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Article ; Online: Solvable Strong-Coupling Quantum-Dot Model with a Non-Fermi-Liquid Pairing Transition.

Wang, Yuxuan

2020 Volume 124, Issue 1, Page(s) 17002

Abstract: We show that a random interacting model exhibits solvable non-Fermi-liquid behavior and exotic pairing behavior. This model, dubbed as the Yukawa-SYK model, describes the random Yukawa coupling between M quantum dots each hosting N flavors of fermions ... ...

Abstract	We show that a random interacting model exhibits solvable non-Fermi-liquid behavior and exotic pairing behavior. This model, dubbed as the Yukawa-SYK model, describes the random Yukawa coupling between M quantum dots each hosting N flavors of fermions and N^{2} bosons that self-tune to criticality at low energies. The diagrammatic expansion is controlled by 1/MN, and the results become exact in a large-M, large-N limit. We find that pairing only develops within a region of the (M,N) plane-even though the pairing interaction is strongly attractive, the incoherence of the fermions can spoil the forming of Cooper pairs, rendering the system a non-Fermi liquid down to zero temperature. By solving the Eliashberg equation and the renormalization group equation, we show that the transition into the pairing phase exhibits Kosterlitz-Thouless quantum-critical behavior.
Language	English
Publishing date	2020-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.124.017002
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Article ; Online: Blood Test for Multicancer Detection in Symptomatic Individuals.

Wang, Yuxuan / Tie, Jeanne

JCO precision oncology

2023 Volume 7, Page(s) e2300305

MeSH term(s)	Humans ; Neoplasms ; Hematologic Tests
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.23.00305
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Article ; Online: Spatial and temporal analysis of HCHO response to drought in South Korea.

Wasti, Shailaja / Wang, Yuxuan

The Science of the total environment

2022 Volume 852, Page(s) 158451

Abstract: Though drought is known to affect biogenic emissions of volatile organic compounds (BVOC), its effect on isoprene and formaldehyde (HCHO), a high yield product of isoprene, has not been investigated in East Asia where incidences of drought have increased ...

Abstract	Though drought is known to affect biogenic emissions of volatile organic compounds (BVOC), its effect on isoprene and formaldehyde (HCHO), a high yield product of isoprene, has not been investigated in East Asia where incidences of drought have increased in recent years. In this work, we analyzed the impact of drought on HCHO in the South Korea region during the summer period (June, July, and August) from 2005 to 2018 and found increased HCHO due to drought. The tropospheric HCHO column density retrieved by OMI increased by 8.02 % during extreme drought compared to the non-drought period, whereas no significant effect of drought on the NO
MeSH term(s)	Air Pollutants/analysis ; Nitrogen Dioxide/analysis ; Environmental Monitoring ; Volatile Organic Compounds ; Ozone/analysis ; Formaldehyde/analysis
Chemical Substances	isoprene (0A62964IBU) ; Air Pollutants ; Nitrogen Dioxide (S7G510RUBH) ; Volatile Organic Compounds ; Ozone (66H7ZZK23N) ; Formaldehyde (1HG84L3525)
Language	English
Publishing date	2022-09-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.158451
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Particulate matters 2.5 induce tumor progression in lung cancer by increasing the activity of hnRNPA2B1 resulting in retarding mRNA decay of oxidative phosphorylation.

Bian, Wen / Yu, Haifeng / Zhang, Xiaofei / Wang, Yuxuan / Ni, Bin

IUBMB life

2024

Abstract: Particulate matter 2.5 (PM2.5) has been implicated in lung injury and various cancers, yet its precise mechanistic role remains elusive. To elucidate the key signaling pathways underpinning PM2.5-induced lung cancer progression, we embarked on a study ... ...

