LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 127

Search options

  1. Article ; Online: Downregulation of ROR2 attenuates LPS-induced A549 cell injury through JNK and ERK signaling pathways.

    Wang, Zhonglin / Yang, Liu

    Immunity, inflammation and disease

    2023  Volume 11, Issue 4, Page(s) e803

    Abstract: Background: We aimed to determine whether receptor tyrosine kinase-like orphan receptor 2 (ROR2) is involved in the occurrence of acute lung injury (ALI) by an animal study and explore the effect of ROR2 downregulation on lipopolysaccharide (LPS)- ... ...

    Abstract Background: We aimed to determine whether receptor tyrosine kinase-like orphan receptor 2 (ROR2) is involved in the occurrence of acute lung injury (ALI) by an animal study and explore the effect of ROR2 downregulation on lipopolysaccharide (LPS)-treated human lung carcinoma A549 cells by a cytological study.
    Methods: Murine models of ALI were successfully constructed by intratracheal instillation of LPS. Meanwhile, A549 cell line stimulated with LPS was used for a cytological study. The expression of ROR2 and its effect on proliferation, cell cycle, apoptosis, and inflammation were detected.
    Results: It was found that LPS administration markedly inhibited the cell proliferation, resulted in cell cycle arrest at G1 phage, elevated levels of pro-inflammatory cytokines and apoptosis rate of A549 cells. However, LPS-mediated adverse effects mentioned above were significantly ameliorated by downregulation of ROR2 in comparison with LPS treatment. In addition, administration of ROR2 siRNA notably decreased the phosphorylation level of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in LPS-challenged A549 cells.
    Conclusions: Thus, the present data indicate that downregulation of ROR2 may decrease LPS-induced inflammatory responses and cell apoptosis through inhibiting JNK and ERK signaling pathway, which attenuates ALI.
    MeSH term(s) Animals ; Humans ; Mice ; A549 Cells ; Acute Lung Injury/chemically induced ; Acute Lung Injury/metabolism ; Down-Regulation ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Lipopolysaccharides/toxicity ; Receptor Tyrosine Kinase-like Orphan Receptors/genetics ; Receptor Tyrosine Kinase-like Orphan Receptors/metabolism ; Signal Transduction
    Chemical Substances Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Lipopolysaccharides ; Receptor Tyrosine Kinase-like Orphan Receptors (EC 2.7.10.1) ; ROR2 protein, human (EC 2.7.10.1) ; Ror2 protein, mouse (EC 2.7.10.1)
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2740382-8
    ISSN 2050-4527 ; 2050-4527
    ISSN (online) 2050-4527
    ISSN 2050-4527
    DOI 10.1002/iid3.803
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Synergizing Machine Learning Algorithm with Triboelectric Nanogenerators for Advanced Self-Powered Sensing Systems.

    Li, Roujuan / Wei, Di / Wang, Zhonglin

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: The advancement of the Internet of Things (IoT) has increased the demand for large-scale intelligent sensing systems. The periodic replacement of power sources for ubiquitous sensing systems leads to significant resource waste and environmental pollution. ...

    Abstract The advancement of the Internet of Things (IoT) has increased the demand for large-scale intelligent sensing systems. The periodic replacement of power sources for ubiquitous sensing systems leads to significant resource waste and environmental pollution. Human staffing costs associated with replacement also increase the economic burden. The triboelectric nanogenerators (TENGs) provide both an energy harvesting scheme and the possibility of self-powered sensing. Based on contact electrification from different materials, TENGs provide a rich material selection to collect complex and diverse data. As the data collected by TENGs become increasingly numerous and complex, different approaches to machine learning (ML) and deep learning (DL) algorithms have been proposed to efficiently process output signals. In this paper, the latest advances in ML algorithms assisting solid-solid TENG and liquid-solid TENG sensors are reviewed based on the sample size and complexity of the data. The pros and cons of various algorithms are analyzed and application scenarios of various TENG sensing systems are presented. The prospects of synergizing hardware (TENG sensors) with software (ML algorithms) in a complex environment and their main challenges for future developments are discussed.
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14020165
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: N7-methylguanosine modification: from regulatory roles to therapeutic implications in cancer.

