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Article ; Online: Can the establishment of an innovative city improve the level of technological entrepreneurship?

Xu, Ye / Wang, Zhi-Chao

2023 Volume 18, Issue 10, Page(s) e0289806

Abstract: Based on the data of 278 prefecture-level city panels in China from 2008 to 2020, this paper presents the policy of innovative pilot city as a quasi-natural experiment. It is found that (1) the implementation of innovative urban policy can significantly ... ...

Abstract	Based on the data of 278 prefecture-level city panels in China from 2008 to 2020, this paper presents the policy of innovative pilot city as a quasi-natural experiment. It is found that (1) the implementation of innovative urban policy can significantly improve the level of science and technology entrepreneurship, but the pilot policy has a time lag effect and has a continuous promoting effect since the third year. (2) For large cities, areas with high levels of economic development, central and eastern regions and cities with high new infrastructure, innovative cities can improve the level of technological entrepreneurship; (3) Innovative cities improve the level of technological entrepreneurship by improving the incubator of technological enterprises and strengthening the flow of human capital; (4) The effect of the establishment of innovative cities on the level of technological entrepreneurship mainly shows that the siphon effect does not show radiation effect, and this siphon effect mainly improves the level of technological entrepreneurship by increasing the number of incubators of technological enterprises.
MeSH term(s)	Humans ; Cities ; Entrepreneurship ; China ; Economic Development ; Technology
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0289806
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Gene therapy strategies and prospects for neurofibromatosis type 1].

Zheng, Tingting / Zhu, Beiyao / Wang, Zhichao / Li, Qingfeng

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

2024 Volume 38, Issue 1, Page(s) 1–8

Abstract: Objective: To summarize the gene therapy strategies for neurofibromatosis type 1 (NF1) and related research progress.: Methods: The recent literature on gene therapy for NF1 at home and abroad was reviewed. The structure and function of the NF1 gene ... ...

Abstract	Objective: To summarize the gene therapy strategies for neurofibromatosis type 1 (NF1) and related research progress. Methods: The recent literature on gene therapy for NF1 at home and abroad was reviewed. The structure and function of the NF1 gene and its mutations were analyzed, and the current status as well as future prospects of the transgenic therapy and gene editing strategies were summarized. Results: NF1 is an autosomal dominantly inherited tumor predisposition syndrome caused by mutations in the NF1 tumor suppressor gene, which impair the function of the neurofibromin and lead to the disease. It has complex clinical manifestations and is not yet curable. Gene therapy strategies for NF1 are still in the research and development stage. Existing studies on the transgenic therapy for NF1 have mainly focused on the construction and expression of the GTPase-activating protein-related domain in cells that lack of functional neurofibromin, confirming the feasibility of the transgenic therapy for NF1. Future research may focus on split adeno-associated virus (AAV) gene delivery, oversized AAV gene delivery, and the development of new vectors for targeted delivery of full-length NF1 cDNA. In addition, the gene editing tools of the new generation have great potential to treat monogenic genetic diseases such as NF1, but need to be further validated in terms of efficiency and safety. Conclusion: Gene therapy, including both the transgenic therapy and gene editing, is expected to become an important new therapeutic approach for NF1 patients.
MeSH term(s)	Humans ; Neurofibromatosis 1/genetics ; Neurofibromatosis 1/therapy ; Neurofibromatosis 1/pathology ; Neurofibromin 1/genetics ; Neurofibromin 1/metabolism ; GTPase-Activating Proteins ; Mutation ; Genetic Predisposition to Disease ; Genetic Therapy
Chemical Substances	Neurofibromin 1 ; GTPase-Activating Proteins
Language	Chinese
Publishing date	2024-01-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1420212-8
ISSN	1002-1892
ISSN	1002-1892
DOI	10.7507/1002-1892.202309071
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Zs.A 4866: Show issues

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Article ; Online: Hierarchical Polyimide Microparticles with Controllable Morphology.

Wang, Zhichao / Hu, Jianhua / Wang, Haitao

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2400487

Abstract: Hierarchical polyimides (PIs) not only show outstanding thermal stability and high mechanical strength but also have great advantages in terms of microstructure and surface area, which makes them highly valuable in various fields such as aerospace, ... ...