Abstract	Particulate matter 2.5 (PM2.5) has been implicated in lung injury and various cancers, yet its precise mechanistic role remains elusive. To elucidate the key signaling pathways underpinning PM2.5-induced lung cancer progression, we embarked on a study examining the impact of PM2.5 both in vitro and in vivo. Lung cancer cell lines, A549 and H157, were employed for the in vitro investigations. Overexpression or knockdown techniques targeting the hnRNPA2B1 protein were implemented. Lung cancer cells were treated with a medium containing PM2.5 and subsequently prepared for in vitro evaluations. Cell growth, invasion, and migration were gauged using transwell and CCK-8 assays. Apoptosis was ascertained through flow cytometry and western blotting of pertinent proteins. Seahorse analyses probed the influence of PM2.5 on lung cancer energy metabolism. The RNA stability assay was employed to discern the impact of PM2.5 on the stability of oxidative phosphorylation-related genes in lung cancer. Our findings revealed that PM2.5 augmented cell proliferation, migration, and invasion rates. Similarly, a diminished apoptosis rate was observed in PM2.5-treated cells. Elevated expression of hnRNPA2B1 was detected in lung cancer cells exposed to PM2.5. Moreover, in cells treated with PM2.5, hnRNPA2B1 knockdown markedly curtailed cell proliferation by inducing G1-S cell cycle arrest and bolstered lung cancer cell apoptosis in vitro; it also curbed xenograft tumor growth. Mechanistically, our data suggest that PM2.5 undermines the stability of mRNA transcripts associated with oxidative phosphorylation (OXPHOS) and augments the formation of processing bodies (P-bodies), leading to an upsurge in OXPHOS levels. In conclusion, PM2.5 appears to drive lung cancer progression and migration by modulating the energy metabolism of lung cancer in a hnRNPA2B1-dependent manner.
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1492141-8
ISSN	1521-6551 ; 1521-6543
ISSN (online)	1521-6551
ISSN	1521-6543
DOI	10.1002/iub.2813
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Article ; Online: Relationship between dietary fiber and all-cause mortality, cardiovascular mortality, and cardiovascular disease in patients with chronic kidney disease: a systematic review and meta-analysis.

Gai, Wei / Lin, Lihua / Wang, Yuxuan / Bian, Jia / Tao, Yanling

Journal of nephrology

2024 Volume 37, Issue 1, Page(s) 77–93

Abstract: Background: The potential protective effects of dietary fiber against all-cause mortality, cardiovascular mortality, and cardiovascular disease in patients with chronic kidney disease have not been definitively established. To verify this relationship, ... ...

Abstract	Background: The potential protective effects of dietary fiber against all-cause mortality, cardiovascular mortality, and cardiovascular disease in patients with chronic kidney disease have not been definitively established. To verify this relationship, a systematic review and a meta-analysis were undertaken. Methods: PubMed, The Cochrane Library, Web of Science, Embase, ProQuest, and CINAHL were used to systematically search for prospective cohort studies that investigate the association between dietary fiber and all-cause mortality, cardiovascular mortality, and cardiovascular disease in individuals with chronic kidney disease (CKD). This search was conducted up to and including March 2023. Results: The analysis included 10 cohort studies, with a total of 19,843 patients who were followed up for 1.5-10.1 y. The results indicated a significant negative correlation between dietary fiber and all-cause mortality among patients with CKD (HR 0.80, 95% CI 0.58-0.97, P < 0.001). Subgroup analysis further revealed that the study population and exposure factors were significantly associated with all-cause mortality (P < 0.001). Increased dietary fiber intake was associated with a reduced risk of cardiovascular mortality (HR 0.78; 95% CI 0.67-0.90) and a reduced incidence of cardiovascular disease (HR 0.87; 95% CI 0.80-0.95) among patients with CKD. Conclusions: The pooled results of our meta-analysis indicated an inverse association between dietary fiber intake and all-cause mortality, cardiovascular mortality, and cardiovascular disease.
MeSH term(s)	Humans ; Cardiovascular Diseases/mortality ; Dietary Fiber ; Prospective Studies ; Renal Insufficiency, Chronic/complications ; Mortality
Chemical Substances	Dietary Fiber
Language	English
Publishing date	2024-01-02
Publishing country	Italy
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01808-4
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Article ; Online: Research on predicting the driving forces of digital transformation in Chinese media companies based on machine learning.