    Cai, Mengyuan / Yang, Chuang / Wang, Zhonglin

    American journal of cancer research

    2023  Volume 13, Issue 5, Page(s) 1640–1655

    Abstract: N7-methylguanosine (m7G) is one of the most common post-transcriptional epigenetic modifications. Different m7G methyltransferases (writers) load the m7G-cap at the 5'-terminal or inside the RNAs. For example, writers such as methyltransferase-like 1 ( ... ...

    Abstract N7-methylguanosine (m7G) is one of the most common post-transcriptional epigenetic modifications. Different m7G methyltransferases (writers) load the m7G-cap at the 5'-terminal or inside the RNAs. For example, writers such as methyltransferase-like 1 (METTL1)/WD repeat domain 4 (WDR4) and Williams-Beuren syndrome chromosome region 22 (WBSCR22) have been reported in mammals to promote cell proliferation, EMT, and chemoresistance in massive quantities of cancers. The underlying mechanism includes modulating the RNA secondary structure, preventing RNA degradation from exonucleases, and improving codon-dependent translation. However, some studies have shown that in colorectal and lung cancers, m7G inhibits tumor progression. m7G binding proteins (readers), such as eukaryotic translation initiation factor 4E (eIF4E), promote the efficiency of cap-dependent translation and accelerate the cell cycle to improve cancer progression. Due to the more profound understanding of m7G regulatory proteins in cancer, numerous studies aim to investigate the clinical efficiency of m7G-targeted therapy. eIF4E antisense oligonucleotide drug (4EASO) and Ribavirin are the most mature trials that competitively inhibit the binding of eIF4E to m7G-cap. These drugs have encouraging results in halting cancer progression and improving prognosis, including AML and non-small cell lung cancer, which provide a promising perspective for developing more m7G-targeted drugs. In the future, we look forward to an ongoing investigation into the role of m7G modification in tumors and drug resistance to m7G-related therapies to be solved. Therefore, the clinical application would be put into practice as soon as possible.
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Tuning Surface Molecular Design of Porous Carbon for Blue Energy Harvesting.

    Yu, Jian / Wang, Zhong-Lin / Ma, Tianwei

    Research (Washington, D.C.)

    2023  Volume 6, Page(s) 173

    Abstract: Capacitive mixing is a promising blue energy technology due to its membrane-free electricity generation and long electrode life cycle. However, because of limited performance, existing systems do not lend themselves to practical implementation. Although ... ...

    Abstract Capacitive mixing is a promising blue energy technology due to its membrane-free electricity generation and long electrode life cycle. However, because of limited performance, existing systems do not lend themselves to practical implementation. Although it is a crucial factor directly influencing electrode behavior, surface chemistry has largely been overlooked in capacitive mixing. Here, we show that manipulating surface functionalization alone can tune the responses of electrodes to produce a high voltage rise without altering the pore structure of the electrodes. Our findings reveal that the spontaneous electrode potential of a surface-modified carbon electrode shifts negatively proportional to the surface charge due to the surface groups, which explains why and how manipulating the surface chemistry can improve the power generation capacity. Using electrodes fabricated with identical activated carbon material but with different surface treatments, we have achieved a remarkably high power density of 166 mW/m
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ISSN 2639-5274
    ISSN (online) 2639-5274
    DOI 10.34133/research.0173
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: The Role of Adipocyte Endoplasmic Reticulum Stress in Obese Adipose Tissue Dysfunction: A Review.

    Xu, Shengjie / Xi, Jiaqiu / Wu, Tao / Wang, Zhonglin

    International journal of general medicine

    2023  Volume 16, Page(s) 4405–4418

    Abstract: Adipose tissue dysfunction plays an important role in metabolic diseases associated with chronic inflammation, insulin resistance and lipid ectopic deposition in obese patients. In recent years, it has been found that under the stimulation of adipocyte ... ...