Abstract	Hierarchical polyimides (PIs) not only show outstanding thermal stability and high mechanical strength but also have great advantages in terms of microstructure and surface area, which makes them highly valuable in various fields such as aerospace, microelectronics, adsorption, catalysis, and energy storage. However, great challenges still remain in the synthesis of hierarchical PIs with well-defined microstructure. Herein, polyamide acid salts (PAAS) with tunable ionization degree are synthesized first via the polymerization of dianhydride and diamine monomers in deionized water with 1,2-dimethylimidazole (DMIZ). Then cationic cetyltrimethylammonium chloride (CTAC) is added to the PAAS aqueous solution to induce the formation of polyelectrolyte-surfactant complexes based on electrostatic interaction. After a typical hydrothermal reaction (HTR) procedure, hierarchical PIs with different microstructures such as urchin-like PI microparticles, flower-like PI microparticles, and lamellar PI petals can be fabricated simply by changing the additive amount of DMIZ and CTAC. The nanostructure self-assemblies of PAAS are dominated by the charges on macromolecular chains and the formation of hierarchical structures of polymers is ascribed to a geometrical selection process during crystal growth. This work provides valuable insights into the self-assembly behaviors of polyelectrolyte systems for synthesizing well-defined hierarchical polymers.
Language	English
Publishing date	2024-03-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202400487
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Article ; Online: Éléments sur l’implicite dans la poésie de la Pléiade

Meng Yao / Wang Zhichao

SHS Web of Conferences, Vol 138, p

pour une approche figurale et énonciative

2022 Volume 05002

Abstract: Visant à ennoblir la langue française, la poésie de la Pléiade est perçue par la critique littéraire française comme ambitieuse et provocatrice, si bien que la question de l’implicite y est souvent négligée. Cependant, nous considérons que la question de ...

Abstract	Visant à ennoblir la langue française, la poésie de la Pléiade est perçue par la critique littéraire française comme ambitieuse et provocatrice, si bien que la question de l’implicite y est souvent négligée. Cependant, nous considérons que la question de l’implicite touche à celle de la philosophie de l’amour et de son expression poétique. Au XVIe siècle, les membres de la Pléiade ont beaucoup recours aux figures de style et développent notamment les « figures de sens », les « figures de pensée » et les figures de contradiction qui mettent en oeuvre un travail à la fois lexical et sémantique. En nous appuyant sur leurs traités rhétoriques et poétiques, nous proposons de réévaluer l’apport sémantique et l’éthique des figures de la poésie amoureuse. En nous attachant à l’étude des unités lexicales qui constituent les figures de style et aux méthodes de l’analyse énonciative, nous rechercherons les manifestations de l’implicite dans la construction lexicale des figures et leur dimension énonciative, en particulier à travers les épithètes subjectives et les adressages différents de la répétition des déictiques.
Keywords	Social Sciences ; H
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Cascade BP Neural Network Tuned PID Controller for a High-Voltage Cable-Stripping Robot.

Zhong, Jun / Hu, Shaoguang / Wang, Zhichao / Han, Zhenfeng

Micromachines

2023 Volume 14, Issue 3

Abstract: A 10 kV distribution network is a crucial piece of infrastructure to guarantee enterprises' and households' access to electricity. Stripping cables is one of many power grid maintenance procedures that are now quickly expanding. However, typical cable- ... ...

Abstract	A 10 kV distribution network is a crucial piece of infrastructure to guarantee enterprises' and households' access to electricity. Stripping cables is one of many power grid maintenance procedures that are now quickly expanding. However, typical cable-stripping procedures are manual and harmful to workers. Although numerous automated solutions for grid maintenance have been created, none of them focus on cable stripping, and most of them have large dimensions to guarantee multi-functions. In this paper, a new cable-stripping robot for the 10 kV power system is introduced. The design of a live working cable-stripping robot that is appropriate for installing insulating rods is introduced, taking into account the working environment of 10 kV overhead lines and the structural characteristics of overhead cables. The robot is managed by an auxiliary remote control device. A cascade PID control technology based on the back propagation neural network (BPNN) method was developed, as the stripper robot's whole system is nonlinear and the traditional PID controller lacked robustness and adaptability in complex circumstances. To validate the structural feasibility of the cable-stripping robot, as well as the working stability and adaptability of the BPNN-PID controller, a 95 mm
Language	English
Publishing date	2023-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14030689
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Article ; Online: Diverse Functions of MiR-425 in Human Cancer.