Wang, Zhan / Li, Yao / Zhao, Xu / Wang, Yuxuan / Xiao, Zihan

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7286

Abstract: Chinese media companies are facing opportunities and challenges brought about by digital transformation. Media economics takes the evaluation of the business results of media companies as the main research topic. However, overcoming the internal ... ...

Abstract	Chinese media companies are facing opportunities and challenges brought about by digital transformation. Media economics takes the evaluation of the business results of media companies as the main research topic. However, overcoming the internal differences in the industry and comprehensively predicting the digital transformation of Chinese media companies from multiple dimensions has become an important issue to be understood. Based on the "TOE-I" theoretical framework, this study innovatively uses machine learning methods to predict the digital transformation of Chinese media companies and to analyze specific modes of the main driving factors affecting the digital transformation, using data from China's A-share-listed media companies from 2010 to 2020. The study found that environmental drivers can most effectively and accurately predict the digital transformation of Chinese media companies. Therefore, under sustained and stable economic and financial policies, guiding inter-industry competition and providing balanced digital infrastructure conditions are keys to bridging internal barriers in the media industry and promoting digital transformation. In the process of transformation from traditional content to digital production, media companies should focus on policy changes, economic benefits, the decision-making role of core managers, and the training and preservation of digital technology talent.
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57873-7
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Article ; Online: Construction and evaluation of near-infrared fluorescent probes for imaging lipid droplet and lysosomal viscosity.

Li, Yuming / Wang, Yuxuan / Li, Yanping / Shi, Wenjing / Yan, Jinwu

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 316, Page(s) 124356

Abstract: Microenvironmental viscosity is a crucial parameter for biological systems, and its abnormal fluctuations are closely associated with various functional disorders and diseases. However, it is still important and urgent to develop improved near-infrared ... ...

Abstract	Microenvironmental viscosity is a crucial parameter for biological systems, and its abnormal fluctuations are closely associated with various functional disorders and diseases. However, it is still important and urgent to develop improved near-infrared fluorescent probes for micro-viscosity with dual-organelle targeting properties, low background noise, and high sensitivity. Herein, two BODIPY-based small-molecule fluorescent probes were designed and synthesized, which were explored for their viscosity- and polarity-responsive properties, and were further applied to imaging sub-cellular viscosity in living cells. Interestingly, BSZ-Ph and BSZ-R displayed near-infrared fluorescence (more than 650 nm) and were sensitive to environmental viscosity and polarity due to the introduction of a benzothiazole at the 2-position and electron-rich aniline groups at the 5-position of the BODIPY core, respectively. The fluorescence intensity increased exponentially with the viscosity changes. Furthermore, the probe BSZ-Ph could successfully target lipid droplets and image cellular viscosity changes by treating lipopolysaccharides (LPS) and nystatin. Comparatively, the probe BSZ-R could successfully target the dual organelles of lipid droplets and lysosomes and image cellular viscosity changes by treating LPS and monensin. Therefore, in this work, we reported two new BODIPY-based near-infrared fluorescent probes, BSZ-Ph and BSZ-R, for cellular viscosity imaging, which could target lipid droplets and the dual organelles of lysosomes and lipid droplets, respectively. The study could provide a reference for the future development of fluorescent probes for viscosity in lipid droplets and lysosomes.
Language	English
Publishing date	2024-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.124356
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Article ; Online: Assessing the predictability of surrogate safety measures as crash precursors based on vehicle trajectory data prior to crashes.

