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Article ; Online: Interleukin 32 participates in cardiomyocyte-induced oxidative stress, inflammation and apoptosis during hypoxia/reoxygenation via the NOD2/NOX2/MAPK signaling pathway.

Li, Yuanyuan / Wang, Zhongyan

2022 Volume 24, Issue 3, Page(s) 567

Abstract: Although reperfusion of the ischemic myocardium has been used as a vital treatment of various patients with cardiovascular disease, the accompanying myocardial ischemia-reperfusion injury (MIRI) can cause further damage, resulting in a poor prognosis. ... ...

Abstract	Although reperfusion of the ischemic myocardium has been used as a vital treatment of various patients with cardiovascular disease, the accompanying myocardial ischemia-reperfusion injury (MIRI) can cause further damage, resulting in a poor prognosis. The present study aimed to explore the roles and regulatory mechanisms of interleukin (IL)-32, a pro-inflammatory cytokine, in MIRI. Cardiomyocytes were subjected to hypoxia and reoxygenation (H/R) to mimic MIRI. The effects of IL-32 on oxidative stress, inflammation and apoptosis of H/R-treated cells were assessed. Given that the nucleotide-binding oligomerization domain 2 (NOD2) and NADPH oxidase 2 (NOX2) play roles in the inflammatory response and myocardial ischemia, the role of this regulatory axis in the function of IL-32 was evaluated. The results indicated that IL-32 levels were elevated following H/R treatment. Downregulation of IL-32 expression attenuated H/R-induced reduction in cell viability, LDH release, oxidative stress, inflammation and apoptosis. Moreover, downregulation of IL-32 expression reversed the activation of the NOD2/NOX2/MAPK signaling pathway caused by H/R treatment. NOD2 overexpression altered the effects of the downregulation of IL-32 expression on the cells, indicating that this regulatory axis mediated the function of IL-32. Collectively, the data indicated that IL-32 participated in the induction of oxidative stress, inflammation, and apoptosis in cardiomyocytes during H/R treatment via the NOD2/NOX2/MAPK signaling pathway.
Language	English
Publishing date	2022-07-12
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2022.11504
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Alterations in Human Hippocampus Subregions across the Lifespan: Reflections on White Matter Structure and Functional Connectivity.

Tan, Jianling / Wang, Zhongyan / Tang, Yi / Tian, Yin

Neural plasticity

2023 Volume 2023, Page(s) 7948140

Abstract: During growth and aging, the role of the hippocampus in memory depends on its interactions with related brain regions. Particularly, two subregions, anterior hippocampus (aHipp) and posterior hippocampus (pHipp), play different and critical roles in ... ...

Abstract	During growth and aging, the role of the hippocampus in memory depends on its interactions with related brain regions. Particularly, two subregions, anterior hippocampus (aHipp) and posterior hippocampus (pHipp), play different and critical roles in memory processing. However, age-related changes of hippocampus subregions on structure and function are still unclear. Here, we investigated age-related structural and functional characteristics of 106 participants (7-85 years old) in resting state based on fractional anisotropy (FA) and functional connectivity (FC) in aHipp and pHipp in the lifespan. The correlation between FA and FC was also explored to identify the coupling. Furthermore, the Wechsler Abbreviated Scale of Intelligence (WASI) was used to explore the relationship between cognitive ability and hippocampal changes. Results showed that there was functional separation and integration in aHipp and pHipp, and the number of functional connections in pHipp was more than that in aHipp across the lifespan. The age-related FC changes showed four different trends (U-shaped/inverted U-shaped/linear upward/linear downward). And around the age of 40 was a critical period for transformation. Then, FA analyses indicated that all effects of age on the hippocampal structures were nonlinear, and the white matter integrity of pHipp was higher than that of aHipp. In the functional-structural coupling, we found that the age-related FA of the right aHipp (aHipp.R) was negatively related to the FC. Finally, through the WASI, we found that the age-related FA of the left aHipp (aHipp.L) was positively correlated with verbal IQ (VERB) and vocabulary comprehension (VOCAB.T), the FA of aHipp.R was only positively correlated with VERB, and the FA of the left pHipp (pHipp.L) was only positively correlated with VOCAB.T. These FC and FA results supported that age-related normal memory changes were closely related to the hippocampus subregions. We also provided empirical evidence that memory ability was altered with the hippocampus, and its efficiency tended to decline after age 40.
MeSH term(s)	Humans ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; White Matter/diagnostic imaging ; Longevity ; Magnetic Resonance Imaging ; Hippocampus/diagnostic imaging ; Brain
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1454938-4
ISSN	1687-5443 ; 2090-5904 ; 0792-8483
ISSN (online)	1687-5443
ISSN	2090-5904 ; 0792-8483
DOI	10.1155/2023/7948140
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Article ; Online: Improving performance of human action intent recognition: Analysis of gait recognition machine learning algorithms and optimal combination with inertial measurement units.