Wang, Zhichao / Xie, Wenjie / Guan, Hongzai

DNA and cell biology

2023 Volume 42, Issue 3, Page(s) 113–129

Abstract: miRNAs are a type of small endogenous noncoding RNA composed of 20-22 nucleotides that can regulate gene expression by targeting the 3' untranslated region of mRNA. Many investigations have discovered that miRNAs have a role in the development and ... ...

Abstract	miRNAs are a type of small endogenous noncoding RNA composed of 20-22 nucleotides that can regulate gene expression by targeting the 3' untranslated region of mRNA. Many investigations have discovered that miRNAs have a role in the development and progression of human cancer. Several aspects of tumor development are affected by miR-425, including growth, apoptosis, invasion, migration, epithelial-mesenchymal transition, and drug resistance. In this article, we discuss the properties and research development of miR-425, focusing on the regulation and function of miR-425 in various cancers. Furthermore, we discuss the clinical implications of miR-425. This review may broaden our horizon for better understanding the role of miR-425 as biomarkers and therapeutic targets in human cancer.
MeSH term(s)	Humans ; Cell Movement/genetics ; Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Cell Line, Tumor ; Cell Proliferation ; 3' Untranslated Regions
Chemical Substances	MicroRNAs ; 3' Untranslated Regions ; MIRN425 microRNA, human
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1024454-2
ISSN	1557-7430 ; 0198-0238 ; 1044-5498
ISSN (online)	1557-7430
ISSN	0198-0238 ; 1044-5498
DOI	10.1089/dna.2022.0557
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Zs.A 2061: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Testicular ischemia secondary to acute epididymitis: A case report.

Wang, Zhichao / Qiu, Mengzhen / Gao, Xinghua / Zhang, Longyang

Medicine

2023 Volume 102, Issue 20, Page(s) e33843

Abstract: Rationale: Rare side effects of acute epididymitis include testicular infarction and ischemia. Distinguishing them from testicular torsion is challenging, both clinically and radiologically. However, only a few such cases have been reported to date.: ... ...

Abstract	Rationale: Rare side effects of acute epididymitis include testicular infarction and ischemia. Distinguishing them from testicular torsion is challenging, both clinically and radiologically. However, only a few such cases have been reported to date. Patient concerns: A 12-year-old child presented with persistent right testicular pain for 3 days. It developed after trauma and was accompanied by gradual swelling and enlargement of the right scrotum, with nausea and vomiting. Scrotal color Doppler ultrasonography demonstrated right epididymitis, right scrotal wall swelling, and right testicular torsion. Routine blood tests revealed leukocyte and neutrophil counts were both above normal. Diagnosis: Scrotal exploration revealed edema and adhesions in all layers of the scrotal wall. The right testicle was pale. The patient was diagnosed with testicular ischemia secondary to acute epididymitis. Interventions: The patient underwent simultaneous lower spermatic cord sheath dissection and decompression, testicular sheath reversal, and right testicular fixation. Outcomes: Blood flow to the testicles gradually recovered after decompression, as did the color. Postoperatively, the patient's scrotal swelling and pain improved significantly. Lessons: Despite the rarity of this condition, it is a potentially serious consequence of epididymitis and should be considered when patients experience sudden scrotal pain.
MeSH term(s)	Child ; Male ; Humans ; Spermatic Cord Torsion/complications ; Spermatic Cord Torsion/surgery ; Epididymitis/complications ; Epididymitis/diagnosis ; Scrotum/diagnostic imaging ; Scrotum/injuries ; Genital Diseases, Male ; Testicular Diseases/etiology ; Acute Pain/etiology ; Acute Disease
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033843
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Ua VI Zs.171: Show issues

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Article ; Online: Emission characteristics of cellulosic jet biofuel blend under laminar and turbulent combustion.

Liu, Ziyu / Wang, Zhichao / Yang, Xiaoyi

Biotechnology for biofuels and bioproducts

2023 Volume 16, Issue 1, Page(s) 196

Abstract: Alternative biofuels have the potential to reduce greenhouse gas emissions and particulate matter due to free of aromatics compared to traditional petroleum-based aviation fuel. The potential mitigating emission of hydrothermal-condensation-hydrotreating ...