Wang, Yuxuan / Xu, Chengcheng / Liu, Pan / Li, Zhibin / Chen, Kequan

Accident; analysis and prevention

2024 Volume 201, Page(s) 107573

Abstract: This study aims to investigate the predictability of surrogate safety measures (SSMs) for real-time crash risk prediction. We conducted a year-long drone video collection on a busy freeway in Nanjing, China, and collected 20 rear-end crashes. The ... ...

Abstract	This study aims to investigate the predictability of surrogate safety measures (SSMs) for real-time crash risk prediction. We conducted a year-long drone video collection on a busy freeway in Nanjing, China, and collected 20 rear-end crashes. The predictability of SSMs was defined as the probability of crash occurrence when using SSMs as precursors to crashes. Ridge regression models were established to explore contributing factors to the predictability of SSMs. Four commonly used SSMs were tested in this study. It was found that modified time-to-collision (MTTC) outperformed other SSMs when the early warning capability was set at a minimum of 1 s. We further investigated the cost and benefit of SSMs in safety interventions by evaluating the number of necessary predictions for successful crash prediction and the proportion of crashes that can be predicted accurately. The result demonstrated these SSMs were most efficient in proactive safety management systems with an early warning capability of 1 s. In this case, 308, 131, 281, and 327,661 predictions needed to be made before a crash could be successfully predicted by TTC, MTTC, DRAC, and PICUD, respectively, achieving 75 %, 85 %, 35 %, and 100 % successful crash identifications. The ridge regression results indicated that the predefined threshold had the greatest impact on the predictability of all tested SSMs.
MeSH term(s)	Accidents, Traffic/prevention & control ; Accidents, Traffic/statistics & numerical data ; Humans ; China ; Safety/statistics & numerical data ; Risk Assessment/methods ; Video Recording ; Regression Analysis ; Automobile Driving/statistics & numerical data ; Forecasting
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2024.107573
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Zs.A 2461: Show issues

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Article ; Online: N vacancy and self-enhancement induced high anodic electrochemiluminescence of 3D g-C

Wang, Yuxuan / Jiang, Xinya / Cao, Weiwei / Wang, Haijun / Yuan, Ruo

Talanta

2024 Volume 275, Page(s) 126144

Abstract: Here, 3D g- ... ...

Abstract	Here, 3D g-C
Language	English
Publishing date	2024-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2024.126144
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Article: Spatial and temporal analysis of HCHO response to drought in South Korea

Wasti, Shailaja / Wang, Yuxuan

Science of the total environment. 2022 Dec. 15, v. 852

2022

Abstract	Though drought is known to affect biogenic emissions of volatile organic compounds (BVOC), its effect on isoprene and formaldehyde (HCHO), a high yield product of isoprene, has not been investigated in East Asia where incidences of drought have increased in recent years. In this work, we analyzed the impact of drought on HCHO in the South Korea region during the summer period (June, July, and August) from 2005 to 2018 and found increased HCHO due to drought. The tropospheric HCHO column density retrieved by OMI increased by 8.02 % during extreme drought compared to the non-drought period, whereas no significant effect of drought on the NO₂ column was found. Regional variation of HCHO response to drought correlates significantly with the tree percentage of the region. This correlation indicates that the drought-led HCHO increases are most likely driven by the increase in isoprene emissions during drought. Indeed, model predicts isoprene emissions to be higher by 27.87 % during the extreme drought compared to the non-drought period in South Korea. From 2005 to 2018, the HCHO column has been increasing in South Korea by 0.16 × 10¹⁵ molecules/cm²/year (1.56 % per year) during summer months, correlated with the increasing incidences of drought. HCHO increase is linked to higher ozone as most of South Korea is in the NOx-saturated or transitional regime.
Keywords	drought ; environment ; formaldehyde ; isoprene ; models ; ozone ; summer ; trees ; troposphere ; volatile organic compounds ; South Korea
Language	English
Dates of publication	2022-1215
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.158451
Database	NAL-Catalogue (AGRICOLA)

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