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Article ; Online: Real-time monitoring of abnormal mitochondrial viscosity in glioblastoma with a novel mitochondria-targeting fluorescent probe.

Zhang, Qing / Liu, Wei / Jiang, Ling / He, Yan-Jun / Wu, Chang-Jian / Ren, Shen-Zhen / Wang, Bao-Zhong / Liu, Li / Zhu, Hai-Liang / Wang, Zhong-Chang

The Analyst

2024

Abstract: Glioblastoma is the most fatal and insidious malignancy, due to the existence of the blood-brain barrier (BBB) and the high invasiveness of tumor cells. Abnormal mitochondrial viscosity has been identified as a key feature of malignancies. Therefore, ... ...

Abstract	Glioblastoma is the most fatal and insidious malignancy, due to the existence of the blood-brain barrier (BBB) and the high invasiveness of tumor cells. Abnormal mitochondrial viscosity has been identified as a key feature of malignancies. Therefore, this study reports on a novel fluorescent probe for mitochondrial viscosity, called ZVGQ, which is based on the twisted intramolecular charge transfer (TICT) effect. The probe uses 3-dicyanomethyl-1,5,5-trimethylcyclohexene as an electron donor moiety and molecular rotor, and triphenylphosphine (TPP) cation as an electron acceptor and mitochondrial targeting group. ZVGQ is highly selective, pH and time stable, and exhibits rapid viscosity responsiveness.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d4an00226a
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Article ; Online: Recent Progress in the Development of Small Molecule c-Met Inhibitors.

Lv, Peng-Cheng / Yang, Yu-Shun / Wang, Zhong-Chang

Current topics in medicinal chemistry

2019 Volume 19, Issue 15, Page(s) 1276–1288

Abstract: C-Met, also referred to as Hepatocyte Growth Factor Receptor (HGFR), is a heterodimeric receptor tyrosine kinase. It has been determined that c-Met gene mutations, overexpression, and amplification also occur in a variety of human tumor types, and these ... ...

Abstract	C-Met, also referred to as Hepatocyte Growth Factor Receptor (HGFR), is a heterodimeric receptor tyrosine kinase. It has been determined that c-Met gene mutations, overexpression, and amplification also occur in a variety of human tumor types, and these events are closely related to the aberrant activation of the HGF/c-Met signaling pathway. Meanwhile, high c-Met expression is closely associated with poor prognosis in cancer patients. The c-Met kinase has emerged as an attractive target for developing antitumor agents. In this review, we cover the recent advances on the small molecule c-Met inhibitors discovered from 2018 until now, with a main focus on the rational design, synthesis and structureactivity relationship analysis.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-met/antagonists & inhibitors ; Proto-Oncogene Proteins c-met/metabolism ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology
Chemical Substances	Protein Kinase Inhibitors ; Small Molecule Libraries ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
Language	English
Publishing date	2019-09-17
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026619666190712205353
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Zs.A 5572: Show issues

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Article ; Online: A novel quinoline-based fluorescent probe for real-time monitoring of Cys in glioma.

Zeng, Shang-Ming-Zhu / Zhang, Qing / Li, Qin / Yuan, Liang-Chao / Abbas, Muhammad / He, Zhen-Xiang / Zhu, Hai-Liang / Wang, Zhong-Chang

The Analyst

2022 Volume 147, Issue 19, Page(s) 4257–4265

Abstract: Cysteine (Cys), a small-molecule biothiol, has recently been identified as a novel Glioblastoma (GBM) biomarker. The highly selective real-time monitoring and fluorescence imaging of Cys ... ...

Abstract	Cysteine (Cys), a small-molecule biothiol, has recently been identified as a novel Glioblastoma (GBM) biomarker. The highly selective real-time monitoring and fluorescence imaging of Cys levels
MeSH term(s)	Cysteine ; Fluorescent Dyes ; Glioma/diagnostic imaging ; Glutathione ; HeLa Cells ; Homocysteine ; Humans ; Quinolines
Chemical Substances	Fluorescent Dyes ; Quinolines ; Homocysteine (0LVT1QZ0BA) ; Glutathione (GAN16C9B8O) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2022-09-26
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d2an01115h
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Article ; Online: A new mitochondria-targeted fluorescent probe for exogenous and endogenous superoxide anion imaging in living cells and pneumonia tissue.