Abstract	Alternative biofuels have the potential to reduce greenhouse gas emissions and particulate matter due to free of aromatics compared to traditional petroleum-based aviation fuel. The potential mitigating emission of hydrothermal-condensation-hydrotreating jet biofuel (HCHJ) derived from agriculture residue was investigated. The effects of aviation biofuel components, blend ratio and equivalent ratio on emission characteristics were conducted by Premixed Pre-evaporated Bunsen burner (PPBB) for laminar combustion and ZF850 jet engine for turbulent combustion. In compositions, HCHJ had a higher concentration of cycloparaffins (mostly in C8-C10) while petroleum-based aviation fuel (RP-3) had a higher concentration of alkylbenzenes (mostly in C8-C11). In laminar combustion, HCHJ and both 50% blend HCHJ appear no unburned hydrocarbon (UHC) due to low aromatics content and no sulfur in the biofuel. Moreover, there were no significant differences in NO and NO
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ISSN	2731-3654
ISSN (online)	2731-3654
DOI	10.1186/s13068-023-02439-4
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Article ; Online: Long History of Multiple Painless Scalp Nodules in a Middle-aged Woman.

Li, Yue-Hua / Wei, Cheng-Jiang / Wang, Zhi-Chao

JAMA dermatology

2023 Volume 159, Issue 4, Page(s) 452–453

MeSH term(s)	Middle Aged ; Female ; Humans ; Scalp ; Skin Neoplasms/diagnosis
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2023.0024
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Article ; Online: MiR-409-3p regulates the proliferation and apoptosis of THP-1 through targeting Rab10.

Xie, Wenjie / Wang, Zhichao / Guo, Xiaofang / Guan, Hongzai

Leukemia research

2023 Volume 132, Page(s) 107350

Abstract: Acute myeloid leukemia cytogenetics and molecular subtypes are connected with microRNAs, although it is unclear how miRNAs affect AML pathogenesis. miR-409-3p expression is downregulated in bone marrows, as we have previously demonstrated in our team. ... ...

Abstract	Acute myeloid leukemia cytogenetics and molecular subtypes are connected with microRNAs, although it is unclear how miRNAs affect AML pathogenesis. miR-409-3p expression is downregulated in bone marrows, as we have previously demonstrated in our team. Nevertheless, the tumor-suppressing activities and molecular mechanisms of miR-409-3p remain unknown. Hence, in this study, we investigate at the functional significance of miR-409-3p in the development of AML. We found that a significant decrease in miR-409-3p expression was observed in THP-1 cell. The expression of miR-409-3p was altered in THP-1 by transfecting with agomiR-409-3p and agomiR-409-3p NC. A series of experiments showed that overexpression of miR-409-3p expression significantly suppressed proliferation and increased the apoptosis of THP-1. Moreover, Rab10 was confirmed as a direct target gene of miR-409-3p and was negatively modulated by miR-409-3p. Rab10 downregulation imitated the suppressed proliferation and increased the apoptosis of THP-1. Furthermore, miR-409-3p overexpression or Rab10 knockdown obviously down-regulated the expression levels of Bcl-2, but up-regulated Bax expression. In a xenograft mouse model, miR-409-3p-overexpressed THP-1 cells resulted in much less tumor weight and size in the mice bearing the cells as compared to the mock-transfected mice. Collectively, our findings demonstrated that miR-409-3p exerted tumor suppressor gene effects in AML by directly targeting Rab10, which might provide a promising therapeutic target for AML.
MeSH term(s)	Humans ; Animals ; Mice ; Cell Proliferation/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Leukemia, Myeloid, Acute/pathology ; Bone Marrow/pathology ; Apoptosis/genetics ; Cell Line, Tumor ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism
Chemical Substances	MicroRNAs ; Rab10 protein, human (EC 3.6.1.-) ; rab GTP-Binding Proteins (EC 3.6.5.2) ; MIRN409 microRNA, human ; Rab10 protein, mouse (EC 3.6.1.-)
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2023.107350
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Zs.A 1321: Show issues

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