Liu, Yifan / Liu, Xing / Wang, Zhongyan / Yang, Xu / Wang, Xingjun

Computers in biology and medicine

2023 Volume 163, Page(s) 107192

Abstract: Human action intent recognition has become increasingly dependent on computational accuracy, real-time responsiveness, and model lightness. Model selection, data filtering, and experimental design are three critical factors for the recognition of human ... ...

Abstract	Human action intent recognition has become increasingly dependent on computational accuracy, real-time responsiveness, and model lightness. Model selection, data filtering, and experimental design are three critical factors for the recognition of human intention in research. However, the performance of machine learning algorithms can vary depending on factors such as sensor location, the number of sensors used, channel selection, and dimensional combinations. Moreover, the collection of adequate and balanced data in such scenarios can be challenging. To address this issue, we present a comparative analysis of 12 commonly used machine learning algorithms for human action intention recognition. The synthetic minority oversampling technique is applied to fill in missing data. Traversing all possible combinations would require conducting 686 experiments, which is a daunting task in terms of both cost and efficiency. To tackle this challenge, we employ an orthogonal experiment design based on the Quasi-horizontal method. Our analysis indicates that lightGBM outperforms other algorithms in recognizing eight human daily activities. Furthermore, we conduct a polar difference and variance analysis based on a comprehensive balanced multi-metric orthogonal experiment for lightGBM using various sensor combinations and dimensions. The optimal combinations of different sensor numbers in terms of position, channel, and dimension are derived using this approach. Notably, our experimental design reduces the number of experiments required to only 49 times.
MeSH term(s)	Humans ; Intention ; Gait ; Algorithms ; Activities of Daily Living ; Machine Learning
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2023.107192
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The histidine phosphatase LHPP of

Wang, Zhongyan / Zhang, Yueling / Aweya, Jude Juventus / Lin, Zhongyang / Yao, Defu / Zheng, Zhihong

Fish and shellfish immunology reports

2023 Volume 5, Page(s) 100109

Abstract: LHPP (Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase) is a protein histidine phosphatase that modulates a hidden posttranslational modification called histidine phosphorylation. LHPP also acts as a tumor suppressor, which plays a ... ...

Abstract	LHPP (Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase) is a protein histidine phosphatase that modulates a hidden posttranslational modification called histidine phosphorylation. LHPP also acts as a tumor suppressor, which plays a pivotal role in various cellular processes. However, whether LHPP participates in the regulation of invertebrate's immunity is still unknown. Here we characterized a LHPP homolog in
Language	English
Publishing date	2023-06-26
Publishing country	England
Document type	Journal Article
ISSN	2667-0119
ISSN (online)	2667-0119
DOI	10.1016/j.fsirep.2023.100109
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Article ; Online: Achieving higher hierarchical structures by cooperative assembly of tripeptides with reverse sequences.

Wang, Zhongyan / Shang, Yuna / Luo, Hongjing / Yang, Cuihong / Yang, Zhimou / Ren, Chunhua / Liu, Jianfeng

Nanoscale

2023 Volume 15, Issue 16, Page(s) 7502–7509

Abstract: Hierarchical self-assembly based on peptides in nature is a multi-component interaction process, providing a broad platform for various bionanotechnological applications. However, the study of controlling the hierarchical structure ... ...

Abstract	Hierarchical self-assembly based on peptides in nature is a multi-component interaction process, providing a broad platform for various bionanotechnological applications. However, the study of controlling the hierarchical structure transformation
MeSH term(s)	Nanotubes, Carbon ; Peptides/chemistry ; Nanofibers/chemistry ; Nanospheres ; Protein Structure, Secondary
Chemical Substances	Nanotubes, Carbon ; Peptides
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr00983a
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Article ; Online: Fast-Response Nickel-Promoted Indium Oxide Catalysts for Carbon Dioxide Hydrogenation from Intermittent Solar Hydrogen.