    Abstract Adipose tissue dysfunction plays an important role in metabolic diseases associated with chronic inflammation, insulin resistance and lipid ectopic deposition in obese patients. In recent years, it has been found that under the stimulation of adipocyte endoplasmic reticulum stress (ERS), the over-activated ER unfolded protein response (UPR) exacerbates the inflammatory response of adipose tissue by interfering with the normal metabolism of adipose tissue, promotes the secretion of adipokines, and affects the browning and thermogenic pathways of adipose tissue, ultimately leading to the manifestation of metabolic syndrome such as ectopic lipid deposition and disorders of glucolipid metabolism in obese patients. This paper mainly summarizes the relationship between adipocyte ERS and obese adipose tissue dysfunction and provides an overview of the mechanisms by which ERS induces metabolic disorders such as catabolism, thermogenesis and inflammation in obese adipose tissue through the regulation of molecules and pathways such as NF-κB, ADPN, STAMP2, LPIN1, TRIP-Br2, NF-Y and SIRT2 and briefly describes the current mechanisms targeting adipocyte endoplasmic reticulum stress to improve obesity and provide ideas for intervention and treatment of obese adipose tissue dysfunction.
    Language English
    Publishing date 2023-09-27
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S428482
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Flexible iontronics based on 2D nanofluidic material.

    Wei, Di / Yang, Feiyao / Jiang, Zhuoheng / Wang, Zhonglin

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 4965

    Abstract: Iontronics focuses on the interactions between electrons and ions, playing essential roles in most processes across physics, chemistry and life science. Osmotic power source as an example of iontronics, could transform ion gradient into electrical energy, ...

    Abstract Iontronics focuses on the interactions between electrons and ions, playing essential roles in most processes across physics, chemistry and life science. Osmotic power source as an example of iontronics, could transform ion gradient into electrical energy, however, it generates low power, sensitive to humidity and can't operate under freezing point. Herein, based on 2D nanofluidic graphene oxide material, we demonstrate an ultrathin (∼10 µm) osmotic power source with voltage of 1.5 V, volumetric specific energy density of 6 mWh cm
    MeSH term(s) Electric Power Supplies ; Electronics ; Humans ; Ions ; Nanotechnology
    Chemical Substances Ions
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-32699-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Flexible Sensors Array Based on Frosted Microstructured Ecoflex Film and TPU Nanofibers for Epidermal Pulse Wave Monitoring.

    Wang, Xue / Feng, Zhiping / Zhang, Gaoqiang / Wang, Luna / Chen, Liang / Yang, Jin / Wang, Zhonglin

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 7

    Abstract: Recent advances in flexible pressure sensors have fueled increasing attention as promising technologies with which to realize human epidermal pulse wave monitoring for the early diagnosis and prevention of cardiovascular diseases. However, strict ... ...

    Abstract Recent advances in flexible pressure sensors have fueled increasing attention as promising technologies with which to realize human epidermal pulse wave monitoring for the early diagnosis and prevention of cardiovascular diseases. However, strict requirements of a single sensor on the arterial position make it difficult to meet the practical application scenarios. Herein, based on three single-electrode sensors with small area, a 3 × 1 flexible pressure sensor array was developed to enable measurement of epidermal pulse waves at different local positions of radial artery. The designed single sensor holds an area of 6 × 6 mm
    MeSH term(s) Humans ; Polyurethanes ; Nanofibers/chemistry ; Pulse Wave Analysis ; Radial Artery/physiology
    Chemical Substances Polyurethanes ; ecoflex
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23073717
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Predicting the prognosis of operable gastric cancer patients by dynamic changes in platelets before and after surgery: a retrospective cohort study.

    Li, Jiante / Yang, Xinxin / Wang, Xiang / Jiang, Yiwei / Wang, Zhonglin / Shen, Xian / Li, Zhaoshen

    Journal of cancer research and clinical oncology

    2023  Volume 149, Issue 17, Page(s) 15479–15487

    Abstract: Purpose: Since the relationship between postoperative platelet count and prognosis is still unclear, we designed a standardized index of platelet count to predict the prognosis of gastric cancer (GC).: Methods: We designed a development validation ... ...