Ye, Ya-Xi / Pan, Jian-Cheng / Chen, Xin-Yue / Jiang, Li / Jiao, Qing-Cai / Zhu, Hai-Liang / Liu, Jun-Zhong / Wang, Zhong-Chang

The Analyst

2022 Volume 147, Issue 15, Page(s) 3534–3541

Abstract: As a precursor of all reactive oxygen species (ROS), superoxide anions play an important role in organisms. However, excessive superoxide anions can cause various diseases. Thus, it is highly urgent to develop efficient tools ... ...

Abstract	As a precursor of all reactive oxygen species (ROS), superoxide anions play an important role in organisms. However, excessive superoxide anions can cause various diseases. Thus, it is highly urgent to develop efficient tools for
MeSH term(s)	Animals ; Fluorescent Dyes/toxicity ; Humans ; MCF-7 Cells ; Mice ; Mitochondria ; Optical Imaging ; Superoxides
Chemical Substances	Fluorescent Dyes ; Superoxides (11062-77-4)
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d2an00690a
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Article ; Online: Recent Advances in the Design and Synthesis of c-Met Inhibitors as Anticancer Agents (2014-Present).

Lv, Peng-Cheng / Wang, Zhong-Chang / Zhu, Hai-Liang

Current medicinal chemistry

2017 Volume 24, Issue 1, Page(s) 57–64

Abstract: c-Met, also known as the surface receptor of hepatocyte growth factor receptor (HGFR), is a receptor tyrosine kinase with heterodimer transmembrane. c-Met involves in the activation of several signaling pathways, most of them are implicated in aggressive ...

Abstract	c-Met, also known as the surface receptor of hepatocyte growth factor receptor (HGFR), is a receptor tyrosine kinase with heterodimer transmembrane. c-Met involves in the activation of several signaling pathways, most of them are implicated in aggressive cancer phenotypes. In a variety of human malignances, c-Met/HGF signaling has been found aberrant, and in many instances, has been correlated with advanced disease stage and poor prognosis. Thus, the c-Met has identified as an emerging and interesting target for cancer chemotherapy. In this review, we briefly summarize signaling pathways of c-Met, and discuss the crystal structures of representative c-Met and the binding modes with their ligands. We also present updates on the design, synthesis and structure-activity relationship analysis of c-Met inhibitors developed from 2014 till now. At last, we review the c-Met inhibitors that are in clinical development and highlight the future prospects.
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; Ligands ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-met/antagonists & inhibitors ; Proto-Oncogene Proteins c-met/metabolism
Chemical Substances	Antineoplastic Agents ; Ligands ; Protein Kinase Inhibitors ; MET protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
Language	English
Publishing date	2017
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867323666161028161441
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Zs.A 4432: Show issues

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Article ; Online: Clinical evaluation of plasma coagulation parameters in patients with advanced-stage non-small cell lung cancer treated with palliative chemotherapy in China.

Abbas, Muhammad / Kassim, Said Abasse / Wang, Zhong-Chang / Shi, Meiqi / Hu, Yiqiao / Zhu, Hai-Liang

International journal of clinical practice

2020 Volume 74, Issue 12, Page(s) e13619

Abstract: Aims of the study: Blood coagulation parameters are colossally important for clinical evaluation of palliative chemotherapy; however, this niche was not explored earlier for advanced-stage non-small cell lung cancer (NSCLC). Study focuses to explore the ...