Li, Xianghong / Zhang, Peng / Yang, Chengsheng / Wang, Zhongyan / Song, Xiwen / Wang, Tuo / Gong, Jinlong

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 34, Page(s) e202301901

Abstract: Construction of a "net-zero-emission" system through ... ...

Abstract	Construction of a "net-zero-emission" system through CO
Language	English
Publishing date	2023-07-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202301901
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Article ; Online: An enzyme-instructed self-assembly system induces tumor acidosis via sequential-dual effect for cancer selective therapy.

Zhang, Hao / Wang, Zhilong / Gao, Tongxin / Wang, Zhongyan / Ren, Chunhua / Liu, Jianfeng

Acta biomaterialia

2023 Volume 164, Page(s) 447–457

Abstract: The acidosis anti-tumor therapy, based on the altered energy metabolism pathway of tumor cells, has been proposed as an attractive method for cancer selective treatment. However, the strategy of inducing tumor acidosis by using a single drug to ... ...

Abstract	The acidosis anti-tumor therapy, based on the altered energy metabolism pathway of tumor cells, has been proposed as an attractive method for cancer selective treatment. However, the strategy of inducing tumor acidosis by using a single drug to simultaneously inhibit both lactate efflux and consumption has not been reported yet. Herein, an in situ enzyme-instructed self-assembly (EISA) system was rationally fabricated to induce tumor acidosis apoptosis for cancer selective therapy. Depending on the sequential effect of the in situ EISA system, the targeted drug was successively distributed on the membrane and intracellular, inhibiting MCT4 mediated lactate efflux and mitochondrial tricarboxylic acid (TCA) cycle mediated lactate consumption, respectively. Through the dual obstruction of lactate metabolism to trigger tumor acidosis, the in situ EISA nanomedicine showed selective growth and migration inhibition against cancer cells. In addition, the nanomedicine also displayed a radio-sensitization effect in vitro due to causing the mitochondrial dysfunction, and exhibited a prominent synergistic chemo-radiotherapy anti-tumor performance in vivo. Accordingly, this work demonstrated that the in situ EISA system could endow the LND with sequential-dual effects to induce tumor acidosis, which may provide an enlightening strategy for anticancer drug delivery and cancer selective therapy. STATEMENT OF SIGNIFICANCE: With the help of the sequential effect of in situ EISA , the serial attack of LND against different targets was effectively realized to induce tumor acidosis and combined chemo-radiotherapy, implying the importance of the relationship between structure and function, which could offer a distinctive inspiration for future drug delivery system design and anti-tumor application.
MeSH term(s)	Humans ; Antineoplastic Agents/pharmacology ; Neoplasms/drug therapy ; Neoplasms/pathology ; Apoptosis ; Lactates/pharmacology ; Lactates/therapeutic use ; Acidosis/drug therapy ; Cell Line, Tumor
Chemical Substances	Antineoplastic Agents ; Lactates
Language	English
Publishing date	2023-03-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2023.03.036
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Article ; Online: Mitochondrial Localized In Situ Self-Assembly Reprogramming Tumor Immune and Metabolic Microenvironment for Enhanced Cancer Therapy.

Wang, Zhilong / Wang, Qian / Cao, Hongmei / Wang, Zhongyan / Wang, Dianyu / Liu, Jinjian / Gao, Tongxin / Ren, Chunhua / Liu, Jianfeng

Advanced materials (Deerfield Beach, Fla.)

2024 Volume 36, Issue 15, Page(s) e2311043

Abstract: The inherent immune and metabolic tumor microenvironment (TME) of most solid tumors adversely affect the antitumor efficacy of various treatments, which is an urgent issue to be solved in clinical cancer therapy. In this study, a mitochondrial localized ... ...

