSH term(s)	Algorithms ; Electric Impedance ; Image Processing, Computer-Assisted/methods ; Phantoms, Imaging ; Tomography/methods
Language	English
Publishing date	2022-09-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2022.3161526
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