    Abstract Purpose: Since the relationship between postoperative platelet count and prognosis is still unclear, we designed a standardized index of platelet count to predict the prognosis of gastric cancer (GC).
    Methods: We designed a development validation cohort for the pre/post platelet ratio. We determined the ability of PPR to predict mortality in gastric cancer patients and validated them by a separate cohort. Survival was assessed by Kaplan-Meier analysis and associations explored by multivariate and multivariate analyses. The usefulness of the prediction was estimated by measuring the time-dependent ROC. Decision-curve analysis was used to validate the net clinical benefit.
    Results: The sample distribution was similar in the two cohorts, and the 1-, 3-, and 5-year OS evaluation of the postoperative/preoperative platelet ratio was the largest for AUC in the two cohorts. Meanwhile, PPR has a good predictive value and a net clinical benefit.
    Conclusions: PPR has been identified and validated to be independently concerned about OS of patients with GC and was a reliable and economic indicator to evaluate the prognosis.
    MeSH term(s) Humans ; Stomach Neoplasms/surgery ; Retrospective Studies ; Prognosis ; Blood Platelets ; Platelet Count
    Language English
    Publishing date 2023-08-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-05334-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: 1,6-Hydride Transfer-Enabled [6 + 1] Annulation to Access Polycyclic 3,4-Fused Azepinoindoles.

    An, Xiao-De / Wang, Zhonglin / Shen, Yao-Bin / Qiu, Bin / Xiao, Jian

    The Journal of organic chemistry

    2023  Volume 88, Issue 13, Page(s) 8791–8801

    Abstract: A [6 + 1] annulation reaction via cascade 1,6-hydride transfer/cyclization is reported to construct a polycyclic 3,4-fused azepinoindole skeleton. The newly designed 4-amino-indole-3-carbaldehyde is applied as a novel six-atom synthon, interacting with ... ...

    Abstract A [6 + 1] annulation reaction via cascade 1,6-hydride transfer/cyclization is reported to construct a polycyclic 3,4-fused azepinoindole skeleton. The newly designed 4-amino-indole-3-carbaldehyde is applied as a novel six-atom synthon, interacting with arylamines and malononitrile to achieve the [6 + 1] annulation. Notably, the reaction proceeds smoothly under redox-neutral and metal-free conditions, providing a wide range of azepinoindoles in up to 94% yields, with water as the only byproduct. Besides, the advantage of high step- and atom-economy further highlights the practicality of this methodology.
    MeSH term(s) Catalysis ; Cyclization ; Oxidation-Reduction ; Palladium
    Chemical Substances Palladium (5TWQ1V240M)
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c00631
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Primary and Acquired Resistance against Immune Check Inhibitors in Non-Small Cell Lung Cancer.

    Sun, Qinying / Wei, Xiangzhen / Wang, Zhonglin / Zhu, Yan / Zhao, Weiying / Dong, Yuchao

    Cancers

    2022  Volume 14, Issue 14

    Abstract: Immune checkpoint inhibitors have emerged as the treatment landscape of advanced non-small cell lung cancer (NSCLC) in recent years. However, approximately 80% of NSCLC patients do not benefit from ICIs due to primary resistance (no initial response) or ... ...

    Abstract Immune checkpoint inhibitors have emerged as the treatment landscape of advanced non-small cell lung cancer (NSCLC) in recent years. However, approximately 80% of NSCLC patients do not benefit from ICIs due to primary resistance (no initial response) or acquired resistance (tumor relapse after an initial response). In this review, we highlight the mechanisms of primary and secondary resistance. Furthermore, we provide a future direction of the potential predictive biomarkers and the tumor microenvironmental landscape and suggest treatment strategies to overcome these mechanisms.
    Language English
    Publishing date 2022-07-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14143294
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top