Abstract	The inherent immune and metabolic tumor microenvironment (TME) of most solid tumors adversely affect the antitumor efficacy of various treatments, which is an urgent issue to be solved in clinical cancer therapy. In this study, a mitochondrial localized in situ self-assembly system is constructed to remodel the TME by improving immunogenicity and disrupting the metabolic plasticity of cancer cells. The peptide-based drug delivery system can be pre-assembled into nanomicelles in vitro and form functional nanofibers on mitochondria through a cascade-responsive process involving reductive release, targeted enrichment, and in situ self-assembly. The organelle-specific in situ self-assemblyeffectively switches the role of mitophagy from pro-survival to pro-death, which finally induces intense endoplasmic reticulum stress and atypical type II immunogenic cell death. Disintegration of the mitochondrial ultrastructure also impedes the metabolic plasticity of tumor cells, which greatly promotes the immunosuppresive TME remodeling into an immunostimulatory TME. Ultimately, the mitochondrial localized in situ self-assembly system effectively suppresses tumor metastases, and converts cold tumors into hot tumors with enhanced sensitivity to radiotherapy and immune checkpoint blockade therapy. This study offers a universal strategy for spatiotemporally controlling supramolecular self-assembly on sub-organelles to determine cancer cell fate and enhance cancer therapy.
MeSH term(s)	Humans ; Mitochondria ; Neoplasms/drug therapy ; Cell Differentiation ; Drug Delivery Systems ; Immunogenic Cell Death ; Tumor Microenvironment ; Cell Line, Tumor ; Immunotherapy
Language	English
Publishing date	2024-01-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202311043
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Article: Evaluation and optimization of blends for attracting Trichogramma dendrolimi based on semiochemicals mediating tritrophic interactions in the orchard habitat

Zhao, Jinhao / Liang, Minmin / Wang, Zhongyan / Zhao, Yanyan / Cheng, Jingli / Du, Yongjun

Biological control. 2022 Oct., v. 173

2022

Abstract: Trichogramma dendrolimi Matsumura (Hymenoptera: Trichogrammatidae) is one of the most important parasitic natural enemies of Grapholita molesta (Busck) (Lepidoptera: Tortricidae) in peach and pear orchards. The artificial rearing T. dendrolimi have been ... ...

Abstract	Trichogramma dendrolimi Matsumura (Hymenoptera: Trichogrammatidae) is one of the most important parasitic natural enemies of Grapholita molesta (Busck) (Lepidoptera: Tortricidae) in peach and pear orchards. The artificial rearing T. dendrolimi have been widely used in biological control programs in recent years. However, its actual parasitic effect on the pest in the field is less, so it is important to develop attractants to increase the parasitic efficiency of the parasitoids. T. dendrolimi can be easily attracted by semiochemicals derived from flowers, intact plants, herbivore-attacked plants, and insects in its orchard habitats. In this paper, 73 semiochemicals were evaluated as potential attractants at three concentrations (0.1 mg/mL, 1 mg/mL, and 10 mg/mL) to T. dendrolimi by Y-tube olfactometer bioassays and Electroantennogram (EAG) technology, and then the mixtures of active individual compounds were further tested and evaluated in the field. As a result, 17 individual compounds showed attractive bioactivity to T. dendrolimi. Interestingly, when methyl salicylate and benzaldehyde mixed with linalool oxide or cis-3-hexenyl caproate in a volume ratio of 10:3:3 respectively showed excellent attractant bioactivity for T. dendrolimi in the orchard field. Thus, introducing such parasitoid attractants in orchard habitat may improve the biological control effect to pests.
Keywords	Grapholita molesta ; Trichogramma dendrolimi ; attractants ; benzaldehyde ; bioactive properties ; biological control ; electroantennography ; habitats ; hexanoic acid ; linalool ; methyl salicylate ; olfactometers ; orchards ; parasitoids ; peaches ; pears ; semiochemicals
Language	English
Dates of publication	2022-10
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1149971-0
ISSN	1049-9644
ISSN	1049-9644
DOI	10.1016/j.biocontrol.2022.104998
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inkjet printing-based fabrication of microscale 3D ice structures.

Zheng, Fengyi / Wang, Zhongyan / Huang, Jiasheng / Li, Zhihong

Microsystems & nanoengineering

2020 Volume 6, Page(s) 89

Abstract: This study proposed a method for fabricating 3D microstructures of ice without a supporting material. The inkjet printing process was performed in a low humidity environment to precisely control the growth direction of the ice crystals. In the printing ... ...

Abstract	This study proposed a method for fabricating 3D microstructures of ice without a supporting material. The inkjet printing process was performed in a low humidity environment to precisely control the growth direction of the ice crystals. In the printing process, water droplets (volume = hundreds of picoliters) were deposited onto the previously formed ice structure, after which they immediately froze. Different 3D structures (maximum height = 2000 µm) could be formed by controlling the substrate temperature, ejection frequency and droplet size. The growth direction was dependent on the landing point of the droplet on the previously formed ice structure; thus, 3D structures could be created with high degrees of freedom.
Language	English
Publishing date	2020-10-19
Publishing country	England
Document type	Journal Article
ISSN	2055-7434
ISSN (online)	2055-7434
DOI	10.1038/s41378-020-00199-x
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