Abstract	Aims of the study: Blood coagulation parameters are colossally important for clinical evaluation of palliative chemotherapy; however, this niche was not explored earlier for advanced-stage non-small cell lung cancer (NSCLC). Study focuses to explore the clinical relevancy of Coagulation parameters; prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), D-dimer and international normalised ratio (INR) and their response to palliative chemotherapy in advanced-stage NSCLC. Methods: A retrospective study was conducted between 2013 and 2019 in Jiangsu Cancer hospital, Nanjing, PR. China. Medical records of 5445 patients were succinctly reviewed and classified accordingly to the inclusion and exclusion criteria. A total of 216 advanced NSCLC patients who used a first-line chemotherapy and antiangiogenic therapy regimen were enrolled in this study under ethical approval (JSCH-2020C-009). Blood samples were collected from these patients to measure the response levels of these coagulation parameters at time of admission to hospital and at the beginning of 4 cycles of Palliative therapy. We find the clinical value of all these coagulation parameters by using SPSS 24. Univariate Cox regression and Multivariate Cox regression models were used to identify the factors that were associated with progression-free survival (PFS) and the response to palliative chemotherapy. Results: In the Kaplan-Meier survival analysis for overall median (95% CI) survival of high pre-treatment coagulation parameters showed shorter PFS compared with normal pre-treatment except TT and their overall median (95% CI) follow-up was 3.3 (3.12-3.47). Coagulation parameters have showed clinical relevance as a potential independent prognostic factor of PFS in the Univariate Cox regression. In multivariable model, Age (≥60 years vs < 60 years), cancer differentiation (Unknown vs Poor), PT (High vs Normal) range, FIB (High vs Normal) range and D-dimer (High vs Normal) range, (P = .025, P = .045, P = .029, P = .049 and P = .011, respectively) were associated as a prognostic factor of PFS in NSCLC. Patients on 3-drugs regimen found to have better PFS compared with the ones taking the 2-drugs treatment regimen (P = .043). Conclusion: The high range of PT, FIB and D-dimers was associated with poor prognosis of advanced-stage NSCLC. Our findings also confirmed that patients on 3-drugs regimen showed longer PFS compared with 2-drugs regimen.
MeSH term(s)	Blood Coagulation ; Carcinoma, Non-Small-Cell Lung/drug therapy ; China ; Humans ; Lung Neoplasms/drug therapy ; Middle Aged ; Palliative Care ; Pharmaceutical Preparations ; Plasma ; Prognosis ; Retrospective Studies
Chemical Substances	Pharmaceutical Preparations
Keywords	covid19
Language	English
Publishing date	2020-09-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.13619
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Article: Improving effect of vegetation on the coastal salt marshes in Yancheng, Eastern China: A five-year observation (2013–2017)

Yang, Yu-Shun / Wang, Zhong-Chang / Chen, Li-Li / An, Shu-Qing / Zhu, Hai-Liang

Ecological Society of China Acta ecologica Sinica. 2020 Oct. 08,

2020

Abstract: Coastal wetlands reclamation is facing the problem of salinization. Along with the alternation of ecosystem status, studying the following effect on soil properties becomes emergency. Here we reported the pH, salinity and elemental content (mainly metals) ...

Abstract	Coastal wetlands reclamation is facing the problem of salinization. Along with the alternation of ecosystem status, studying the following effect on soil properties becomes emergency. Here we reported the pH, salinity and elemental content (mainly metals) variation affected by the vegetation situations, water sources and geographic positions. The results showed that vegetation could lead the pH and salinity of seawater zones closer to that of freshwater zones in both spatial and time scales. Spartina alterniflora (SA) was the most efficient species among the investigated plants, causing decreases of 0.15–0.69 in pH and 2.250–3.821 in salinity. This result might be caused by the absorption of Ca and K from salt marshes by SA and Suaeda salsa (SS), due to the fact that the component content of calcium (all reduced to approximate one-third) and potassium (reduced in some samples) both decreased. Meanwhile, vegetation could improve soil in seawater zones in Fe content with no extra negative influences in elemental analysis. Thus, ecological engineered vegetation indicated great potential in alternating coastal salt marshes to favorable wetlands or farmlands with almost primitive ecosystem. The results might be significant for ecological engineering and agricultural management in future.
Keywords	Spartina alterniflora ; Suaeda salsa ; absorption ; agricultural management ; calcium ; ecosystems ; freshwater ; pH ; potassium ; salinity ; seawater ; vegetation ; China
Language	English
Dates of publication	2020-1008
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean ; Pre-press version
ZDB-ID	2233694-1
ISSN	1872-2032 ; 1000-0933
ISSN (online)	1872-2032
ISSN	1000-0933
DOI	10.1016/j.chnaes.2020.10.001
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Design, synthesis and biological evaluation of 2-H pyrazole derivatives containing morpholine moieties as highly potent small molecule inhibitors of APC-Asef interaction.

Yan, Xiao-Qiang / Wang, Zhong-Chang / Qi, Peng-Fei / Li, Guigen / Zhu, Hai-Liang

European journal of medicinal chemistry

2019 Volume 177, Page(s) 425–447

Abstract: Mutated adenomatous polyposis coli (APC) selectively combining with Asef has been reported to be implicated in promoting colon cancer proliferation, invasion and metastasis in several cancer biotherapy studies. However, there were universally resistance ... ...

Abstract	Mutated adenomatous polyposis coli (APC) selectively combining with Asef has been reported to be implicated in promoting colon cancer proliferation, invasion and metastasis in several cancer biotherapy studies. However, there were universally resistance and harsh terms in disrupting APC-Asef interaction in biotherapy. Under the circumstances small-molecule inhibitors as the new APC interface could resolve the problems. In this research, a series of novel dihydropyrazole derivatives containing morpholine as high potent interaction inhibitors between APC and Asef were first synthesized after selection by means of docking simulation and virtual screening. Afterwards they were evaluated interaction inhibition of APC-Asef and pharmacological efficiency both in vitro and in vivo utilizing orthotopic transplantation model with multi-angle of view. Among them, compound 7g exhibited most excellent anti-proliferation activities against HCT116 cells with IC
MeSH term(s)	Adenomatous Polyposis Coli Protein/chemistry ; Adenomatous Polyposis Coli Protein/metabolism ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Cell Line, Tumor ; Female ; Humans ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Docking Simulation ; Morpholines/chemical synthesis ; Morpholines/pharmacology ; Morpholines/therapeutic use ; Neoplasm Transplantation ; Protein Binding ; Pyrazoles/chemical synthesis ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Rho Guanine Nucleotide Exchange Factors/chemistry ; Rho Guanine Nucleotide Exchange Factors/metabolism ; Structure-Activity Relationship ; Thermodynamics ; Xenograft Model Antitumor Assays
Chemical Substances	APC protein, human ; ARHGEF4 protein, human ; Adenomatous Polyposis Coli Protein ; Antineoplastic Agents ; Morpholines ; Pyrazoles ; Rho Guanine Nucleotide Exchange Factors
Language	English
Publishing date	2019-05-26
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2019.05.056
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Zs.B 784: Show issues

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Article: Clinical Evaluation of Serum Tumor Markers in Patients With Advanced-Stage Non-Small Cell Lung Cancer Treated With Palliative Chemotherapy in China.

Abbas, Muhammad / Kassim, Said Abasse / Habib, Murad / Li, Xiaoyou / Shi, Meiqi / Wang, Zhong-Chang / Hu, Yiqiao / Zhu, Hai-Liang

Frontiers in oncology

2020 Volume 10, Page(s) 800

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2020-06-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2020.00800
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Article ; Online: A DNA-based nanocarrier for efficient cancer therapy.

Abbas, Muhammad / Baig, Mirza Muhammad Faran Ashraf / Zhang, Yaliang / Yang, Yu-Shun / Wu, Songyu / Hu, Yiqiao / Wang, Zhong-Chang / Zhu, Hai-Liang

Journal of pharmaceutical analysis

2020 Volume 11, Issue 3, Page(s) 330–339

Abstract: The study aimed to achieve enhanced targeted cytotoxicity and cell-internalization of cisplatin-loaded deoxyribonucleic acid-nanothread (CPT-DNA-NT), mediated by scavenger receptors into HeLa cells. DNA-NT was developed with stiff-topology utilizing ... ...

Abstract	The study aimed to achieve enhanced targeted cytotoxicity and cell-internalization of cisplatin-loaded deoxyribonucleic acid-nanothread (CPT-DNA-NT), mediated by scavenger receptors into HeLa cells. DNA-NT was developed with stiff-topology utilizing circular-scaffold to encapsulate CPT. Atomic force microscopy (AFM) characterization of the DNA-NT showed uniformity in the structure with a diameter of 50-150 nm and length of 300-600 nm. The successful fabrication of the DNA-NT was confirmed through native-polyacrylamide gel electrophoresis analysis, as large the molecular-weight (polymeric) DNA-NT did not split into constituting strands under applied current and voltage. The results of cell viability confirmed that blank DNA-NT had the least cytotoxicity at the highest concentration (512 nM) with a viability of 92% as evidence of its biocompatibility for drug delivery. MTT assay showed superior cytotoxicity of CPT-DNA-NT than that of the free CPT due to the depot release of CPT after DNA-NT internalization. The DNA-NT exhibited targeted cell internalizations with the controlled intracellular release of CPT (from DNA-NT), as illustrated in confocal images. Therefore, in vitro cytotoxicity assessment through flow cytometry showed enhanced apoptosis (72.7%) with CPT-DNA-NT (compared to free CPT; 64.4%). CPT-DNA-NT, being poly-anionic, showed enhanced endocytosis via scavenger receptors.
Language	English
Publishing date	2020-03-09
Publishing country	China
Document type	Journal Article
ISSN	2214-0883
ISSN (online)	2214-0883
DOI	10.1016/j.jpha.2020.03.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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